We present a patient with metastatic melanoma who had a complete response to second line chemotherapy with paclitaxel and carboplatin. [ncbi.nlm.nih.gov]

Oncology Paclitaxel October 14, 2017 Saladax is Awarded “Best Poster Presentation” for Study on Individualized Dosing of Paclitaxel Saladax Biomedical, Inc., recently presented a study on the value of adjusting paclitaxel doses. [saladax.com]

Presented at: LINC 2019. January 22, 2019. Leipzig, Germany. [scai.org]

• Intravenous Administration

  Preparation for Intravenous Administration TAXOL (paclitaxel) Injection must be diluted prior to infusion. [globalrph.com]

  It is essentially insoluble in water, so for intravenous administration to cancer patients, it is dissolved in an oil base, Cremophor ® Solution, to form the drug Taxol ®. [cathlabdigest.com]

  Preparation for Intravenous Administration Paclitaxel Injection, USP must be diluted prior to infusion. [drugs.com]

  Due to the poor aqueous solubility, polyoxyethylated castor oil solvent (Cremaphor) was used to solubilize paclitaxel for intravenous administration ( Cre -paclitaxel; Taxol). [clincancerres.aacrjournals.org]

• Arthralgia

  Adverse Reactions: Bone marrow suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia [empr.com]

  Arthralgia/Myalgia : There was no consistent relationship between dose or schedule of TAXOL and the frequency or severity of arthralgia/myalgia. Sixty percent of all patients treated experienced arthralgia/myalgia; 8% experienced severe symptoms. [rxlist.com]

  Myalgias, arthralgias, and peripheral neuropathy were mild. No hypersensitivity reactions and no cardiac toxicity were observed. Conclusion: Taxol is highly active as initial chemotherapy for metastatic breast cancer. [pubmed.ncbi.nlm.nih.gov]

  Arthralgia/Myalgia There was no consistent relationship between dose or schedule of Paclitaxel and the frequency or severity of arthralgia/myalgia. Sixty percent of all patients treated experienced arthralgia/myalgia; 8% experienced severe symptoms. [drugs.com]

  […] than 1 patient in 10) are neutropenia (low levels of neutrophils, a type of white blood cells), gastrointestinal disorders (disorders of the digestive system), peripheral neuropathy (nerve damage including damage to the nerves in the hand and feet), arthralgia [ema.europa.eu]

• Alopecia

  […] suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia, GI upset, mucositis, alopecia [empr.com]

  Adverse effects included generalized alopecia in all patients. Myalgias, arthralgias, and peripheral neuropathy were mild. No hypersensitivity reactions and no cardiac toxicity were observed. [pubmed.ncbi.nlm.nih.gov]

  Slight alopecia is also common. Chemical Properties White Powder Uses glucocorticoid, antiinflammatory Uses An antineoplastic. Used in the study of structure and function of microtubles into tubulin. [chemicalbook.com]

  Additional side effects, including fever, infection, nausea, vomiting, increase or decrease in blood pressure, diarrhea, weight loss, pain, and hair loss ( alopecia ) may occur. [encyclopedia.com]

  Other Clinical Events : Alopecia was observed in almost all (87%) of the patients. [rxlist.com]

• Peripheral Neuropathy

  Segal said having discovered the mechanism that causes peripheral neuropathy in patients treated with taxane chemotherapy might be valuable in other ways. [ascopost.com]

  There were no significant differences in measures of neuropathy or pain between treated and untreated hands or feet. CONCLUSIONS: Strategies to prevent painful peripheral neuropathy are urgently needed. [ncbi.nlm.nih.gov]

  Objective chemotherapy-induced peripheral neuropathy (CIPN) events at a cumulative dose of 960 mg/m 2. [academic.oup.com]

Among patients who received treatment for 4 months (the average treatment duration), the rate of grade 3 neuropathy was 7%. [nejm.org]

Ask how long you should use it before starting treatment and after treatment has finished. [cancerresearchuk.org]

Treatment was well tolerated with no significant toxicity or need for dose reduction. [ncbi.nlm.nih.gov]

Cited by Metronomic doses and drug schematic combination response tested within chambered coverslips for the treatment of breast cancer cells (JIMT-1). [pubmed.ncbi.nlm.nih.gov]

Metastatic melanoma is an aggressive cancer with poor prognosis and 10 year survival less than 10%. We present a patient with metastatic melanoma who had a complete response to second line chemotherapy with paclitaxel and carboplatin. [ncbi.nlm.nih.gov]

Although our patient's history was significant for previous radiation therapy, the lack of accompanying funduscopic findings and absence of leakage at angiography makes radiation therapy an unlikely etiologic factor. [jamanetwork.com]

Using the CEC narratives and the etiology of deaths provided, the causes of death were categorized by organ system classification. Statistical analyses All descriptive summaries were based on nonmissing assessments. [onlinejacc.org]

PATIENTS AND METHODS: This study aimed to describe the outcome following first-line paclitaxel with or without bevacizumab in the French Epidemiological Strategy and Medical Economics (ESME) database of MBC patients, established in 2014 by Unicancer. [unicancer.fr]

Electronic address: [email protected] 6 Department of Hygiene, Epidemiology and Preventive Medicine, Third Faculty of Medicine, Charles University, Ruská 87, 110 00 Prague, Czech Republic. [ncbi.nlm.nih.gov]

Meta‐Regression Analysis In line with Bradford Hill's criteria 61 for establishing epidemiological evidence for causation, we explored presence of a biological gradient, that is, whether greater exposure leads to greater incidence of the effect. [ahajournals.org]

Mortality rates across the individual trials of DCBs are well within the ranges reported in other adjudicated nondrug vascular device trials and also reported in epidemiological studies of patients with PAD. [onlinejacc.org]

Harnett & Anna de Fazio Chris O’Brien Lifehouse, Sydney, Australia Philip Beale & Michelle Harrison Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge University, Cambridge, UK Craig Luccarini & Don Conroy Sydney West Translational [nature.com]

Its pathophysiology remains poorly understood. Here, we report on a 69-year-old woman who developed cystoid macular edema associated with the albumin-bound formulation of paclitaxel after several months of therapy for breast cancer. [ncbi.nlm.nih.gov]

There has been 1 reported case of CME without leakage on fluorescein angiograms associated with docetaxel therapy. 3 The pathophysiology of angiographically negative CME is unclear. [jamanetwork.com]

Toxicity to Müller cells is the theory for the pathophysiological mechanism, with subsequent accumulation of intracellular fluid and subclinical extracellular extravasation ( 3, 5, 6 ). [scielo.br]

It is currently unclear whether protein kinase C inhibition can prevent chemotherapy-induced neuropathy. [ncbi.nlm.nih.gov]

Adding the Bclw protein to the nerve axons before exposing them to paclitaxel prevented the nerves from dying off. [ascopost.com]