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Penicillin G

Benzylpenicillin


Presentation

  • The case and a review of the literature are presented.[ncbi.nlm.nih.gov]
  • We present four cases of delayed allergic skin reactions to amoxicillin or ampicillin with good tolerance to benzyl penicillin and phenoxymethyl penicillin.[ncbi.nlm.nih.gov]
  • In this paper, we present the detailed synthetic protocol and characterization of Fmoc-Lys(Pac)-OH, its use for the preparation of octapeptides H-Gly-Phe-Tyr-N-MePhe-Thr-Lys(Pac)-Pro-Thr-OH and H-Gly-Phe-Phe-His-Thr-Pro-Lys(Pac)-Thr-OH by solid-phase[ncbi.nlm.nih.gov]
  • In the present study, we evaluated the use of monthly intramuscular injections of benzathine penicillin G to prevent recurrences of cellulitis.[ncbi.nlm.nih.gov]
  • A personal record of a pseudoanaphylactic reaction to procaine penicillin G is presented, together with a brief discussion of the topic.[ncbi.nlm.nih.gov]
Fever
  • KEYWORDS: Benzathine; Fever; Heart; Penicillin; Prophylaxis; Rheumatic[ncbi.nlm.nih.gov]
  • BACKGROUND: Benzathine penicillin G every 3 weeks is the standard protocol for secondary prophylaxis for recurrent rheumatic fever.[ncbi.nlm.nih.gov]
  • A need for review of the current recommendations for rheumatic fever prophylaxis is suggested.[ncbi.nlm.nih.gov]
  • , or irregular heartbeat return of fever, sore throat, chills, or other signs of infection Penicillin G injection may cause other side effects.[nlm.nih.gov]
  • KEYWORDS: dried blood spot; penicillin; rheumatic fever[ncbi.nlm.nih.gov]
Intravenous Administration
  • We report a child with a 6-year history of linear morphea in whom intravenous administration of 5 MU aqueous penicillin G three times a day for 10 consecutive days caused reduction in the thickness of the corium as demonstrated by ultrasound measurements[ncbi.nlm.nih.gov]
  • Local reactions: Phlebitis and thrombophlebitis may occur, and pain at the injection site has been reported with intravenous administration.[web.archive.org]
  • Mulhall ( 25 ) performed a study on the pharmacokinetics of penicillin G after intravenous administration in four neonates with gestational ages ranging from 27 to 40 weeks and found a CL of 0.12 0.07 liter/h/kg (mean standard deviation), a V of 0.61[aac.asm.org]
Localized Pain
  • Its main disadvantage is local pain and discomfort associated with the injection. Lidocaine as a diluent may reduce this discomfort.[ncbi.nlm.nih.gov]
Metallic Taste
  • The patient complained of a metallic taste, dizziness, ringing of the ears, and the fear of imminent death. No cardiovascular or pulmonary disturbances were noted.[ncbi.nlm.nih.gov]
Urticaria
  • Adverse effects can include hypersensitivity reactions including urticaria, fever, joint pains, rashes, angioedema, anaphylaxis, serum sickness-like reaction.[en.wikipedia.org]
  • Symptoms of exposure to this compound include hypersensitivity, skin rashes (ranging from maculopapular eruptions to exfoliative dermatitis), urticaria, chills, fever, edema, arthralgia, prostration, severe and occasionally fatal anaphylaxis, hemolytic[cameochemicals.noaa.gov]
  • Another type of immediate reaction, an accelerated reaction, may occur between 20 minutes and 48 hours after administration and may include urticaria, pruritus, fever and, occasionally, laryngeal edema.[web.archive.org]
Eczema
  • In individuals predisposed to develop allergic disease(s), the sequence of sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and bronchospasm) in infants and children less than 5 years due to food sensitivity[mayomedicallaboratories.com]
  • Make sure you tell your doctor if you have any other medical problems, especially: Allergy, general (such as asthma, eczema, hay fever, hives), history of—Patients with a history of general allergies may be more likely to have a severe reaction to penicillins[drugs.com]
Seizure
  • Psychosis and/or seizures following the administration of intramuscular penicillin G procaine have not been reported in the pediatric literature to our knowledge.[ncbi.nlm.nih.gov]
  • If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.[nlm.nih.gov]
  • Two long-acting forms benzathine benzylpenicillin and procaine benzylpenicillin are available for use by injection into a muscle.Side effects include diarrhea, seizures, and allergic reactions including anaphylaxis.[en.wikipedia.org]
  • […] child TDLo parenteral 15000units/kg (15000units/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA SENSE ORGANS AND SPECIAL SENSES: CHANGES IN COCHLEAR STRUCTURE OR FUNCTION: EAR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Lancet.[chem.nlm.nih.gov]
  • Gram negative cocci Spirochaetes Prophylaxis: endocarditis orthopaedics surgery post splenectomy CONTRAINDICATIONS hypersensitivity resistant organism high dose in renal dysfunction ADVERSE EFFECTS superinfection (pseudomembranous colitis) GI upset seizures[lifeinthefastlane.com]

Workup

  • For each subject, the leukocyte count, platelet count, and blood and superficial specimen cultures were performed as part of the routine workup. Pharmacokinetics study. The pharmacokinetics of penicillin G were studied on day 3 of life.[aac.asm.org]

Treatment

  • Furthermore, treatment response was not affected by the number of CD 4 cells.[ncbi.nlm.nih.gov]
  • Abstract Doxycycline is the preferred recommended second-line treatment for the treatment of early syphilis. Recent reports showed a declining efficacy trend of doxycycline in treatment of early syphilis.[ncbi.nlm.nih.gov]
  • Subjects who received penicillin G treatment had complete ulcer healing and pain relief significantly earlier than those in the placebo and no-treatment arms. No allergic reactions were observed.[ncbi.nlm.nih.gov]
  • Treatment response was the same among those receiving 1 or 1 dose of BPG (92%).[ncbi.nlm.nih.gov]
  • Rapid plasma reagin (RPR) titers were followed every 3-6 months after treatment. The serological response was defined as a 4-fold or greater decline in RPR titers at 12 months of treatment.[ncbi.nlm.nih.gov]

Etiology

  • […] treatment of pneumococcal pneumonia, penicillin G is seldom used for this purpose in clinical practice for at least three reasons: (1) concern about penicillin-resistant Streptococcus pneumoniae (PRSP) strains; (2) the difficulty of making an early etiologic[ncbi.nlm.nih.gov]
  • Interpretation Provides information to assist in interpretation of the test results Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens[mayomedicallaboratories.com]
  • Página 330 - Intestinal infections in patients with the acquired immunodeficiency syndrome (AIDS): etiology and response to therapy. ‎[books.google.es]

Epidemiology

  • This investigation was conducted under the sponsorship of the Commission on Streptococcal Diseases, Armed Forces Epidemiological Board. It was supported by the Office of the Surgeon General, departments of the Army and Air Force, Washington, D.[nejm.org]
  • In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Contraindications A history of a hypersensitivity (anaphylactic) reaction to any penicillin is a contraindication.[web.archive.org]
Sex distribution
Age distribution

Pathophysiology

  • Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Clinical manifestations of immediate hypersensitivity (allergic) diseases are caused by the release of proinflammatory mediators[mayomedicallaboratories.com]
  • Página 302 - Groszmann RJ, Atterbury CE: The pathophysiology of portal hypertension: a basis for classification. Semin Liver Dis 1982; 2:177. ‎[books.google.es]

Prevention

  • CONCLUSION: A single 1.0-g dose of azithromycin seems to be efficacious for prevention of syphilis in persons exposed to infected sexual partners.[ncbi.nlm.nih.gov]
  • In the present study, we evaluated the use of monthly intramuscular injections of benzathine penicillin G to prevent recurrences of cellulitis.[ncbi.nlm.nih.gov]
  • Timing of PA is effective in preventing SSIs when administered 30min before the start of surgery. Copyright 2012. Production and hosting by Elsevier B.V.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: The results of this study suggest that penicillin values may be inadequate for prevention of rheumatic fever by Week 3 of administration in a majority of children.[ncbi.nlm.nih.gov]
  • Administration of benzathine penicillin (BPG) every 3 to 4 weeks is recommended as a secondary prophylaxis to prevent recurrent episodes of acute rheumatic fever and subsequent RHD.[ncbi.nlm.nih.gov]

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