Poor visual acuity at first presentation, snowbanks and vitreoretinal traction were associated with a higher risk for poor BCVA at last presentation. [ncbi.nlm.nih.gov]

• Inflammation

  Occasionally inflammation can spill into the front portion of the eye (iritis) causing redness, pain, and sensitivity to light (photophobia). The inflammation waxes and wanes over many years and usually becomes inactive over several decades. [eyecenters.com]

  Abstract Intermediate uveitis is an intraocular inflammation involving the anterior vitreous, peripheral retina and pars plana. It usually affects patients from 5 to 30 years old, without gender or racial preferences. [ncbi.nlm.nih.gov]

  Primary sites of inflammation include the vitreous of which other such entities as pars planitis, posterior cyclitis, and hyalitis are encompassed. [oftalmologia.es-academic.com]

  However, the time to the disappearance of postoperative inflammation was longer when intraocular inflammation was not controlled. [hindawi.com]

• Pain

  It also helps with eye pain and stops the pupil from sticking to the lens. There may be blurred vision and unusual sensitivity to light, known as photophobia. [medicalnewstoday.com]

  They include eye redness, pain and blurred vision. The condition can affect one or both eyes. It primarily affects people ages 20 to 50, but it may also affect children. [mayoclinic.org]

  When to get medical advice Contact a GP as soon as possible if you have persistent eye pain or an unusual change in your vision, particularly if you've had previous episodes of uveitis. [nhs.uk]

  Light sensitivity Blurred vision Pain Floaters Redness of the eye Uveitis may develop suddenly, with redness and pain, or with a painless blurring of your vision. A case of simple “red eye” may in fact be a serious problem of uveitis. [randeye.com]

• Cat Scratch

  Some experts also suggest a possible association with multiple sclerosis, sarcoidosis, cat scratch or Lyme disease. [autoimmune.org]

  Infectious causes of intermediate uveitis include Epstein-Barr virus infection, Lyme disease, HTLV-1 virus infection, cat scratch disease, and hepatitis C. [en.wikipedia.org]

  If a cause can be determined, it may be one of the following: Eye injury or surgery An autoimmune disorder, such as sarcoidosis or ankylosing spondylitis An inflammatory disorder, such as Crohn's disease or ulcerative colitis An infection, such as cat-scratch [mayoclinic.org]

  • antigen may be infectious(Lyme's, syphilis and cat-scratch fever), autoimmune-(multiple sclerosis and sarcoidosis) • Type II collagen in the vitreous may be an autoantigen in some patients contd... 11. • Intermediate uveitis seems to be a T-cell- [slideshare.net]

  Infectious diseases that can cause uveitis include: Tuberculosis Syphyllis Cat-Scratch Fever Lyme Disease Auto-immune diseases that can cause uveitis include: Rheumatoid arthritis Sarcoid Lupus Scleroderma Behcet's disease Anklylosing spondylitis Reiter's [ceceyes.com]

• Hodgkin Lymphoma

  To report a case of intraocular non-Hodgkin lymphoma (NHL) manifesting as persistent intermediate uveitis, facial mass, and Bell palsy. Retrospective, interventional case report. [ncbi.nlm.nih.gov]

• Macula

  Surgery should be reserved only for macula threatening lesions. [ncbi.nlm.nih.gov]

  Complications include cataract formation, cystoid macula edema, neovascularization with and without vitreous hemorrhage, and retinal detachment. Therapy ranges from observation to vitrectomy. [aaopt.org]

  The macula can swell (cystoid macular edema) resulting in central blurriness. Occasionally inflammation can spill into the front portion of the eye (iritis) causing redness, pain, and sensitivity to light (photophobia). [eyecenters.com]

  The medical term for this is “vitritis” and its effects can reach the lens and iris, leading to cataract and scarring, and to the central retina, leading to swelling of the macula and blurred vision. [retinalmd.com]

• Blurred Vision

  Symptoms The signs, symptoms and characteristics of uveitis include: Eye redness Eye pain Light sensitivity Blurred vision Dark, floating spots in your field of vision (floaters) Decreased vision Symptoms may occur suddenly and get worse quickly, though [mayoclinic.org]

  Methods A 16 year old man with a history of Retinosis pigmentosa since birth presented blurred vision associated with a bilateral intermediate uveitis. The visual acuity was 0,4, Tyndall ++, and intense vitritis with snowballs in both eyes. [onlinelibrary.wiley.com]

  Symptoms experienced by patients with the condition include blurred vision and dark floating spots that interfere with clarity of eyesight. Swelling inside the eyes, especially on the peripheral retina, can also cause decreased vision. [nmceyecare.ae]

  vision in his both eyes and a history of neurological problems. [longdom.org]

  Abstract The aim is to report a case of multiple sclerosis with a significant reduction in visual acuity in a 37 young male has a longstanding history of blurred vision in his both eyes and a history of neurological problems. [omicsonline.org]

• Photophobia

  Occasionally inflammation can spill into the front portion of the eye (iritis) causing redness, pain, and sensitivity to light (photophobia). The inflammation waxes and wanes over many years and usually becomes inactive over several decades. [eyecenters.com]

  Symptoms include decreased vision, ocular ache, redness, photophobia, and floaters. Although uveitis is identified clinically, identifying the cause typically requires testing. [merckmanuals.com]

  There may be blurred vision and unusual sensitivity to light, known as photophobia. With prompt and proper treatment and close monitoring, the chances of complications are significantly reduced. [medicalnewstoday.com]

  These eyeglass lenses darken automatically in sunlight to reduce photophobia-related discomfort when going outdoors. Page updated April 2019 [allaboutvision.com]

  Photophobia typically causes a need to squint or close the eyes, and headache, nausea, or other symptoms may be associated with photophobia. Symptoms may be worse with bright light. [medicinenet.com]

• Vitreous Floaters

  Piri, MD, present 25G vitrectomy surgery for an intermediate chronic uveitis of unknown etiology with heavy vitreous floaters. [eyetube.net]

  White inflammatory material overlying the peripheral retina White clumps of vitreous floaters Mild cases can be totally asymptomatic. As the inflammation becomes more extensive, inflammatory debris can extend into the vitreous causing floaters. [eyecenters.com]

  Amit Khosla: Intermediate uveitis is a clinical diagnosis, presenting with vitreous cells, macular edema and vitreous floaters. It may present with normal to severe visual impairment. [djo.org.in]

• Macula Edema

  Complications include cataract formation, cystoid macula edema, neovascularization with and without vitreous hemorrhage, and retinal detachment. Therapy ranges from observation to vitrectomy. [aaopt.org]

  Intermediate uveitis patients should be followed up every 1 to 4 weeks during the active phase of the disease, more frequently if cystoid macula edema or severe inflammation is present. [journals.lww.com]

• Irritability

  Sometimes, the artificial lens put in place by an eye doctor during cataract surgery can irritate the eye and cause anterior uveitis. [preventblindness.org]

  Symptoms: Uveitis usually results in a red, tearing, painful, light-sensitive, irritated eye. The vision may also be blurred. [ceceyes.com]

  Chronic anterior uveitis may have less dramatic symptoms and present with eye irritation or decreased vision. Intermediate and posterior uveitis tend to cause less pain and eye redness but more floaters and decreased vision. [merckmanuals.com]

  Symptoms of uveitis may include: Eye redness and irritation. Blurred vision. Eye pain or soreness. Increased sensitivity to light. Floating spots before the eyes. Flashing lights. [healthcare.utah.edu]

  Symptoms of uveitis include eye redness and irritation; blurred vision; eye pain; and increased sensitivity to light. [visionaware.org]

Laboratory workup has not revealed the inflammation etiology. [eyetube.net]

A detailed discussion of this case along with color photos, laboratory workup, a table of associated diseases, and a schematic for management of intermediate uveitis will be presented in this poster. [aaopt.org]

The authors’ findings supported the role of routine MRI in the workup of patients with intermediate uveitis. [retinalphysician.com]

In all patients, an extensive workup based on clinical suspicion, showed a positive result from the first visit. [meajo.org]

• Borrelia Burgdorferi

  • IU has been described to occur in Lyme's disease caused by another spirocheate- Borrelia burgdorferi, both in adults and in children 24. [slideshare.net]

  This fibroglial tissue consists of vitreous collagen, Muller cells and probable fibrous astrocytes.[38] Differential Diagnosis IU has been associated with infectious conditions like Lyme's disease (Borrelia burgdorferi), toxoplasmosis, toxocariasis, tuberculosis [ncbi.nlm.nih.gov]

In case of treatment failure, switching to the other treatment arm was possible. RESULTS: Nineteen patients were included. Ten were randomized to MTX, and 9 were randomized to IFN beta. [ncbi.nlm.nih.gov]

The key to improving treatment outcomes for pars planitis is early and aggressive treatment. Because the disease can become chronic, your healthcare provider may recommend routine follow-up appointments to monitor your condition. [verywellhealth.com]

Visual prognosis was good and it was not age-related. Childhood onset was more frequent in boys, adult onset in women. Endocrinal factors could be involved. [ncbi.nlm.nih.gov]

Etiology of IU was idiopathic in 59%. Multiple sclerosis (MS) (20%) and sarcoidosis (10%) were frequent systemic causes of IU. [ncbi.nlm.nih.gov]

Laboratory workup has not revealed the inflammation etiology. [eyetube.net]

Fisher’s Exact test was used to determine any association between etiologies with ethnicity, as well as etiologies with complications. [journals.plos.org]

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. [ncbi.nlm.nih.gov]

Symptoms Onset / Epidemiology Clinical features which can be seen by an ophthalmologist Frequency of complications Tests The diagnosis of intermediate uveitis is on the clinical judgement of the ophthalmologist. There is no specific test. [iritis.co.uk]

Uveitis epidemiology varies widely with geographic location; however, it remains a significant cause of vision loss throughout the world. [dovepress.com]

Keywords: inflammation • uveitis–clinical/animal model • clinical (human) or epidemiologic studies: outcomes/complications © 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. [iovs.arvojournals.org]

[…] immunosuppressive agents) found that while the steroid implant treatment possibly prevents the recurrence of uveitis, there may be adverse safety outcomes, such as the increased risk for needing cataract surgery and surgery to lower intraocular pressure.[1] Epidemiology [en.wikipedia.org]

Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets. [ncbi.nlm.nih.gov]

It is evident that genetics plays some role in the pathophysiology of intermediate uveitis, but the importance remains unclear. [en.wikipedia.org]

These phenotypes are descriptive only and do not reflect differences in pathophysiology.7 Most patients with CIS will evolve to RRMS, the most common phenotype of MS. [retinalphysician.com]

Pathophysiology There may be an immunogenetic predisposition for the disorder in some cases (see Causes), accounting for family clustering that is seen on occasion, indicating environmental or hereditary associations. [emedicine.medscape.com]

Pathophysiology IU seems to be a T-cell mediated disease, as these cells account for up to 95% of all cell types in the vitreous of patients with IU; most of these cells are CD4+. [eyewiki.aao.org]

Posterior synechiae in one eye and vitreous opacities in another eye with severe hypotony prevented fundoscopy. [iovs.arvojournals.org]

An increase awareness of its efficacy is required among paediatricians and ophthalmologists to prevent sight threatening complication of chronic uveitis and its treatment with long term use of steroids. [ncbi.nlm.nih.gov]

Is it possible to prevent uveitis? It is not always possible to prevent uveitis, particularly since many cases do not have a known cause. [medicinenet.com]

The best way to prevent vision loss from glaucoma is by going to the eye doctor and following your treatment plan as directed. Cataracts Cataracts are a clouding of the eye’s lens. [preventblindness.org]

This reduces pain, prevents the pupil from becoming permanently small or odd-shaped, and helps prevent glaucoma. [newcastle-hospitals.org.uk]