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Parathion Poisoning


Presentation

  • Seven selected cases are presented exemplifying toxicokinetic peculiarities.[ncbi.nlm.nih.gov]
  • On the fourth day,he presents consciousness disorders. Upon ICU admission,Glasgow scale was 7/15. He had bilateral pin point pupils without signs of motor weakness as paraparesis or paraplegia.[toxicology.imedpub.com]
  • The reason for this correlation is not known at present.[jpgmonline.com]
  • The families filed a suit against Bayer in October of 2001 asserting that the company should have taken steps to prevent the foreseeable misuse of this extremely toxic product, given the severe health risks presented by methyl parathion, and the indigenous[panna.org]
  • However, organophosphate poisoning may still be present without pinpoint pupils, and dilation of the pupils may even be noted occasionally.[homeobook.com]
Gastric Lavage
  • She was treated by gastric lavage, administration of pralidoxime and atropine, and mechanical ventilation. As signs of intoxication disappeared at day 3, treatment was discontinued.[ncbi.nlm.nih.gov]
  • The treatment followed was briefly as follows: gastric lavage or induced vomiting; intravenous followed by intramuscular atropine, the dose being adjusted to keep the pupils fully dilated for 24 to 48 hours; intravenous oximes in severe cases; anti ancillary[jpgmonline.com]
Fatigue
  • CNS effects such as confusion, fatigue, irritability, nervousness, and impairment of memory can occasionally last for several weeks.[homeobook.com]
Hunting
  • Poultry Processing Tory Ashdown 67 17 Forestry Peter Poschen Chapter Editor Hunting George A Conway Chapter Editor Lumber Paul Demers and Kay Teschke Chapter Editors Paper and Pulp Industry Kay Teschke and Paul Demers Chapter Editors Bleaching George[books.google.com]
Rigor
  • Written in an accessible style with just the right amount of technical rigor, the book covers: General fundamentals and specific hazards and effects of chemical substances The basics of exposures and responses to chemical substances in the work environment[books.google.com]
Malaise
  • In the immediate aftermath,he had general malaise,vomiting and asthenia with a progressive deterioration of general condition evolving for three days. On the fourth day,he presents consciousness disorders. Upon ICU admission,Glasgow scale was 7/15.[toxicology.imedpub.com]
Bronchorrhea
  • Intubation may be necessary in cases of respiratory distress due to laryngospasm, bronchospasm, bronchorrhea, or seizures. Immediate aggressive use of atropine may eliminate the need for intubation.[openanesthesia.org]
  • Complications include severe bronchorrhea, seizures, weakness, and neuropathy. Respiratory failure is the most common cause of death. Age Organophosphates (OPs) may affect children or other at-risk populations differently.[emedicine.medscape.com]
Pneumonia
  • Our therapeutic management was intubation and mechanical ventilation,antibiotics to treat aspiration pneumonia,symptomatic treatment of muscarinic signs using Atropin 1 mg per 15 min until they disappear,a clinical and laboratory monitoring.[toxicology.imedpub.com]
Snoring
Rales
Abdominal Pain
  • Parathion poisoning meaning in Hindi (हिन्दी मे मीनिंग ) is a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.English definition[dict.hinkhoj.com]
  • Princeton's WordNet (0.00 / 0 votes) Rate this definition: parathion poisoning (noun) a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating[definitions.net]
  • 辞書 WordNet parathion poisoning 名詞 殺虫剤パラチオンの吸入または摂取による中毒症状 a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.[ei-navi.jp]
  • Muscarinic effects include pinpoint pupils; blurred vision; hypersecretion by salivary, lacrimal, sweat, and bronchial glands; narrowing of the bronchi; nausea, vomiting, diarrhoea, and crampy abdominal pains; urinary and fecal incontinence and slow heart[homeobook.com]
  • Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) is not uncommon.[cameochemicals.noaa.gov]
Nausea
  • Parathion poisoning meaning in Hindi (हिन्दी मे मीनिंग ) is a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.English definition[dict.hinkhoj.com]
  • Symptoms include nausea, vomiting, abdominal cramps, confusion, headache, lack of muscular control, convulsions, and dyspnea. parathion poisoning Poisoning contracted by accidental inhalation or ingestion while working with the pesticide or because of[medical-dictionary.thefreedictionary.com]
  • Princeton's WordNet (0.00 / 0 votes) Rate this definition: parathion poisoning (noun) a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating[definitions.net]
  • 辞書 WordNet parathion poisoning 名詞 殺虫剤パラチオンの吸入または摂取による中毒症状 a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.[ei-navi.jp]
  • Gastrointestinal Nausea, vomiting, abdominal cramps, diarrhoea, and faecal incontinence are common manifestations, regardless of the exposure route. These are again generally the earliest symptoms to occur.[homeobook.com]
Nausea
  • Parathion poisoning meaning in Hindi (हिन्दी मे मीनिंग ) is a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.English definition[dict.hinkhoj.com]
  • Symptoms include nausea, vomiting, abdominal cramps, confusion, headache, lack of muscular control, convulsions, and dyspnea. parathion poisoning Poisoning contracted by accidental inhalation or ingestion while working with the pesticide or because of[medical-dictionary.thefreedictionary.com]
  • Princeton's WordNet (0.00 / 0 votes) Rate this definition: parathion poisoning (noun) a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating[definitions.net]
  • 辞書 WordNet parathion poisoning 名詞 殺虫剤パラチオンの吸入または摂取による中毒症状 a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.[ei-navi.jp]
  • Gastrointestinal Nausea, vomiting, abdominal cramps, diarrhoea, and faecal incontinence are common manifestations, regardless of the exposure route. These are again generally the earliest symptoms to occur.[homeobook.com]
Diarrhea
  • Shortly after exposure, headache, sweating, salivation, lacrimation, vomiting, diarrhea, muscular twitching, convulsions, dyspnea, and blurred vision occur.[medical-dictionary.thefreedictionary.com]
  • Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) is not uncommon.[cameochemicals.noaa.gov]
Abdominal Cramps
  • Symptoms include nausea, vomiting, abdominal cramps, confusion, headache, lack of muscular control, convulsions, and dyspnea. parathion poisoning Poisoning contracted by accidental inhalation or ingestion while working with the pesticide or because of[medical-dictionary.thefreedictionary.com]
  • Gastrointestinal Nausea, vomiting, abdominal cramps, diarrhoea, and faecal incontinence are common manifestations, regardless of the exposure route. These are again generally the earliest symptoms to occur.[homeobook.com]
Hypotension
  • Signs and Symptoms Muscarinic signs (SLUDGE) salivation, lacrimation, urination, diaphoresis, gastrointestinal upset, emesis and progressing to bronchospasm, bronchorrhea, blurred vision, bradycardia or tachycardia, hypotension, confusion, and shock.[openanesthesia.org]
  • Hypotension (low blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur.[cameochemicals.noaa.gov]
Hypersalivation
  • After his hospitalization on his third day of poisoning, the patient was comatose, had a tight myosis and a diffuse tremor hypersalivation. His hemodynamic parameters were correct.[toxicology.imedpub.com]
Eruptions
  • A case of subacute parathion poisoning with an erysipeloid-like eruption of the left index finger is reported.[ncbi.nlm.nih.gov]
Lacrimation
  • Shortly after exposure, headache, sweating, salivation, lacrimation, vomiting, diarrhea, muscular twitching, convulsions, dyspnea, and blurred vision occur.[medical-dictionary.thefreedictionary.com]
  • Signs and Symptoms Muscarinic signs (SLUDGE) salivation, lacrimation, urination, diaphoresis, gastrointestinal upset, emesis and progressing to bronchospasm, bronchorrhea, blurred vision, bradycardia or tachycardia, hypotension, confusion, and shock.[openanesthesia.org]
  • Muscarinic effects include pinpoint pupils; blurred vision; hypersecretion by salivary, lacrimal, sweat, and bronchial glands; narrowing of the bronchi; nausea, vomiting, diarrhoea, and crampy abdominal pains; urinary and fecal incontinence and slow heart[homeobook.com]
Miosis
  • The evolution was marked by a neurological improvement with the disappearance of miosis on the fifth day of hospitalization. The pralidoxime could not be administered as it was not available.[toxicology.imedpub.com]
Muscle Weakness
  • Necrotic fibers were noted in muscle biopsies, but these fibers were too sparse to explain severe muscle weakness and were similar in patients with and without the intermediate syndrome. No patients developed delayed neuropathy.[journals.lww.com]
  • Start with 1-2 g (20-40 mg/kg) IV in 100 mL isotonic sodium chloride over 15-30 min; repeat in 1 h if muscle weakness is not relieved; then repeat q3-8h if signs of poisoning recur; other dosing regimens have been used, including continuous drip.[openanesthesia.org]
Muscle Twitch
  • Nicotinic effects include muscle twitching, cramping, and weakness. Nicotinic stimulation can obscure certain muscarinic effects and produce rapid heart rate and high blood pressure.[homeobook.com]
  • The remaining, 123 patients were classified into three groups of severity of poisoning, based on their clinical presentation: (i) Mild (81 cases): no symptoms, normal vital functions, normal pupils; (ii) Moderate (23 cases): Muscle twitches, increased[jpgmonline.com]
Suggestibility
  • Scrapings of residue from the floor of the truck that had brought the wheat flour from the mill to the general store where the baker purchased it were positive for parathion, suggesting that the flour had been contaminated during transport.[ncbi.nlm.nih.gov]
  • All these data suggest that the chronological clinical expression in the case reported is due to the prolonged toxic effects of methyl-parathion associated to dermal and subcutaneous absorption.[toxicology.imedpub.com]
  • […] poisoning by these agents. [9], [11] In addition to this, various reports of ingestion of OPC with suicidal intent are available. [4], [7], [11] Not rarely, a patient of OPC poisoning dies suddenly after an initial apparently good clinical recovery, suggesting[jpgmonline.com]
Impulsivity
  • Most cases of intentional pesticide poisoning appear to be impulsive acts undertaken during stressful events,and the availability of pesticides strongly influences the incidence of self-poisoning.[toxicology.imedpub.com]
Headache
  • Shortly after exposure, headache, sweating, salivation, lacrimation, vomiting, diarrhea, muscular twitching, convulsions, dyspnea, and blurred vision occur.[medical-dictionary.thefreedictionary.com]
  • Parathion poisoning meaning in Hindi (हिन्दी मे मीनिंग ) is a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.English definition[dict.hinkhoj.com]
  • Princeton's WordNet (0.00 / 0 votes) Rate this definition: parathion poisoning (noun) a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating[definitions.net]
  • 辞書 WordNet parathion poisoning 名詞 殺虫剤パラチオンの吸入または摂取による中毒症状 a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.[ei-navi.jp]
  • Exposure can cause loss of consciousness, dizziness, confusion, headaches, breathing difficulties, chest tightness and blurred vision.[nytimes.com]
Seizure
  • Intubation may be necessary in cases of respiratory distress due to laryngospasm, bronchospasm, bronchorrhea, or seizures. Immediate aggressive use of atropine may eliminate the need for intubation.[openanesthesia.org]
  • Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma.[cameochemicals.noaa.gov]
  • Complications include severe bronchorrhea, seizures, weakness, and neuropathy. Respiratory failure is the most common cause of death. Age Organophosphates (OPs) may affect children or other at-risk populations differently.[emedicine.medscape.com]
Paresis
  • An intermediate syndrome characterized by respiratory paresis, weakness in the territory of several motor cranial nerves and of proximal limb and neck flexor muscles, persisted for 3 weeks.[ncbi.nlm.nih.gov]
Asthenia
  • The immediate evolution was marked by asthenia, progressive deterioration of general condition and vomiting. After his hospitalization on his third day of poisoning, the patient was comatose, had a tight myosis and a diffuse tremor hypersalivation.[toxicology.imedpub.com]
Asthenia
  • The immediate evolution was marked by asthenia, progressive deterioration of general condition and vomiting. After his hospitalization on his third day of poisoning, the patient was comatose, had a tight myosis and a diffuse tremor hypersalivation.[toxicology.imedpub.com]

Workup

  • See Workup. Treatment begins with decontamination. Airway control and oxygenation are paramount. The mainstays of pharmacological therapy include atropine, pralidoxime (2-PAM), and benzodiazepines (eg, diazepam).[emedicine.medscape.com]

Treatment

  • Awareness of this complication of parathion poisoning, proper monitoring and treatment could prevent fatalities.[ncbi.nlm.nih.gov]
  • The symptomatic treatment is always to put more and to use no antidote as in our case.[toxicology.imedpub.com]
  • Treatment Termination of the exposure including removing all soiled clothing. Gently cleanse with soap and water to hydrolyze organophosphate solutions. Airway control and adequate oxygenation.[openanesthesia.org]

Prognosis

  • The clinical relevance of these changes to prognosis is not yet clear. This study was therefore, undertaken to evaluate the importance of ECG changes to the ultimate prognosis in OPC poisoning.[jpgmonline.com]
  • Keywords Subcutaneous injection; Organophosphate poisoning; Parathion; Prognosis Introduction Organophosphates poisoning is an important occupational health issue because they are pesticides worldwide used in industries and agriculture and in different[toxicology.imedpub.com]

Etiology

  • The etiology of so-called ginger paralysis (third report). Arch. Neurol. Psychiat. 26:976, 1931. [ Links ] 45. SMORTO, M. P. & BASMAJIAN, J. V. - Clinical Electroneurography. Williams & Williams Co., Baltimore, 1972. [ Links ] 46. TAYLOR, W. J.[scielo.br]

Epidemiology

  • Although most patients rapidly become symptomatic, the onset and severity of symptoms depend on the specific compound, amount, route of exposure, and rate of metabolic degradation. [5] Epidemiology Frequency United States In 2016, the American Association[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • These have included difficulties in executive functions, psychomotor speed, verbal, memory, attention, processing speed, visual-spatial functioning, and coordination. [4] Pathophysiology The primary mechanism of action of organophosphate pesticides is[emedicine.medscape.com]

Prevention

  • Awareness of this complication of parathion poisoning, proper monitoring and treatment could prevent fatalities.[ncbi.nlm.nih.gov]
  • AND MANAGEMENT Health Risks of Underground Construction Work Bohuslav Mdlek 93 8 MAJOR SECTORS AND THEIR HAZARDS TOOLS EQUIPMENT AND MATERIALS Elevators Escalators and Hoists J Staal and John Quackenbush 93 40 Prevention of Occupational Dermatosis among[books.google.com]
  • The suit seeks justice for the children that perished, guarantees of medical monitoring for the surviving children, and regulatory reforms to prevent future tragedies.[panna.org]
  • (EPA, 1998) Protective Clothing Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact.[cameochemicals.noaa.gov]

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