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Pancreatic Disease


Presentation

  • Present day and probable future developments, such as the use of robotics, natural orifice techniques, and major vascular reconstruction are also presented.[ncbi.nlm.nih.gov]
  • We describe a patient with systemic lupus erythematosus (SLE) who presented with severe refractory pannicular lesions diffusely involving the buttocks and lower extremities.[ncbi.nlm.nih.gov]
  • Here we present methods for using the adult zebrafish to analyze pancreas function and structure, with an emphasis on the endocrine pancreas and the beta cells.[ncbi.nlm.nih.gov]
  • Presentation was varied, including rectal bleeding (2). clinical deterioration during severe pancreatitis (4). and large bowel obstruction (3).[ncbi.nlm.nih.gov]
  • Present detection methods do not provide accurate diagnosis in the disease's early stages.[ncbi.nlm.nih.gov]
Developmental Delay
  • Two index patients with IMNEPD in the original report had multiple neurological symptoms such as postnatal microcephaly, intellectual disability, developmental delay, sensorineural deafness, cerebellar atrophy, ataxia, and peripheral neuropathy.[ncbi.nlm.nih.gov]
Abdominal Pain
  • METHODS: Patients with unknown cause of upper abdominal pain suggesting pancreatic disease without a history of alcohol consumption were prescribed a low-fat diet ( RESULTS: Of 45 patients, 14 were in the suggestive group, 18 were in the indeterminate[ncbi.nlm.nih.gov]
  • Extension of contiguous inflammation or neoplasm, autodigestive effects of enzymes, or dissection of a pseudocyst or abscess may involve the colon producing obstruction, perforation, hemorrhage, or abdominal pain.[ncbi.nlm.nih.gov]
  • METHODS: Patients with upper abdominal pain suggesting pancreatic disease (persistent over hours, pain aggravated by ingestion of food, epigastric pain radiating to the back), without a history of alcohol consumption and who exhibited no abnormalities[ncbi.nlm.nih.gov]
  • Chronic pancreatitis can also manifest with abdominal pain, and diabetes. Diagnosis of pancreatic insufficiency Pancreatic insufficiency is suspected in a patient who develops diabetes , upper abdominal pain and features of malabsorption.[ddc.musc.edu]
  • However, pancreatic cancer can have the following symptoms: Upper abdominal pain that may spread to the back Yellowing of the skin and the whites of the eyes ( jaundice ) Loss of appetite Weight loss Depression Blood clots Cleveland Clinic News & More[my.clevelandclinic.org]
Dyspepsia
  • OBJECTIVES: The objective of this study was to examine the efficacy of low-fat diet against dyspepsia in patients who had endosonographic evidence of nonalcoholic mild pancreatic disease.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Camostat mesilate may serve as a therapeutic agent for patients with dyspepsia associated with mild pancreatic disease, who do not habitually drink alcohol.[ncbi.nlm.nih.gov]
Epigastric Pain
  • METHODS: Patients with upper abdominal pain suggesting pancreatic disease (persistent over hours, pain aggravated by ingestion of food, epigastric pain radiating to the back), without a history of alcohol consumption and who exhibited no abnormalities[ncbi.nlm.nih.gov]
Rectal Bleeding
  • Presentation was varied, including rectal bleeding (2). clinical deterioration during severe pancreatitis (4). and large bowel obstruction (3).[ncbi.nlm.nih.gov]
Mid Back Pain
  • Mid-back pain or discomfort Where a bra strap would sit and may be eased by leaning forward. Indigestion Not responding to medication. Pale and smelly stools That don’t flush easily.[pancreaticcanceraction.org]

Workup

Pancreatic Calcification
  • Also, tropical pancreatitis, seen predominantly in South India and Africa, can lead to early onset diabetes and pancreatic calcifications and is associated with a probable increased risk. C.[clinicaladvisor.com]

Treatment

  • PURPOSE OF REVIEW: The purpose of this review is to provide an update on the diagnosis and treatment of pancreatic disorders using endoscopy.[ncbi.nlm.nih.gov]
  • Some patients with Zollinger-Ellison syndromes are managed with medical antiulcer treatment, others are treated with total gastrectomy.[ncbi.nlm.nih.gov]
  • Abstract Pyloric exclusion with gastrojejunostomy has been shown to be an effective adjuvant in the treatment of severe duodenal and pancreatic trauma.[ncbi.nlm.nih.gov]
  • Symptom severity was recorded before and after treatment using a 10-cm visual analog scale (VAS). RESULTS: Among 95 patients, 40 were in the suspected pancreatic disease group, 30 were in the equivalent group and 25 served as controls.[ncbi.nlm.nih.gov]
  • CONCLUSION: We conclude that operative treatment for pancreatic or hepatic disease has an adverse effect on body composition, physiological function and psychological state.[ncbi.nlm.nih.gov]

Prognosis

  • In those patients undergoing surgical resection for pancreatic duct-cell carcinomas, the prognosis of patients who were negative for the anti-p53 antibodies was better than patients who were positive.[ncbi.nlm.nih.gov]
  • BACKGROUND/OBJECTIVES: The loss of skeletal muscle mass (sarcopenia) is associated with the poor prognosis of pancreatic cancer.[ncbi.nlm.nih.gov]
  • "Knowing which sub-type a patient has would allow a doctor to provide a more accurate prognosis and treatment recommendations.[independent.co.uk]
  • “Knowing which sub-type a patient has would allow a doctor to provide a more accurate prognosis and treatment recommendations.”[theguardian.com]
  • Prognosis for pancreatic cancer Prognosis means the expected outcome of a disease. You will need to discuss your prognosis and treatment options with your doctor, but it is impossible for any doctor to predict the exact course of your disease.[cancer.org.au]

Etiology

  • This case illustrates that an uncharacteristic presentation of panniculitis in a patient with lupus does not necessarily imply lupus panniculitis, and a biopsy is imperative to distinguish other sometimes life threatening etiologies.[ncbi.nlm.nih.gov]
  • EUS cyst morphology, as well as fluid analysis obtained by fine needle aspiration, can often be used to diagnose the etiology of these lesions, helping the clinician to more accurately assess the presence or potential for malignancy.[ncbi.nlm.nih.gov]
  • These studies and others also defined distinctive roles of alcohol and genetics in the etiology and progression of chronic pancreatitis. Copyright 2011 by the Research Society on Alcoholism.[ncbi.nlm.nih.gov]
  • Advances in the Etiology of Chronic Pancreatitis. Dig Dis 28 p324-329, 2010. Available online at through . Accessed April 2011.[labtestsonline.org]
  • "Epidemiologic and etiologic factors of pancreatic cancer.". Hematol Oncol Clin N Am. vol. 16. 2002. pp. 1-16. Sharma, C,, Eltawil, K,, Renfrew, P,, Walsh, M,, Molinari, M..[clinicaladvisor.com]

Epidemiology

  • Abstract Findings from epidemiologic studies and research with experimental animal models provide insights into alcohol-related disease pathogeneses.[ncbi.nlm.nih.gov]
  • Author information 1 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.[ncbi.nlm.nih.gov]
  • BACKGROUND: The epidemiology of acute alcoholic pancreatitis (AP), chronic alcoholic pancreatitis (CP), acute alcoholic hepatitis (AH), and chronic alcoholic hepatitis with cirrhosis (CH) alone or in combination is not well described.[ncbi.nlm.nih.gov]
  • Vitamin D found to slash risk of pancreatic cancer 9/12/2006 - New research published in the journal Cancer Epidemiology Biomarkers and Prevention indicates that vitamin D could significantly reduce the risk of pancreatic cancer.[naturalnews.com]
  • Given the close developmental and physiological relatedness of pancreatic exocrine and endocrine cells and the significant epidemiological association between pancreatic cancer and diabetes, it is especially felt that a forum for scientific exchange among[grc.org]
Sex distribution
Age distribution

Pathophysiology

  • Diabetes mellitus [ edit ] The pancreas is central in the pathophysiology of both major types of diabetes mellitus.[en.wikipedia.org]
  • 11:35 am Discussion 11:35 am - 11:50 am Selected from Poster Abstracts: Anguraj Sadanandam (Institute of Cancer Research (ICR), United Kingdom) "Multi-Omics and Cross-Species Subtypes in Pancreatic Neuroendocrine Tumors with Distinct Cellular Origin, Pathophysiology[grc.org]

Prevention

  • Second, screening for NAFPD may identify individuals at risk for developing type 2 diabetes mellitus for targeted prevention.[ncbi.nlm.nih.gov]
  • , National Cancer Institute, National Institutes of Health, Bethesda, MD; Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; ¶Cancer Biomarkers Research Group, Division of Cancer Prevention[ncbi.nlm.nih.gov]
  • Understanding the effects of alcohol use on the pancreas may prove beneficial in the prevention of both pancreatitis and pancreatic cancer.[ncbi.nlm.nih.gov]
  • Their findings reveal magnesium can help prevent pancreatic cancer. Indulging in dark chocolate could, therefore, be more than just a treat - it could actually benefit a person's health.[dailymail.co.uk]
  • In recent years, there has been a focus on improving its safety in the prevention of post-ERCP pancreatitis. Pancreatic endotherapy by ERCP for the treatment of biliary strictures and chronic pain in chronic pancreatitis will also be reviewed.[ncbi.nlm.nih.gov]

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