Presentation
Abstract A case of a 49-year-old housewife with persistent hyperamylasemia, intractable amylase-rich ascites, and papillary serous cystadenocarcinoma of the ovaries is presented. [ncbi.nlm.nih.gov]
Cutaneous metastasis is a late manifestation often presenting as subcutaneous nodules. 6,7 Carcinoma erysipeloides is an even rarer presentation of ovarian cancer, with a poor prognosis and a median survival of 18 months. 8 A PubMed search of articles [mdedge.com]
Involvement of 1 out of 10 lymph nodes on right side and 1 out of 9 lymph nodes on left side was present. Metastasis to omentum was present [Fig.2]. [casereports.in]
At a minimum, the characteristic micropapillary architecture must be present in a continuous 5 mm area on a single slide in order for a diagnosis of MPSC to be made. [path.upmc.edu]
Entire Body System
-
Lymphadenopathy
CT can be used for preoperative staging to look for lymphadenopathy, peritoneal, and distant metastases. [radiopaedia.org]
CT scan for ovarian tumors is helpful in staging of disease as it gives information pre-operatively about lymphadenopathy, peritoneal deposits and distant metastasis. [casereports.in]
Gastrointestinal
-
Abdominal Mass
pelvic pain, abdominal mass, vaginal bleeding, involuntary weight loss and ascites), a sign of advanced disease. [medical-dictionary.thefreedictionary.com]
The patient may feel an abdominal mass. Most cases are diagnosed in an advanced stage. [emedicine.medscape.com]
Skin
-
Subcutaneous Nodule
Cutaneous metastasis is a late manifestation often presenting as subcutaneous nodules. 6,7 Carcinoma erysipeloides is an even rarer presentation of ovarian cancer, with a poor prognosis and a median survival of 18 months. 8 A PubMed search of articles [mdedge.com]
-
Erythema
To the Editor: A 40-year-old woman with a history of stage IIIC ovarian cancer presented with progressing abdominal erythema and pain of 1 month’s duration. [mdedge.com]
-
Ulcer
Appendix showed ulcerated lining mucosa and mucosal glands. Underneath submucosa and muscularis were infiltrated by tumor tissue. [scopemed.org]
Workup
See Workup for more detail. Management Standard treatment for women with ovarian cancer involves aggressive debulking surgery and chemotherapy. [emedicine.medscape.com]
Treatment
OVCARE has led a number of unique initiatives recently, and has new projects in place to find better treatment for these diseases. [ovcare.ca]
Early diagnosis with close monitoring and treatment of the tumor is important. [dovemed.com]
Several studies evaluating treatment have indicated that there is no advantage to adjuvant radiation or chemotherapy compared with no post-operative treatment for borderline ovarian tumors [ 5 ]. [gynecolsurg.springeropen.com]
Immunohistochemistry using ovarian tumor markers (eg, paired-box gene 8, cancer antigen 125) is an additional tool to accurately identify malignant cells in skin biopsy. 8,10 Once diagnosed, primary treatment for carcinoma erysipeloides is treatment of [mdedge.com]
Women with PPC usually get the same treatment as those with widespread ovarian cancer. [cancer.org]
Prognosis
(Outcomes/Resolutions) The prognosis of Serous Papillary Cystadenoma of Ovary is excellent after its complete surgical removal The prognosis is generally good when the lesions are small and found below the ovarian surface. [dovemed.com]
Serous papillary adenocarcinoma of the endometrium: a unique entity with a grave prognosis—case report and review of the literature. Eur J Gynaecol Oncol 1993;14:46–50 2. [cogprints.org]
There is a consensus that peritoneal “implants” associated with serous borderline tumors that display invasive features (“invasive implants”) have a poor prognosis with a 7-year survival of 66%, and can also be referred to as invasive carcinoma. [journals.lww.com]
Serous tumors being most common around one-fourth of all and clear cell tumors are comparatively rare 2-5% of all ovarian tumors and having poorer prognosis compared with serous tumors. [ijpmonline.org]
Poor prognosis. May be associated with a BRCA1 gene or BRCA2 gene mutation. [1] Approximately 20% of high-grade serous carcinoma are associated with BRCA1 or BRCA2. [2] Precursors lesions: Serous borderline tumours for low-grade serious carcinoma. [librepathology.org]
Etiology
The markedly hyperechoic solid component was seen in benign masses such as teratomas or endometriomas, and was specific for a benign etiology in this study. [sonoworld.com]
(Etiology) The exact cause of Serous Papillary Cystadenoma of Ovary is currently unknown; they are thought to occur spontaneously Researchers have documented certain genetic changes within the tumor. [dovemed.com]
(See Etiology.) Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. [emedicine.medscape.com]
[…] into the following: Serous cystadenoma Borderline serous tumour Serous cystadenocarcinoma Adenofibroma Cystadenofibroma Mucinous tumours are further classified as: Mucinous cystadenoma Borderline mucinous tumour Mucinous cystadenocarcinoma Adenofibroma Etiology [atlasgeneticsoncology.org]
Epidemiology
Katsube Y, Berg J W, Silverberg S G 1982 Epidemiologic pathology of ovarian tumours: a histopathologic review of primary ovarian neoplasms diagnosed in the Denver Standard Metropolitan statistical Area, 1 July – 31 December 1969 and 1 July 31 December [cogprints.org]
Primary peritoneal and ovarian cancers: An epidemiological comparative analysis. Cancer Causes Control 2010;21:991-8. 2. Goodman MT, Shvetsov YB. Incidence of ovarian, peritoneal, and fallopian tube carcinomas in the United States, 1995-2004. [jscisociety.com]
(See Epidemiology.) Early disease causes minimal, nonspecific, or no symptoms. Therefore, most cases are diagnosed in an advanced stage. [emedicine.medscape.com]
PMID 8275457 Epidemiology and primary prevention of cancers of the breast, endometrium, and ovary. A brief overview. Kelsey JL, Whittemore AS Annals of epidemiology. 1994 ; 4 (2) : 89-95. [atlasgeneticsoncology.org]
Pathophysiology
Pathophysiology Historically, most theories of the pathophysiology of ovarian cancer included the concept that it begins with the dedifferentiation of the cells overlying the ovary. [emedicine.medscape.com]
PAX genes: roles in development, pathophysiology, and cancer. Biochem Pharmacol 2007; 73 :1–14. 6. Torres M, Gomez-Pardo E, Dressler GR, et al. Pax-2 controls multiple steps of urogenital development. Development 1995; 121 :4057–4065. 7. [nature.com]
Prevention
How can Serous Papillary Cystadenoma of Ovary be Prevented? The cause of Serous Papillary Cystadenoma of Ovary is unknown. Hence, there are no known methods to prevent the tumor occurrence. [dovemed.com]
Reconstitution Instructions These slides are paraffin coated to prevent sample oxidization, it is recommended that slides are first de-paraffinized by baking at 62 degrees C for 1 hour in a vertical orientation prior to performing antigen retrieval procedures [novusbio.com]
OVCARE has developed a promising strategy to tackle this form of ovarian cancer and prevent it before it has the chance to develop. [ovcare.ca]
This new paradigm has profound clinical implications in ovarian cancer prevention strategies. Authors' information Dr. [jhoonline.biomedcentral.com]
Preventive Services Task Force. Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014 Feb 18. 160 (4):271-81. [Medline]. [emedicine.medscape.com]