Presentation
Seven selected cases are presented exemplifying toxicokinetic peculiarities. [ncbi.nlm.nih.gov]
The reason for this correlation is not known at present. [jpgmonline.com]
The families filed a suit against Bayer in October of 2001 asserting that the company should have taken steps to prevent the foreseeable misuse of this extremely toxic product, given the severe health risks presented by methyl parathion, and the indigenous [panna.org]
On the fourth day,he presents consciousness disorders. Upon ICU admission,Glasgow scale was 7/15. He had bilateral pin point pupils without signs of motor weakness as paraparesis or paraplegia. [toxicology.imedpub.com]
However, organophosphate poisoning may still be present without pinpoint pupils, and dilation of the pupils may even be noted occasionally. [homeobook.com]
Entire Body System
- Unconsciousness
In the rest of the cases, death was due either to unrelieved pulmonary oedema or to respiratory paralysis with irreversible brain damage/unconsciousness setting in before or soon after admission. [jpgmonline.com]
The main signs were unconsciousness as in brain manifestation,miosis,vomiting,diffuse tremors and excessive salivation. All these signs delayed more than 48 h after subcutaneous injection of methyl-parathion which half-life is within this range. [toxicology.imedpub.com]
Typical symptoms of acute poisoning are headache, sweating and faintness followed by impaired vision, gastrointestinal disorders, shortness of breath, tremors, convulsions, unconsciousness, pulmonary paralysis and finally cardiac arrest. [wgbis.ces.iisc.ernet.in]
- Fatigue
CNS effects such as confusion, fatigue, irritability, nervousness, and impairment of memory can occasionally last for several weeks. [homeobook.com]
Respiratoric
- Bronchorrhea
Intubation may be necessary in cases of respiratory distress due to laryngospasm, bronchospasm, bronchorrhea, or seizures. Immediate aggressive use of atropine may eliminate the need for intubation. [openanesthesia.org]
Complications include severe bronchorrhea, seizures, weakness, and neuropathy. Respiratory failure is the most common cause of death. Age Organophosphates (OPs) may affect children or other at-risk populations differently. [emedicine.medscape.com]
Respiratory failure results from respiratory depression coupled with paralysis of the respiratory muscles and progressive airway obstruction from bronchorrhea. [wwwn.cdc.gov]
- Respiratory Distress
Intubation may be necessary in cases of respiratory distress due to laryngospasm, bronchospasm, bronchorrhea, or seizures. Immediate aggressive use of atropine may eliminate the need for intubation. [openanesthesia.org]
A 25 year old patient was admitted to intensive care for respiratory distress which was complicated by an intentional subcutaneous injection of parathion "METYPHON50®" two days before. [toxicology.imedpub.com]
Gastrointestinal
- Nausea
Parathion poisoning meaning in Hindi (हिन्दी मे मीनिंग ) is a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.English definition [dict.hinkhoj.com]
Symptoms include nausea, vomiting, abdominal cramps, confusion, headache, lack of muscular control, convulsions, and dyspnea. parathion poisoning Poisoning contracted by accidental inhalation or ingestion while working with the pesticide or because of [medical-dictionary.thefreedictionary.com]
Princeton's WordNet (0.00 / 0 votes) Rate this definition: parathion poisoning (noun) a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating [definitions.net]
辞書 WordNet parathion poisoning 名詞 殺虫剤パラチオンの吸入または摂取による中毒症状 a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating. [ei-navi.jp]
Parathion can cause nausea, vomiting, stomach cramps, and diarrhea, as well as confusion, blurred vision, sweating, muscle twitching, irregular heartbeat, convulsions, and death. [wwwn.cdc.gov]
- Abdominal Pain
Parathion poisoning meaning in Hindi (हिन्दी मे मीनिंग ) is a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.English definition [dict.hinkhoj.com]
Princeton's WordNet (0.00 / 0 votes) Rate this definition: parathion poisoning (noun) a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating [definitions.net]
辞書 WordNet parathion poisoning 名詞 殺虫剤パラチオンの吸入または摂取による中毒症状 a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating. [ei-navi.jp]
Muscarinic effects include pinpoint pupils; blurred vision; hypersecretion by salivary, lacrimal, sweat, and bronchial glands; narrowing of the bronchi; nausea, vomiting, diarrhoea, and crampy abdominal pains; urinary and fecal incontinence and slow heart [homeobook.com]
Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) is not uncommon. [cameochemicals.noaa.gov]
- Abdominal Cramps
Symptoms include nausea, vomiting, abdominal cramps, confusion, headache, lack of muscular control, convulsions, and dyspnea. parathion poisoning Poisoning contracted by accidental inhalation or ingestion while working with the pesticide or because of [medical-dictionary.thefreedictionary.com]
Gastrointestinal Nausea, vomiting, abdominal cramps, diarrhea, and fecal incontinence are common manifestations, regardless of the exposure route. These are generally the earliest symptoms to occur. [wwwn.cdc.gov]
Gastrointestinal Nausea, vomiting, abdominal cramps, diarrhoea, and faecal incontinence are common manifestations, regardless of the exposure route. These are again generally the earliest symptoms to occur. [homeobook.com]
- Diarrhea
Shortly after exposure, headache, sweating, salivation, lacrimation, vomiting, diarrhea, muscular twitching, convulsions, dyspnea, and blurred vision occur. [medical-dictionary.thefreedictionary.com]
Parathion can cause nausea, vomiting, stomach cramps, and diarrhea, as well as confusion, blurred vision, sweating, muscle twitching, irregular heartbeat, convulsions, and death. [wwwn.cdc.gov]
Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) is not uncommon. [cameochemicals.noaa.gov]
Cardiovascular
- Hypotension
Signs and Symptoms Muscarinic signs (SLUDGE) salivation, lacrimation, urination, diaphoresis, gastrointestinal upset, emesis and progressing to bronchospasm, bronchorrhea, blurred vision, bradycardia or tachycardia, hypotension, confusion, and shock. [openanesthesia.org]
Patients who are comatose, hypotensive, or have seizures or ventricular arrhythmias should be treated in the conventional manner. Basic Decontamination Patients who are able may assist with their own decontamination. [wwwn.cdc.gov]
Hypotension (low blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur. [cameochemicals.noaa.gov]
Jaw & Teeth
- Hypersalivation
After his hospitalization on his third day of poisoning, the patient was comatose, had a tight myosis and a diffuse tremor hypersalivation. His hemodynamic parameters were correct. [toxicology.imedpub.com]
Eyes
- Lacrimation
Shortly after exposure, headache, sweating, salivation, lacrimation, vomiting, diarrhea, muscular twitching, convulsions, dyspnea, and blurred vision occur. [medical-dictionary.thefreedictionary.com]
Signs and Symptoms Muscarinic signs (SLUDGE) salivation, lacrimation, urination, diaphoresis, gastrointestinal upset, emesis and progressing to bronchospasm, bronchorrhea, blurred vision, bradycardia or tachycardia, hypotension, confusion, and shock. [openanesthesia.org]
Muscarinic effects include pinpoint pupils; blurred vision; hypersecretion by salivary, lacrimal, sweat, and bronchial glands; narrowing of the bronchi; nausea, vomiting, diarrhoea, and crampy abdominal pains; urinary and fecal incontinence and slow heart [homeobook.com]
Muscarinic effects include: pinpoint pupils; blurred vision; hypersecretion by salivary, lacrimal, sweat, and bronchial glands; narrowing of the bronchi; nausea, vomiting, diarrhea, and crampy abdominal pains; urinary and fecal incontinence; and slow [wwwn.cdc.gov]
Musculoskeletal
- Muscle Weakness
Necrotic fibers were noted in muscle biopsies, but these fibers were too sparse to explain severe muscle weakness and were similar in patients with and without the intermediate syndrome. No patients developed delayed neuropathy. [journals.lww.com]
Peripheral Neurologic Peripheral neurologic effects include muscle twitching and weakness due to inhibition of acetylcholinesterase at neuromuscular junctions. [wwwn.cdc.gov]
Nicotinic effects Skeletal muscle initially exhibits fasciculation (involuntary irregular, violent muscle contractions) followed by the inability to repolarize cell membranes resulting in weakness and paralysis. [openanesthesia.org]
- Muscle Twitch
Nicotinic effects include muscle twitching, cramping, and weakness. Nicotinic stimulation can obscure certain muscarinic effects and produce rapid heart rate and high blood pressure. [homeobook.com]
Peripheral Neurologic Peripheral neurologic effects include muscle twitching and weakness due to inhibition of acetylcholinesterase at neuromuscular junctions. [wwwn.cdc.gov]
The remaining, 123 patients were classified into three groups of severity of poisoning, based on their clinical presentation: (i) Mild (81 cases): no symptoms, normal vital functions, normal pupils; (ii) Moderate (23 cases): Muscle twitches, increased [jpgmonline.com]
Neurologic
- Headache
Shortly after exposure, headache, sweating, salivation, lacrimation, vomiting, diarrhea, muscular twitching, convulsions, dyspnea, and blurred vision occur. [medical-dictionary.thefreedictionary.com]
Parathion poisoning meaning in Hindi (हिन्दी मे मीनिंग ) is a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating.English definition [dict.hinkhoj.com]
Princeton's WordNet (0.00 / 0 votes) Rate this definition: parathion poisoning (noun) a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating [definitions.net]
辞書 WordNet parathion poisoning 名詞 殺虫剤パラチオンの吸入または摂取による中毒症状 a toxic condition resulting from inhalation or ingestion of the insecticide parathion; characterized by nausea and abdominal pains and headache and convulsions and sweating. [ei-navi.jp]
Exposure can cause loss of consciousness, dizziness, confusion, headaches, breathing difficulties, chest tightness and blurred vision. [nytimes.com]
- Seizure
Patients who have seizures most often respond to atropine and pralidoxime; however, if they do not respond, administer diazepam or lorazepam. [wwwn.cdc.gov]
Intubation may be necessary in cases of respiratory distress due to laryngospasm, bronchospasm, bronchorrhea, or seizures. Immediate aggressive use of atropine may eliminate the need for intubation. [openanesthesia.org]
Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. [cameochemicals.noaa.gov]
Complications include severe bronchorrhea, seizures, weakness, and neuropathy. Respiratory failure is the most common cause of death. Age Organophosphates (OPs) may affect children or other at-risk populations differently. [emedicine.medscape.com]
- Asthenia
The immediate evolution was marked by asthenia, progressive deterioration of general condition and vomiting. After his hospitalization on his third day of poisoning, the patient was comatose, had a tight myosis and a diffuse tremor hypersalivation. [toxicology.imedpub.com]
- Unable to Walk
Victim Removal If victims can walk, lead them out of the Hot Zone to the Decontamination Zone. Victims who are unable to walk may be removed on backboards or gurneys; if these are not available, carefully carry or drag victims to safety. [wwwn.cdc.gov]
Workup
See Workup. Treatment begins with decontamination. Airway control and oxygenation are paramount. The mainstays of pharmacological therapy include atropine, pralidoxime (2-PAM), and benzodiazepines (eg, diazepam). [emedicine.medscape.com]
Treatment
Awareness of this complication of parathion poisoning, proper monitoring and treatment could prevent fatalities. [ncbi.nlm.nih.gov]
Treatment Termination of the exposure including removing all soiled clothing. Gently cleanse with soap and water to hydrolyze organophosphate solutions. Airway control and adequate oxygenation. [openanesthesia.org]
The symptomatic treatment is always to put more and to use no antidote as in our case. [toxicology.imedpub.com]
Prognosis
The clinical relevance of these changes to prognosis is not yet clear. This study was therefore, undertaken to evaluate the importance of ECG changes to the ultimate prognosis in OPC poisoning. [jpgmonline.com]
Keywords Subcutaneous injection; Organophosphate poisoning; Parathion; Prognosis Introduction Organophosphates poisoning is an important occupational health issue because they are pesticides worldwide used in industries and agriculture and in different [toxicology.imedpub.com]
Etiology
The etiology of so-called ginger paralysis (third report). Arch. Neurol. Psychiat. 26:976, 1931. [ Links ] 45. SMORTO, M. P. & BASMAJIAN, J. V. - Clinical Electroneurography. Williams & Williams Co., Baltimore, 1972. [ Links ] 46. TAYLOR, W. J. [scielo.br]
Epidemiology
Pesticide Exposures andDevelopmental Outcomes: The Epidemiological Evidence.Journal of Toxicology and Environmental Healt. Part B.2007;10:41-80. Vale J A. Toxicokinetic and Toxicodynamic Aspects of OrganophosphorousInsecticide Poisoning. [revistas.unimilitar.edu.co]
Although most patients rapidly become symptomatic, the onset and severity of symptoms depend on the specific compound, amount, route of exposure, and rate of metabolic degradation. [5] Epidemiology Frequency United States In 2016, the American Association [emedicine.medscape.com]
Pathophysiology
These have included difficulties in executive functions, psychomotor speed, verbal, memory, attention, processing speed, visual-spatial functioning, and coordination. [4] Pathophysiology The primary mechanism of action of organophosphate pesticides is [emedicine.medscape.com]
Prevention
AND MANAGEMENT Health Risks of Underground Construction Work Bohuslav Mdlek 93 8 MAJOR SECTORS AND THEIR HAZARDS TOOLS EQUIPMENT AND MATERIALS Elevators Escalators and Hoists J Staal and John Quackenbush 93 40 Prevention of Occupational Dermatosis among [books.google.com]
Awareness of this complication of parathion poisoning, proper monitoring and treatment could prevent fatalities. [ncbi.nlm.nih.gov]
The suit seeks justice for the children that perished, guarantees of medical monitoring for the surviving children, and regulatory reforms to prevent future tragedies. [panna.org]
(EPA, 1998) Protective Clothing Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. [cameochemicals.noaa.gov]