Upon presentation patients often have evidence of multiple previous asymptomatic lesions, and the diagnosis of multiple sclerosis can be strongly inferred. In other instances patients present with the first plaque. [radiopaedia.org]

Although the clinical findings in the present cases resemble those of several recognized hereditary neurologic diseases, we believe the mode of inheritance and the distinctive electron microscopic findings on sural nerve biopsies may represent a new genetic [jamanetwork.com]

• Fever

  The first signs of the condition usually include headaches, feelings of discomfort, and fever. In cerebral sclerosis, the nerve signals cannot be transmitted as quickly because a substance called myelin gets degraded in the brain and spinal cord. [globalgenes.org]

• Suggestibility

  Nine other siblings are clinically normal; but the parents are consanguineous, suggesting that the disease is genetically determined and transmitted as an autosomal recessive trait. [jamanetwork.com]

  Some authors also suggested that "chronic cerebrospinal venous insufficiency" can cause or exacerbate MS but this theory has not been proven by further investigations 15. [radiopaedia.org]

• Personality Change

  Common symptoms of cerebral sclerosis specifically include weakness on one side of the body, slow movement, seizures, speech problems, hearing problems, memory problems, personality changes, nutrition problems, and changes in breathing, blood pressure [globalgenes.org]

• Encephalopathy

  These include 20,21: progressive multifocal leukoencephalopathy (PML) and other less common CNS JC virus manifestations (JC virus granule cell neuronopathy, JC virus encephalopathy, and JC virus meningitis) particularly in patients treated with natalizumab [radiopaedia.org]

• White Matter Lesions

  Radiologically isolated syndrome (RIS) is another entity based on MRI brain findings which described as incidental white matter lesions suggestive of MS on imaging in a patient without associated clinical symptoms 17. [radiopaedia.org]

A type of drug called corticosteroids is often used in the treatment of this condition. Other options to alleviate symptoms include physical and occupational therapy, and improved diet. [globalgenes.org]

Features favoring progressive disease include: large numerous plaques hyperintense T1 lesions Treatment and prognosis The aim of treatment is twofold: to curtail progression (disease-modifying agents) and symptomatic relief. [radiopaedia.org]

Prognosis is variable and depends on the pattern of disease a patient has (e.g. primary progressive carries a worse prognosis than relapsing-remitting). [radiopaedia.org]

[…] various investigations (see McDonald diagnostic criteria for multiple sclerosis), including 19: typical history oligoclonal bands in CSF immunoglobulin G in serum abnormal visual evoked potential MR imaging lack of viable alternative diagnosis The exact etiology [radiopaedia.org]

[…] interferon beta: inhibition of T-lymphocyte proliferation glatiramer acetate: immunomodulation teriflunomide (Aubagio®): reduces both T-cell and B-cell activation and proliferation dimethyl fumarate (Tecfidera®): immunomodulation fingolimod (Gilenya®): prevents [radiopaedia.org]