We describe an extremely rare and previously unreported presentation of acute progressive paraparesis secondary to traumatic thoracic disc herniation in a child presenting to our institution. [ncbi.nlm.nih.gov]

• Unable to Stand

  The patient was unable to stand on either leg alone and failed a trial of ambulation secondary to lower extremity weakness. Deep tendon reflexes were 2 throughout. Sensation to touch, pinprick, and temperature was intact. [anesthesiology.pubs.asahq.org]

  Eight patients were unable to stand or walk and were bed bound at presentation. In 1 infant (aged 8 months) with paraparesis, the parents noticed paucity in limb movements, and another child older than 1 year could not walk, even with support. [thejns.org]

• Euthyroid

  Episodes can be prevented by achieving a euthyroid state. This report describes a young gentleman presenting with thyrotoxic hypokalemic paraparesis. [ncbi.nlm.nih.gov]

• Macrocephaly

  Infantile Alexander disease is a rare progressive leukodystrophy caused by autosomal dominant mutations in the (GFAP) gene typically presenting with psychomotor retardation, progressive macrocephaly and refractory epilepsy. [ncbi.nlm.nih.gov]

• Progressive Macrocephaly

  Infantile Alexander disease is a rare progressive leukodystrophy caused by autosomal dominant mutations in the (GFAP) gene typically presenting with psychomotor retardation, progressive macrocephaly and refractory epilepsy. [ncbi.nlm.nih.gov]

• Urinary Retention

  Complications such as eschars due to a prolonged decubitus, urinary retention to sphincter dysfunction, fractures, etc. make these patients potential surgery candidates. [scielo.org.co]

Therefore, upper endoscopy should be part of the diagnostic workup of vitamin B 12 deficiency. Multiple factors can lead to misdiagnosis of vitamin B 12 deficiency. [dovepress.com]

• Liver Biopsy

  Although clinical history appeared too long, we considered the hypothesis of IVLBCL on the basis of the laboratory constellation and proposed a liver biopsy, but the patient refused the procedure. The diagnosis was confirmed only at autopsy. [ncbi.nlm.nih.gov]

Our patient was a 41-year-old female, affected by PsA in treatment since 2 years with low-dose methylprednisolone and low-dose subcutaneous MTX. The treatment was effective. [ncbi.nlm.nih.gov]

Therefore, we now need the therapeutic regimens to protect the development, or be able to commence the treatments as soon as possible after the development safely and inexpensively even in long-term course or lifelong course of treatment. [eurekaselect.com]

During the treatments I felt very relaxed and calm. Even though I hate needles acupuncture treatments are really OK. The clinic is quiet and the staff is friendly. [acupuncturerestoreshealth.com]

Prognosis HAM/TSP is a progressive disease, but it is rarely fatal. Most individuals live for several decades after the diagnosis. [brainfacts.org]

Prognosis Prognosis depends on the phenotype (pure/complex form), genotype, and is highly variable due to incomplete penetrance and variable gene expression. [orpha.net]

Michaelis LS (1969) International inquiry on neurological terminology and prognosis in paraplegia and tetraplegia. Paraplegia 7:1–5 PubMed Google Scholar 24. [link.springer.com]

Differentiation between HSP and PLS is important for genetic counseling of family members and for the patients' prognosis because HSP generally has a more favorable prognosis than PLS. 1 Furthermore, progression to ALS, as may occur in PLS, 24 is not [jamanetwork.com]

Burkitt’s lymphoma with paraparesis is a sign of advanced disease and is often associated with a poor prognosis. Both thorough clinical assessment to estab- lish the level of the lesion, and reassessment to look for changes, are essential. [books.mcai.org.uk]

An intrahepatic portosystemic venous shunt (IPSVS) was observed on enhanced computed tomography, and hyperammonemia suggested leakage of neurotoxins from the shunt as the etiology of the patient's symptoms. [ncbi.nlm.nih.gov]

Etiology The disease is due to the dysfunction of the upper motor neurons of the corticospinal tract. To date, more than 80 genes have been linked. [orpha.net]

Hypokalemic paralysis: a review of the etiologies, pathophysiology, presentation, and therapy. Am J Emerg Med. 1992; 10:143-8. 9.Magsino CH Jr, Ryan AJ Jr. Thyrotoxic periodic paralysis. [bjmp.org]

The etiology of stroke in diabetes can be either microvascular disease from fibrinoid necrosis, causing small subcortical infarcts called lacunar stroke, or large-vessel intracranial vascular disease, producing atherosclerotic occlusion and/or thrombosis [clinical.diabetesjournals.org]

In addition to the above, signs and symptoms specific to the underlying etiology may also be present, e.g. headaches, diplopia, and bilateral visual defects in the case of a pituitary tumor. [medicaljoyworks.com]

How to use this case study General instructions : Case studies in applied epidemiology allow students to practice applying epidemiologic skills in the classroom to address real-world public health problems. [panafrican-med-journal.com]

Summary Epidemiology It has been described in affecting at least six male members spanning three generations of a large family. [orpha.net]

HSP data were compared to data from HUNT-3, a Norwegian epidemiological population study that enrolled more than 46,000 individuals. The survey was based on 19 items, each of which was also covered in HUNT3. [mdmag.com]

Epidemiology of tropical spastic paraparesis in Colombia and associated HTLV-1 infection. Ann Neurol 1988;23:161-5. 11. Roman GC, Roman LN. [neurologyindia.com]

In a study in Martinique looking at the epidemiology of adult T-cell leukaemia, 59% of those patients who had TSP were found to have antibodies to HTLV-1, as opposed to 13% of controls. [ 2 ] Since then, several other studies have confirmed these findings [patient.info]

We review previously reported cases and current understanding of the pathophysiology of this complication. All cases had symptom onset several hours after the procedure. There seems to be a trend toward better outcomes with earlier treatment. [ncbi.nlm.nih.gov]

It could be argued that the observed findings are an epiphenomenon, resulting from longstanding retrograde degeneration, rather than a direct reflection of the underlying TSP pathophysiology. [hippokratia.gr]

Hypokalemic paralysis: a review of the etiologies, pathophysiology, presentation, and therapy. Am J Emerg Med. 1992; 10:143-8. 9.Magsino CH Jr, Ryan AJ Jr. Thyrotoxic periodic paralysis. [bjmp.org]

Pathophysiology Pathology is based on specific deficiency or deficiencies. [unboundmedicine.com]

Pathophysiology The effects of hypopituitarism in children depend on the affected hormones. GH deficiency can result in hypoglycemia and short stature. [emedicine.medscape.com]

Episodes can be prevented by achieving a euthyroid state. This report describes a young gentleman presenting with thyrotoxic hypokalemic paraparesis. [ncbi.nlm.nih.gov]

O Contractures: all joints need to be moved through their full range of movement to prevent contractures develop- ing. [books.mcai.org.uk]

Tropical Spastic Paraparesis - Get information and read articles on Tropical Spastic Paraparesis sign, symptoms, causes, treatment, prevention and diagnosis at onlymyhealth.com, your complete health guide. [onlymyhealth.com]

Their prognosis improves if they take steps to prevent urinary tract infection and skin sores, and if they participate in physical and occupational therapy programs. [brainfacts.org]

[…] encouraging the adoption of primary and secondary preventive measures. [clinical.diabetesjournals.org]