Presentation
The first chapter presents a general approach to differential diagnosis, diagnosis, and treatment of poisoning. [books.google.com]
Bronchial Asthma: A Genetic, Population and Psychiatric Study presents the main theories of the cause of asthma which states that attacks occurred as a result of pathological changes in the lungs, heart, or large vessels. [books.google.de]
Previous anaphylaxis to the medication Hives that rapidly spread after using penicillin If these are present, the individual must receive another course of antibiotic or start desensitization therapy. [firstaidreddeer.ca]
Penicillins are distributed rapidly in the ECF of most tissues, particularly when inflammation is present. All penicillins are at least partially excreted in urine, and most reach high levels in urine. [msdmanuals.com]
Serum sickness is an immune-complex reaction that presents with fever, lymphadenopathy, arthralgia, and cutaneous lesions. [aacijournal.biomedcentral.com]
Entire Body System
- Anemia
Hemolytic anemia may be confirmed with a positive direct and/or indirect Coombs' test, reflecting the presence of complement and/or drug-hapten on the red cell membrane. [aafp.org]
It is also prescribed as a palliative in the treatment of systemic sclerosis (scleroderma) and rheumatoid arthritis when other medications have failed. contraindications Known hypersensitivity to this drug or penicillamine-related aplastic anemia prohibits [medical-dictionary.thefreedictionary.com]
Hemolytic anemia : This disorder may develop when an antibody-drug-RBC interaction occurs or when a drug (eg, methyldopa ) alters the RBC membrane, uncovering an antigen that induces autoantibody production. [merckmanuals.com]
Penicillins can also cause CNS toxicity (eg, seizures) if doses are high, especially in patients with renal insufficiency Nephritis Coombs-positive hemolytic anemia Leukopenia Thrombocytopenia Leukopenia seems to occur most often with nafcillin. [msdmanuals.com]
A complete blood count can help diagnose hemolytic (type II) drug-induced reactions, such as hemolytic anemia, thrombocytopenia, or neutropenia. [aacijournal.biomedcentral.com]
- Collapse
If not corrected immediately, circulatory collapse can prove fatal because of cardiac arrest. [livestrong.com]
In 1996 I had double pneumonia with collapse of my lung. Steroids caused significant weight gain and my body rejected penicillin (rash and itching). [healthquestions.medhelp.org]
Warning signs of impending cardiovascular collapse include urticaria, laryngeal or upper airway edema, wheezing, and hypotension. [aafp.org]
- Fatigue
The symptoms of vitamin A toxicity may include bone and muscle aches, orange discoloration of skin, fatigue, and headache. [medicinenet.com]
SJS begins with a maculopapular rash that often progresses to bullae, mucous membrane ulcerations, conjunctivitis, fever, sore throat and fatigue. [aacijournal.biomedcentral.com]
- Surgical Procedure
Latex allergy Look for presence of risk factors for latex allergy (e.g. repeated surgical procedures, spina bifida, VP shunt, repeated catheterisation, health care worker. [rch.org.au]
- Asymptomatic
Medical Management of Asymptomatic Lead Poisoning Clinical management of asymptomatic lead-poisoned children with blood lead levels high enough to require chelation is similar to that of symptomatic children. [cdc.gov]
Gastrointestinal
- Nausea
Anaphylactic reactions due to antibiotics may include: Shortness of breath Wheezing Nausea/vomiting Lightheadedness, dizziness Fast heart rate Swelling of the face, lips or tongue Shock Immediately call for medical help if any of these symptoms should [drugs.com]
Side effects Nausea is a common side effect of taking penicillins. [medicalnewstoday.com]
Side effects of antibiotics that affect the digestive system include: vomiting nausea (feeling like you may vomit) diarrhoea bloating and indigestion abdominal pain loss of appetite These side effects are usually mild and should pass once you finish your [nhs.uk]
Symptoms of nitrofurantoin hepatitis include: fatigue, fever, muscle and joint aches, poor appetite, nausea, weight loss, vomiting, jaundice, and sometimes itching. [medicinenet.com]
As for the side effects that are a bit more serious and that have been reported, they refer to bloody diarrhea, severe nausea and vomiting, and severe cramps in the stomach or abdomen. [ic.steadyhealth.com]
- Diarrhea
Antibiotic-associated diarrhea : Antibiotic-associated diarrhea occurs in patients receiving antibiotics due to no explainable reason. Five to twenty-five percent of patients may develop antibiotic-associated diarrhea. [drugs.com]
If only sports drinks are available, dilute them with water since the sugar in these drinks can worsen diarrhea. In addition, health care providers usually discourage people from using medication to prevent and/or stop the vomiting or diarrhea. [goaskalice.columbia.edu]
This can result in the child experiencing allergic reactions, diarrhea, fungal infections, and skin rash. Interactions: Some other drugs can interact with penicillins. Checking with a doctor before taking multiple medications is vital. [medicalnewstoday.com]
Side effects of penicillin antibiotics include diarrhea, dizziness, heartburn, insomnia, nausea, itching, vomiting, confusion, abdominal pain, easy bruising, bleeding, rash, and allergic reactions. [medicinenet.com]
Severe diarrhea warning: This drug may cause diarrhea during and after your treatment with it. This diarrhea can be caused by an infection in your intestine called Clostridium difficile. [healthline.com]
- Abdominal Pain
Side effects of penicillin antibiotics include diarrhea, dizziness, heartburn, insomnia, nausea, itching, vomiting, confusion, abdominal pain, easy bruising, bleeding, rash, and allergic reactions. [medicinenet.com]
erythromycin-sulfisoxazole, sulfadiazine Nausea/vomiting, diarrhea, anorexia, abdominal pain, rash, photosensitivity, headache, dizziness Avoid prolonged sunlight exposure; use sunscreen, wear protective clothing; antibiotic cause of Stevens Johnson [drugs.com]
Side effects of antibiotics that affect the digestive system include: vomiting nausea (feeling like you may vomit) diarrhoea bloating and indigestion abdominal pain loss of appetite These side effects are usually mild and should pass once you finish your [nhs.uk]
Most antibiotics have the potential to cause abdominal pain, nausea or diarrhoea; these are symptoms not allergies, and shouldn’t prevent anyone from having what may be an essential medicine. [ft.com]
Acute pancreatitis can cause shock, which may result in death if not treated quickly. _____ Symptoms : Extremely sharp abdominal pain, perhaps with other acute symptoms. [healthquestions.medhelp.org]
Cardiovascular
- Hypotension
IV Dopamine Poison-induced hypotension IV Epinephrine Anaphylaxis SC/IV Esmolol Sympathomimetics (e.g., theophylline) IV זהירות במקרי אסתמה, אי-ספיקת לב, קוקאין, אמפטמינים Labetalol Hypertension and tachycardia associated with stimulants (e.g., cocaine [wikirefua.org.il]
Psychiatrical
- Fear
Initial symptoms of anaphylaxis are often the same as above and can lead to: a rapid heartbeat increasing difficulty breathing caused by swelling and tightening of the neck a sudden intense feeling of apprehension and fear a sharp and sudden drop in your [nhs.uk]
[…] redness of the face scaly, red skin vaginal itching and discharge, due to either a yeast infection or bacterial vaginosis sore mouth and tongue, sometimes with white patches abdominal cramps, spasms, tenderness, or pain Rare side effects include: anxiety, fear [medicalnewstoday.com]
I'm sure fear is not helping my UTI sensations. How big of trouble may I be in concerning this situation? What can they do? Any input would be grateful. penicillin, Erc/ Zithromax, clydomyicin, anything penicllin related. Can take some sulfa drugs. [healthquestions.medhelp.org]
The last phase consisted of the appearance of abscesses and ulcers, and the gumma referred to by Girolamo Fracastoro, often ending with severe debility, madness or death. [7] It was this phase of the disease for which syphilis was greatly feared, because [jmvh.org]
Lack of knowledge and experience in this important area can lead to fear of multiple “drug allergies” and unnecessary avoidance of appropriate medications, with reliance on more expensive, or less effective, alternatives without a rational basis. [mja.com.au]
Neurologic
- Seizure
IV Prednisolone sodium Irritant gas inhalation IV/IM ניתן להשתמש בסטרואידים אחרים במנות שקולות Prednisone Irritant gas inhalation PO Propofol Poison-induced refractory seizures IV Propranolol Excessive sinus tachycardia or ventricular arrhythmias caused [wikirefua.org.il]
- Confusion
[…] and can lead to: a rapid heartbeat increasing difficulty breathing caused by swelling and tightening of the neck a sudden intense feeling of apprehension and fear a sharp and sudden drop in your blood pressure, which can make you feel light-headed and confused [nhs.uk]
Side effects of penicillin antibiotics include diarrhea, dizziness, heartburn, insomnia, nausea, itching, vomiting, confusion, abdominal pain, easy bruising, bleeding, rash, and allergic reactions. [medicinenet.com]
[…] more than three days Vomits to the point that s/he cannot keep anything down Has serious abdominal cramping Has bloody stool Has symptoms ofdehydration: dry mouth or sticky saliva, does not urinate or dark urine, dizziness, and/or, lightheadedness Is confused [goaskalice.columbia.edu]
[…] face scaly, red skin vaginal itching and discharge, due to either a yeast infection or bacterial vaginosis sore mouth and tongue, sometimes with white patches abdominal cramps, spasms, tenderness, or pain Rare side effects include: anxiety, fear, or confusion [medicalnewstoday.com]
- Headache
vaginal candidiasis, metallic taste Avoid alcohol use during treatment and for up to 3 days after, combined use may lead to cramps, nausea/vomiting, flushing, headache; may discolor urine red-brown There are several side effects that are common to most [drugs.com]
Other possible side effects include diarrhea, vomiting and headache, but it is possible also that white patches in the mouth or throat will appear, or sore tongue. [ic.steadyhealth.com]
Symptoms show up usually between 18 and 36 hours after eating contaminated food and may include headache, blurred vision, muscle weakness, nausea, vomiting, constipation, urinary retention, reduced salivation, and/or eventual paralysis. [goaskalice.columbia.edu]
[…] depression of CNS resulting in seizures and coma patients appear "drunk without smelling like alcohol" within 4 - 12 hours, calcium oxalate crystals deposit in the brain causing CNS toxicity, cerebral edema, meningismus (nuchal rigidity, photophobia, headache [medbullets.com]
The most commmon side effects of taking penicillins include: diarrhea nausea a headache skin rashes and hives Less common side effects include: shortness of breath or irregular breathing joint pain sudden lightheadedness and fainting puffiness and redness [medicalnewstoday.com]
- Agitation
Ca-channel blockers Black widow spider (Latrodectus) IV g 15 A A A B Carnitine Valproic acid IV g 20 B Cyproheptadine Serotonin syndrome PO mg 32 C יוחזק באגף לשע"ח, משרד הבריאות Deferoxamine Iron IV g 8 A Diazepam Poison-induced convulsions, anxiety, agitation [wikirefua.org.il]
Treatment
The first chapter presents a general approach to differential diagnosis, diagnosis, and treatment of poisoning. [books.google.com]
But if you're concerned, or your symptoms don't respond to treatment, you should call your GP for advice. If you can't contact your GP, call NHS 111. [nhs.uk]
It is also used as a disease-modifying antirheumatic drug in treatment of refractory rheumatoid arthritis. pen·i·cil·la·mine ( pen'i-sil'ă-mēn ), A degradation product of penicillin; a chelating agent used in the treatment of lead poisoning, hepatolenticular [medical-dictionary.thefreedictionary.com]
Treatment is drug discontinuation, supportive treatment (eg, with antihistamines), and sometimes desensitization. [merckmanuals.com]
During treatment, evaluate renal and hepatic function and serum electrolyte levels regularly. Do not continue CaNa 2 EDTA treatment for more than 5 days (Piomelli et al., 1984). [cdc.gov]
Prognosis
the prognosis is good. [45] Even if the cause is unknown, if appropriate preventative medication is available, the prognosis is generally good. [12] If death occurs, it is usually due to either respiratory (typically asphyxia ) or cardiovascular causes [en.wikipedia.org]
Etiology
The etiology of this reaction is yet under cover. Beta-lactam is the family to which penicillin antibiotic belongs. Amoxicillin also falls under the same category. [home-remedies-for-you.com]
Drug reactions can be classified into immunologic and nonimmunologic etiologies ( Table 1 ). [aafp.org]
The possibility of lead encephaliopathy should be considered in the differential diagnosis of children presenting with coma and convulsions of unknown etiology. [cdc.gov]
Epidemiology
"An update on epidemiology of anaphylaxis in children and adults". Current Opinion in Allergy and Clinical Immunology. 11 (5): 492–6. doi : 10.1097/ACI.0b013e32834a41a1. PMID 21760501. ^ Fromer, L (December 2016). [en.wikipedia.org]
Epidemiology Adverse drug reactions caused by immune and nonimmune mechanisms are a major cause of morbidity and mortality worldwide. [aafp.org]
Epidemiology Drug allergy accounts for 11.3% of all adverse drug reaction [ 1 ]. Betalactams antibiotics are the most frequent drugs that cause allergic reactions [ 4, 5 ]. [omicsonline.org]
View Article Google Scholar Barranco P, Lopez-Serrano MC: General and epidemiological aspects of allergic drug reactions. Clin Exp Allergy. 1998, 28 (Suppl 4): 61-62. PubMed Google Scholar Adkinson NF: Risk factors for drug allergy. [aacijournal.biomedcentral.com]
Pathophysiology
Subsequent chapters focus on specific drugs, chemicals, and toxidromes and provide details on clinical presentation, pathophysiology, diagnosis, and treatment. [books.google.com]
"Pathophysiology of anaphylaxis". Current Opinion in Allergy and Clinical Immunology. 11 (4): 319–25. doi : 10.1097/ACI.0b013e3283481ab6. [en.wikipedia.org]
Copeland, PharmD Educational Objectives Upon completion of this educational activity, participants should be able to: Describe the pathophysiology of and risk factors for anaphylaxis. http://www.ikatanapotekerindonesia.net/articles/pharma-update/pharmaceutical-research [pharmacistschools.org]
Prevention
Peptidoglycans create a mesh-like structure around the plasma membrane of bacterial cells, which increases the strength of the cell walls and prevents external fluids and particles from entering the cell. [medicalnewstoday.com]
Probenecid (Benemid) causes an increase in the amount of penicillins in the body by preventing excretion of penicillin by the kidneys. Combining ampicillin with allopurinol (Zyloprim) can increase the incidence of drug-related skin rash. [medicinenet.com]
[…] doi=10.2340/00015555-0650&html=1 Peanut Allergy http://www.medsafe.govt.nz/Profs/PUarticles/peanut.htm Preventing Allergic Reactions to Drugs Documenting and reporting drug allergies is a multidisciplinary process involving several steps. [pharmacistschools.org]
Sometimes, these medications are used in order to prevent particular infections before or after the surgery. [ic.steadyhealth.com]
In addition, health care providers usually discourage people from using medication to prevent and/or stop the vomiting or diarrhea. [goaskalice.columbia.edu]