Although these data are encouraging, PDAC is usually asymptomatic, and the disease only becomes apparent after the tumor invades surrounding tissues or metastasizes to distant organs [ 6 ]. [journals.plos.org]

[…] non-functioning types. [23] Somewhere between 45% and 90% of PanNETs are thought to be of the non-functioning types. [19] [26] Studies of autopsies have uncovered small PanNETs rather frequently, suggesting that the prevalence of tumors that remain inert and asymptomatic [en.wikipedia.org]

All hospitals and pathology and haematology laboratories as well as dentists submit mandatory data on cancer patients to the cancer registry. Additional data on survival and cause of death were obtained from Statistics Finland. [gut.bmj.com]

Pancreatic Cancer Recruiting NCT03401827 Phase 4 Chemotherapy (Gemcitabine nab-paclitaxel) 2 Prevention of Upper Gastrointestinal Hemorrhage Using Albis in the Patients of Locally Advanced Pancreatic Cancer Who Underwent Concurrent Chemoradiotherapy Withdrawn [malacards.org]

More specifically, one study has reported the following frequency of sign and symptoms in patients with PDAC, in descending order (13): Weakness/fatigue (asthenia)—86% Loss of appetite (anorexia)—85% Weight loss—85% Abdominal pain—79% Dark urine—59% Jaundice [pancreapedia.org]

A randomized clinical trial testing repeated immunization with a Listeria monocytogenes-based vaccine encoding for mesothelin in combination with a GM-CSF-transfected allogeneic pancreatic cell vaccine reports no survival benefit for the vaccinated patients [clincancerres.aacrjournals.org]