The charts of 60 patients who presented to the emergency room with the diagnosis of epistaxis and who required medical management were reviewed. Sixty-five percent of these patients were successfully managed with oxymetazoline as their sole therapy. [ncbi.nlm.nih.gov]

In the presentation […] Continue Reading Two small updates on the progress of topical oxymetazoline (now known as Rhofade) towards being available as another treatment for the redness of rosacea. [rosacea-support.org]

• Hypertension

  Severe hypertension with reflex bradycardia progressed to sinus arrest and was successfully treated with alropine and cardiopulmonary resuscitation. Decreasing the dose of oxymetazoline and pretreatment with an anticholinergic is recommended. [ncbi.nlm.nih.gov]

  Category: Decongestant Description: Topical decongestant Indications: Nasal congestion Precautions: Pregnancy category C Children Hyperthyroidism, heart disease Hypertension, diabetes mellitus Adverse Reactions (Side Effects): CNS: dizziness, headache [medicalcorps.org]

  Headache, insomnia, tachycardia, hypertension, nervousness, nausea, dizziness, palpitation, arrhythmia. Eye drops: Dryness of eye. Precautions Information Not Available Special Precautions Pregnancy, lactation. [drugsupdate.com]

  Hyperthyroidism, diabetes, use of a monoamine oxidase inhibitor within 14 days, or known hypersensitivity to this drug prohibits its use. adverse effects Among the more serious adverse effects are rebound congestion, central nervous system stimulation, hypertension [medical-dictionary.thefreedictionary.com]

  Like all medicines oxymetazoline can cause side effects, including: high blood pressure (hypertension) unpleasant feelings of rapid or strong heartbeats slow heart rate dizziness headache, insomnia irritability transient dryness and burning sensation [euromeds-doctor.com]

• Hypotension

  Because of his urinary retention, he was placed on the 1 antagonist tamsulosin but he could not tolerate it because of worsening of orthostatic hypotension. [web.archive.org]

  Advise patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension/hypotension to seek immediate medical care if their condition worsens. [prnewswire.com]

  Gradman Bradycardia, hypotension, and near‐syncope associated with afrin (oxymetazoline) nasal spray N Engl J Med, 309 (1983), pp. 73 [2] A. Khan, N. [elsevier.pt]

  Bradycardia, hypotension, and near‐syncope associated with afrin (oxymetazoline) nasal spray. N Engl J Med, 309 (1983), pp. 73 [2] A. Khan, N. Dewhurst. [revportcardiol.org]

• Conjunctival Hyperemia

  Thirty-nine patients with moderate bilateral conjunctival hyperemia instilled one drop of either oxymetazoline 0.025% solution or its vehicle twice daily for one week. [ncbi.nlm.nih.gov]

  Oxymetazoline elicits relief of conjunctival hyperemia by causing vasoconstriction of superficial conjunctival blood vessels. The drug's action has been demonstrated in acute allergic conjunctivitis and in chemical (chloride) conjunctivitis. [druglib.com]

  Among TEAEs occurring in 2% or more of participants, 3 were ocular: punctate keratitis, blurred vision, and conjunctival hyperemia. [jamanetwork.com]

• Eye Pain

  […] replace cap after each use Stop use and ask a doctor if you feel eye pain changes in vision occur redness or irritation of the eye lasts condition worsens or lasts more than 72 hours If pregnant or breast-feeding, ask a health professional before use [web.archive.org]

• Stupor

  Fifty-three cases reported hospitalization due to symptoms including nausea, vomiting, lethargy, tachycardia, decreased respiration, bradycardia, hypotension, hypertension, sedation, somnolence, mydriasis, stupor, hypothermia, drooling, and coma. [fda.gov]

  […] naphazoline, tetrahydrozoline) in children has resulted in serious adverse events requiring hospitalization, including nausea, vomiting, lethargy, tachycardia, decreased respiration, bradycardia, hypotension, hypertension, sedation, somnolence, mydriasis, stupor [drugs.com]

• Sinus Arrest

  Severe hypertension with reflex bradycardia progressed to sinus arrest and was successfully treated with alropine and cardiopulmonary resuscitation. Decreasing the dose of oxymetazoline and pretreatment with an anticholinergic is recommended. [ncbi.nlm.nih.gov]

NAR and VAS measurements were also made following withdrawal of treatment on Days 8 and 9. [ncbi.nlm.nih.gov]

Areas covered : Current treatment options for the treatment of rosacea include metronidazole, azelaic acid, sodium sulfacetamide-sulfur, and brimonidine. [doi.org]

[…] appearance-related distress.6 Current evidence identifies ptosis as a common disorder of the eyelid, particularly among elderly patients.7-9 Ptosis is broadly categorized as either congenital or acquired,10 with the acquired form classified based on underlying etiology [jamanetwork.com]

BACKGROUND: Impairment of sinus ostial function is considered an important factor in the pathophysiology of sinus disease. The use of the decongestants such as alpha2-agonists is thought to improve sinus ostial function. [ncbi.nlm.nih.gov]

Rhinitis medicamentosa: Aspects of pathophysiology and treatment. Allergy 1997 ;52: 28 – 34. Google Scholar | Medline | ISI 5. Graf, P. Adverse effects of benzalkonium chloride on the nasal mucosa: Allergic rhinitis and rhinitis medicamentosa. [dx.doi.org]

Connecting the dots between pathophysiological mechanisms and common clinical features of rosacea with emphasis on vascular changes and facial erythema. J Clin Aesthet Dermatol. 2012;5(3):16-25. [rhofadehcp.com]

The alpha-adrenergic agonist oxymetazoline was compared to cocaine and to lidocaine with epinephrine with respect to prevention of epistaxis on nasotracheal intubation. [ncbi.nlm.nih.gov]

[…] and oxymetazoline was 86% effective in preventing bleeding during this procedure. [intranasal.net]

Efficacy of pseudoephedrine for the prevention of barotrauma during air travel. Ann Emerg Med. 1994; 23:1324-7. http://www.ncbi.nlm.nih.gov/pubmed/8198308?dopt=AbstractPlus 101. Jones JS, Sheffield W, White LJ et al. [drugs.com]