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Palmoplantar Keratosis

Hyperkeratosis Palmaris Et Plantaris


  • The present study was conducted on 12 unrelated Chinese patients who were clinically predicted to suffer from NPPK.[ncbi.nlm.nih.gov]
  • We report the case of a 61-year-old woman who presented with a long history of multiple symptomatic hyperkeratotic papules on the palms and soles.[mdedge.com]
  • Furthermore, indexed unaffected parents in the present cohort were all heterozygous carriers.[spandidos-publications.com]
  • Gene Identification Often, the clinical presentation is not as straight forward as the texts present. Clinical evaluation can present with diffuse as well as punctuate keratodermas and associated nail dystrophy.[faoj.org]
  • Palmoplantar keratosis as a primary presentation of secondary syphilis Journal Issue: Volume 38: Issue 3: 2008[rcpe.ac.uk]
  • M Ghadiri-Sani, I Mann, M Lobo, ASM Jawad A 36-year-old man of Bangladeshi origin presented with a febrile illness, arthralgia, generalised lymphadenopathy and palmoplantar keratosis.[rcpe.ac.uk]
  • Patients also present halitosis, intense destruction of alveolar bone, and, in some cases, calcification of cortical bone, pathological tooth mobility and migration, reddish gingiva, with deep periodontal pockets (Tommasi, 2002; Fermin & Carranza, 1986[clinicadavilla.com.br]
Cardiac Signs and Symptoms
  • All patients with cardiac signs and symptoms showed echocardiographic enlargement of the right ventricle and a right ventricular band; in three the left ventricle was also affected.[ncbi.nlm.nih.gov]
  • Cardiomegaly on chest x ray and electrocardiographic abnormalities were common findings. Three cases had episodes of ventricular tachycardia and a fourth patient died suddenly.[ncbi.nlm.nih.gov]
Sparse, Abnormal Hair
  • As its name suggests, this disease is characterized by cystic nodules on the eyelids, thickening of the skin on the palms of the hands and soles of the feet, missing teeth, and sparse, abnormal hair growth.[nutritionhouse.com]
Palmar Keratosis
  • Figure 4 As in case 1, this 39 year-old female has very little palmar keratosis. Distal nail discoloration is observed (A and B). Her family history shows that most family members were affected by the disease.[faoj.org]
Hypoplastic Nails
  • Huriez syndrome Huriez syndrome is an autosomal dominant genodermatosis, characterized by the triad of congenital scleroatrophy of the distal extremities, PPK, and hypoplastic nail changes. The soles are not commonly involved.[intechopen.com]
Nail Hypertrophy
  • JLS-1 is characterized by nail hypertrophy, nail dystrophy, PPK, follicular keratosis and oral leukokeratosis and is the most common form of PC (56.2%). [4] JLS-2 usually lacks oral leukokeratosis and is commonly associated with epidermolytic bullae of[faoj.org]


  • […] sporadically from unaffected parent carriers , and autosomal dominant PPK can also occur sporadically due to a new mutation in an affected person (a de novo mutation). [4] Histopathology of a biopsy from affected skin should be part of the diagnostic workup[rarediseases.info.nih.gov]
Cardiomegaly on Chest X-ray
  • Cardiomegaly on chest x ray and electrocardiographic abnormalities were common findings. Three cases had episodes of ventricular tachycardia and a fourth patient died suddenly.[ncbi.nlm.nih.gov]


  • A 48-year-old woman developed palmoplantar hyperkeratosis during treatment with imatinib (400mg/day) for treatment of chronic myeloid leukemia.[ncbi.nlm.nih.gov]
  • The final chapters discuss treatment methods including drugs and lasers.[books.google.de]
  • Treatment Treatment regimes are based on surgical techniques, medications and ancillary treatments designed to decrease painful keratosis. Surgical debridement or paring of keratosis is effective, but only temporary.[faoj.org]
  • Please consult your own licensed physician regarding diagnosis and treatment of any medical condition! Please see also our disclaimer . This site complies with the HONcode standard for health information: verify here . Database updated 2019-02-19.[diseasesdatabase.com]
  • CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes.[diseaseinfosearch.org]


  • This syndrome requires a multidisciplinary team for treatment and control and the prognosis is still poor.[clinicadavilla.com.br]
  • Diagnosis - Keratosis palmoplantaris adenocarcinoma of the colon * Home Colorectal Cancer Tests * Home Fecal Occult Bleeding Tests Prognosis - Keratosis palmoplantaris adenocarcinoma of the colon Not supplied.[checkorphan.org]
  • Prognosis The prognosis of tylosis with oesophageal cancer is difficult to determine due to the limited number of affected individuals.[ojrd.biomedcentral.com]


  • The third volume of Recent Advances in Dermatology has been fully revised to bring clinicians and trainees fully up to date with the latest advances in dermatology, with emphasis on etiology, clinical features, diagnosis and treatment.[books.google.de]
  • They are organised into groups, and further divided into clinical, etiological or histopathological sub-types.[orpha.net]
  • In terms of treatment, the most successful results occur when the underlying etiology is diagnosed and treated.[ncbi.nlm.nih.gov]
  • Furthermore, the most common mutation (c.796C T) exerts a founder effect and contributes to NPPK etiology ( 2 ).[spandidos-publications.com]
  • Therefore, no etiologic or neoplastic agent was demonstrated. The histological analysis was inconclusive but helped ruling out many common diseases in the oral cavity.[clinicadavilla.com.br]


  • […] mechanisms of one of the most toxic minerals in the world • Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models • Discusses outcomes, epidemiology[books.google.de]
  • Disorder Synonyms PPK Column* ICD-9 Selected Epidemiologic Features Genetic Cause Syndromic Associations Distinguishing features Age of onset (for disorder manifistation) Erythema Transgrediens Other Epidermal Features** Systemic Features*** Relevant[dermatologyadvisor.com]
  • Epidemiology The condition is rare in Europe but more common in the East [ 6 ] . It occurs much more commonly in smokers and ex-smokers. It may run in families and rarely occurs in childhood.[patient.info]
  • Recent perspectives on the global epidemiology of childhood eczema. Allergol Immunopathol (Madr). 2011;39:174-182. Bieber T. Mechanisms of disease: atopic dermatitis. New Engl J Med. 2008;358:1483. Kurian A, Barankin B.[dermatology.exeltisusa.com]
  • Genetic epidemiology of breast cancer and associated cancers in high risk families. I. Segregation analysis. JNCI 71 , 455–461 (1983). 17 Hall, J.M., Lee, M.K., Morrow, J., Anderson, L. & King, M.-C.[nature.com]
Sex distribution
Age distribution


  • Its pathophysiology is still unclear. However the combination of impairment of genetic and environmental factors is most likely. The transmission is often autosomal dominant, rarely autosomal recessive. [ 5 , 6 , 7 ] .[pubs.sciepub.com]
  • […] epidermolytic leukoplakia Terminology Other names: Epidermolytic ichthyosis Bullous congenital ichthyosiform erythroderma Bullous ichthysosis Bullous erythroderma ichthyosiformis congenita of Brocq Disorder of cornification type 3 Vorner's syndrome Pathophysiology[pathologyoutlines.com]
  • Decubitus ulcers: pathophysiology and primary prevention. Dtsch Arztebl Int. 2010;107:371-382. Beers MH, Berkow, R, eds. The Merck Manual of Diagnosis and Therapy. 17th ed. Whitehouse Station, NJ: Merck & Company, Inc; 1999.[dermatology.exeltisusa.com]


  • Oral hygiene : Regular tooth care to prevent cavities is recommended.[nutritionhouse.com]
  • Prevention - Keratosis palmoplantaris adenocarcinoma of the colon Not supplied.[checkorphan.org]
  • Antiarrhythmic drugs are indicated for preventing recurrence of episodes of sustained ventricular tachycardia.[intechopen.com]
  • Lobmann, R, Kayser, R, Kasten, G: Effects of preventative footwear on foot pressure as determined by pedobarography in diabetic patients: a prospective study. Diabet. Med. 18: 314 – 319, 2001. Google Scholar Crossref Medline ISI 6.[dx.doi.org]

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