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Oxybutynin

4 (diethylamino) 2 Butynyl Alpha Cyclohexyl Alpha Hydroxybenzeneacetate


Presentation

  • The 181 patients with more than 6 months of follow-up (median: 17 months, range: 6-72) were analyzed as follows: 82.9% of patients presented moderate or great improvement in AH and 89% of patients presented improvement in other sites of hyperhidrosis[ncbi.nlm.nih.gov]
Edema of the Tongue
  • Patients should be advised to promptly discontinue Oxybutynin therapy and seek immediate medical attention if they experience edema of the tongue, edema of the laryngopharynx, or difficulty breathing.[drugs.com]
Eye Irritation
  • irritation; Cardiac Disorders: palpitations, sinus arrhythmia; Vascular Disorders: flushing; Respiratory, Thoracic and Mediastinal Disorders: nasal dryness, cough, pharyngolaryngeal pain, dry throat, sinus congestion, hoarseness, asthma, nasal congestion[drugs.com]
Esotropia
  • A 5-year-old girl with previously unrecognized hyperopia of approximately 3.00 D developed esotropia while being treated with oxybutynin for enuresis. The esotropia disappeared with cessation of oxybutynin and correction of her hyperopia.[ncbi.nlm.nih.gov]
Hyperhidrosis
  • BACKGROUND: Facial hyperhidrosis can lead to serious emotional distress.[ncbi.nlm.nih.gov]
Decreased Sweating
  • ., fever and heat stroke due to decreased sweating) when administered during hot weather. 100 116 120 Diarrhea may be a symptom of partial intestinal obstruction, especially in patients with ileostomies or colostomies; in this instance, treatment with[drugs.com]
  • The most commonly reported side effects when taking Apo-Oxybutynin tablets 5mg include: palpitations, tachycardia, vasodilation, chest pains, syncope (fainting), decreased sweating, rash, urticaria (hives), flushing, gonstipation, decreased gastrointestinal[inhousepharmacy.vu]
  • Trouble emptying the bladder Increased risk of stomach problems in some patients Headache, dizziness, sleepiness Worsening of myasthenia gravis Swelling (angioedema) Heat prostration in hot environments (oxybutynin can decrease sweating) This is not a[news.cancerconnect.com]
  • Limit alcoholic beverages .This drug may increase the risk for heatstroke because it causes decreased sweating .[medicinenet.com]
Palmar Hyperhidrosis
  • PURPOSE: To evaluate the effectiveness and patient satisfaction with the use of oxybutynin at low doses for treating palmar hyperhidrosis in a large series of patients.[ncbi.nlm.nih.gov]
Sinus Headache
  • headache; Eye Disorders: keratoconjunctivitis sicca, eye irritation; Cardiac Disorders: palpitations, sinus arrhythmia; Vascular Disorders: flushing; Respiratory, Thoracic and Mediastinal Disorders: nasal dryness, cough, pharyngolaryngeal pain, dry throat[drugs.com]
Macroscopic Hematuria
  • Dry mouth was the most common adverse in patients with oral oxybutynin (72%) and transient macroscopic hematuria in patients with onabotulinumtoxinA (28%). Only one patient with oral oxybutynin dropped out the study because of adverse effects.[ncbi.nlm.nih.gov]
Nocturnal Polyuria
  • As predictive factors, bladder volume and wall thickness index, nocturnal polyuria and voiding latency were considered. RESULTS: There was no significant difference between the 120 µg and 240 µg patients in terms of response.[ncbi.nlm.nih.gov]

Workup

  • Physical exam-ination reveals an area of hypopigmented skin measuring cm on her right footWhich of the following is the most likely diagnosis for this patient, and what further workup isindicated?.[retain24.com]
Glucose Increased
  • increased, blood pressure decreased; Injury, Poisoning, and Procedural Complications: fall.[drugs.com]
Chloride Increased
  • In patients with conditions characterized by involuntary bladder contractions, cystometric studies have demonstrated that Oxybutynin chloride increases bladder (vesical) capacity, diminishes the frequency of uninhibited contractions of the detrusor muscle[drugs.com]
Sinus Arrhythmia
  • arrhythmia; Vascular Disorders: flushing; Respiratory, Thoracic and Mediastinal Disorders: nasal dryness, cough, pharyngolaryngeal pain, dry throat, sinus congestion, hoarseness, asthma, nasal congestion; Gastrointestinal Disorders: diarrhea, abdominal[drugs.com]

Treatment

  • Irritative urinary symptoms are a common side effect of treatment and frequently limit treatment tolerance.[ncbi.nlm.nih.gov]

Etiology

  • No infectious etiology could be found. He was discharged in an improved state after a 48-hour observation period. The drug was discontinued.[ncbi.nlm.nih.gov]
  • Ureteral stent discomfort: Etiology and management. Indian J Urol. 2009;25(4):455-60. Chew BH, Knudsen BE, Denstedt JD. The use of stents in contemporary urology. Curr Opin Urol. 2004;14(2):111-5. Knudsen BE, Beiko DT, Denstedt JD.[revistamedica.imss.gob.mx]

Epidemiology

  • Epidemiological variables, effectiveness (using the Hyperhidrosis Disease Severity Scale) and tolerance to transdermal oxybutynin were compiled concerning two different groups (patients previously treated or untreated with oral oxybutynin), at baseline[ncbi.nlm.nih.gov]
  • No epidemiological studies of congenital anomalies among infants born to women who were treated with oxybutynin during pregnancy have been reported.[inchem.org]
  • Definition of overactive bladder and epidemiology of urinary incontinence. Urology. 1997; 50:4-14. 109. Abrams P, Freeman R, Anderstróm C et al.[drugs.com]
  • Next, we included the Center for Epidemiologic Studies Depression Scale score category at each visit in the model rather than a history of depressive symptoms.[archinte.jamanetwork.com]
Sex distribution
Age distribution

Pathophysiology

  • This last point is important because the pathophysiological changes in the brains of patients with AD require several years to occur. 16 Finally, these studies did not take into account that certain anticholinergics are used to manage insomnia and depression[doi.org]

Prevention

  • Cyclosporin is an important immunosuppressive medication used to prevent organ rejection. Drug interactions that alter its blood levels can cause serious problems with toxicity or transplant rejection.[ncbi.nlm.nih.gov]
  • The effect is to prevent spasms of the stomach, intestine or urinary bladder. muscle relaxant A drug used to produce muscle relaxation (excepting neuromuscular blocking agents).[ebi.ac.uk]

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