On univariate analysis, factors associated with a worse prognosis were synchronous (p 0.05) or metachronous metastases (p 0.001), non-resectable disease at presentation (p 0.001) and age 16 years at time of presentation (p 0.02). [ncbi.nlm.nih.gov]

Symptoms[edit] Children with pancreatoblastoma rarely present with early-stage disease, instead, most present with locally advanced or metastatic disease. Common presenting symptoms include abdominal pain, emesis, and jaundice. [en.wikipedia.org]

• Abdominal Lymphadenopathy

  The patient is a 24-yr-old African American woman, who presented with a pancreatic mass, hepatic masses, and abdominal lymphadenopathy. [ncbi.nlm.nih.gov]

• Fatigue

  A 3-year-old boy with nausea and general fatigue was referred to our center. Imaging studies showed an approximately 7.5-cm, left-sided abdominal mass and multiple metastases in the lung. [ncbi.nlm.nih.gov]

  Symptoms - Pancreatoblastoma * Asymptomatic in early stages * Upper abdominal pain * Abdominal pain above the bellybutton * Gastrointestinal obstruction * Vomiting * Jaundice * Weight loss * Enlarged abdomen * Abdominal mass * Loss of appetite * Fatigue [checkorphan.org]

  They include growth problems (in children), obesity (in adults), hair loss, slow heart rate, low blood sugar, low blood pressure, fatigue, and problems with reproduction. [cancer.gov]

  The following signs and symptoms may be noted: Failure to thrive (infants) Distended abdomen Abdominal pain, back pain Loss of appetite Weight loss Indigestion Yellowing of skin (jaundice) Nausea and vomiting Dark-colored urine Fatigue (getting tired [dovemed.com]

• Hunting

  [PMID 16185976] Savides TJ, Donohue M, Hunt G, Al-Haddad M, Aslanian H, Ben-Menachem T, et al. EUS-guided FNA diagnostic yield of malignancy in solid pancreatic masses: a benchmark for quality performance measurement. [pancreas.imedpub.com]

• Abdominal Pain

  One was a 3.5-year-old boy who presented with abdominal pain. Physical examination demonstrated abdominal masses. Multiple pancreatic and hepatic masses were noted by magnetic resonance imaging. [ncbi.nlm.nih.gov]

• Recurrent Vomiting

  Case report: A 7 year old boy presented with recurrent vomiting, weight loss and an abdominal lump. Work up revealed a large tumor arising from the pancreas encasing major vessels and the biopsy was suggestive of a pancreatoblastoma. [hpbonline.org]

• Liver Mass

  The aspiration smears of the liver mass showed a biphasic tumor composed of bland-appearing primitive spindled stromal fragments with "spider-web"-like long fibrils interconnecting with sharply angulated islands of cohesive epithelium. [ncbi.nlm.nih.gov]

  An initial fine needle aspiration of the pancreatic mass was nondiagnostic, and a subsequent fine needle aspiration of a liver mass was read as metastatic acinar cell carcinoma. [springerlink.com]

  Therefore, a needle biopsy of the liver mass was obtained and was initially diagnosed as a neuroendocrine carcinoma, consistent with metastasis from a pancreatic primary. [archivesofpathology.org]

• Shoulder Pain

  CASE REPORT A 27-year-old woman with a past medical history of iron deficiency anemia from dysfunctional uterine bleeding presented with a 2-month history of pressure like chest pain, shortness of breath, and right shoulder pain. [pancreas.imedpub.com]

• Keratosis

  Large epithelioid cells islands or whorled nests of spindled cells, as well as keratosis, may be visible. In contrast to the surrounding cells, cells in the squamoid corpuscle has large oval nuclei, with inconspicuous nucleoli. [ijpmonline.org]

Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate. [books.google.com]

Neonatal workup confirmed the presence of an abdominal mass in the region of the pancreas, but precise anatomic localization was not possible. [ncbi.nlm.nih.gov]

Based on initial findings on contrast-enhanced computed tomography (CT, Figure 1A), additional workup included ultrasound (US, Figure 1B) and MRI (MRI, Figure 1C) through the abdomen. [jaocr.org]

To review the current knowledge on nomenclature, etiology, pathophysiology, clinical presentation, diagnostic workup and management of adult patients w... Meso-Rex bypass for extrahepatic portal vein obstruction in children. [allmedx.com]

The best example clearly is the SPN, in which virtually all cases have the same underlying CTNNB1 mutation and immunohistochemistry for β-catenin is routinely used in the diagnostic workup. [diagnosticpathology.biomedcentral.com]

• Liver Function Tests Abnormal

  Occasionally, adult pancreatoblastoma causes liver function test abnormalities due to biliary obstruction or hepatic metastasis. Imaging Most tumors are well-defined on crosssectional imaging. [pancreas.imedpub.com]

  Liver function test abnormalities [ 11 ] and anemia are sometimes reported [ 12 ]. [ncbi.nlm.nih.gov]

• Liver Biopsy

  The initial liver biopsy diagnosis was metastatic neuroendocrine carcinoma based on morphology and synaptophysin positivity. At pancreatic resection, the diagnostic features of pancreatoblastoma were recognized. [ncbi.nlm.nih.gov]

  The neuroendocrine-appearing component was positive for synaptophysin, which was also seen in the original liver biopsy and which helped lead to the initial diagnosis of neuroendocrine carcinoma. [archivesofpathology.org]

  (d) Histological image showing the surgical resection of the pancreatic tumour, the characteristics of which were similar to those observed in the previous liver biopsy (H & E, 200 ). [ecancer.org]

Surgical resection is the only treatment associated with long-term survival. Chemotherapy may play a role as palliative treatment in advanced disease. [ncbi.nlm.nih.gov]

Prognosis The prognosis for pediatric cases is usually good if the tumor is resectable, but recurrences still occur. If unresectable and in the presence of metastasis, pancreatoblastoma has an aggressive course and prognosis is poor. [orpha.net]

The biology may help define prognosis and therapy for this kind of tumor. [ncbi.nlm.nih.gov]

Etiology The etiology is unknown but pancreatoblastoma can occur in any part of the pancreas. [orpha.net]

The author review the clinical presentation, etiology, diagnosis, treatment and prognosis of PB in this presentation. [ncbi.nlm.nih.gov]

Summary Epidemiology The incidence is less than 1/1,000,000 in Europe. Pancreatoblastoma accounts for 0.5% of all pancreatic exocrine tumors and occurs equally in females and males. [orpha.net]

From 1973 to 2006, 69 patients under 20 years of age were registered in the North American population-based Surveillance, Epidemiology, and End Results database with a diagnosis of tumor arising from the pancreas. [journals.lww.com]

Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: Clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore) 1977; 56:1. Shaib W, Deng Y, Zilterman D, Lundberg B, Saif MW. [serena.unina.it]

Trousseau's syndrome and othermanifestations of chronic disseminated coagulopathy in patients withneoplasms: Clinical, pathophysiologic, and therapeutic features.Medicine (Baltimore) 1977; 56:1. [pancreas.imedpub.com]

Pathophysiology Pathology is based on specific deficiency or deficiencies. [unboundmedicine.com]

Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: Clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore) 1977; 56:1. 9. [143.225.131.3]

This has been linked to the displacement of E-cadherin and beta-catenin from their normal membrane location, which prevents adherens junctions to form. [ncbi.nlm.nih.gov]

Prevention - Pancreatoblastoma Not supplied. [checkorphan.org]

Currently, there are no specific methods or guidelines to prevent Pancreatoblastoma Children with a family history of Beckwith-Wiedemann syndrome or familial polyposis syndrome may benefit from increased monitoring for pancreatic tumors What is the Prognosis [dovemed.com]

Personal hygiene can go a long way towards preventing paraphimosis. If treated quickly, the condition is not serious. [medicalnewstoday.com]