We present a case of a 62 year-old-male who presented with altered liver function tests, anemia and unintentional weight loss. Initial laboratories revealed anemia and a cholestatic pattern. [ncbi.nlm.nih.gov]

Metabolic workup documented elevated cerebrospinal fluid lactate. Initial genetic analyses excluded the three most common LHON mutations. Subsequently, Sanger sequencing of the entire mitochondrial DNA (mtDNA) genome was performed. [ncbi.nlm.nih.gov]

The workup for other causes of liver disease including hepatitis B, HIV, Wilson disease, and α-1-antitrypsin phenotype was negative, and there was no history of drug or alcohol use. An abdominal ultrasound showed normal liver size and echogenicity. [journals.lww.com]

The data collection contains information of symptoms, physical examination, laboratory workup, as well as annually performed pulmonary-function test results, echocardiography, right-heart catheterization, and high-resolution computed tomography (HRCT) [arthritis-research.biomedcentral.com]

Before treatment, HCV RNA was 36,100 IU/mL, with AST 124 U/L and ALT 171 U/L. She was a rapid responder to the treatment with undetectable HCV RNA after 4 weeks of treatment (Fig. 2). She completed 48 weeks of antiviral treatment and achieved SVR. [journals.lww.com]

The treatment recommendation for patients, whose differential diagnosis is equally balanced between asthma and COPD, is to start treatment for asthma until further investigations are performed. [northeast.devonformularyguidance.nhs.uk]

Andrew Schorr: …for treatment. Dr. Daver: …we had the Jakafi for treatment. [patientpower.info]

Currently, the most effective treatment for ACOS is unknown and omalizumab for ACOS has not yet been reported. We report our experience with anti-IgE, omalizumab treatment on 3 patients with ACOS as a retrospective case study. [ncbi.nlm.nih.gov]

Many questions remain, however, with regard to disease definition, prognosis, and optimal treatment. Treatment currently consists of continuous positive airway pressure, and oxygen as needed. [rc.rcjournal.com]

Patients with antisynthetase syndrome are generally considered to have a poor prognosis, with mortality 3 times greater than that of myositis without antisynthetase syndrome. [online.epocrates.com]

Interstitial pneumonia is a common and major comorbidity affecting the prognosis of patients with systemic sclerosis (SSc). However, there are few reported cases of SSc-rheumatoid arthritis (RA) overlap-associated interstitial pneumonia. [ncbi.nlm.nih.gov]

This is a necessary starting point from which to design studies to investigate the clinical features, aetiology, pathophysiology and prognosis of these patients, and ultimately determine treatment strategies. [um.edu.mt]

While the etiology of connective tissue diseases remains unknown, the classification of individual cases will continue to depend on identifying certain patterns of clinical and laboratory features. [ncbi.nlm.nih.gov]

Current Opinion in Rheumatology. 3(6):995–1000, DEC 1991 PMID: 1772755 Issn Print: 1040-8711 Publication Date: 1991/12/01 Checking for direct PDF access through Ovid Abstract While the etiology of connective tissue diseases remains unknown, the classification [doi.org]

Later, etiologies included prion, autoimmune disease, and various toxic etiologies ( Antelmi et al 2015 ). The content you are trying to view is available only to logged in, current MedLink Neurology subscribers. [medlink.com]

B, Enlarged ovaries with multiple ovarian cysts; left ovary, 21.6 cm3, right ovary, 25.3 cm3 A fasting study to understand the etiology of her hypoglycemia was performed in a supervised clinical environment ( Table 2 ). [pediatrics.aappublications.org]

Epidemiology and survival of systemic sclerosis-systemic lupus erythematosus overlap syndrome [published online July 15, 2018]. J Rheumatol. doi:10.3899/jrheum.170953 [rheumatologyadvisor.com]

This is a cross-sectional study with a community-based sample of 1298 participants (mean age, 59.7   6.7) from the cohort of Korean Genomic and Epidemiologic Study during 2013 to 2014. [insights.ovid.com]

Little is known about the epidemiology, clinical characteristics, and survival of SSc-SLE overlap. We evaluated the prevalence of SSc-SLE overlap and differences in SSc characteristics, and compared survival with SSc without SLE. [jrheum.org]

This article will review the identification, epidemiology, diagnostic evaluation, and basic treatment strategy for ACOS. This information should assist the primary care physician (PCP) in his or her approach to this condition. [mdedge.com]

Our primary aim was to identify prevalence and predictors of the overlap syndrome in Koreans.This is a cross-sectional study with a community-based sample of 1298 participants (mean age, 59.7   6.7) from the cohort of Korean Genomic and Epidemiologic [ncbi.nlm.nih.gov]

We report 3 cases of patients with COPD in a stable clinical condition, referred to the Department of Respiratory Pathophysiology at the "Mariano Santo" Hospital in Cosenza, due to possible symptoms suggestive of obstructive sleep apnea, and who were [ncbi.nlm.nih.gov]

This is a necessary starting point from which to design studies to investigate the clinical features, aetiology, pathophysiology and prognosis of these patients, and ultimately determine treatment strategies. [um.edu.mt]

It is acknowledged that within this description of ACOS will lie a number of phenotypes that may in due course be identified by more detailed characterization on the basis of clinical, pathophysiological and genetic identifiers. [goldcopd.org]

McNicholas WT: Chronic obstructive pulmonary disease and obstructive sleep apnea: overlaps in pathophysiology, systemic inflammation, and cardiovascular disease. Am J Respir Crit Care Med 2009; 180: 692–700. [karger.com]

CPAP alone may not fully correct hypercapnia or hypoxemia, so non-invasive ventilation (NIV) treatment and/or supplemental oxygen may increase the clinical benefit to the patient. 18 NIV therapy can theoretically rest overloaded respiratory muscles, prevent [resmed.com]

Keep reading: 5 diet tips for people with COPD » As far as researchers know, there is no way to prevent asthma, but you can lower your risk of developing COPD. It’s unclear if lowering your risk of COPD also lowers your risk of developing ACOS. [healthline.com]

A perceptive diagnostic approach toward these diseases is critical, and early diagnosis and treatment are needed to prevent dystrophic calcinosis. [ncbi.nlm.nih.gov]

COPD is defined by the Global Initiative for Chronic Obstructive Lung disease (GOLD) as: A preventable and treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients. [sleepapnea.org]

This approach recognises the pivotal role of inhaled corticosteroids in preventing morbidity and even death in patients with uncontrolled asthma symptoms, for whom even seemingly 'mild' symptoms (compared to those of moderate or severe COPD) might indicate [northeast.devonformularyguidance.nhs.uk]