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Parapharyngeal Abscess

Abscess Parapharyngeal Space

A parapharyngeal abscess develops principally as a complication of deep neck infections caused by various gram-positive and gram-negative bacterial pathogens, and its life-threatening nature mandates early recognition. Symptoms include fever, limited neck movement, voice changes, stridor, proximal lymphadenopathy with swelling of the neck, and breathing difficulties. A thorough clinical examination, microbiological confirmation of the underlying cause, and imaging studies of the neck (mainly computed tomography) are vital components of the diagnostic workup.


Presentation

Deep neck space infections can be particularly troubling in the absence of an early diagnosis. A parapharyngeal abscess, roughly defined as an infection of the parapharyngeal space, is seen after dissemination of other more common deep neck space infections (for example peritonsillar, tonsillar, or retropharyngeal abscesses, as well as tonsillitis) [1] [2] [3], or previous upper respiratory tract infections [4], but it may be the primary source of infection as well [5]. The clinical presentation is diverse and most frequent symptoms are fever, the stiffness of the neck accompanied by a swelling or a bulging mass, lymphadenopathy, and trismus (spasm of the jaw that results in impaired temporomandibular joint activity) [3] [4] [5]. Additional findings include torticollis, a range of respiratory complaints (stridor, voice changes, and sleep apnea), drooling, and odynophagia [3] [4] [5]. Most studies address that children in their first decade of life are the principal population in whom parapharyngeal abscesses are recognized [3] [4] [5], but the condition may be seen in patients of all ages. Because of the close proximity to the bronchial tree, complications such as aspiration pneumonia, mediastinitis and rheumatic fever/glomerulonephritis in the setting of streptococcal infection have been reported [4].

Fever
  • OBJECTIVE: We present the first reported case of parapharyngeal abscess in a child with periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome, an uncommon syndrome of recurrent, self-limiting fever in children.[ncbi.nlm.nih.gov]
  • Symptoms include fever, limited neck movement, voice changes, stridor, proximal lymphadenopathy with swelling of the neck, and breathing difficulties.[symptoma.com]
  • Symptoms and Signs Most patients have fever, sore throat, odynophagia, and swelling in the neck down to the hyoid bone.[msdmanuals.com]
  • Symptoms include fever, sore throat, painful swallowing, and swelling in the neck.[en.wikipedia.org]
  • Here we report a Chinese case of KD initially mimicking PPA, which is the first one reported in Asia.A 3-year-old male patient presented with fever, drooling, and bilateral painful cervical lymphadenopathy for 3 days.[ncbi.nlm.nih.gov]
Malaise
  • RPA is a relatively uncommon illness, and therefore may not receive early diagnosis in children presenting with stiff neck, malaise, difficulty swallowing, or other symptoms listed below.[icd.codes]
  • Drooling, malaise, decreased oral intake, irritability, neck mass, and respiratory distress or stridor, decreased appetite, jaw stiffness or neck stiffness, or muffled voice can also be seen.[radiologykey.com]
  • It is usually seen in an infant or young child with high fever, agitation, neck pain, malaise, fever, dysphagia, drooling, cough, respiratory distress, and stridor. [ 3 ] There is a stiff neck with the head tilted to one side.[patient.info]
  • […] the mouth Trismus: difficulty in opening the mouth Respiratory problems, such as stridor (abnormal breathing sound that is very high-pitched) High-grade fever Airways obstruction Cough Agitation Neck pain, stiff neck, presence of swelling in the neck Malaise[dovemed.com]
  • Patients with retropharyngeal abscess present with constitutional complaints such as fever, chills, malaise, decreased appetite, muffled "hot potato" voice [ 4 ] and irritability [ 2 ] as seen in our index case.[jmedicalcasereports.biomedcentral.com]
Stridor
  • The physical examination revealed cervical lymphadenopathy in 30 children (77%), limitation of neck movements in 25 (64%), torticollis in 21 (54%), drooling in three (8%), and stridor in two (5%).[ncbi.nlm.nih.gov]
  • Symptoms include fever, limited neck movement, voice changes, stridor, proximal lymphadenopathy with swelling of the neck, and breathing difficulties.[symptoma.com]
  • Clinical findings at presentation were: fever (93%), cervical lymphadenopathy (93%), neck pain (90%), torticollis (74%), odynophagia (64%), trismus (32%), drooling (22%) and stridor (6%).[ncbi.nlm.nih.gov]
  • Stridor Commonly seen in infants.[1] occurs due to the narrowing of the airway lumen. Drooling Commonly encountered among the pediatric population. Note that stridor and drooling are signs which indicate potential airway compromise.[explainmedicine.com]
  • Progression of the signs and symptoms is key as it pertains to inflammation and obstruction of the upper airways and/or gastrointestinal tract and there may be dysphagia, dyspnea, stridor, neck stiffness, drooling, trismus and/or chest pain.[radiopaedia.org]
Sleep Apnea
  • Additional findings include torticollis, a range of respiratory complaints (stridor, voice changes, and sleep apnea), drooling, and odynophagia.[symptoma.com]
Odynophagia
  • Symptoms and Signs Most patients have fever, sore throat, odynophagia, and swelling in the neck down to the hyoid bone.[msdmanuals.com]
  • Neck stiffness (64%) and odynophagia (55%) were the most common symptoms. Fever (64%), stiff neck (64%), bulging of the oropharyngeal wall (55%), mass in the neck (55%) and lymphadenopathy (36%) were the most prevalent physical findings.[ncbi.nlm.nih.gov]
  • Clinical findings at presentation were: fever (93%), cervical lymphadenopathy (93%), neck pain (90%), torticollis (74%), odynophagia (64%), trismus (32%), drooling (22%) and stridor (6%).[ncbi.nlm.nih.gov]
  • Six months after etanercept therapy was started, the patient presented to our emergency department with a swelling of his neck, odynophagia, otalgia, and trismus. The clinical course was consistent with parapharyngeal abscess.[ncbi.nlm.nih.gov]
  • Additional findings include torticollis, a range of respiratory complaints (stridor, voice changes, and sleep apnea), drooling, and odynophagia.[symptoma.com]
Trismus
  • Trismus is minimal. Posterior abscesses may involve structures within the carotid sheath, possibly causing rigors, high fever, bacteremia, neurologic deficits, and massive hemorrhage caused by carotid artery rupture.[msdmanuals.com]
  • Examination found trismus, through which a lateral pharyngeal bulge could be observed.[ncbi.nlm.nih.gov]
  • Clinical examination revealed a 3 cm left parotid and left level I neck swelling with left medialised tonsil but no trismus.[ncbi.nlm.nih.gov]
  • The first patient, with an abscess associated with chronic otitis media and presenting hypoglossal nerve palsy, quickly recovered from pharyngodinia, otalgia and trismus.[ncbi.nlm.nih.gov]
  • Clinical findings at presentation were: fever (93%), cervical lymphadenopathy (93%), neck pain (90%), torticollis (74%), odynophagia (64%), trismus (32%), drooling (22%) and stridor (6%).[ncbi.nlm.nih.gov]
Drooling
  • The case presented here, had not been diagnosed at the first examination; however, there were enough clinical clues (such as respiratory distress, drooling, torticollis, bulging of theneck, previous viral respiratory infection, possible pharyngeal trauma[ncbi.nlm.nih.gov]
  • Children's Memorial Hospital Abstract 6 year old child with drooling Keywords parapharyngeal abscess , plain film, CT Publication Date: 2004-07-14 History 6 year old child with drooling Differential Phlegmon (no other real differential in the context[mirc.luriechildrens.org]
  • Clinical findings at presentation were: fever (93%), cervical lymphadenopathy (93%), neck pain (90%), torticollis (74%), odynophagia (64%), trismus (32%), drooling (22%) and stridor (6%).[ncbi.nlm.nih.gov]
  • Here we report a Chinese case of KD initially mimicking PPA, which is the first one reported in Asia.A 3-year-old male patient presented with fever, drooling, and bilateral painful cervical lymphadenopathy for 3 days.[ncbi.nlm.nih.gov]
  • The physical examination revealed cervical lymphadenopathy in 30 children (77%), limitation of neck movements in 25 (64%), torticollis in 21 (54%), drooling in three (8%), and stridor in two (5%).[ncbi.nlm.nih.gov]
Neck Pain
  • Clinical findings at presentation were: fever (93%), cervical lymphadenopathy (93%), neck pain (90%), torticollis (74%), odynophagia (64%), trismus (32%), drooling (22%) and stridor (6%).[ncbi.nlm.nih.gov]
  • The most common symptoms at presentation included fever (n 27, 70%) and neck pain (n 24, 62%).[ncbi.nlm.nih.gov]
  • Neck pain and stiffness Compression of the adjacent group of neck muscles and soft tissues by the abscess causing inflammatory response.[2] References MARTINS RH, CASTILHO EC, WEBER ST, SEMENZATI GDE O, CAMPOS LM.[explainmedicine.com]
  • A 19-year-old female patient presented to our Medicine Outpatient Department (OPD) at All India Institute of Medical Sciences (AIIMS) with odynophagia and neck pain for two months, without any other constitutional symptoms.[lungindia.com]
Neck Mass
  • Healy GB (1989) Inflammatory neck masses in children: a comparison of computed tomography, ultrasound, and magnatic resonance imaging. Arch Otolaryngol Head Neck Surg 115:1027–1028 Google Scholar 11.[doi.org]
  • Physical findings include fever, cervical adenopathy, decreased range of neck motion, neck mass, posterior pharyngeal mass, and respiratory distress.[radiologykey.com]
  • Katya Rozovasky et al performed Ultrasound in 210 patients with neck masses and found 99.5% accuracy in diagnosis. Additional CT was done in 25 patients that helped to detect airway obstruction in 4 patients.[apicareonline.com]
Neck Stiffness
  • An otherwise healthy 2-year-old female presented with a 4-day history of fevers, decreased oral intake, neck stiffness, and voice changes.[ncbi.nlm.nih.gov]
  • Neck stiffness (64%) and odynophagia (55%) were the most common symptoms. Fever (64%), stiff neck (64%), bulging of the oropharyngeal wall (55%), mass in the neck (55%) and lymphadenopathy (36%) were the most prevalent physical findings.[ncbi.nlm.nih.gov]
  • Progression of the signs and symptoms is key as it pertains to inflammation and obstruction of the upper airways and/or gastrointestinal tract and there may be dysphagia, dyspnea, stridor, neck stiffness, drooling, trismus and/or chest pain.[radiopaedia.org]
  • Meningitis Important to consider as fever and neck stiffness are classical signs of meningeal irritation.[2] Peritonsillar Abscess and Cellulitis Usually presents with a history of preceding episodes of tonsillitis.[explainmedicine.com]
  • Drooling, malaise, decreased oral intake, irritability, neck mass, and respiratory distress or stridor, decreased appetite, jaw stiffness or neck stiffness, or muffled voice can also be seen.[radiologykey.com]

Workup

The diagnosis of a deep neck space infection must be suspected in the presence of a bulging mass in the neck accompanied by voice changes, fever, and respiratory difficulties. A thoroughly obtained patient history that will note the course and progression of symptoms, and a detailed physical examination during which inspection and palpation of the neck, pulmonary auscultation, and a complete ear, nose, and throat (ENT) exam are conducted, are the first steps that will allow sufficient evidence to be raised towards a parapharyngeal abscess. Once a presumptive diagnosis is made, a microbiological investigation is recommended as the next step in the workup. Bronchoalveolar aspirates, blood cultures, or needle aspiration have all been described as potential methods to obtain a viable sample for identification of the underlying cause [1] [6]. Klebsiella pneumoniae, streptococcal, and staphylococcal species are primary pathogens involved in the development of deep neck space infections, but it is not uncommon for a polymicrobial infection to be present [4] [6]. Imaging studies are equally important in the assessment of a parapharyngeal abscess. Ultrasonography of the neck and chest X-rays (if the involvement of pulmonary system is suspected) are viable first-line methods, but computed tomography (CT) is the gold-standard due to its ability to confirm the exact location of the abscess and determine its spread into adjacent tissues [5] [7].

Francisella Tularensis
  • Microagglutination test antibody titres for Francisella tularensis were positive (1/1280). The patient healed completely after definitive drainage of the abscess and antimicrobial therapy for 14 days (streptomycin, 2 1 g intramuscularly).[ncbi.nlm.nih.gov]
  • The most common bacterial organisms causing acute unilateral infection associated with facial trauma or impetigo are S. aureus and GABHS. 10-12 Other causes include Bartonella henselae, Haemophilus influenzae, Francisella tularensis, Pasteurella multocida[anaerobicinfections.blogspot.com]

Treatment

  • Treatment with etanercept plus methotrexate was started. Three months later, methotrexate was discontinued.[ncbi.nlm.nih.gov]
  • Therefore, until now, the recommended treatment of parapharyngeal abscess has been early open surgical drainage.[ncbi.nlm.nih.gov]
  • CONCLUSION: Based on the good clinical outcomes and low incidence of complications, the present study suggests that antibiotic therapy complemented with a timely surgical treatment, is a valid treatment option in refractory parapharyngeal abscesses.[ncbi.nlm.nih.gov]
  • His neck incision became infected but healed gradually following dressing change and antibiotic treatment.[ncbi.nlm.nih.gov]
  • Two were complicated by mediastinitis despite early treatment by wide spectrum antibiotics.[doi.org]

Prognosis

  • It is important to establish early diagnosis, and complications to be aware of getting a good prognosis.[thieme-connect.com]
  • […] spread from other deep head and neck spaces (e.g. parotid , retropharyngeal or submandibular spaces ) secondary to penetrating trauma of the neck iatrogenic e.g. injection of local anesthetic for tonsillectomy or mandibular nerve block Treatment and prognosis[radiopaedia.org]
  • […] throat, blockage of the airways, swallowing difficulties, respiratory problems, and stiff neck with neck pain Early diagnosis and management of Retropharyngeal Abscess is necessary to prevent severe complications from developing in the child or adult The prognosis[dovemed.com]
  • Septic thrombosis of the jugular vein or haemorrhage secondary to erosion into the carotid artery, Prognosis [ 10 ] Prognosis is generally good if the condition is diagnosed early, is managed promptly and effectively and if no complications occur.[patient.info]
  • Outlook (Prognosis) It is important to get medical help right away. This condition can lead to blockage of the airway. This is life threatening. With prompt treatment, a full recovery is expected.[ufhealth.org]

Etiology

  • DISCUSSION/CONCLUSION: Parapharyngeal abscess with an etiology of Pott's disease is rare. Modern imaging is highly contributive to diagnosis and follow-up of lesion regression under treatment. Copyright 2011 Elsevier Masson SAS. All rights reserved.[ncbi.nlm.nih.gov]
  • Lateropharyngeal and retropharyngeal abscesses are potentially life threatening infections in children AIM: To review the etiologic, clinical, and imaging signs of lateropharyngeal and retropharyngeal abscesses in children as well as treatment-outcomes[ncbi.nlm.nih.gov]
  • It is important to know that there are differences in etiological factors and clinical behaviors between the adult case and pediatric one.[jstage.jst.go.jp]
  • Etiology Pharyngeal abscess 1. Adjacent tissue inflammation, such as acute pharyngitis, tonsillitis and acute rhinitis, sinusitis, etc., direct invasion or blood infection into the pharyngeal space to form abscess. 2.[healthfrom.com]
  • Diagnosis Establishment of the infection's etiology is important whenever the infection does not resolve within a few days. Aspiration of the lesion may provide important clues.[anaerobicinfections.blogspot.com]

Epidemiology

  • Clindamycin should only be used if the MRSA isolate is susceptible to clindamycin, or local epidemiology supports its empiric use (clindamycin resistance 10%).[clinicaladvisor.com]
  • Chronic retropharyngeal abscess is rare but is usually due to tuberculosis of the spine. [ 2 ] Epidemiology Uncommon and occurs much less commonly today than in the past because of the widespread use of antibiotics for suppurative upper respiratory infections[patient.info]
  • Grisaru-Soen G, Komisar O, Aizenstein O, Soudack M, Schwartz D, et al. (2010) Retropharyngeal and parapharyngeal abscess in children--epidemiology, clinical features and treatment. Int J Pediatr Otorhinolaryngol 74: 1016-1020.[omicsonline.org]
Sex distribution
Age distribution

Pathophysiology

  • We discuss the possible pathophysiology of neck abscess as a presenting feature of nasopharyngeal carcinoma, and the relationship between the parapharyngeal abscess and endogenous bacterial endophthalmitis.[ncbi.nlm.nih.gov]
  • Conclusions on causality cannot be drawn from this retrospective study, but the pathophysiology behind the increased risk of PTA in smokers may be related to, previously shown, alterations in the tonsillar, bacterial flora or the local and systemical[ncbi.nlm.nih.gov]
  • Pathophysiology The pathophysiology of this disease is unknown. The condition is usually the endpoint of a disease that starts with acute follicular tonsillitis, progresses to peritonsillitis, and ends with formation of an abscess.[tonsilitisunderstood.blogspot.com]
  • The exact pathophysiology through which KD leads to PPA is unknown.[journals.lww.com]

Prevention

  • We believe that early diagnosis and aggressive antibiotic treatment with early surgical drainage in cases associated with pus collection are the key points in preventing serious and fatal complications.[ncbi.nlm.nih.gov]
  • Prevention Pharyngeal abscess prevention Pharyngeal abscess occurs in children, in addition to fever, the first family to find more swallowing disorders, speech is unclear, mistakenly believe that children have foreign body pharynx, this situation should[healthfrom.com]
  • This process is a reaction of protection by the tissue to prevent the spread / extension of infection to other parts of the body. Parapharyngeal abscess is a collection of pus that forms in the parapharyngeal space.[purba-java-indo.blogspot.com]
  • As it may prevent additional discomfort to the patient caused by unnecessary surgical or pharmaceutical interventions.[6] References LON SA, LATEEF M, SAJAD M. Acute epiglottitis: A review of 50 patients.[explainmedicine.com]

References

Article

  1. Page C, Biet A, Zaatar R, Strunski V. Parapharyngeal abscess: diagnosis and treatment. Eur Arch Otorhinolaryngol. 2008;265(6):681-686.
  2. Galioto NJ. Peritonsillar Abscess. Am Fam Physician. 2017;95(8):501-506.
  3. Marques PM, Spratley JE, Leal LM, Cardoso E, Santos M. Parapharyngeal abscess in children: five year retrospective study. Braz J Otorhinolaryngol. 2009;75(6):826-830.
  4. Gharib B, Mohammadpour M1, Sharifzadeh M, et al. A 15-Month-Old Boy With Respiratory Distress and Parapharyngeal Abscess: A Case Report. Acta Med Iran. 2016;54(12):812-816.
  5. Brito TP, Hazboun IM, Fernandes FL, et al. Deep neck abscesses: study of 101 cases. Braz J Otorhinolaryngol. 2016;pii:S1808-8694(16)30082-9.
  6. Lee YQ, Kanagalingam J. Bacteriology of deep neck abscesses: a retrospective review of 96 consecutive cases. Singapore Med J. 2011;52(5):351-355.
  7. Capps EF, Kinsella JJ, Gupta M, Bhatki AM, Opatowsky MJ. Emergency imaging assessment of acute, nontraumatic conditions of the head and neck. Radiographics. 2010;30(5):1335-1352.

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Last updated: 2018-06-22 00:12