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Pancreatic Atrophy

Pancreas Atrophy


Presentation

  • We report a case of pancreatic atrophy following blunt injury in an 8 year old boy who presented 3 years later with diabetes mellitus. Further analysis revealed significant genetic predisposition to diabetes.[ncbi.nlm.nih.gov]
  • Pancreatic atrophy 6 months after the beginning of steroid therapy was defined to be present when the width of the pancreatic body was less than 10 mm.[ncbi.nlm.nih.gov]
  • The objective of the present study was to investigate the prevalence of pancreatic atrophy among a cohort of patients with hepatocellular carcinoma (HCC) who were treated with sorafenib for 2 y.[ncbi.nlm.nih.gov]
  • Coverage of symptoms, nutrition, and chronic and acute disorders presents a thorough discussion of gastroenterology. A new diagnostic modality (BIPS) is covered, detailing this useful technique for general practice applications.[books.google.com]
  • Reports on ITPN have been rare, and most have described it in the classic macroscopic presentation.[pancreas.imedpub.com]
Lower Abdominal Pain
  • Gastroenterology Community 31.3k Members i am a 44 year old woman,went and got ct scan ,having lower abdominal pain,the scan showed fatty pancreatic atrophy subtle heterogeneity in the head of the pancreas.i have no idea what this is.any help will be[medhelp.org]

Treatment

  • Pancreatic atrophy has recently been reported in 2 patients as a novel side effect after long-term sorafenib treatment.[ncbi.nlm.nih.gov]
  • Pancreatic atrophy occurred in many HCC patients after 2 y of treatment with sorafenib. Patients who experienced pancreatic atrophy had a better tumor response and OS.[ncbi.nlm.nih.gov]
  • After 3 months of sorafenib treatment, the patient developed intermittent grade 2 diarrhea, which resolved when treatment was interrupted and recurred when treatment was reinitiated.[ascopost.com]
  • After 3 months of sorafenib treatment, the patient had an intermittent grade 2 diarrhea with remissions when treatment was interrupted and recurrence when it was reinitiated.[nejm.org]
  • Discover different perspectives, leave with practical information you can immediately implement, and hear about potential treatments on the horizon. See you there on February 7–9, 2019, in Las Vegas.[journals.lww.com]

Prognosis

  • Weight loss occurs in 20–30% of patients after transplantation and is highly common among those with chronic GVHD (cGVHD). 1 The cGVHD scoring system associates severe weight loss with a poor prognosis. 1 The etiology of weight loss is not well understood[nature.com]
  • What does this mean -source my 83 year old moms brain mri what does this mean -source my 83 year old moms brain mri and what is the prognosis conclusion Atrophy chronic ischemic changes no eveidence of accute intercanriel hemmorrage … read more Dr.[justanswer.com]
  • However, the long-term prognosis and outcome of AIP remain unclear.[ojrd.biomedcentral.com]
  • Prognosis The overall survival of patients with pancreatic cancer is poor, with less than 5% survival at 5 years from diagnosis.[surgwiki.com]

Etiology

  • The common etiology in all these processes is fat malabsorption, steatorrhea, saponification of calcium, and absorption of free oxalate.[ncbi.nlm.nih.gov]
  • Current science supports multiple etiologies that converge on one common biochemical pathway.[pedclerk.bsd.uchicago.edu]
  • Weight loss occurs in 20–30% of patients after transplantation and is highly common among those with chronic GVHD (cGVHD). 1 The cGVHD scoring system associates severe weight loss with a poor prognosis. 1 The etiology of weight loss is not well understood[nature.com]
  • The etiology for acute pancreatitis includes gallstones (40%), alcohol abuse (30%-35%), andidiopathic causes (20%).[appliedradiology.com]
  • The etiologies of pancreatitis were listed in the previous table .[med-ed.virginia.edu]

Epidemiology

  • Chronic Pancreatitis - Epidemiology Little is known about the epidemiology of chronic pancreatitis in children. The prevalence is less than that of acute pancreatitis, but the incidence may be increasing.[pedclerk.bsd.uchicago.edu]
  • Epidemiological study by Ludvigsson et al. [ 5 ] has suggested that patients with celiac disease have a higher risk than the general population for the development of acute pancreatitis.[omicsonline.org]
  • […] present diffusely in dilated ducts Micro description: pancreatic ducts with denuded epithelium, squamous metaplasia, periductal lymphoplasmacytic infiltrate, acinar and islets atrophy, fibrosis Infectious pancreatitis: In immunocompromised patients Epidemiology[pathologyoutlines.com]
  • Epidemiology of pancreatic calcification The frequency of pancreatic calcification in AIP ranges from 4% to 40%[ 14 , 29 , 30 , 32 , 34 – 36 , 38 , 41 , 42 ].[ojrd.biomedcentral.com]
Sex distribution
Age distribution

Pathophysiology

  • […] metabolism for energy - Leads to metabolic acidosis - Little or no insulin is produced by the pancreas - Formerly known as juvenile onset or insulin dependent diabetes mellitus (IDDM) - Most often occurs in people under 30 y/o Type 1 DM etiology and pathophysiology[quizlet.com]
  • In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. . Accessed July 26, 2016. Complementary pancreatitis therapies.[mayoclinic.org]
  • These studies, taken together, provide a striking indication that the disease process leading to type 1 diabetes can produce pathophysiological changes in the exocrine pancreas before the onset of hyperglycaemia, opening up a fascinating new area for[diapedia.org]
  • Acute Pancreatitis - Pathophysiology Acute pancreatitis is a reversible process characterized by the presence of interstitial edema, infiltration by acute inflammatory cells, and varying degrees of necrosis, apoptosis, and hemorrhage.[pedclerk.bsd.uchicago.edu]
  • These results suggest a possible deterioration in pancreatic exocrine or endocrine function in stone-forming patients with AIP over a long-term course, albeit with a different pathophysiology from that of ordinary chronic pancreatitis.[ojrd.biomedcentral.com]

Prevention

  • It may be possible to use induced hypergastrinemia in the treatment or prevention of pancreatic insufficiency following resection or injury.[ncbi.nlm.nih.gov]
  • Many surgeons prefer to insert a drainage tube into the remnant pancreatic duct primarily to prevent pancreatic leakage at the pancreaticojejunostomy (PJ) after PPPD.[ncbi.nlm.nih.gov]
  • "Another may be that preventive strategies aimed at preserving the mass of the pancreas might help to combat disease development," he added, noting that this would require a better understanding of the potential mechanisms by which diabetes is linked[medpagetoday.com]
  • Therefore, treatment is directed at minimising the progression of the disease and preventing complications.[surgwiki.com]
  • Chronic Pancreatitis Treatment of chronic pancreatitis emphasizes prevention of additional pancreatic injury, pain relief, nutritional support, and replacement of lost endocrine/exocrine function.[physio-pedia.com]

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