CONCLUSION: Osteosarcoma complicated by pathological fracture as first presentation had higher incidence of lung and bone metastases at presentation and worse survival rate when compared with patients without pathological fracture. [read.qxmd.com]

Around 32% of patients had stage IV disease at presentation. Around 37% of patients from rural areas and 20% of patients from urban areas presented with metastatic disease. [ijmrhs.com]

Calcaneal osteosarcoma usually has a nonspecific presentation such as pain and tenderness in the heel. Swelling can also be one of the presentations. [ojionline.org]

Clinical Presentation The presenting symptoms of cranial osteosarcoma vary based on the anatomical site of the lesion. 59 Like osteosarcoma of the long bones, craniofacial osteosarcomas often present as slow-growing masses. 51 Unlike long bone lesions [thejns.org]

Case Presentation An 8-year-old African American male presented with his mother to Nova Southeastern University Department of Oral and Maxillofacial Surgery with a history of diffuse swelling above his upper right front teeth consistently for two months [clinicsinsurgery.com]

Further workup showed no distant metastasis. She underwent below knee amputation and completed four cycles of adjuvant chemotherapy with cisplatin, doxorubicin, and methotrexate. [ojionline.org]

Further workup demonstrated a large calcified eroding mass of the skull base, extending into the nasopharynx, left maxillary sinus, ethmoidal sinuses, and sphenoid sinus and along the midline of the anterior skull base to involve the sella turcica and [thejns.org]

Initial metastatic workup for all patients included computed tomography scan of the chest and bone scan. [ascopubs.org]

Physical examination usually reveals a soft-tissue mass at the primary tumor site, and laboratory workup is seldom remarkable except for elevations of alkaline phosphatase and lactate dehydrogenase, which have been reported with prognostic significance [ncbi.nlm.nih.gov]

Your treatment team will do everything they can to reduce or prevent side effects of treatment. Does treatment cause infertility? You and your child should talk to your doctor about the reproductive risks associated with cancer treatment. [uchicagomedicine.org]

Treatment is usually chemotherapy and surgery. Surgery may be limb-sparing or amputation. Ongoing follow-up care during and after treatment is needed. [urmc.rochester.edu]

Conclusions: CIRT was safe and efficacious in the treatment of inoperable pediatric osteosarcoma with improved local control and overall survival compared to conventional treatments. [oncotarget.com]

Our program offers comprehensive treatment under one roof, something unique in the Twin Cities. We can provide your child with a customized treatment plan that addresses his or her specific needs. [mhealth.org]

Chemotherapy is the main treatment, along with surgery to remove the primary tumor. Most children and teens can fully recover from osteosarcoma. [spectrumhealth.org]

A delay in the diagnosis has a deleterious effect on the prognosis of osteosarcoma. [ojionline.org]

Our study revealed the dismal prognosis of patients with synchronous multifocal osteosarcoma; there were no survivors among the three patients with multifocal disease. [ascopubs.org]

One recurrently amplified gene, KDR, was highly expressed in advanced cases and associated with poor prognosis. 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [onlinelibrary.wiley.com]

Maintenance of angiogenin-IgM may also be an important aspect of osteosarcoma tumorigenesis and could be linked to prognosis. [clinicalsarcomaresearch.biomedcentral.com]

[…] osteosarcoma. ( 26116768 ) Zhuo B...Wang R 2015 35 Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma. ( 26512351 ) Ahn JH...Lim JS 2015 36 Upregulated expression of microRNA-214 is linked to tumor progression and adverse prognosis [malacards.org]

Etiology The etiology of most cases is unknown. [unboundmedicine.com]

Several lines of evidence point to the importance of the role of two recessive oncogenes, the retinoblastoma susceptibility gene (RB1) and the p53 gene in the etiology of osteosarcomas. [grantome.com]

Etiology and etiopathogenesis Etiology and pathogenesis is usually unknown, most of the osteosarcomas are sporadic. [telemedicina.med.muni.cz]

Trauma has not been found to cause osteosarcoma. 1 Describe the Etiology and Pathogenesis of Osteosarcoma Although osteosarcoma is not characterized by a specific gene translocation and has a highly variable genetic profile, several mutations have been [journals.sagepub.com]

Etiology/Causes [1] • The pathogenesis and etiology of osteosarcoma remains obscure • Chemical agents such as beryllium • Viruses such as FBJ (which contain the src-oncogene) • Radiation • Paget’s disease • Electrical burn and trauma • Genetic predisposition [physio-pedia.com]

Epidemiology Osteosarcoma is the most common pediatric primary bone cancer and is the 8th most common malignancy of childhood. [unboundmedicine.com]

Race The incidence is slightly higher in African Americans than in Caucasians (data from the National Cancer Institute [NCI] Surveillance, Epidemiology, and End Results [SEER] Study Pediatric Monograph, 1975-1995). [1] In African Americans, the annual [emedicine.medscape.com]

Epidemiology Annual incidence of osteosarcoma is 3.5–5 : 1 million for persons less than 20 years of the age Osteosarcoma is more common in males than in females, M : F 1.6 - 2 : 1 It is the 6th most common cancer in children 15 let and accounts for 5% [telemedicina.med.muni.cz]

Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the surveillance, epidemiology, and end results program. Cancer 2009;115:1531-43. 2. Pattnaik K, Pradhan P, Kar A, Burma S, Panda S. [ojionline.org]

[…] adult) Being female The tumor being on an arm or leg (as opposed to the hip bones) The tumor(s) being completely resectable (removable) Normal blood alkaline phosphatase and LDH levels The tumor having a good response to chemotherapy *SEER Surveillance, Epidemiology [cancer.org]

[…] and increased risk of a range of sarcomas, among other malignancies Rothmund-Thomson syndrome Bloom syndrome Enchondromatosis Hereditary multiple exostoses Fibrous dysplasia Paget disease of the bone, although less relevant to pediatric populations Pathophysiology [unboundmedicine.com]

Pathophysiology Osteosarcoma is a bone tumor that can occur in any bone. It most commonly occurs in the long bones of the extremities near metaphyseal growth plates. [emedicine.medscape.com]

“Knowing the initial results from blocking Notch in mice, we are encouraged to keep investigating the entire metastasis process, so we can find additional therapies and targets to prevent cancer from spreading and growing,” Hughes said in a press release [healio.com]

It is given before surgery in order to shrink the tumor, and in an attempt to prevent or control the spread of the tumor. Chemotherapy after surgery targets potential tumor sites not removed completely by surgery. [uchicagomedicine.org]

Therefore, surgical therapy is often supplemented with adjuvant treatment to prevent recurrence. [clinicsinsurgery.com]

Based on chemosensitivity of osteosarcoma and in order to prevent amputation the standard treatment is recommended as follows: neoadjuvant (preoperative) chemotherapy – surgery –adjuvant chemotherapy Surgery The mail goal for the surgery is to safely [telemedicina.med.muni.cz]

Understanding these side effects can help you, your child, and your care team prepare for, and, in some cases, prevent these symptoms from occurring. [danafarberbostonchildrens.org]