Presentation
It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. [books.google.com]
Abstract A 53-year-old woman presented with hirsutism of long duration and virilization of recent onset. She was gravida 12 para 9. [ncbi.nlm.nih.gov]
In this article, we present the first published cases of the magnetic resonance imaging appearance of these conditions, which may mimic that of ovarian neoplasm. [dx.doi.org]
Entire Body System
- Galactorrhea
She had no symptoms of easy bruisability, moon facies, galactorrhea, headaches or visual changes. She has been hypertensive for more than 20 years, and has had several emergency room consults over the last 5 years due to hypertensive urgency. [asean-endocrinejournal.org]
Skin
- Hirsutism
CASE: A postmenopausal woman sought treatment for progressive hirsutism. Endocrine evaluation revealed androgen excess. Transvaginal ultrasound revealed enlarged ovaries. Hysterectomy and bilateral oophorectomy were recommended. [jhu.pure.elsevier.com]
A score of 8 to 15 is classified as mild hirsutism, while moderate hirsutism is a score greater than 15. This patient had severe hirsutism with virilizing signs. Therefore, it was not necessary to grade her level of hirsutism. [arcfertility.com]
Abstract A 53-year-old woman presented with hirsutism of long duration and virilization of recent onset. She was gravida 12 para 9. [ncbi.nlm.nih.gov]
Aquino, A simplified questionnaire for self-assessment of hirsutism in population-based studies, European Journal of Endocrinology, 172, 4, (451), (2015). [doi.org]
Differential Diagnosis Idiopathic hirsutism Idiopathic hirsutism is defined as hirsutism in a woman with regular, ovulatory menstrual cycles. [what-when-how.com]
- Erythema
CMV Parvovirus affects preschoolers and mothers in kids it causes fifth disease, erythema infectiosum pregnant woman can transmit it to fetus fever, cough, sore throat in mother. [quizlet.com]
Neurologic
- Headache
Clinical evidence shows that chasteberry can alleviate PMS symptoms such as depression, rashes, acne, allergies and headache. [bionova.co.in]
She had no symptoms of easy bruisability, moon facies, galactorrhea, headaches or visual changes. She has been hypertensive for more than 20 years, and has had several emergency room consults over the last 5 years due to hypertensive urgency. [asean-endocrinejournal.org]
The most common side effects of clomiphene include vasomotor symptoms (20%), ad-nexal tenderness (5%), nausea (3%), headache (1%), and, rarely, blurring of vision or scotomata. [what-when-how.com]
- Confusion
Clinical behavior This condition may be confused clinically with an ovarian neoplasm. It has no malignant potential. Most patients have been treated by oophorectomy but conservative management has been advocated for young patients. [med-ed.virginia.edu]
Histopathology 2001 May;38(5):403-8 Abstract quote AIMS: Ovarian sex cord-stromal tumours are a heterogeneous group of neoplasms which may be confused morphologically with a wide variety of tumours. [thedoctorsdoctor.com]
As a result, some juvenile granulosa cell tumors have a highly malignant appearance microscopically and are sometimes confused with yolk sac tumors or embryonal carcinomas by inexperienced pathologists. [glowm.com]
Urogenital
- Adnexal Mass
A transvaginal ultrasound revealed bilateral solid adnexal masses, likely to be ovarian in nature, although no normal ovarian tissue was identified. [endocrine-abstracts.org]
Nonetheless, a small painless mobile firm and solid left adnexal mass was detected in the bimanual pelvic examination. Pelvic sonography also showed enlarged left ovary (40 mm × 21 mm) without visible mass. [mjdrdypu.org]
Transvaginal ultrasound showed a normal uterus with endometrial thickness of 5 mm and no adnexal masses. Figure 1. Facial features of the patient with frontal balding and prominent facial hair requiring regular shaving Questions: 1. [hkmj.org]
Local genital examination showed mild clitoromegaly; per speculum examination showed healthy cervix and vagina; on bimanual examination the uterus was normal in size with no palpable adnexal mass. [jpgo.org]
Doppler examination of the left adnexal mass showed rich intratumoral vascularity on color flow mapping with high resistance wave pattern, suggestive of a benign nature (B). Click here to download Figure 4 Figure 4. [asean-endocrinejournal.org]
- Oligomenorrhea
The usual clinical presentation is a young woman (between 15 and 30 years) with secondary amenorrhea, oligomenorrhea or irregular menses, infertility and hirsutism. About 50% exhibit virilism and 40% are obese. [med-ed.virginia.edu]
Conclusion Steroid cell tumors of the ovary form a rare entity that can cause symptoms of virilization, isosexual precocity, oligomenorrhea or amenorrhea and postmenopausal bleeding. [omicsonline.org]
It is clinically characterized by anovulation, oligomenorrhea and hyperandrogenism, and polycystic ovary on ultrasound imaging ( 2 ). [journal.frontiersin.org]
Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. J Clin Endocrinol Metab. 2004;89:2114-8. Apridonidze T, Essah PA, Iuorno MJ, Nestler JE. [har-journal.com]
Fewer than 5% of the patients are younger than the age of normal puberty, and approximately three quarters of these children exhibit isosexual pseudoprecocity. 4 In adult patients, menstrual disturbances such as menometrorrhagia, oligomenorrhea, and amenorrhea [glowm.com]
- Ovarian Disorder
Albert Altchek, Liane Deligdisch, Nathan Kase Elsevier, ٠٤/٠٩/٢٠٠٣ - 568 من الصفحات This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders [books.google.com]
Young and Scully´s 1979 classification of ovarian tumors with endocrine manifestations ( Figure 1 ) includes sex-cord stromal tumors, steroid-cell tumors and other ovarian disorders with endocrine function. [omicsonline.org]
Workup
Further workup with transvaginal ultrasonography showed a thickened, hyperechoic endometrium (0.72 cm) at the upper half of the uterus, with minimal intracavitary fluid. The lower endometrium measured 0.37cm. [asean-endocrinejournal.org]
Ultrasound
- Ovarian Mass
At initial MR imaging, the central areas of the bilateral ovarian masses showed hypointensity on T1-weighted images and hyperintensity on T2-weighted images, while the peripheries of the bilateral masses showed isointensity to myometrium on T1-weighted [ncbi.nlm.nih.gov]
Here, we report a case of a 55-year-old woman who referred to our center due to incidental finding of left ovarian mass in pelvic sonography. [mjdrdypu.org]
CT of the abdomen and pelvis did not show an adrenal or ovarian mass. [healio.com]
Hysterectomy with removal of both ovaries was discussed with the patient because of the presence of bilateral ovarian masses, which required diagnosis and treatment. [arcfertility.com]
Most ovarian hemangiomas are of the cavernous type and they may present either as an isolated ovarian mass, usually discovered incidentally, or in conjunction with diffuse abdominopelvic hemangiomatosis 1 - 3. [turkjpath.org]
Treatment
3 months of treatment. c After 13 months of treatment. d After 8 months of treatment. [dx.doi.org]
Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. [books.google.com]
CASE: A postmenopausal woman sought treatment for progressive hirsutism. Endocrine evaluation revealed androgen excess. Transvaginal ultrasound revealed enlarged ovaries. Hysterectomy and bilateral oophorectomy were recommended. [jhu.pure.elsevier.com]
[…] for the treatment of hirsutism in PCOS. [what-when-how.com]
Prognosis
The prognosis is similar to that of the latter tumor. [glowm.com]
Treatment and prognosis postmenopausal women: bilateral oophorectomy is suggested; however, if the patient has multiple comorbidities, then long-term GnRH agonist treatment may be an option when malignancy has been excluded premenopausal women: treatment [radiopaedia.org]
TTF-1 meningioma: may be microcystic but also shows whorls: positive for EMA Brenner tumour with microcystic change Surface epithelial carcinomas with microcystic change Ovarian adenomatoid tumour: positive for calretinin and inhibin Myxoid sarcoma Prognosis [e-immunohistochemistry.info]
Prognosis is good for most SCT of the ovary, although malignancy has been reported in as high as 28.6- 43 % of cases [ 3, 25 ]. [omicsonline.org]
Etiology
Clinical, laboratory, radiologic and pathologic findings are presented, and a review of the literature pertaining to ovarian hyperthecosis and stromal Leydig cell tumor as etiologies of virilization is performed. [journals.lww.com]
There are multiple etiologies, and each etiology might also be complicated by the medical condition of insulin resistance which also tends to have some relationship to the liver "fatty liver" condition, NASH. [palpath.com]
Definition / general Hyperplastic ovarian stroma with clusters of luteinized stromal cells Epidemiology Typically seen in the 6th to 7th decade, less common in reproductive age Etiology Luteinized stromal cells produce androgens Clinical features Similar [pathologyoutlines.com]
(605) 328-8800 Abstract Hirsutism is a common problem affecting women that is usually the result of a benign etiology. [arcfertility.com]
Given the etiological role of insulin resistance and the impact of obesity on both hyperinsulinemia and hyperandrogenism, multidisciplinary lifestyle improvement aimed at normalizing insulin resistance, improving androgen status and aiding weight management [medigoo.com]
Epidemiology
Definition / general Hyperplastic ovarian stroma with clusters of luteinized stromal cells Epidemiology Typically seen in the 6th to 7th decade, less common in reproductive age Etiology Luteinized stromal cells produce androgens Clinical features Similar [pathologyoutlines.com]
Epidemiology, diagnosis and management of hirsutism: A consensus statement by the androgen excess and polycystic ovary syndrome society. Hum Reprod Update 2012; 18 (2): 146-70. doi:10.1093/humupd/dmr042 [ Links ] 10. Robert E. Scully, Robert H. [scielo.org.mx]
Epidemiology, diagnosis and management of hirsutism: A consensus statement by the androgen excess and polycystic ovary syndrome society. Hum Reprod Update 2012; 18 (2): 146-70. doi:10.1093/humupd/dmr042 Robert E. Scully, Robert H. [medigraphic.com]
One epidemiologic study that included a 30-year follow-up of women with PCOS found no increase in mortality from cardiovascular disease.66 [what-when-how.com]
J Clin Endocrinol Metab 2004, 89: 2745–49. 10.1210/jc.2003-032046 View Article PubMed Google Scholar Hull MG: Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. [ovarianresearch.biomedcentral.com]
Pathophysiology
Pathophysiology of ovarian hyperthecosis remains poorly understood but the metabolic syndrome observed in most patients suggests that insulin resistance associated with high, postmenopausal LH levels, might play a role as in polycystic ovarian syndrome [ncbi.nlm.nih.gov]
Although the exact pathophysiology is not known, disturbances in gonadotropins and reduced insulin sensitivity are known to contribute to the overproduction of androgens. [har-journal.com]
Furuya M (2012) Ovarian cancer stroma: pathophysiology and the roles in cancer development. Cancers (Basel) 4: 701-724. Roth LM, Talerman A (2006) Recent advances in the pathology and classification of ovarian germ cell tumors. [omicsonline.org]
Even though ovarian stromal hypertrophy is largely involved in the pathophysiology of PCOS [ 6 ] and it could be properly identified by vaginal endosonography [ 9 ], the acceptance of ultrasound ovarian stromal hypertrophy as a additional criterion for [ovarianresearch.biomedcentral.com]
Prevention
Multivitamins prevent multiple birth defects such as heart and limb defects, neural tube defects, urinary tract anomalies and oral facial clefts. [bionova.co.in]
PC has since, gained widespread acceptance as a method of choice for preventing OHSS and has established itself as the “standard of care”. [drgeoffreysherivf.com]
Preventive Services Task Force Reaffirmation Recommendation Statement. USPSTF [On-line information]. Available online at http://www.uspreventiveservicestaskforce.org/uspstf12/ovarian/ovarartaddend.htm. [labtestsonline.it]
The addition of an oral contraceptive prevents GnRH agonist-induced hypoestrogenism and vasomotor symptoms and preserves bone density. [what-when-how.com]
Preventative measures for PCOD are limited. Clinical management is primarily focused on treating symptoms and manifestations and preventing long-term complications. [har-journal.com]