Preparation for Intravenous Administration TAXOL (paclitaxel) Injection must be diluted prior to infusion. [globalrph.com]

It is essentially insoluble in water, so for intravenous administration to cancer patients, it is dissolved in an oil base, Cremophor Solution, to form the drug Taxol . [cathlabdigest.com]

Due to the poor aqueous solubility, polyoxyethylated castor oil solvent (Cremaphor) was used to solubilize paclitaxel for intravenous administration ( Cre -paclitaxel; Taxol). [clincancerres.aacrjournals.org]

Preparation for Intravenous Administration Paclitaxel Injection, USP must be diluted prior to infusion. [drugs.com]

Elimination from ascites fluid is also extremely slow with detectable levels still present after 18 days and an apparent disappearance half-life in ascites fluid of about 140 hours. [pdr.net]

Plasma paclitaxel exposure following 260- or 200-mg/m 2 dose in patients with mild or moderate hepatic impairment, respectively, was similar to exposure observed in patients with normal hepatic function. 354 364 Conventional paclitaxel is detected in ascitic [drugs.com]

Raynaud's phenomenon, esophageal dysmotility, and pulmonary fibrosis), temporal association with chemotherapy administration, and the absence of detectable autoantibodies. [ncbi.nlm.nih.gov]

On day 13 of cycle 1, the patient presented with elevated lipase and mild epigastric pain with a suspicion of acute pancreatitis. [ncbi.nlm.nih.gov]

HSC-4) than human normal epithelial and mesenchymal (human gingival fibroblast, human periodontal ligament fibroblast, human pulp cell) normal cells, confirming its antitumor potential. [ncbi.nlm.nih.gov]

Slight alopecia is also common. Chemical Properties White Powder Uses glucocorticoid, antiinflammatory Uses An antineoplastic. Used in the study of structure and function of microtubles into tubulin. [chemicalbook.com]

Additional side effects, including fever, infection, nausea, vomiting, increase or decrease in blood pressure, diarrhea, weight loss, pain, and hair loss ( alopecia ) may occur. [encyclopedia.com]

[…] suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia, GI upset, mucositis, alopecia [empr.com]

Other Clinical Events : Alopecia was observed in almost all (87%) of the patients. [rxlist.com]

Hair loss (alopecia) Paclitaxel causes hair loss. Most people will lose all their hair, including eyebrows, eyelashes and body hair. For some people, scalp cooling may be possible to try to prevent or lessen hair loss. [breastcancercare.org.uk]

Side effects Return to top Side effects from paclitaxel are common, and include: nausea and vomiting loss of appetite change in taste thinned or brittle hair pain in the joints of the arms or legs lasting 2-3 days changes in the color of the nails tingling [web.archive.org]

Side effects [ edit ] Common side effects include nausea and vomiting, loss of appetite, change in taste, thinned or brittle hair, pain in the joints of the arms or legs lasting two to three days, changes in the color of the nails, and tingling in the [en.wikipedia.org]

Arthralgia/Myalgia : There was no consistent relationship between dose or schedule of TAXOL and the frequency or severity of arthralgia/myalgia. Sixty percent of all patients treated experienced arthralgia/myalgia; 8% experienced severe symptoms. [rxlist.com]

Adverse Reactions: Bone marrow suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia [empr.com]

Arthralgia/Myalgia There was no consistent relationship between dose or schedule of Paclitaxel and the frequency or severity of arthralgia/myalgia. Sixty percent of all patients treated experienced arthralgia/myalgia; 8% experienced severe symptoms. [drugs.com]

Incidences of arthralgia (grade 1 or 2) were comparable between patients who received docetaxel or nab -paclitaxel 100 mg/m 2 weekly (22% and 19%, respectively). [doi.org]

The toxicity profile seems favorable, especially regarding myelosuppression and myalgia/arthralgia. No severe hypersensitivity reaction occurred. [link.springer.com]

PURPOSE: This case-control study was designed to assess the efficacy of cryotherapy to prevent paclitaxel-induced painful peripheral neuropathy in women with breast cancer. [ncbi.nlm.nih.gov]

Segal said having discovered the mechanism that causes peripheral neuropathy in patients treated with taxane chemotherapy might be valuable in other ways. [ascopost.com]

Objective chemotherapy-induced peripheral neuropathy (CIPN) events at a cumulative dose of 960 mg/m 2. [academic.oup.com]

The frequency and grade of peripheral neuropathy were similar in all arms. [jco.ascopubs.org]

Imaging revealed diffuse bilateral pulmonary infiltrates. Other causes of respiratory failure were excluded with laboratory work-up, imaging, biopsy studies and results of antibiotic treatment. [ncbi.nlm.nih.gov]

We have previously documented a series of lung cancer patients who developed pre-malignant colonic polyps and/or colon cancer either during or weeks following chemotherapy with paclitaxel, suggesting a potential role of this agent in their pathogenesis [ncbi.nlm.nih.gov]