CONCLUSIONS: This study identified the increasing use of gabapentinoids in IDO, describing the profile and overdose characteristics of presentations. [ncbi.nlm.nih.gov]

• Hypothermia

  Symptoms of alcohol poisoning include: Mental confusion Vomiting Seizures Slow breathing (fewer than 8 breaths per minute) Irregular breathing (10 seconds or more between breaths) Hypothermia, bluish skin color, paleness The most common risk factors that [addictioncenter.com]

  Hypothermia is common in patients with deep coma, especially if the victim has ... [accessmedicine.mhmedical.com]

  Part 12.9: Cardiac Arrest in Accidental Hypothermia Unintentional or accidental hypothermia is a serious and preventable health problem. [doi.org]

  hyperthermia/hypothermia). Passing out or an unresponsive loss of consciousness. Skin color changes (e.g., pallor or bluish tint to skin if a respiratory depressant was used; ruddy or flushed after cardiovascular overstimulation). [americanaddictioncenters.org]

• Congestive Heart Failure

  CASE REPORT: A 71-year-old man with atrial fibrillation, aortic valve replacement, and congestive heart failure presented to the emergency department after an intentional ingestion of 97 (1940 mg total) rivaroxaban tablets in a suicide attempt. [ncbi.nlm.nih.gov]

  Heart Failure (Baystate Incubator Fund-NON-industry, academic hospital funding) None None None None None Elizabeth Sinz Penn State Hershey Medical Center–Professor of Anesthesiology and Neurosurgery; AHA–Associate Science Editor None None None None None [doi.org]

• Fatigue

  People who become tolerant to or addicted to stimulants can also take too much of the medication in desperation if they miss a dose or feel withdrawal effects like extreme fatigue, confusion, or even psychosis. [deserthopetreatment.com]

  Weak, or thready pulse Cold, clammy skin Unconsciousness and coma Blue-tinged skin Agitation and confusion Seizures Unconsciousness Agitation and confusion Delusions Seizures Unconsciousness Paranoia Anxiety Rapid heart rate and high blood pressure Fatigue [sbtreatment.com]

  Cessation of intake after prolonged or heavy use may produce a withdrawal syndrome, with depressed mood, fatigue, sleep disturbance, and increased dreaming. [who.int]

  Some symptoms or co-morbid conditions may include unintentional weight loss, feeling helpless, feeling alone, excessive fatigue, low self-esteem, presence of consistent mania, excessively talkative, intent on previously dormant goals, feel like one's [en.wikipedia.org]

• Snoring

  Don’t ignore snoring and gurgling. Snoring and gurgling can indicate that a person is having trouble breathing. [overdoseday.com]

  It is critical not to ignore snoring, even if the person is a known snorer, or gurgling. Snoring can be an indication of breathing trouble, and any obstruction of the breathing airways can be fatal. [dualdiagnosis.org]

  the report says, and his cellmate heard him snoring that night. Staff writer Sean Emery and City News Service contributed to this story. [ocregister.com]

• Nausea

  By now there is limited clinical trial experience regarding human overdose with vortioxetine and the maximum single dose tested was 75 mg in men associated with increased rates of nausea, dizziness, diarrhea, abdominal discomfort, generalized pruritus [ncbi.nlm.nih.gov]

  Other gastrointestinal symptoms of an opiate overdose can include nausea or vomiting. A loss of appetite or spasms of the stomach or intestines may also occur with an overdose. [web.archive.org]

  Nausea and vomiting. Often a person will aspirate during an overdose, causing the body to respond by vomiting contents out of the system. [altamirarecovery.com]

  Diuretic overdose symptoms include slow breathing, confusion, drowsiness, fever, muscle cramps, skin sensitivity to sunlight, seizures, pale urine, weakness, vomiting, coma, dizziness, fainting, low blood pressure, nausea, rash, frequent urination, vision [livestrong.com]

  Opioid withdrawal symptoms may include body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goose bumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramping, weakness [narcan.com]

• Abdominal Pain

  Tamara McCorkindale had been plagued by mysterious abdominal pains for nine years but doctors were never able to establish what was wrong with her. [thesun.co.uk]

  Symptoms of liver failure include abdominal pain and yellowing of the skin, or jaundice. Some patients may exhibit changes in thinking, mood or personality. [drugrehab.com]

  pain Chest pain Rapid heartbeat Changes in breathing, such as slowed breathing or shallow, rapid breaths Convulsions Any of these symptoms can be a sign of a drug overdose. [deserthopetreatment.com]

  Signs of paracetamol overdose include drowsiness, coma, seizures, abdominal pain, nausea and vomiting. Another name for paracetamol is acetaminophen (often known by its brand name, Panadol ). [betterhealth.vic.gov.au]

  Abdominal pain, nausea, vomiting, and diarrhea are possible. Vomiting blood, or blood in bowel movements, can be life threatening. Specific drugs can damage specific organs, depending on the drug. [webmd.com]

• Acute Abdomen

  Analgesic administration to patients with an acute abdomen: a survey of emergency medicine physicians. Am J Emerg Med. 2000;18(3):250–253. PubMed CrossRef Google Scholar 46. Gerbert B, Maguire BT, Bleecker T, Coates TJ, McPhee SJ. [doi.org]

• Hypotension

  Methylene blue boluses were initiated when hypotension persisted despite conventional treatments. Refractory hypotension prompted the use of plasmapheresis in an attempt to lower serum amlodipine levels. [ncbi.nlm.nih.gov]

• Muscle Twitch

  Symptoms include restlessness, insomnia, flushed face, muscle twitching, tachycafdia, gastrointestinal disturbances including abdominal pain, pressured or rambling thought and speech, and sometimes exacerbation of pre-existing anxiety or panic states, [who.int]

• Confusion

  A 39-year-old homeless man was found confused and incoherent after ingesting an estimated total of 200 tablets of various medications. He presented to the emergency department with delirium, tachycardia, clonus and hyperthermia of 38.0 C. [ncbi.nlm.nih.gov]

  According to The New York Times Health Guide, symptoms of a beta-blocker overdose include difficulty breathing, wheezing, blurred vision, irregular heartbeat, double vision, lightheadedness, shock, heart failure, slow or rapid heartbeat, confusion, coma [livestrong.com]

  Confusion and disorientation/violent behavior. Confusion and disorientation, accompanied by severe anxiety can also exhibit signs that a person is overdosing. [altamirarecovery.com]

  They may also be confused.14 Seizures Overdose from certain drugs such as stimulants and alcohol are associated with seizure risk.5,14 If someone is experiencing a seizure, call 911 and stay with the person until medical personnel arrive. [sunrisehouse.com]

• Headache

  We present a case of a 64-year-old woman who presented with acute onset headache, bilateral tinnitus, and left-sided facial numbness and tingling in the setting of accidentally overdosing on hydroxychloroquine. [ncbi.nlm.nih.gov]

  They’re also prescribed for headaches and sleep if other medications have not worked. However, barbiturates are still misused through illicit access. Illegal use has led to overdose deaths because the medications are dangerous for self-treatment. [healthline.com]

  Signs and symptoms of an overdose may vary depending on the substance, but can include: severe headache chest pain or heart palpitations difficulty breathing confusion or paranoia seizure hallucinations or delusions heavy sweating pale or blue skin low [kidshelpphone.ca]

  Experiencing severe headache. Experiencing chest pain. Experiencing breathing difficulties. Extremely paranoid, agitated and/or confused. It is not necessary for someone to have all of these signs or symptoms for them to be overdosing. [overdoseday.com]

• Stupor

  Negative side effects from mixing these two drugs include lack of sleep, incoherence, confusion, paranoia, and stupor. [treatmentsolutions.com]

  Common Symptoms Sleepiness Nausea or vomiting Dizziness Fever Confusion Rapid heartbeat Agitation Shakiness Severe Symptoms Fainting Heart problems Changes in blood pressure (higher or lower than normal) Seizures Delirium Hallucinations Stupor Mania Inflammation [verywell.com]

  […] drugs include: Central nervous system (CNS) depressants: shallow breathing, weak pulse, clammy skin, coma, death from respiratory arrest Hallucinogens: psychotic features, agitation, delirium Inhalants: marked CNS depression, loss of consciousness, stupor [americanaddictioncenters.org]

  […] rapid speech, or hyper-attention Emotional changes, like depression, aggression, or euphoria Hallucinations, delusions of grandeur, or suicidal ideation Body temperature changes, either hypothermia or hyperthermia Nausea and vomiting Extreme sleepiness Stupor [deserthopetreatment.com]

• Lethargy

  Physical examination revealed bilateral pupils dilatation, lethargy, slurred speech, and ataxia. Computer-aided tomographic scan of the brain revealed no definite evidence of intracranial lesions. [ncbi.nlm.nih.gov]

  Lethargy, slurred speech, nystagmus, and ataxia are common with mild to moderate intoxication. With higher doses, hypotension, coma, and respiratory arrest commonly occur. [accessmedicine.mhmedical.com]

  […] and coma Blue-tinged skin Agitation and confusion Seizures Unconsciousness Agitation and confusion Delusions Seizures Unconsciousness Paranoia Anxiety Rapid heart rate and high blood pressure Fatigue Psychosis Clammy skin Blue-tinged skin Convulsions Lethargy [sbtreatment.com]

  Clinical features: CNS: Ataxia, lethargy, slurred speech, drowsiness, vertigo and nystagmus followed by coma, hypotonia, hypothermia and respiratory arrest. [litfl.com]

  Nausea and Vomiting Slowed Breathing Change in Heart Rate Extreme Lethargy Confusion or Delirium Loss of Alertness Despite the lack of change in levels of pain reported by patients, opioid prescriptions nearly quadrupled in 15 years. [drugrehab.com]

• Altered Mental Status

  A 62-year-old man with a medical history of AF was admitted to our emergency department for altered mental status. [ncbi.nlm.nih.gov]

  Any patient with an altered mental status should have a capillary glucose determined. [clinicaladvisor.com]

  Symptoms of overdose include altered mental status, high blood sugar, slow heartbeat and very low blood pressure. Lactic acidosis, a buildup of lactic acid in the body, can also occur as the result of a calcium channel blocker overdose. [livestrong.com]

  mental status, the patient is suicidal, or there is a lack of time to explain treatment alternatives. 219 The majority of questions addressing cardiac arrest due to drug toxicity remain unanswered. [doi.org]

There is limited evidence in the literature describing the refractory treatment modalities utilized in this patient. This report is unique as it describes the clinical course of a patient when a multitude of unique treatments were combined. [ncbi.nlm.nih.gov]

Expand access to evidence-based substance abuse treatment, such as Medication-Assisted Treatment, for people already struggling with opioid addiction. Expand access and use of naloxone—a safe antidote to reverse opioid overdose. [web.archive.org]

The county has reduced medical opioid prescribing; increased addiction treatment resources; expanded community access to an anti-overdose drug called naloxone; and provided addiction treatment to prisoners in its county jail, among other measures. [nytimes.com]

Hence, prognosis should not be decided on an isolated parameter, especially if the dynamic is atypical after a new prescription, even for well-known drugs. [ncbi.nlm.nih.gov]

The person may receive: Activated charcoal (in extreme cases) Blood and urine tests Medicines to treat symptoms Outlook (Prognosis) Serious symptoms are very unlikely. [mountsinai.org]

Prognosis In general, patients who arrive alive at health care facilities have a very good prognosis. Most deaths from these agents occur in the prehospital period. Thus, if an individual survives to hospital admission, the prognosis is quite good. [clinicaladvisor.com]

In medical circles, DIC is often referred to as “death is coming,” because it signals a poor prognosis. Multiple organ failure usually follows. [drugrehab.com]

The prognosis for drug overdose can vary. In many cases, a person who overdoses generally recovers completely and without lasting physical disability. Some serious drug overdoses are fatal, even with appropriate and timely treatment. [emedicinehealth.com]

We speculate that an adulterating agent may be the underlying etiology in these cases. [ncbi.nlm.nih.gov]

Diagnostic approach History is the essential in determining the etiology of the symptoms. Certainly aggressive supportive care is key, and patient care should not be delayed while trying to obtain a history. [clinicaladvisor.com]

For example, when two miners fell ill with Marburg hemorrhagic fever at the Kitaka mine in Uganda in early August 2007, CDC staff worked with the Ugandan Ministry of Health to quickly identify the etiology, contain the outbreak, and act on a rare opportunity [cdc.gov]

Non-ethanol components of alcoholic beverages may be involved in the etiology. [who.int]

Providence, RI 02903, USA. 3 Department of Epidemiology, Brown University School of Public Health, 121 South Main St., Providence, RI 02903, USA. 4 Center for Health Equity Research, University of North Carolina at Chapel Hill, 335 S. [ncbi.nlm.nih.gov]

USA 2 Center for Urban Epidemiologic Studies, New York Academy of Medicine, 1216 Fifth Ave, NY, NY 10029, USA 3 Department of Psychiatry, Weill Medical College, Cornell University, 525 E. 68th St, NY, NY 10021 USA 4 Department of Epidemiology, School [web.archive.org]

Pathophysiology Antidepressants Antidepressants work by different mechanisms, but ultimately most attempt to correct an imbalance of the dopaminergic, noradrenergic, and serotonergic systems. [clinicaladvisor.com]

[…] self-poisonings over 10 years (1992–2001), compared with 30 fatal deliberate self-poisonings involving diazepam.[36] In a New Zealand study (2003) of 200 deaths, Zopiclone, a benzodiazepine receptor agonist, had similar overdose potential as benzodiazepines.[37] Pathophysiology [en.wikipedia.org]

Several consensus groups have developed excellent guidelines for the management of asthma that are available on the World Wide Web: Pathophysiology The pathophysiology of asthma consists of 3 key abnormalities: Bronchoconstriction Airway inflammation [doi.org]

Tertiary prevention includes treating opioid use disorders and providing naloxone to prevent overdose death. [ncbi.nlm.nih.gov]

CDC’s work focuses on: Building prevention efforts by equipping states with resources, improving data collection, and supporting the use of evidence-based prevention strategies. [cdc.gov]