When present, the prognosis is the poorest. About 31 (62%) of 50 patients with mammary Paget disease present with a detectable breast mass. [web.archive.org]

Pigmented mammary Paget disease (PMPD) is a rare disease that may mimic cutaneous melanoma both in clinical presentation and on histology. [ncbi.nlm.nih.gov]

Since, the initial presentation is limited to skin; it is the dermatologist who plays a key role in making a diagnosis, thus, facilitating proper management. [ijdvl.com]

A mammogram is an x-ray of the breast tissue and may be used to determine whether Paget cells are present. Mammography is also used to detect or rule out whether an underlying cancer is present. [rarediseases.org]

• Axillary Lesion

  The genital lesion exhibited a moderate acanthosis of the epidermis filled with Paget’s cell nests (Fig. 2 a). In both the axillary lesions and the umbilical one, Paget’s cells were located in the thin epidermis (Figs 2 b–d). [medicaljournals.se]

• Hypopigmented Macule

  macules, ulceration, and crusting may also be present [2]. [file.scirp.org]

• Skin Patch

  In individuals with Paget’s disease of the breast, initial characteristic skin changes may include the appearance of reddish (erythematous), scaling, crusting, and/or abnormally thickened skin patches (plaques) or lesions on the nipple that may extend [rarediseases.org]

• Necrolytic Migratory Erythema

  Other less common pathologies also exist in the differential, such as necrolytic migratory erythema and zinc deficiency, but these are usually present as part of a largely evident composite of skin and mucosal changes instead of just a solitary lesion [dermatologyadvisor.com]

• Nipple Discharge

  Other symptoms include: Redness Swelling Oozing nipple discharge Scaling Bloody nipple discharge Ulceration Inversion of the nipple Scaly, crusty and thickened plaques often form on the nipple, which then spreads to the surrounding area. [dermnetnz.org]

  During a biopsy, your doctor obtains a small sample of tissue from the skin of your nipple for examination under a microscope. If you have nipple discharge, a sample of the discharge might also be collected for microscopic examination. [web.archive.org]

  She reported the appearance of eczema of the nipple-areola complex some years before, and the presence of a palpable mass for about two months; no mention was made of nipple discharge or ulceration. [wjso.biomedcentral.com]

• Bloody Nipple Discharge

  discharge A flattened or inverted nipple Affected areas beyond the nipple and areola A distinct lump underneath the nipple and areola Skin and nipple changes usually in one breast only Fluctuating skin changes early on, making it appear as if your skin [web.archive.org]

  Other symptoms include: Redness Swelling Oozing nipple discharge Scaling Bloody nipple discharge Ulceration Inversion of the nipple Scaly, crusty and thickened plaques often form on the nipple, which then spreads to the surrounding area. [dermnetnz.org]

  nipple discharge A flattened or turned-in (inverted) nipple A lump in the breast Thickening skin on the breast Signs and symptoms usually occur in one breast only. [mayoclinic.org]

• Bleeding from the Nipple

  […] an ulcer the nipple might flatten out or turn inwards (invert) there may be a discharge or bleeding from the nipple the area might feel itchy or sore there may be a lump in the same breast. [breast-cancer.canceraustralia.gov.au]

• Genital Lesions

  The genital lesion exhibited a moderate acanthosis of the epidermis filled with Paget’s cell nests (Fig. 2 a). In both the axillary lesions and the umbilical one, Paget’s cells were located in the thin epidermis (Figs 2 b–d). [medicaljournals.se]

  EMPD usually affects the elderly who may be medically unfit for surgery, and the treatment of genital lesions may involve mutilating surgery. [jmidlifehealth.org]

Proper recognition of this disorder is required to initiate an appropriate workup (eg, skin biopsy) for differentiating it from other benign inflammatory dermatosis and for detecting an underlying breast carcinoma. [web.archive.org]

We propose a treatment algorithm for patients presenting with Paget's disease of the breast. [ncbi.nlm.nih.gov]

The histogenesis of Paget's disease of the breast continues to be debated and is important when considering treatment options. [doi.org]

Surgery Surgery is the main treatment for Paget’s disease. [web.archive.org]

Patients generally have a very good prognosis depending on the extent of the malignancy. [aocd.org]

Prognosis[edit] The presence of three factors for the prognosis has been suggested, whether there is a palpable mass of the disease, whether lymph nodes are positive and whether there is an underlying malignant cancer. [en.wikipedia.org]

The hallmark is relentless progression despite topical therapy and the sharp-raised margin. [2] Three patterns of EMPD are accepted: (1) In situ epithelial form without carcinoma and excellent prognosis, (2) epithelial form with adnexal carcinoma, and [e-ijd.org]

MPD is often associated with extensive underlying malignancy which is of high grade and is frequently Her2 neu positive with a resulting poor prognosis. [scopemed.org]

The purpose of the work is to make a clinical laboratory evaluation of the role of urogenital opportunistic pathogenic flora in etiology and pathogenesis of pathological uterine cervix conditions and to identify possible preventive measures to uterine [giog.it]

Etiology The disease is caused by a mutation in the gene encoding 3-beta-hydroxy-delta-5-C27 steroid oxidoreductase (HSD3B7, 16p12-p11.2). Transmission is autosomal recessive. [orpha.net]

Occasionally two or three bone marrows performed over time are necessary to establish an etiology. Referral to a center that specializes in bone marrow failure disorders is indicated is such cases. [cancertherapyadvisor.com]

[…] genitalia and perineal skin may be associated with bladder, urethra, prostate cancer, or colorectal neoplasia. [3] Due to such associations, a complete investigation for an underlying carcinoma should accompany every confirmed diagnosis of EMPD. [4] Etiology [e-ijd.org]

Etiology MPD and EMPD are neoplastic processes. The causes and cells of origin are controversial. Pathophysiology MPD is largely believed to originate from underlying ductal carcinoma of the breast. [dermatologyadvisor.com]

Oncology, Radiation Therapy (107) Genetics (94) Medical Chemistry and Biochemistry (88) Histology, Embryology (87) Neurology (75) Obstetrics, Gynaecology (72) Cardiology, Angiology (64) Dermatology (54) Otorhinolaryngology (54) Respiratory Medicine (53) Epidemiology [portal.mefanet.cz]

[…] invades the skin; the invasive carcinoma is usually large in size Paget disease with dermal invasion occurs when Paget cells cross the basement membrane of the epidermis; the invasive component is usually small in size ( Arch Pathol Lab Med 2013;137:72 ) Epidemiology [pathologyoutlines.com]

It is a rare type of cancer of the nipple-areola complex presenting as an eczematous lesion of the nipple and is often associated with an underlying in-situ or invasive carcinoma of the breast. [ 1 ] Epidemiology It is seen in 1-4% of cases of female [patient.info]

Summary Epidemiology Prevalence is unknown but may be around 1-9/1,000,000 for overall BAS defects, excluding cerebrotendinous xanthomatosis. [orpha.net]

According to NCI’s Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget disease of the breast between 1988 and 2001 was 82.6 percent. [cancer.gov]

Pathology and Forensic Medicine (310) Internal Medicine (282) Paediatrics, Neonatology (224) Surgery, Traumatology and Orthopaedics (184) Physiology and Pathophysiology (150) Anatomy (149) Dentistry (136) Infectology (117) Microbiology (117) Gastroenterology [portal.mefanet.cz]

[…] of female breast cancer. [ 2 ] It is also seen in male breast cancer but extremely rarely. [ 3 ] Most cases of Paget's disease of the breast are associated with invasive breast cancer - although 40% are associated with ductal carcinoma in situ. [ 2 ] Pathophysiology [patient.info]

In triple or quadruple extra-mammary Paget’s disease, the racial and gender differences in incidence, the pathophysiology underlying simultaneous distant occurrence of three or four lesions, and their malignant potentials are the matters to be elucidated [medicaljournals.se]

Pathophysiology[edit] Paget's disease of the breast is characterised by Paget cells. [en.wikipedia.org]

They usually undergo radiation therapy after the actual procedure to prevent recurrence. A breast-conserving surgery consists in the removal of the nipple, areola and the part of the breast that is affected by cancer. [en.wikipedia.org]

KEY WORDS: Empowerment - Behavior - Cervical cancer prevention - Women of childbearing age. Last Issue Toc Last Viewed [giog.it]

Prevention Because the cause of Paget's disease of the breast is not known, prevention of this disease is not possible. [medical-dictionary.thefreedictionary.com]

Prevention Making changes in your daily life may help reduce your risk of breast cancer. Try to: Ask your doctor about breast cancer screening. [mayoclinic.org]