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Pancreatic Atrophy

Pancreas Atrophy


Presentation

  • We report a case of pancreatic atrophy following blunt injury in an 8 year old boy who presented 3 years later with diabetes mellitus. Further analysis revealed significant genetic predisposition to diabetes. Published by Elsevier Inc.[ncbi.nlm.nih.gov]
  • Pancreatic atrophy 6 months after the beginning of steroid therapy was defined to be present when the width of the pancreatic body was less than 10 mm.[ncbi.nlm.nih.gov]
  • The objective of the present study was to investigate the prevalence of pancreatic atrophy among a cohort of patients with hepatocellular carcinoma (HCC) who were treated with sorafenib for 2 y.[ncbi.nlm.nih.gov]
  • Coverage of symptoms, nutrition, and chronic and acute disorders presents a thorough discussion of gastroenterology. A new diagnostic modality (BIPS) is covered, detailing this useful technique for general practice applications.[books.google.com]
  • New onset diabetes mellitus (NODM) is being evaluated as one such presentation.[gicasym.org]
Increased Energy
  • Possible causes include malabsorption, decreased caloric intake, increased energy expenditure and hypercatabolism. 2 Weight loss may be partially due to pancreatic exocrine insufficiency as seen with steatorrhea 3 , 4 or to gastrointestinal (GI) cGVHD[nature.com]
Lower Abdominal Pain
  • Gastroenterology Community 31.4k Members i am a 44 year old woman,went and got ct scan ,having lower abdominal pain,the scan showed fatty pancreatic atrophy subtle heterogeneity in the head of the pancreas.i have no idea what this is.any help will be[medhelp.org]

Treatment

  • Pancreatic atrophy has recently been reported in 2 patients as a novel side effect after long-term sorafenib treatment.[ncbi.nlm.nih.gov]
  • Median duration of treatment with sorafenib was 35.2 mo. Pancreatic atrophy and a decrease in pancreatic enhancement occurred in 24 patients (77.4%) and 15 patients (48.4%), respectively.[ncbi.nlm.nih.gov]
  • After 3 months of sorafenib treatment, the patient developed intermittent grade 2 diarrhea, which resolved when treatment was interrupted and recurred when treatment was reinitiated.[ascopost.com]
  • Discover different perspectives, leave with practical information you can immediately implement, and hear about potential treatments on the horizon. See you there on February 7–9, 2019, in Las Vegas.[journals.lww.com]
  • Treatment for chronic pancreatitis can involve managing the pain and addressing flare-ups. This includes prescribing pain medications and antioxidants.[reference.com]

Prognosis

  • Weight loss occurs in 20–30% of patients after transplantation and is highly common among those with chronic GVHD (cGVHD). 1 The cGVHD scoring system associates severe weight loss with a poor prognosis. 1 The etiology of weight loss is not well understood[nature.com]
  • What does this mean -source my 83 year old moms brain mri what does this mean -source my 83 year old moms brain mri and what is the prognosis conclusion Atrophy chronic ischemic changes no eveidence of accute intercanriel hemmorrage … read more Dr.[justanswer.com]

Etiology

  • The common etiology in all these processes is fat malabsorption, steatorrhea, saponification of calcium, and absorption of free oxalate.[ncbi.nlm.nih.gov]
  • It occurs principally with fatty replacement of the pancreas (pancreatic lipomatosis), and the etiology overlaps considerably.[radiopaedia.org]
  • Weight loss occurs in 20–30% of patients after transplantation and is highly common among those with chronic GVHD (cGVHD). 1 The cGVHD scoring system associates severe weight loss with a poor prognosis. 1 The etiology of weight loss is not well understood[nature.com]
  • The etiologies of pancreatitis were listed in the previous table .[med-ed.virginia.edu]
  • The cancer risk, even in presence of known potential etiology of acute pancreatitis, was high enough to warrant a search for an underlying pancreatic cancer.[gicasym.org]

Epidemiology

  • Epidemiological study by Ludvigsson et al. [ 5 ] has suggested that patients with celiac disease have a higher risk than the general population for the development of acute pancreatitis.[omicsonline.org]
  • […] present diffusely in dilated ducts Micro description: pancreatic ducts with denuded epithelium, squamous metaplasia, periductal lymphoplasmacytic infiltrate, acinar and islets atrophy, fibrosis Infectious pancreatitis: In immunocompromised patients Epidemiology[pathologyoutlines.com]
Sex distribution
Age distribution

Pathophysiology

  • These studies, taken together, provide a striking indication that the disease process leading to type 1 diabetes can produce pathophysiological changes in the exocrine pancreas before the onset of hyperglycaemia, opening up a fascinating new area for[diapedia.org]

Prevention

  • It may be possible to use induced hypergastrinemia in the treatment or prevention of pancreatic insufficiency following resection or injury.[ncbi.nlm.nih.gov]
  • Many surgeons prefer to insert a drainage tube into the remnant pancreatic duct primarily to prevent pancreatic leakage at the pancreaticojejunostomy (PJ) after PPPD.[ncbi.nlm.nih.gov]
  • "Another may be that preventive strategies aimed at preserving the mass of the pancreas might help to combat disease development," he added, noting that this would require a better understanding of the potential mechanisms by which diabetes is linked[medpagetoday.com]

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