DIFFERENTIAL DIAGNOSIS The clinical differential diagnoses of Paget's cells include inflammatory changes such as atopic or contact dermatitis of the nipple, chronic eczema, psoriasis, mammary ductal ectasia with chronic nipple discharge, syphilitic chancre [ncbi.nlm.nih.gov]

Investigational Therapies Photodynamic therapy (PDT), a procedure in which a drug known as a photosensitizer is used along with a special type light, has been used to treat some individuals with extramammary Paget’s disease and in rare cases of Paget’ [rarediseases.org]

In individuals with Paget’s disease of the breast, initial characteristic skin changes may include the appearance of reddish (erythematous), scaling, crusting, and/or abnormally thickened skin patches (plaques) or lesions on the nipple that may extend [rarediseases.org]

macules, ulceration, and crusting may also be present [2]. [file.scirp.org]

If you have nipple discharge, a sample of the discharge might also be collected for microscopic examination. If cancer cells are detected in the samples collected, you may be referred to a breast surgeon to discuss treatment options. [web.archive.org]

Other symptoms include: Redness Swelling Oozing nipple discharge Scaling Bloody nipple discharge Ulceration Inversion of the nipple Scaly, crusty and thickened plaques often form on the nipple, which then spreads to the surrounding area. [dermnetnz.org]

Paget Disease of the Breast Nipple Discharge Breast discharge is the spontaneous flow of fluid from the nipple at any time other than during nursing. [medicinenet.com]

Possible signs and symptoms of Paget's disease of the breast include: Flaky or scaly skin on your nipple Crusty, oozing or hardened skin resembling eczema, on the nipple, areola or both Redness Itching A burning sensation Straw-colored or bloody nipple [web.archive.org]

Other symptoms include: Redness Swelling Oozing nipple discharge Scaling Bloody nipple discharge Ulceration Inversion of the nipple Scaly, crusty and thickened plaques often form on the nipple, which then spreads to the surrounding area. [dermnetnz.org]

nipple discharge A flattened or turned-in (inverted) nipple A lump in the breast Thickening skin on the breast Signs and symptoms usually occur in one breast only. [mayoclinic.org]

from the nipple the area might feel itchy or sore there may be a lump in the same breast. [breast-cancer.canceraustralia.gov.au]

infiltrate in the dermis, and positivity for EMA and Her - 2 / neu favored a diagnosis of Paget's disease. [ijdvl.com]

FATTY TUMORS THAT MAY INVOLVE THE SKIN HISTIOCYTIC AND HISTIOCYTE-LIKE SKIN INFILTRATES IN CHILDREN AND YOUNG ADULTS CAUSES OF RETICULAR DERMAL EDEMA PATCHY DERMAL LYMPHOHISTIOCYTIC [LYMPHOCYTIC] INFILTRATES. [docplayer.net]

An extensive lymphocytic infiltrate with involvement largely concentrated in the deep epidermis (H and E, 40) Immunohistochemistry is useful not only in the diagnosis of the Paget's disease but also in differentiating it from other entities and in attempting [ncbi.nlm.nih.gov]