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2.1
Paranoid Schizophrenia

Presentation

If there is a significant degree of suspiciousness or paranoia present, people may be very reluctant to discuss these issues with a stranger. There is a broad spectrum to the nature and severity of symptoms that may be present at any one time. [psychcentral.com]

Gender and cultural differences in presentation Schizophrenia presents itself three to six years later in women than in men, but it presents itself the same way between genders. [courses.lumenlearning.com]

Another criterion present in patients with paranoid schizophrenia are auditory hallucinations, in which the person hears voices or sounds that are not really present. [dictionary.cambridge.org]

[…] voices or sounds that are not really present. [en.wikipedia.org]

The hallucinations experienced in cases of schizophrenia may involve seeing, hearing, smelling, feeling or even tasting something that is not actually present. [news-medical.net]

Entire Body System

  • Enuresis

    Enuresis as a premorbid developmental marker of schizophrenia. Brain. 2008 Sep. 131:2489-98. [Medline]. [Full Text]. Jones P, Rodgers B, Murray R, Marmot M. Child development risk factors for adult schizophrenia in the British 1946 birth cohort. [emedicine.medscape.com]

Neurologic

  • Encephalopathy

    Wernicke's encephalopathy. N Engl J Med. 1985 Apr 18. 312(16):1035-9. [Medline]. Salokangas RK. Medical problems in schizophrenia patients living in the community (alternative facilities). Curr Opin Psychiatry. 2007 Jul. 20(4):402-5. [Medline]. [emedicine.medscape.com]

  • No Speech Development

    The illness manifests itself gradually in children and is often preceded by lags in motor development, speech development, etc. The paranoid subtype often manifests itself later than the other subtypes. [courses.lumenlearning.com]

Workup

And did you do a mental status workup or question him about hallucinations or delusions? A. Yes. And what did you learn in that regard? A. Well, I focused on those issues twice. [pbs.org]

See Workup for more detail. Management Antipsychotic medications diminish the positive symptoms of schizophrenia and prevent relapses. There is no clear antipsychotic drug of choice for schizophrenia. [emedicine.medscape.com]

Treatment

When it comes to finding an effective paranoid schizophrenia treatment, it’s important to recognize that every patient is unique and will respond differently to each treatment option. [promisesbehavioralhealth.com]

Alex wants to see the same funding put into finding treatments for mental illness as there is for physical illness. [mqmentalhealth.org]

These symptoms assumedly cause a higher rate of intensive treatment in acute care wards. This difference in treatment context could also account for differences in infrastructure costs in the treatment of SAD patients. [journals.plos.org]

Early diagnosis is critical for the successful treatment of schizophrenia. [en.wikipedia.org]

Psychotherapy also plays an important role in the treatment of schizophrenia. [psycom.net]

Prognosis

Some authors contend that the prognosis for paranoid schizophrenia is fairly good, particularly if the onset is late and the symptoms relatively mild. Sources: Bayley, R. (1996) First person account: schizophrenia. [healthcentral.com]

The prognosis is somewhat better than that for schizophrenia but worse than that for mood disorders. [fortherecordmag.com]

“It both determines the appropriate treatment for the patient and provides the patient and family with an informed prognosis. [treatmentadvocacycenter.org]

What Is the Prognosis for Schizophrenia? The prognosis for people with schizophrenia can vary depending on the amount of support and treatment the patients receives. Many people with schizophrenia are able to function well and lead normal lives. [onhealth.com]

Usually the prognosis is poor because of the rapid development of "negative" symptoms, particularly flattening of affect and loss of volition. Hebephrenia should normally be diagnosed only in adolescents or young adults. [apps.who.int]

Etiology

Etiology Etiological factors for schizophrenia include genetic factors, environmental factors, and physiological factors. The more severe a parent’s schizophrenia, the more likely it is that a child will have schizophrenia. [courses.lumenlearning.com]

2015, 38% of a randomly selected sample of adult outpatients with schizophrenia (n=45) or schizoaffective disorder (n=5) was found to have comorbid SAD, as determined by a cutoff score of 29/30 on the total Liebowitz Social Anxiety Scale score. 3 The etiology [psychiatryadvisor.com]

Thus, inflammation might be related both to the psychopathology of schizophrenia and to metabolic disturbances seen in patients with schizophrenia. [12] Etiology The causes of schizophrenia are not known. [emedicine.medscape.com]

The rare work on this topic, however, supports the assumption that DD is not a genetic variant of PS. 37–39 Cardno and McGuffin, 8 overviewing the genetic research on DD, concluded that it is not clear whether there is a genetic contribution to the etiology [academic.oup.com]

Epidemiology

There is very little epidemiological data for Paranoid Schizophrenia specifically. When the diagnosis of Schizophrenia came in use, almost half were considered in the Paranoid category. [courses.lumenlearning.com]

However, there is a paucity of epidemiological studies on the prevalence of SAD. In particular, no epidemiological studies investigated the prevalence of SAD in Germany. [journals.plos.org]

Scientists at the NIH campus conduct research on numerous areas of study, including cognition, genetics, epidemiology, and psychiatry. The studies take place at the NIH Clinical Center in Bethesda, Maryland and require regular visits. [nimh.nih.gov]

Schizophrenia in Adults: Epidemiology and Pathogenesis. UpToDate. March 13, 2019. Schizophrenia: Questions and Answers About Psychosis. National Institute of Mental Health. Stone DM, Simon TR, Fowler KA, et al. [everydayhealth.com]

Translating the epidemiology of psychosis into public mental health: evidence, challenges and future prospects. J Public Ment Health. 2010 Jun. 9(2):4-14. [Medline]. Kety SS, Wender PH, Jacobsen B, et al. [emedicine.medscape.com]

Pathophysiology

Reciprocal links between impairments in LINE-1 methylation and neuro-immune and neuro-oxidative pathways may underpin the pathophysiology of both MIP and paranoid schizophrenia. Footnotes Assoc. [biorxiv.org]

The pathophysiology of SZ likely reflects genetic, developmental and environmental factors [ 3 ]. The main pathophysiological concept assumes an overstimulation of dopaminergic transmission in striatal, frontal and cingulate brain regions [ 3, 4 ]. [journals.plos.org]

Pathophysiology Anatomic, neurotransmitter, and immune system abnormalities have been implicated in the pathophysiology of schizophrenia. [emedicine.medscape.com]

Prevention

Thought disorder may be obvious in acute states, but if so it does not prevent the typical delusions or hallulcinations from being described clearly. [schizophrenia.com]

There's no sure way to prevent schizophrenia, but sticking with the treatment plan can help prevent relapses or worsening of symptoms. [mayoclinic.org]

Although medical records are often specific as to symptoms and resulting limitations, they often do not describe exactly how a condition prevents you from working, and therefore may not be sufficient for proving total disability according to the SSA. [disability-benefits-help.org]

Commentary Before discussing the clinical and ethical issues raised by Charlie’s current situation, we should reflect on the important distinction between preventive ethics (i.e., anticipating and preventing ethical problems before they arise) and reactive [journalofethics.ama-assn.org]

We’re funding multiple projects looking to improve understanding and treatment of schizophrenia, from looking at how it first develops in the brain to seeing if we could prevent it with folic acid . [mqmentalhealth.org]

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