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Ozena

Ozaena


Presentation

  • We present cases of ozena with nasal Klebsiella in three unrelated patients, including two east African children and one Saudi adult.[ajtmh.org]
  • This should be considered when a patient presents from an endemic region.[docksci.com]
  • We present a case of a patient with ozena secondary to K. ozaenae with extensive destruction of bony structures of the nasal cavity undergoing elective dacryocystorhinostomy.[ncbi.nlm.nih.gov]
  • The bacteria Klebsiella ozaenae is usually found in the nasal area (hence the name, ozena/ozaena), although Proteus vulgaris or E. coli can also be present.[irishexaminer.com]
  • Ozena as presenting symptom of a rare and severe genetic disease: hypohidrotic ectodermal dysplasia . International Journal of Pediatric Otorhinolaryngology, Vol. 8, Issue. 1, p. 97. CrossRef Google Scholar Shehata, M. and Dogheim, Y. 1986.[cambridge.org]
Asymptomatic
  • We report the results of the clinical, genetic and immunologic investigations performed on eight subjects (three with ozena and five asymptomatic), members of the same familial group.[semanticscholar.org]
  • She is currently asymptomatic and treatment was halted, though follow-up surveillance continues. Patient 3: 67-year-old Saudi Arabian male, distant history of work in road construction, long-time U.S. resident.[docksci.com]
Camping
  • Patient 1: 11-year-old Somali male who spent time in a Kenyan refugee camp and recently immigrated.[docksci.com]
Lymphadenopathy
  • The primary otolaryngology visit was a year and a half after his initial presentation of “allergic rhinitis” with pale, edematous turbinates, and cervical lymphadenopathy.[docksci.com]
Gangrene
  • For instance, noma (cancrum oris), a disease of extreme poverty, often begins with gingival ulceration that can progress to gangrenous and deforming skin lesions.[docksci.com]
Gingival Ulceration
  • For instance, noma (cancrum oris), a disease of extreme poverty, often begins with gingival ulceration that can progress to gangrenous and deforming skin lesions.[docksci.com]
Skin Lesion
  • For instance, noma (cancrum oris), a disease of extreme poverty, often begins with gingival ulceration that can progress to gangrenous and deforming skin lesions.[docksci.com]
Tinnitus
  • A Tinnitus is far more common than most people realise. The sensation of a sound in the ear or head, often a ringing or buzzing noise, tinnitus can occur as a continual irritation or intermittently.[irishexaminer.com]
Onset in Adolescence
  • Other common causes are hormonal — particularly during the onset of adolescence, pregnancy, or menopause — or a deficiency in vitamins A, D and iron.[irishexaminer.com]
Irritability
  • By a Catarrh is meant a congested and inflamed condition of the mucous membrane lining the nostrils, generally produced by colds, but often caused by dust and other irritating matters in the air.[nytimes.com]
  • The sensation of a sound in the ear or head, often a ringing or buzzing noise, tinnitus can occur as a continual irritation or intermittently.[irishexaminer.com]
  • Clear rhinorrhea may be the first noticeable symptom along with an irritated nasal mucosa, mimicking allergic rhinitis.[docksci.com]
Neglect
  • They are mild and easily cured in the commencement, but become grave and dangerous when neglected.[nytimes.com]

Treatment

  • […] curable and the aim of treatment is simply abatement of symptoms.[docksci.com]
  • Specialist health care is responsible for the final diagnosis and treatment planning Conservative treatment consists of nasal irrigation as well as moisturising drops and sprays, and an adequate humidification of the room air at night.[ebm-guidelines.com]
  • Secondary cases are more usual, and can appear as a result of sinus surgery, radiation treatment, trauma or infectious diseases.[irishexaminer.com]
  • All three patients grew Klebsiella species in culture and required prolonged treatment with multiple methodologies, including antibiotics, saline rinses, and surgical debridement.[ajtmh.org]
  • The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.[health.ridgeviewmedical.org]

Etiology

  • Abstract Ozaena is the term applied to chronic, fetid, atrophic rhinitis of obscure etiology. It is known that the disorder occurs in conditions of poverty, hunger and dirt.[annals.org]
  • Because of the voluminousness of the literature, this review will be limited to the etiology.[jamanetwork.com]
  • The etiology of ozena still remains enigmatic but hereditary, infectious, developmental, endocrine and nutritional factors have been implicated.[eastjmed.org]
  • Although the etiology is not completely understood, infection with Klebsiella ozaenae is widely believed to contribute to the destructive changes.[ncbi.nlm.nih.gov]
  • Currently, its etiology remains unknown(4).[arquivosdeorl.org.br]

Epidemiology

  • Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis. 2011 Jul 1. 53(1):60-7. [Medline]. van Duin D, Bonomo RA.[medscape.com]
Sex distribution
Age distribution

Prevention

  • Insight into the typical sinonasal anatomic changes in these patients is critical for appropriate preoperative surgical planning and execution of endoscopic procedures to avoid troublesome and preventable complications.[ncbi.nlm.nih.gov]
  • Many physicians may prescribe saline nasal rinses or sprays for daily use in keeping the area clean and preventing crust formation. In some cases, debridement of the overlying crusts and necrotic portions may be required to facilitate healing.[docksci.com]
  • Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis. 2011 Jul 1. 53(1):60-7. [Medline]. van Duin D, Bonomo RA.[medscape.com]

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