Presentation
We present a patient with metastatic melanoma who had a complete response to second line chemotherapy with paclitaxel and carboplatin. [ncbi.nlm.nih.gov]
Oncology Paclitaxel October 14, 2017 Saladax is Awarded “Best Poster Presentation” for Study on Individualized Dosing of Paclitaxel Saladax Biomedical, Inc., recently presented a study on the value of adjusting paclitaxel doses. [saladax.com]
Entire Body System
-
Intravenous Administration
Preparation for Intravenous Administration TAXOL (paclitaxel) Injection must be diluted prior to infusion. [globalrph.com]
It is essentially insoluble in water, so for intravenous administration to cancer patients, it is dissolved in an oil base, Cremophor Solution, to form the drug Taxol . [cathlabdigest.com]
Due to the poor aqueous solubility, polyoxyethylated castor oil solvent (Cremaphor) was used to solubilize paclitaxel for intravenous administration ( Cre -paclitaxel; Taxol). [clincancerres.aacrjournals.org]
Preparation for Intravenous Administration Paclitaxel Injection, USP must be diluted prior to infusion. [drugs.com]
Gastrointestinal
-
Epigastric Pain
On day 13 of cycle 1, the patient presented with elevated lipase and mild epigastric pain with a suspicion of acute pancreatitis. [ncbi.nlm.nih.gov]
Jaw & Teeth
-
Periodontitis
HSC-4) than human normal epithelial and mesenchymal (human gingival fibroblast, human periodontal ligament fibroblast, human pulp cell) normal cells, confirming its antitumor potential. [ncbi.nlm.nih.gov]
Skin
-
Alopecia
Slight alopecia is also common. Chemical Properties White Powder Uses glucocorticoid, antiinflammatory Uses An antineoplastic. Used in the study of structure and function of microtubles into tubulin. [chemicalbook.com]
Additional side effects, including fever, infection, nausea, vomiting, increase or decrease in blood pressure, diarrhea, weight loss, pain, and hair loss ( alopecia ) may occur. [encyclopedia.com]
[…] suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia, GI upset, mucositis, alopecia [empr.com]
Other Clinical Events : Alopecia was observed in almost all (87%) of the patients. [rxlist.com]
Hair loss (alopecia) Paclitaxel causes hair loss. Most people will lose all their hair, including eyebrows, eyelashes and body hair. For some people, scalp cooling may be possible to try to prevent or lessen hair loss. [breastcancercare.org.uk]
-
Brittle Hair
Side effects Return to top Side effects from paclitaxel are common, and include: nausea and vomiting loss of appetite change in taste thinned or brittle hair pain in the joints of the arms or legs lasting 2-3 days changes in the color of the nails tingling [web.archive.org]
Side effects [ edit ] Common side effects include nausea and vomiting, loss of appetite, change in taste, thinned or brittle hair, pain in the joints of the arms or legs lasting two to three days, changes in the color of the nails, and tingling in the [en.wikipedia.org]
Musculoskeletal
-
Arthralgia
Arthralgia/Myalgia : There was no consistent relationship between dose or schedule of TAXOL and the frequency or severity of arthralgia/myalgia. Sixty percent of all patients treated experienced arthralgia/myalgia; 8% experienced severe symptoms. [rxlist.com]
Adverse Reactions: Bone marrow suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia [empr.com]
Arthralgia/Myalgia There was no consistent relationship between dose or schedule of Paclitaxel and the frequency or severity of arthralgia/myalgia. Sixty percent of all patients treated experienced arthralgia/myalgia; 8% experienced severe symptoms. [drugs.com]
Incidences of arthralgia (grade 1 or 2) were comparable between patients who received docetaxel or nab -paclitaxel 100 mg/m 2 weekly (22% and 19%, respectively). [doi.org]
The toxicity profile seems favorable, especially regarding myelosuppression and myalgia/arthralgia. No severe hypersensitivity reaction occurred. [link.springer.com]
Neurologic
-
Peripheral Neuropathy
PURPOSE: This case-control study was designed to assess the efficacy of cryotherapy to prevent paclitaxel-induced painful peripheral neuropathy in women with breast cancer. [ncbi.nlm.nih.gov]
Segal said having discovered the mechanism that causes peripheral neuropathy in patients treated with taxane chemotherapy might be valuable in other ways. [ascopost.com]
Objective chemotherapy-induced peripheral neuropathy (CIPN) events at a cumulative dose of 960 mg/m 2. [academic.oup.com]
The frequency and grade of peripheral neuropathy were similar in all arms. [jco.ascopubs.org]
Workup
X-Ray
-
Bilateral Pulmonary Infiltrate
Imaging revealed diffuse bilateral pulmonary infiltrates. Other causes of respiratory failure were excluded with laboratory work-up, imaging, biopsy studies and results of antibiotic treatment. [ncbi.nlm.nih.gov]
Colonoscopy
-
Polyps
We have previously documented a series of lung cancer patients who developed pre-malignant colonic polyps and/or colon cancer either during or weeks following chemotherapy with paclitaxel, suggesting a potential role of this agent in their pathogenesis [ncbi.nlm.nih.gov]
Treatment
Treatment was well tolerated with no significant toxicity or need for dose reduction. [ncbi.nlm.nih.gov]
Prognosis
Metastatic melanoma is an aggressive cancer with poor prognosis and 10 year survival less than 10%. We present a patient with metastatic melanoma who had a complete response to second line chemotherapy with paclitaxel and carboplatin. [ncbi.nlm.nih.gov]
Etiology
Although our patient's history was significant for previous radiation therapy, the lack of accompanying funduscopic findings and absence of leakage at angiography makes radiation therapy an unlikely etiologic factor. [jamanetwork.com]
Using the CEC narratives and the etiology of deaths provided, the causes of death were categorized by organ system classification. Statistical analyses All descriptive summaries were based on nonmissing assessments. [onlinejacc.org]
Epidemiology
Electronic address: [email protected] 6 Department of Hygiene, Epidemiology and Preventive Medicine, Third Faculty of Medicine, Charles University, Ruská 87, 110 00 Prague, Czech Republic. [ncbi.nlm.nih.gov]
Meta‐Regression Analysis In line with Bradford Hill's criteria 61 for establishing epidemiological evidence for causation, we explored presence of a biological gradient, that is, whether greater exposure leads to greater incidence of the effect. [ahajournals.org]
Harnett & Anna de Fazio Chris O’Brien Lifehouse, Sydney, Australia Philip Beale & Michelle Harrison Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge University, Cambridge, UK Craig Luccarini & Don Conroy Sydney West Translational [nature.com]
Mortality rates across the individual trials of DCBs are well within the ranges reported in other adjudicated nondrug vascular device trials and also reported in epidemiological studies of patients with PAD. [onlinejacc.org]
Pathophysiology
Its pathophysiology remains poorly understood. Here, we report on a 69-year-old woman who developed cystoid macular edema associated with the albumin-bound formulation of paclitaxel after several months of therapy for breast cancer. [ncbi.nlm.nih.gov]
There has been 1 reported case of CME without leakage on fluorescein angiograms associated with docetaxel therapy. 3 The pathophysiology of angiographically negative CME is unclear. [jamanetwork.com]
Toxicity to Müller cells is the theory for the pathophysiological mechanism, with subsequent accumulation of intracellular fluid and subclinical extracellular extravasation ( 3, 5, 6 ). [scielo.br]
Prevention
It is currently unclear whether protein kinase C inhibition can prevent chemotherapy-induced neuropathy. [ncbi.nlm.nih.gov]
Adding the Bclw protein to the nerve axons before exposing them to paclitaxel prevented the nerves from dying off. [ascopost.com]