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Paroxysmal Rhabdomyolysis

Acute Paroxysmal Myoglobinuria


Presentation

  • He has been the Editor in Chief, JAMA Neurology (1997- present) and a member of the Editorial Board of JAMA (1997-present).[books.google.com]
  • Get a quick and memorable overview of anatomy, pathophysiology, and clinical presentation from the precision and beauty of Netter and Netter-style plates that highlight key neuroanatomical and neurologic concepts.[books.google.de]
  • It is recommended that patients use the information presented as a part of a broader decision-making process. Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.[ehealthme.com]
  • Genetic Clinical presentation Patients with genetic induced rhabdomyolysis will present with signs and symptoms of their inherited disease but will also present with secondary signs and symptoms of rhabdomyolysis.[physio-pedia.com]
Physician
  • Michael Aminoff was born and educated in England, graduating from University College London in 1962 and as a physician from University College Hospital Medical School in 1965.[books.google.com]
  • Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.[ehealthme.com]
  • physician assistants, nurse practitioners and nurses.[books.google.de]
  • Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. The use of this website is governed by the UpToDate Terms of Use 2018 UpToDate, Inc.[uptodate.com]
  • Am Fam Physician. 1995 Aug52(2):502-6. Meyer-Betz F; Beobachtugen an einem eigenartigen mit muskellahmungen verbundenen fall von hamoglobinurie. Dtsc Arch Klin Med.1910101:85-127.Original descriptive article.[patient.info]
Limb Pain
  • The calves and low back are the most general muscle groups that are affected. [2] According to the author Efstratiadis, back pain and limb pain are the most frequent sites in patients with rhabdomyolysis. [3] However, over 50% of the patients with rhabdomyolysis[physio-pedia.com]
Myopathy
  • Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies, and miscellaneous neuromuscular disorders and syndromes[books.google.com]
  • […] of acute myopathy.[flipper.diff.org]
  • Recessive mutations in ANO5 (OMIM#608662) cause a wide spectrum of myopathies including LGMD2L, distal myopathy and isolated hyperCKemia.[ojrd.biomedcentral.com]
  • Myopathies such as dermatomyositis or myositis Viral or bacterial infections Metabolic conditions such as hypothyroidism and diabetic ketoacidosis[firstaidcprvictoria.ca]
  • […] idiopathic) NEC - M62.82 Tabular List of Diseases and Injuries References found for the code M62.82 in the Tabular List of Diseases and Injuries: Type 1 Excludes Notes: traumatic rhabdomyolysis (T79.6) Information for Patients Muscle Disorders Also called: Myopathy[icdlist.com]
Myalgia
  • Patients suffered generalized weakness, inability to walk, myalgia, muscle weakness, and dark urine. All patients appeared healthy in between episodes.[cags.org.ae]
  • RM and myalgia may be the dominating symptom in a few cases of LGMD2I [ 82 ].[ojrd.biomedcentral.com]
  • Muscle aches and pain (myalgia), stiffness, and muscle weakness can occur with rhabdomyolysis, and is especially common with severe muscle damage. Rhabdomyolysis may cause a darkening of the urine color.[whereincity.com]
  • Muscle aches and pain ( myalgia ), stiffness, and muscle weakness can occur with rhabdomyolysis, and is especially common with severe muscle damage. Rhabdomyolysis may cause a darkening of the urine color.[medicinenet.com]
Muscle Tenderness
  • Fatigue Nausea and vomiting Weakness Seizures Joint pain Rapid heart rate Fever Tea-colored urine Muscle tenderness and stiffness Reduced urine output Remember that there is a possibility that none of these symptoms will manifest in all cases.[firstaidcprvictoria.ca]
  • Haff disease typically presents as a paroxysm of rhabdomyolysis, with accompanying muscle tenderness, rigidity, and dark brown urine. However, as in patient 3, milder presentations also occur.[cdc.gov]
  • Physical examination of the lumbar region revealed paravertebral muscle tenderness bilaterally. Also during the second postoperative day, his abdomen became slightly distended, and oral intake was withheld because of the possibility of an ileus.[anesthesiology.pubs.asahq.org]
  • As previously mentioned, typical signs and symptoms of rhabdomyolysis include: tea-coloured urine, muscle tenderness, swelling, stiffness and cramping, accompanied by weakness and loss of function in the involved muscle group(s). [13] Idiopathic In many[physio-pedia.com]
Arthritis
  • Therapy: 5 people, 45.45% Anticoagulant Therapy: 3 people, 27.27% Nasopharyngitis (inflammation of the nasopharynx): 3 people, 27.27% Pain: 2 people, 18.18% Urinary Tract Infection: 1 person, 9.09% Folate Deficiency (lack of folic acid): 1 person, 9.09% Arthritis[ehealthme.com]
  • . , Oct 1 2016 , In : Arthritis and Rheumatology. 68 , 10 , p. 2540-2549 10 p. Research output : Contribution to journal › Article Mpl Baltimore: A thrombopoietin receptor polymorphism associated with thrombocytosis Moliterno, A. R. , Williams, D.[jhu.pure.elsevier.com]
  • Clinical Medicine Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders about the journal submit your research Indexing: ESCI, DOAJ, EBSCO, PubMed Central (PMC) and more .[insights.sagepub.com]
Peripheral Neuropathy
  • Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies, and miscellaneous neuromuscular disorders and syndromes[books.google.com]
  • The presence of peripheral neuropathy in patients with history of recurrent abdominal pains should raise the suspicion of Acute Intermittent Porphyria ( AIP).[usmleforum.com]
  • Other disorders which may co-occur with chronic alcoholic myopathy include peripheral neuropathy.[flipper.diff.org]
  • Neuromuscular findings include hypotonia, development delay, weakness, a variably associated peripheral neuropathy, and, rarely, RM [ 15, 95, 96 ]. Triggers for Rhabdomyolysis Infection [ 95, 97 ].[ojrd.biomedcentral.com]
Ataxia
  • He described Machado-Joseph disease (MJD), an autosomal dominant ataxia, with William Nyhan, M.D. Ph.D, in 1976, for the first time. MJD is now the most common autosomal domiant spinocerebellar ataxia world-wide. Dr.[books.google.com]
  • Phenotype Cataracts, cerebellar atrophy and ataxia are usually seen in association with different multisystem signs and symptoms.[ojrd.biomedcentral.com]
Dark Urine
  • Patients suffered generalized weakness, inability to walk, myalgia, muscle weakness, and dark urine. All patients appeared healthy in between episodes.[cags.org.ae]
  • The dark urine color is due to myoglobin being excreted in the urine by the kidney as it tries to rid the body of the muscle breakdown products.[medicinenet.com]
  • International Acute kidney injury due to rhabdomyolysis was first described by Bywaters and Beall during World War II; they noted the hypovolemic shock, dark urine, and kidney failure that developed in survivors from the rubbles of the London bombings[emedicine.medscape.com]
  • The three most common signs and symptoms are muscle pain, weakness, and dark urine. [2] [3] Muscle pain as well as weakness and tenderness may be general or specific to muscle groups.[physio-pedia.com]
  • Episodes of exercise-induced dark urine and myalgia in LGMD 2I. Acta Neurol Scand. 2012;125(4):285–7. PubMed Google Scholar Ceravolo F, Messina S, Rodolico C, Strisciuglio P, Concolino D.[ojrd.biomedcentral.com]
Anuria
  • Type your tag names separated by a space and hit enter Authors Source MeSH Acute Kidney Injury Adolescent Adult Age Factors Anuria Cardiovascular Diseases Child Female Gastrointestinal Diseases Humans Male Muscle Cramp Muscular Diseases Myoglobinuria[unboundmedicine.com]
  • Systemic signs and symptoms of rhabdomyolysis include tea-colored urine, fever, malaise, nausea, emesis, confusion, agaitation, delirium, and anuria.[physio-pedia.com]

Workup

  • These differentials were kept in mind prior to ordering the workup. His laboratory data at admission are outlined in table 1 . A previous renal function test was done in 2007 which showed 97.24 µmol/l serum creatinine and 4.99 mmol/l BUN.[karger.com]
  • Rhabdomyolysis: Differential Diagnoses and Workup. eMedicine 2009. Baxter R, Moore J. Diagnosis and Treatment of Acute Exertional Rhabdomyolysis. Journal of Orthopaedic and Sports Physical Therapy 2003; 33(3): 104-108[physio-pedia.com]

Treatment

  • Part one discusses the approach to neuromuscular disorders, covering principles and basics, neuromuscular investigations, and assessment and treatment of neurological disorders.[books.google.com]
  • Tap into additional treatment information with more clinical vignettes that provide "real-life" illustrative case evaluations.[books.google.de]
  • Recent studies: DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider.[ehealthme.com]
  • Treatment Mostly a urine test can reveal the presence of high protein level and thus confirm existence of Rhabdomyolysis. Under this section lets discuss various treatment options available.[natural-homeremedies.com]
  • It is essential to seek medical treatment quickly, because if it is not treated it can result in kidney failure and muscle damage. The treatment is usually fluids and monitoring for changes in kidney function.[sharecare.com]

Prognosis

  • Detailed discussions of PNH pathogenesis, management, and prognosis are presented separately. (See "Pathogenesis of paroxysmal nocturnal hemoglobinuria" and "Treatment and prognosis of paroxysmal nocturnal hemoglobinuria" .)[uptodate.com]
  • Rhabdomyolysis Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Rhabdomyolysis from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and Prognosis[wikidoc.org]
  • Exactly measuring CA 19.9 concentrations 10,000 kU/L after multiple sample dilution does not add relevant information for patients’ prognosis and treatment.[sibioc.it]
  • What is the prognosis for rhabdomyolysis? The overall prognosis of rhabdomyolysis is favorable as long as it is recognized and treated promptly. Most causes of rhabdomyolysis reversible.[rxlist.com]
  • From What is the prognosis for rhabdomyolysis? The overall prognosis of rhabdomyolysis is favorable as long as it is recognized and treated promptly. Most causes of rhabdomyolysis reversible.[medicinenet.com]

Etiology

  • The etiology of the disorder is controversial. Proposed mechanisms include hyperparathyroidism, increased 1,25-dihydroxyvitamin D levels, and mobilization of calcium from soft-tissue deposits.[mdmag.com]
  • The first two etiologies were deemed most likely because of the abrupt nature and timing of his rhabdomyolysis. Moreover, the other etiologies occur rarely.[anesthesiology.pubs.asahq.org]
  • Evaluation of asymptomatic microscopic hematuria in adults: the American Urological Association best practice policy—part I: definition, detection, prevalence, and etiology.[citeseerx.ist.psu.edu]
  • Although the etiology was not determined, epidemiologic investigations linked illness to ingestion of fish, especially burbot. The first reported case of Haff disease in the United States occurred in Texas in 1984 (M.[cdc.gov]
  • Rhabdomyolysis: a review of clinical presentation, etiology, diagnosis, and management. Pediatr Emerg Care . 2008 Apr. 24(4):262-8. [Medline] . Lima RS, da Silva Junior GB, Liborio AB, Daher Ede F. Acute kidney injury due to rhabdomyolysis.[emedicine.medscape.com]

Epidemiology

  • Rhabdomyolysis Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Rhabdomyolysis from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and[wikidoc.org]
  • EPIDEMIOLOGY PNH is a rare disorder.[uptodate.com]
  • Foodborne and Diarrheal Diseases Br, Div of Bacterial and Mycotic Diseases, National Center for Infectious Diseases; Div of Applied Public Health Training, Epidemiology Program Office; and an EIS Officer, CDC.[cdc.gov]
  • Epidemiology Incidence figures are not available for the general population, but screening of 337 military recruits for myoglobin serum levels, showed rhabdomyolysis in 40%. [ 6 ] It is more common in men, particularly well-educated professionals, who[patient.info]
  • He then did Masters in Science from the Department of Epidemiology at the Medical College of Wisconsin.[karger.com]
Sex distribution
Age distribution

Pathophysiology

  • Get a quick and memorable overview of anatomy, pathophysiology, and clinical presentation from the precision and beauty of Netter and Netter-style plates that highlight key neuroanatomical and neurologic concepts.[books.google.de]
  • Rhabdomyolysis Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Rhabdomyolysis from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and[wikidoc.org]
  • The Gale Encyclopedia of Public Health states, 2002 - Alcoholic cardiomyopathy: incidence, clinical characteristics, and pathophysiology, Piano MR., 2002 SYMPTOMS Alcoholic myopathy can have serious symptoms and side effects.[flipper.diff.org]
  • The syndrome of rhabdomyolysis: Pathophysiology and diagnosis. Eur J Intern Med . 2007 Mar. 18(2):90-100. [Medline] . Kilfoyle D, Hutchinson D, Potter H, George P.[emedicine.medscape.com]
  • However, it may provide pathophysiologic clues to the molecular mechanism of kidney injury and the role of free haeme-containing molecules.[academic.oup.com]

Prevention

  • The authors describe two cases and suggest plans for the prevention and management of attacks.[ncbi.nlm.nih.gov]
  • Summary Rhabdomyolysis is found among people with Paroxysmal nocturnal haemoglobinuria, especially for people who are male, 60 old, take medication Soliris and have Preventive health care.[ehealthme.com]
  • This DNA vaccine has the potential to be a safe and effective therapy to prevent Alzheimer disease. He described Machado-Joseph disease (MJD), an autosomal dominant ataxia, with William Nyhan, M.D. Ph.D, in 1976, for the first time.[books.google.com]
  • Secondary Prevention Cost-Effectiveness of Therapy Future or Investigational Therapies Case Studies Case #1 Rhabdomyolysis On the Web Most recent articles Most cited articles Review articles CME Programs Powerpoint slides Images American Roentgen Ray[wikidoc.org]
  • Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets[books.google.de]

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