Presentation
One possible solution to this problem is to confirm the presence of unique drug metabolites that cannot be present through contamination, such as phase II glucuronide conjugates. [ncbi.nlm.nih.gov]
Entire Body System
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Leg Edema
Aldrete JA, Couto da Silva JM (2000) Leg edema from intrathecal opiate infusions. Eur J Pain 4(4):361–365 CrossRef PubMed Google Scholar 23. Weinberg DS, Inturrisi CE, Reidenberg B et al (1988) Sublingual absorption of selected opioid analgesics. [oadoi.org]
Respiratoric
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Pneumonia
Emergency department evaluation revealed obvious bilateral hearing loss as well as coincidental aspiration pneumonia. [ncbi.nlm.nih.gov]
The most common serious adverse events reported with administration of oxymorphone hydrochloride extended-release tablets were chest pain, pneumonia and vomiting. [rxlist.com]
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Aspiration
Emergency department evaluation revealed obvious bilateral hearing loss as well as coincidental aspiration pneumonia. [ncbi.nlm.nih.gov]
Musculoskeletal
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Low Back Pain
In patients aged or 18 years with chronic low back pain, the dose of oxymorphone ER was titrated to a stable, tolerable, effective dose. [ncbi.nlm.nih.gov]
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Arthritis
The primary end point was the change in VAS score for arthritis pain intensity. [ncbi.nlm.nih.gov]
Oral oxymorphone is a new formulation of an existing parenteral opioid that has become available for the treatment of significant pain: acute postoperative, chronic arthritis, chronic low back, and chronic cancer pain. [dx.doi.org]
Skin
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Ulcer
Not only do all of these agents have their own set of adverse reactions (such as gastric ulcers, renal and liver toxicity, and bleeding) but many patients fail to obtain effective pain relief with analgesics that have a ceiling effect. [ncbi.nlm.nih.gov]
Workup
After workup as in Example 1, 60-70% yield of dihydrocodeinone was isolated. [erowid.org]
Serum
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Creatinine Increased
Oxycodone excretion into urine had a geometric mean of 1.93 mg/g of creatinine and oxymorphone had a value of 0.41 mg/g of creatinine. [ncbi.nlm.nih.gov]
Treatment
MAIN RESULTS: A total of 86 patients entered open-label treatment. [ncbi.nlm.nih.gov]
Etiology
Health-care providers should ask patients with TTP-like illness of unknown etiology about injection-drug abuse. [cdc.gov]
Epidemiology
The 2 case patients who had sequences in cluster 2 reported no injection-drug use and were also not linked epidemiologically to the case patients who had sequences in cluster 1. [doi.org]
The meeting appears to have originated from the FDA's Office of Surveillance and Epidemiology, with a letter from Judy Staffa, PhD, RPh, leading the FDA's meeting materials. Staffa presided over the meeting. [medpagetoday.com]
Pathophysiology
I am a pharmacologist who studies the pathophysiology of pain and delta/mu heterodimeric receptors. But I have been curious about this for a while and my medicinal chemistry skills are mediocre at best. [chemistry.mdma.ch]
Pain causes anxiety, sleeplessness, and other pathophysiologic responses that can adversely affect the patient and extend hospitalization ( 2,3 ). Effective postsurgical pain management is essential to the recovery and rehabilitation process. [journals.lww.com]
Prevention
Author Affiliations From the Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta (P.J.P., K.W.H., M.R.P., R.R.G., M.W.S., W.M.S., Y.K., S.M.O., V.M., P.J.W [doi.org]
Suboxone contains buprenorphine, which, like methadone, suppresses cravings and prevents the onset of withdrawal symptoms. Suboxone also contains a substance called naloxone, which prevents abuse and overdose. [indianactc.com]
Naltrexone hydrochloride was coadministered to prevent opioid-related adverse events. [ncbi.nlm.nih.gov]