When present, the prognosis is the poorest. About 31 (62%) of 50 patients with mammary Paget disease present with a detectable breast mass. [web.archive.org]

Through a collaborative review of patients treated with BCS and RT from seven institutions, 38 cases of Paget disease of the breast presenting without a palpable mass or mammographic density were identified. [ncbi.nlm.nih.gov]

Since, the initial presentation is limited to skin; it is the dermatologist who plays a key role in making a diagnosis, thus, facilitating proper management. [ijdvl.com]

The prognosis, or outlook, for people with Paget disease of the breast depends on a variety of factors, including the following: Whether or not a tumor is present in the affected breast If one or more tumors are present in the affected breast, whether [cancer.gov]

• Chancre

  DIFFERENTIAL DIAGNOSIS The clinical differential diagnoses of Paget's cells include inflammatory changes such as atopic or contact dermatitis of the nipple, chronic eczema, psoriasis, mammary ductal ectasia with chronic nipple discharge, syphilitic chancre [ncbi.nlm.nih.gov]

• Photosensitivity

  Investigational Therapies Photodynamic therapy (PDT), a procedure in which a drug known as a photosensitizer is used along with a special type light, has been used to treat some individuals with extramammary Paget’s disease and in rare cases of Paget’ [rarediseases.org]

• Skin Patch

  In individuals with Paget’s disease of the breast, initial characteristic skin changes may include the appearance of reddish (erythematous), scaling, crusting, and/or abnormally thickened skin patches (plaques) or lesions on the nipple that may extend [rarediseases.org]

• Hypopigmented Macule

  macules, ulceration, and crusting may also be present [2]. [file.scirp.org]

• Nipple Discharge

  If you have nipple discharge, a sample of the discharge might also be collected for microscopic examination. If cancer cells are detected in the samples collected, you may be referred to a breast surgeon to discuss treatment options. [web.archive.org]

  Other symptoms include: Redness Swelling Oozing nipple discharge Scaling Bloody nipple discharge Ulceration Inversion of the nipple Scaly, crusty and thickened plaques often form on the nipple, which then spreads to the surrounding area. [dermnetnz.org]

  Paget Disease of the Breast Nipple Discharge Breast discharge is the spontaneous flow of fluid from the nipple at any time other than during nursing. [medicinenet.com]

• Bloody Nipple Discharge

  Possible signs and symptoms of Paget's disease of the breast include: Flaky or scaly skin on your nipple Crusty, oozing or hardened skin resembling eczema, on the nipple, areola or both Redness Itching A burning sensation Straw-colored or bloody nipple [web.archive.org]

  Other symptoms include: Redness Swelling Oozing nipple discharge Scaling Bloody nipple discharge Ulceration Inversion of the nipple Scaly, crusty and thickened plaques often form on the nipple, which then spreads to the surrounding area. [dermnetnz.org]

  nipple discharge A flattened or turned-in (inverted) nipple A lump in the breast Thickening skin on the breast Signs and symptoms usually occur in one breast only. [mayoclinic.org]

• Bleeding from the Nipple

  from the nipple the area might feel itchy or sore there may be a lump in the same breast. [breast-cancer.canceraustralia.gov.au]

Proper recognition of this disorder is required to initiate an appropriate workup (eg, skin biopsy) for differentiating it from other benign inflammatory dermatosis and for detecting an underlying breast carcinoma. [web.archive.org]

• Lymphocytic Infiltrate

  infiltrate in the dermis, and positivity for EMA and Her - 2 / neu favored a diagnosis of Paget's disease. [ijdvl.com]

  FATTY TUMORS THAT MAY INVOLVE THE SKIN HISTIOCYTIC AND HISTIOCYTE-LIKE SKIN INFILTRATES IN CHILDREN AND YOUNG ADULTS CAUSES OF RETICULAR DERMAL EDEMA PATCHY DERMAL LYMPHOHISTIOCYTIC [LYMPHOCYTIC] INFILTRATES. [docplayer.net]

  An extensive lymphocytic infiltrate with involvement largely concentrated in the deep epidermis (H and E, 40) Immunohistochemistry is useful not only in the diagnosis of the Paget's disease but also in differentiating it from other entities and in attempting [ncbi.nlm.nih.gov]

We propose a treatment algorithm for patients presenting with Paget's disease of the breast. [ncbi.nlm.nih.gov]

Surgery Surgery is the main treatment for Paget’s disease. [web.archive.org]

The histogenesis of Paget's disease of the breast continues to be debated and is important when considering treatment options. [doi.org]

Prognosis[edit] The presence of three factors for the prognosis has been suggested, whether there is a palpable mass of the disease, whether lymph nodes are positive and whether there is an underlying malignant cancer. [en.wikipedia.org]

Patients generally have a very good prognosis depending on the extent of the malignancy. [aocd.org]

The prognosis for extramammary Paget's disease secondary to underlying neoplasia is worse than when the disease has arisen primarily within the epidermis. It depends on the prognosis of the underlying carcinoma. [doi.org]

[…] genitalia and perineal skin may be associated with bladder, urethra, prostate cancer, or colorectal neoplasia. [3] Due to such associations, a complete investigation for an underlying carcinoma should accompany every confirmed diagnosis of EMPD. [4] Etiology [e-ijd.org]

The purpose of the work is to make a clinical laboratory evaluation of the role of urogenital opportunistic pathogenic flora in etiology and pathogenesis of pathological uterine cervix conditions and to identify possible preventive measures to uterine [giog.it]

Etiology The disease is caused by a mutation in the gene encoding 3-beta-hydroxy-delta-5-C27 steroid oxidoreductase (HSD3B7, 16p12-p11.2). Transmission is autosomal recessive. [orpha.net]

Occasionally two or three bone marrows performed over time are necessary to establish an etiology. Referral to a center that specializes in bone marrow failure disorders is indicated is such cases. [cancertherapyadvisor.com]

Etiology MPD and EMPD are neoplastic processes. The causes and cells of origin are controversial. Pathophysiology MPD is largely believed to originate from underlying ductal carcinoma of the breast. [dermatologyadvisor.com]

Epidemiology Paget's disease of the breast, a disorder of the nipple-areola complex, first described by Sir James Paget in 1874, 2 Dermatopathology of the Female Breast Margot S. Peters,Julia S. Lehman,Nneka I. [doi.org]

According to NCI’s Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget disease of the breast between 1988 and 2001 was 82.6 percent. [cancer.gov]

According to NCI's Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget disease of the breast between 1988 and 2001 was 82.6 percent. [medicinenet.com]

The death rate of metastatic breast carcinoma in patients with mammary Paget's disease and underlying cancer is 61.3%, with a 10-year cumulative survival rate of 33%.[20] Epidemiology[edit] Most patients diagnosed with Paget's disease of the nipple are [en.wikipedia.org]

In triple or quadruple extra-mammary Paget’s disease, the racial and gender differences in incidence, the pathophysiology underlying simultaneous distant occurrence of three or four lesions, and their malignant potentials are the matters to be elucidated [medicaljournals.se]

Pathophysiology[edit] Paget's disease of the breast is characterised by Paget cells. [en.wikipedia.org]

Pathophysiology The pathogenesis of mammary Paget disease and the origin of Paget cells were once controversial. [web.archive.org]

Pathophysiology Paget's disease of the breast is characterised by Paget cells. [ipfs.io]

Pathology and Forensic Medicine (310) Internal Medicine (282) Paediatrics, Neonatology (224) Surgery, Traumatology and Orthopaedics (184) Physiology and Pathophysiology (150) Anatomy (149) Dentistry (136) Infectology (117) Microbiology (117) Gastroenterology [portal.mefanet.cz]

They usually undergo radiation therapy after the actual procedure to prevent recurrence. A breast-conserving surgery consists in the removal of the nipple, areola and the part of the breast that is affected by cancer. [en.wikipedia.org]

Prevention Because the cause of Paget's disease of the breast is not known, prevention of this disease is not possible. [medical-dictionary.thefreedictionary.com]

Prevention Making changes in your daily life may help reduce your risk of breast cancer. Try to: Ask your doctor about breast cancer screening. [mayoclinic.org]

Breast Cancer - Get the facts on breast cancer symptoms, signs, stages, types, research, risk factors, diagnosis, prevention information and treatment options: mastectomy, chemotherapy, radiation therapy. [web.archive.org]