Upon presentation patients often have evidence of multiple previous asymptomatic lesions, and the diagnosis of multiple sclerosis can be strongly inferred. In other instances patients present with the first plaque. [radiopaedia.org]

Although the clinical findings in the present cases resemble those of several recognized hereditary neurologic diseases, we believe the mode of inheritance and the distinctive electron microscopic findings on sural nerve biopsies may represent a new genetic [jamanetwork.com]

• Weakness

  Common symptoms of cerebral sclerosis specifically include weakness on one side of the body, slow movement, seizures, speech problems, hearing problems, memory problems, personality changes, nutrition problems, and changes in breathing, blood pressure [globalgenes.org]

• Fever

  The first signs of the condition usually include headaches, feelings of discomfort, and fever. In cerebral sclerosis, the nerve signals cannot be transmitted as quickly because a substance called myelin gets degraded in the brain and spinal cord. [globalgenes.org]

• Hearing Problem

  Common symptoms of cerebral sclerosis specifically include weakness on one side of the body, slow movement, seizures, speech problems, hearing problems, memory problems, personality changes, nutrition problems, and changes in breathing, blood pressure [globalgenes.org]

• Personality Change

  Common symptoms of cerebral sclerosis specifically include weakness on one side of the body, slow movement, seizures, speech problems, hearing problems, memory problems, personality changes, nutrition problems, and changes in breathing, blood pressure [globalgenes.org]

• Headache

  The first signs of the condition usually include headaches, feelings of discomfort, and fever. In cerebral sclerosis, the nerve signals cannot be transmitted as quickly because a substance called myelin gets degraded in the brain and spinal cord. [globalgenes.org]

• Seizure

  Common symptoms of cerebral sclerosis specifically include weakness on one side of the body, slow movement, seizures, speech problems, hearing problems, memory problems, personality changes, nutrition problems, and changes in breathing, blood pressure [globalgenes.org]

• Vertigo

  Examples of common clinical features include 23,24: brainstem and cranial nerve involvement: optic neuritis internuclear ophthalmoplegia (often bilateral) trigeminal neuralgia diplopia (e.g. due to abducens nerve palsy) vertigo cerebellum involvement: [radiopaedia.org]

• Ataxia

  Examples of common clinical features include 23,24: brainstem and cranial nerve involvement: optic neuritis internuclear ophthalmoplegia (often bilateral) trigeminal neuralgia diplopia (e.g. due to abducens nerve palsy) vertigo cerebellum involvement: ataxia [radiopaedia.org]

A type of drug called corticosteroids is often used in the treatment of this condition. Other options to alleviate symptoms include physical and occupational therapy, and improved diet. [globalgenes.org]

Features favoring progressive disease include: large numerous plaques hyperintense T1 lesions Treatment and prognosis The aim of treatment is twofold: to curtail progression (disease-modifying agents) and symptomatic relief. [radiopaedia.org]

Prognosis is variable and depends on the pattern of disease a patient has (e.g. primary progressive carries a worse prognosis than relapsing-remitting). [radiopaedia.org]

[…] various investigations (see McDonald diagnostic criteria for multiple sclerosis), including 19: typical history oligoclonal bands in CSF immunoglobulin G in serum abnormal visual evoked potential MR imaging lack of viable alternative diagnosis The exact etiology [radiopaedia.org]

[…] interferon beta: inhibition of T-lymphocyte proliferation glatiramer acetate: immunomodulation teriflunomide (Aubagio®): reduces both T-cell and B-cell activation and proliferation dimethyl fumarate (Tecfidera®): immunomodulation fingolimod (Gilenya®): prevents [radiopaedia.org]