We think that the coexisting deletion present in each of these patients is responsible for most of the observed differences in clinical manifestations. [onlinelibrary.wiley.com]

Chromosomal studies are necessary to determine whether a balanced translocation is present in one of the parents. Other treatment for the disorder is symptomatic and supportive. [rarediseases.org]

• Fishing

  A partial trisomy 15q due to 15;17 translocation detected by conventional cytogenetic and FISH techniques. Genet Couns. 2000;11:25-32. Zollino M, et al. [rarediseases.org]

• Tall Stature

  However, in certain rare cases (i.e., trisomy 15q25-qter), affected individuals may exhibit abnormally tall stature. (For more information on trisomy 15q25-qter, see the “Causes” section below.) [rarediseases.org]

• Aspiration

  In some cases, swallowing and feeding difficulties may cause food to be inhaled (aspirated) into the lungs, which may result in severe lung infections (aspiration pneumonia). [rarediseases.org]

• Flexion Contracture

  In some cases, abnormalities involving the joints, tendons, muscles, and bones (e.g., flexion contractures, malformations of the fingers and/or toes, scoliosis) may be treated with orthopedic techniques potentially in combination with surgery. [rarediseases.org]

• Bulbous Nose

  nose with a broad nasal bridge; and/or an unusually small, triangular mouth. [rarediseases.org]

Standard Therapies Treatment The treatment of Chromosome 15, Distal Trisomy 15q is directed toward the specific symptoms that are apparent in each individual. Treatment may require the coordinated efforts of a team of specialists. [rarediseases.org]

The variable phenotype makes clinical recognition difficult and precludes making a long‐term prognosis. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. [onlinelibrary.wiley.com]

In addition, physicians may recommend preventive measures for affected infants and children who may be prone to repeated respiratory infections. [rarediseases.org]