Diagnostic criteria Based on findings in their cohort of Finnish patients, Kivitie-Kallio and Norio 29 proposed the following features as essential for the diagnosis of Cohen syndrome: (1) non-progressive mental retardation, motor clumsiness, and microcephaly [jmg.bmj.com]

During the first 3 years of life there was poor growth with a further loss in height. Between ages 4 and 10 years there was constant growth in parallel to the 3rd percentile with a mean height SDS of 4.3. [link.springer.com]

Stridor secondary to laryngomalacia was common in infancy but more significant laryngeal abnormalities were also reported, namely laryngeal stenosis and vocal cord paralysis. [jmg.bmj.com]

[…] eyebrows; Myopia; Strabismus; Microcornea; Nystagmus; Ptosis; Pale optic disc ; [Nose]; Short nose ; [Mouth]; Large mouth; High-arched palate; Thin upper lip; [Teeth]; Diastema; Caries RESPIRATORY: Neonatal respiratory distress; [Larynx]; Laryngeal stridor [findzebra.com]

A high pitched voice was a consistent finding, even in those patients who have not had previous laryngeal problems. [jmg.bmj.com]

However, one patient was recorded in her medical notes as having a neutrophil count of 0.04 10 9 /mm 3 which coincided with severe oral ulceration infected with Pseudomonas aeruginosa. [jmg.bmj.com]

murmur without appar- ent structural abnormality, and myopia. [documents.mx]

However, one patient was recorded in her medical notes as having a neutrophil count of 0.04 10 9 /mm 3 which coincided with severe oral ulceration infected with Pseudomonas aeruginosa. [jmg.bmj.com]

ulcerative, ulerythema, ulna, ulnar, umbilical, umbilicus, unclassifiable, unclassified, unexplained, unilateral, uniparental, univentricular, universalis, unknown, unna, unresponsive, unspecified, unusual, upper, upward, urachal, uremic, ureteral, [rapsodyonline.eurordis.org]

: Obstructive uropathy after panproctocolectomy for ulcerative colitis. G.U.T., 21; 808 ( 1980 ). Google Scholar 344. Winkler, R., Wagenchnecht, L. V., Schumpelick, V. : Sekundäre retroperitoneale Narbenfibrose nach Rectumextirpation. [journals.sagepub.com]

Six pregnancies were monitored because of poor fetal growth, three had oligohydramnios, and in three reduced fetal movements were noted. The majority, (30/33, 91%), of babies were born at term (range 38–42 weeks’ gestation). [jmg.bmj.com]

It involved pronounced trilobed deformation of the skull associated with synostosis of the lambdoidal and sagittal sutures, hydrocephalus, downward displacement of the ears, hypertelorism, exophthalmus, a sunken nasal root and antimongoloid slant of the [link.springer.com]

Warburg M, Pedersen SA, Horlyk H (1990): The Cohen syndrome; Retinal lesions and granulocytopenia. Ophthal Paediatr Genet 11:7-13. [documents.mx]

NOTE ADDED IN PROOF The gene of the Cohen syndrome has recently been mapped in 11 Finnish patients to the long arm of chro- mosome 8 [Tahvanainen et al., 19941. [documents.mx]

Cohen syndrome gene assigned to the long arm of chromosome 8 by linkage analysis. Nat Genet 1994 ; 7 : 201 –4. Kolehmainen J, Norio R, Kivitie-Kallio S, Tahvanainen E, de la Chapelle A, Lehesjoki AE. [jmg.bmj.com]

pain and psychosocial interactions, biomechanics, and more. [books.google.com]

Asghar Chapter 273 Diagnosis and Management of Diskogenic Lower Back Pain Frank L. Acosta and Christopher P. Ames Chapter 274 Metabolic and Other Nondegenerative Causes of Low Back Pain Omar N. Syed, Christopher E. Mandigo, and Michael G. [elsevier.com]

[…] with epicanthi, ptosis of the eyelids, upslanted palpebral fissures, microcornea with pale optic discs, sparse and laterally broad eyebrows, flat philtrum, congenital hypotonia, micrognathia with neonatal respiratory distress, high and narrow palate, lordosis [findzebra.com]

[…] seen initially in Cohen syndrome. [jmg.bmj.com]

The following manifestations reported in the article are seen in the Cohen syndrome: low birth weight, psy- chomotor retardation with slow development of speech, microcephaly, growth retardation, hypotonia, motor clumsiness, friendly personality, thick [documents.mx]

Neonatal hypotonia was reported in 56%. Stridor, usually secondary to laryngomalacia, was described in 21% of patients. [jmg.bmj.com]

Hypotonia Miles-Carpenter syndrome miliaria Milner Khallouf Gibson Syndrome Mirhosseini-Holmes-Walton Syndrome Mirizzi Syndrome Mitchell-Riley Syndrome mitochondrial DNA depletion syndrome 8A mitochondrial pyruvate carrier deficiency mixed connective [rgd.mcw.edu]

The following manifestations reported in the article are seen in the Cohen syndrome: low birth weight, psy- chomotor retardation with slow development of speech, microcephaly, growth retardation, hypotonia, motor clumsiness, friendly personality, thick [documents.mx]

Delayed motor milestones and clumsiness are compounded by hypotonia and joint laxity. Speech delay is universal and often severe, but many patients achieve reasonable communication by the age of 8 years. [jmg.bmj.com]