Presentation
Hobnail cells are present; however they do not exhibit stromal invasion. hemorrhage is repeatedly associated with this malignant transformation. [file.scirp.org]
Women typically present between the ages of 40 and 70 with the peak incidence at age 52. Between 1/3 and 2/3 are nulliparous. Presenting symptoms are usually related to an enlarging abdominal mass. [path.upmc.edu]
Case 3 A 48 years old, P5L5, postmenopausal since 9 months, a known case of carcinoma ovary presented with abdominal pain since 15 days. [casereports.in]
No cancer cells are present in the abdomen IIB: Cancer is present in one or both of the ovaries and has spread to other pelvic organs, such as the bladder, colon, or rectum IIC: Cancer is present in one or both ovaries, and it has spread to the pelvic [dovemed.com]
A recently published case series describes bone metastases via hematogenous spread at initial presentation. [hindawi.com]
Entire Body System
- Goiter
[…] endometrium (95% CI, 17.1%–39.3%), and 9% for colon (95% CI, 3.8%–14.1%).3,5,6 Other CS-associated features include Lhermitte-Duclos disease; hamartomatous polyposis; and noncancer manifestations, such as autism and benign thyroid lesions (eg, multinodular goiter [jnccn.org]
クルック変性:Crooke change ◎ 下垂体腺腫 :pituitary adenoma GH産生,PRL産生,ACTH産生,非機能性 頭蓋咽頭種:craniopharyngioma ラトケ裂嚢胞:Rathoke's cleft cyst 2)甲状腺 ◎橋本甲状腺:Hashimoto's disease ◎Graves' disease(Basedow病) ◎亜急性甲状腺炎:subacute thyroiditis ◎腺腫様(結節性)甲状腺種:adenomatous (nodular) goiter [medical-e.net]
Urogenital
- Adnexal Mass
The tumors on MRI were classified into two categories: (a) “cystic adnexal mass with solid protrusions” in 12 (57%) and (b) “solid adnexal mass with cystic areas or necrosis” in 9 (43%). [journals.plos.org]
Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. Página 46 - Kelly, SJ (1977). [books.google.es]
Adnexal masses with the most complex morphology were included in the study. [clinicaladvisor.com]
At the time of surgery, a 6.0-cm partially cystic right adnexal mass was noted. A frozen section was performed, and a stromal ovarian tumor was considered. [archivesofpathology.org]
Intra-operatively, there was a presence of right adnexal tumor adhered to appendix and omentum. Right adnexal mass was sent for frozen section. Diagnosis of adult granulosa cell tumor (AGCT) was given. [jmidlifehealth.org]
- Pelvic Pain
Patients are often diagnosed in early stages and usually present with pelvic pain and pressure, an abdominal mass and/or gastrointestinal problems, such as early satiety or bloating. Association with Lynch syndrome has been reported. [orpha.net]
These include, among others: abdominal distension, pelvic pain, ascites, and dysuria [15–17]. Chronic and especially severe endometriosis may also have this characteristic pelvic pain making it a part of our differential diagnosis [18]. [ncbi.nlm.nih.gov]
Furthermore, this disease is typically associated with painful symptoms, dysmenorrhea, dyspareunia, pelvic pain, infertility, and malignant transformation [2]. [file.scirp.org]
Clinical manifestations commonly include abdominal and pelvic pain with bloating, distention, urinary urgency and frequency, and unintended weight loss in the presence of tenderness to palpation and an adnexal mass on bimanual examination. [hindawi.com]
- Salpingitis
◎アデノマトイド腫瘍:adenomatoid tumor ◎悪性中胚葉性混合腫瘍:malignant mixed mesodermal tumor 5)胎盤 ◎胞状奇胎(全・部分):hydatidiform mole (total/pertial) ◎侵入(破壊)胞状奇胎:invasive (destructive) hydatidiform mole 絨毛癌:choriocarcinoma Placental site trophoblastic tumor (PSTT) 6)卵管 卵管炎:salpingitis [medical-e.net]
Workup
Ultrasound
- Ovarian Mass
At the time of the exploratory laparotomy, the whole lower abdomen was filled with bilateral ovarian masses, slightly larger on the left. Right ovarian mass was cystic with intact capsule. [ijp.iranpath.org]
We describe here a 52-year-old postmenopausal woman with an ovarian clear cell cystadenofibroma that was misdiagnosed before surgery as a borderline malignant cystic mass of the ovary. The ovarian mass had cystic and solid components. [dbpia.co.kr]
CT Typically seen as a large unilocular, mainly cystic, smooth marginated mass with lumen protruding solid portion and high-attenuated cystic portion 5. MRI Often seen as a cystic ovarian mass with the margin being generally smooth. [radiopaedia.org]
The characterization of an ovarian mass is of the utmost importance in the preoperative evaluation of an ovarian neoplasm because it enables the surgeon to anticipate an ovarian carcinoma or predict the type of ovarian carcinoma prior to surgery so that [journals.plos.org]
In most cases, the ovarian mass was detected after the diagnosis of the renal tumor [ 3 ]. However, our case presented as a clear cell RCC with simultaneous ovarian metastasis. [npplweb.com]
Treatment
For stage II to IV, adjuvant treatment may have similar options like those given to treat epithelial ovarian cancer. (See Guide 8 on page 54 for possible treatment options). [nccn.org]
[…] evaluating innovative treatment strategies. [texasoncology.com]
When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. [my.clevelandclinic.org]
Lead researcher: Professor Iain McNeish Location: University of Glasgow Research strand: Treatment This project is looking at developing new treatments for ovarian clear cell carcinoma, a rare subtype of ovarian cancer. [targetovariancancer.org.uk]
Prognosis
In some studies, the prognosis appears similar to that for other ovarian carcinomas, but in others, the prognosis is said to be worse. [ovariancancer.jhmi.edu]
Clear cell epithelial ovarian cancer (mesonephroid): bad prognosis only in early stages. Gynecol Oncol.1993;49:250-254. Sugawa T, Umesaki N, Yajima A, Satoh S, Terashima Y, Ochiai K, et al. A group study on prognosis of ovarian cancer. [casereports.in]
Women with stage IA disease have an excellent prognosis. [ncbi.nlm.nih.gov]
Etiology
This chapter will discuss the basic terms associated with neoplasia, features used to distinguish benign neoplasms from malignant neoplasms, epidemiology and etiology of neoplasms, effects of tumors (including paraneoplastic syndromes), basic carcinogenesis [accessmedicine.mhmedical.com]
They classify the cutaneous manifestations into two etiological groups: immunologically mediated conditions; and conditions resulting from the complications of CD. [ncbi.nlm.nih.gov]
Right ovary showed heterogeneously enhancing adnexal lesion likely to be of malignant etiology. Serum CA-125 level was normal. [npplweb.com]
"Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression". Mod Pathol. 28 (1): 14–29. doi:10.1038/modpathol.2014.81. PMC 4265316. [en.wikipedia.org]
Epidemiology
This chapter will discuss the basic terms associated with neoplasia, features used to distinguish benign neoplasms from malignant neoplasms, epidemiology and etiology of neoplasms, effects of tumors (including paraneoplastic syndromes), basic carcinogenesis [accessmedicine.mhmedical.com]
Epidemiologie – Epidemiology is the study and analysis of the patterns, causes, and effects of health and disease conditions in defined populations. [wikivisually.com]
[현재위치]: 홈> 임상의학> 부인과학> 여성생식기의 종양> 상피성 난소종양 상피성 난소종양 역학(疫學, Epidemiology) 난소종양의 분류 상피종양 (common epithelial tumors) 장액성 종양 (Serous tumor) 양성 경계성 종양 (borderline malignancy) 악성 선암 (adenocarcinoma), 유두상선암 (papillary adenocarcinoma)과 유두상 낭선암 (papillary cystadenocarcinoma [clinicclinic2.cafe24.com]
General Prognosis: Worse prognosis versus other surface epithelial tumours. [1] Poor response to platinum-based chemotherapy. [2] ~2.5x risk for thromboembolism compared to other ovarian carcinomas. [3] Epidemiology: Asians appear to be at an increased [librepathology.org]
This assumes epidemiological relevance because mucinous cystadenocarcinomas have not been found in intimate association with endometriosis, which is frequently found with other ovarian neoplasms such as endometrioid and clear cell carcinomas.3,8,9 No [jcp.bmj.com]
Pathophysiology
Endometriosis and ovarian cancer: thoughts on shared pathophysiology. Am J Obstet Gynecol. 2003;189:280–94. [PubMed] [Google Scholar] 17. Wiegand KC, Shah SP, Al-Agha OM, Zhao Y, Tse K, Zeng T, et al. [ncbi.nlm.nih.gov]
Prevention
Opportunistic salpingectomy: uptake, risks, and complications of a regional initiative for ovarian cancer prevention. Am J Obstet Gynecol. 2014;210(471):e1–e11. 84. Salpingectomy for ovarian cancer prevention. Committee Opinion No 620. [dovepress.com]
You Should Know Anatomy Prevention Risk Factors Genetics Screening CA 125 Symptoms Early Detection Diagnosis Radiology Pathologists Staging Treatment Recurrent Disease Recurrent Q & A Nutrition Prognosis Clinical Trials Glossary Discussion Board Questions [ovariancancer.jhmi.edu]
There is no evidence as yet for any maintenance chemotherapy to prevent or delay relapse. NICE guidelines recommend paclitaxel or PLD for recurrent disease but not alternatives gemcitabine, trabectedin or topotecan [ 23 ]. [patient.info]
These aggressive treatments prevent the cancer from moving to nearby organs. They also cause infertility. These rare subtypes may be unique among the other ovarian cancers. [healthline.com]
BRCA genes are involved with repairing damaged DNA and normally work to prevent tumor development. [texasoncology.com]