Presentation
Both diseases can present with involvement of the entire colon (pancolitis) with ulceration, diffuse polyposis, a (pseudo) tumoural mass, or a combination of these. Footnotes Contributors: JC wrote the manuscript. [ncbi.nlm.nih.gov]
Susceptibility Such susceptibility has been suggested for many years in light of the high number of patients in specific ethnic groups, the rare association with genetic diseases and especially the observation of family cases (where similarities in disease presentation [digestscience.com]
Entire Body System
- Fatigue
Pancolitis patients exhibit these symptoms and may also experience fatigue, fever, and night sweats. [2] [3] Due to the loss of function in the large intestine patients may lose large amounts of weight from being unable to procure nutrients from food. [en.wikipedia.org]
Severe flare-ups may result in weight loss, severe fatigue and fever. [digestscience.com]
Gastrointestinal
- Abdominal Pain
He also referred mild abdominal pain, constipation and tenesmus intermittently in the past 4 months. He had been submitted to a colonoscopy 1 year before, and it was unremarkable. [ncbi.nlm.nih.gov]
Symptoms: pain and severity The most frequently observed symptom in UC is the presence of blood in stools (rectorrhagias). It may be associated with mucus discharges, diarrhea, abdominal pains, etc. [digestscience.com]
Musculoskeletal
- Arthralgia
Extra-intestinal symptoms may appear: in the joints (arthralgia, low back pain), on the skin (erythema nodosum), sometimes in the eyes or the liver. In children, ulcerative colitis leads to malnutrition, which may cause severe failure to thrive. [digestscience.com]
Treatment
PMID 25920500. ^ a b c d "Ulcerative Colitis Symptoms, Diet, Treatment & Medication". Retrieved 2016-06-27. ^ "Ulcerative colitis". 2016-03-17. [en.wikipedia.org]
As their onset of action occurs within a few months, they cannot be used as a monotherapy for the treatment of flare-ups. They are used in progressive forms or challenging treatment. [digestscience.com]
Prognosis
The patient was started on chemotherapy and is currently alive, 6 months after diagnosis, despite the poor prognosis. [ncbi.nlm.nih.gov]
Epidemiology
Epidemiology shows a higher incidence in industrialized countries and an increasing incidence in westernizing countries. [digestscience.com]
Pathophysiology
The role of these risk genes, their interactions and the consequences of their mutations are researched intensively, but their burden in the pathophysiology of IBDs remain moderate and IBDs are never hereditary diseases. [digestscience.com]
Prevention
In this case the entire colon and rectum are removed which both cures the pancolitis and prevents any chance of colon cancer. [en.wikipedia.org]
All these observations pave the way for new research prospects, the implementation of new diagnostic tools and new hopes for treatment and prevention. [digestscience.com]