Presentation
The first chapter presents a general approach to differential diagnosis, diagnosis, and treatment of poisoning. [books.google.com]
Bronchial Asthma: A Genetic, Population and Psychiatric Study presents the main theories of the cause of asthma which states that attacks occurred as a result of pathological changes in the lungs, heart, or large vessels. [books.google.de]
Previous anaphylaxis to the medication Hives that rapidly spread after using penicillin If these are present, the individual must receive another course of antibiotic or start desensitization therapy. [firstaidreddeer.ca]
Penicillins are distributed rapidly in the ECF of most tissues, particularly when inflammation is present. All penicillins are at least partially excreted in urine, and most reach high levels in urine. [msdmanuals.com]
Serum sickness is an immune-complex reaction that presents with fever, lymphadenopathy, arthralgia, and cutaneous lesions. [aacijournal.biomedcentral.com]
Entire Body System
- Inflammation
Other chapters explore the inherited susceptibility of the bronchial tree to dysfunction, be it inflammation, as with bronchitis, or spasm, as with asthma. [books.google.de]
Kidney or liver inflammation. Read the leaflet that comes with the medicine or talk to your doctor, nurse or pharmacist if you want any more information about the possible side effects of Tazocin. [netdoctor.co.uk]
Like other antibiotics, penicillin antibiotics can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile, which causes inflammation of the colon ( C. difficile colitis or pseudomembranous colitis [medicinenet.com]
Rash, or redness, itching and inflammation to the skin, can indicate a mild reaction to penicillin or it can be a precursor to more severe reactions like anaphylaxis. [livestrong.com]
The most common symptoms of penicillin allergy are hives, itchy eyes, inflammation of the face, lips and tongue and rashes. Alternative medicines are prescribed, in case of an individual experiencing penicillin allergy. [home-remedies-for-you.com]
- Anemia
Hemolytic anemia may be confirmed with a positive direct and/or indirect Coombs' test, reflecting the presence of complement and/or drug-hapten on the red cell membrane. [aafp.org]
It is also prescribed as a palliative in the treatment of systemic sclerosis (scleroderma) and rheumatoid arthritis when other medications have failed. contraindications Known hypersensitivity to this drug or penicillamine-related aplastic anemia prohibits [medical-dictionary.thefreedictionary.com]
Hemolytic anemia : This disorder may develop when an antibody-drug-RBC interaction occurs or when a drug (eg, methyldopa ) alters the RBC membrane, uncovering an antigen that induces autoantibody production. [merckmanuals.com]
Penicillins can also cause CNS toxicity (eg, seizures) if doses are high, especially in patients with renal insufficiency Nephritis Coombs-positive hemolytic anemia Leukopenia Thrombocytopenia Leukopenia seems to occur most often with nafcillin. [msdmanuals.com]
A complete blood count can help diagnose hemolytic (type II) drug-induced reactions, such as hemolytic anemia, thrombocytopenia, or neutropenia. [aacijournal.biomedcentral.com]
- Weakness
Symptoms show up usually between 18 and 36 hours after eating contaminated food and may include headache, blurred vision, muscle weakness, nausea, vomiting, constipation, urinary retention, reduced salivation, and/or eventual paralysis. [goaskalice.columbia.edu]
This all leads to the weight loss and general feeling of weakness and tiredness, and in such cases, medical help should be sought. [ic.steadyhealth.com]
Symptoms range from swelling and pain in the joints, called arthralgia, swollen lymph glands, fever, weakness and pain, to angioedema or swelling throughout the body. [livestrong.com]
Various other symptoms are slurred speech, diarrhea, weak or fast pulse, vomiting, wheezing, skin blueness, lightheadedness and nausea. Penicillin allergy calls for immediate care with antihistamines (diphenhydramine) for the rash and itching. [home-remedies-for-you.com]
Symptoms include difficulty breathing, hives, wheezing, dizziness, loss of consciousness, rapid or weak pulse, skin turning blue, diarrhea, nausea, and vomiting. [healthlinkbc.ca]
- Fatigue
The symptoms of vitamin A toxicity may include bone and muscle aches, orange discoloration of skin, fatigue, and headache. [medicinenet.com]
SJS begins with a maculopapular rash that often progresses to bullae, mucous membrane ulcerations, conjunctivitis, fever, sore throat and fatigue. [aacijournal.biomedcentral.com]
- Shivering
Now the nurses reported that she had a temperature of 40C and rigors, or uncontrollable shivering. When I got to her, she was drowsy and breathing fast; her skin was hot when I touched it. [ft.com]
Shivers CH De T. The clinical value of bismuth in the treatment of syphilis. Arch Derm Syphilol 1924; 10 (4): 414-423. Available at : http://archderm.ama-assn.org/cgi/content/summary/10/4/414, accessed on 15.2.12. 20. Burn JH. [jmvh.org]
Gastrointestinal
- Nausea
Anaphylactic reactions due to antibiotics may include: Shortness of breath Wheezing Nausea/vomiting Lightheadedness, dizziness Fast heart rate Swelling of the face, lips or tongue Shock Immediately call for medical help if any of these symptoms should [drugs.com]
Side effects Nausea is a common side effect of taking penicillins. [medicalnewstoday.com]
Side effects of antibiotics that affect the digestive system include: vomiting nausea (feeling like you may vomit) diarrhoea bloating and indigestion abdominal pain loss of appetite These side effects are usually mild and should pass once you finish your [nhs.uk]
Symptoms of nitrofurantoin hepatitis include: fatigue, fever, muscle and joint aches, poor appetite, nausea, weight loss, vomiting, jaundice, and sometimes itching. [medicinenet.com]
As for the side effects that are a bit more serious and that have been reported, they refer to bloody diarrhea, severe nausea and vomiting, and severe cramps in the stomach or abdomen. [ic.steadyhealth.com]
- Abdominal Pain
Side effects of penicillin antibiotics include diarrhea, dizziness, heartburn, insomnia, nausea, itching, vomiting, confusion, abdominal pain, easy bruising, bleeding, rash, and allergic reactions. [medicinenet.com]
erythromycin-sulfisoxazole, sulfadiazine Nausea/vomiting, diarrhea, anorexia, abdominal pain, rash, photosensitivity, headache, dizziness Avoid prolonged sunlight exposure; use sunscreen, wear protective clothing; antibiotic cause of Stevens Johnson [drugs.com]
Side effects of antibiotics that affect the digestive system include: vomiting nausea (feeling like you may vomit) diarrhoea bloating and indigestion abdominal pain loss of appetite These side effects are usually mild and should pass once you finish your [nhs.uk]
Most antibiotics have the potential to cause abdominal pain, nausea or diarrhoea; these are symptoms not allergies, and shouldn’t prevent anyone from having what may be an essential medicine. [ft.com]
Acute pancreatitis can cause shock, which may result in death if not treated quickly. _____ Symptoms : Extremely sharp abdominal pain, perhaps with other acute symptoms. [healthquestions.medhelp.org]
Cardiovascular
- Irregular Heart Rhythm
Amiodarone (Cordarone) Amiodarone (Cordarone) is an important medication that is used to treat irregular heart rhythms such as atrial fibrillation and ventricular tachycardia. [medicinenet.com]
Neurologic
- Seizure
IV Prednisolone sodium Irritant gas inhalation IV/IM ניתן להשתמש בסטרואידים אחרים במנות שקולות Prednisone Irritant gas inhalation PO Propofol Poison-induced refractory seizures IV Propranolol Excessive sinus tachycardia or ventricular arrhythmias caused [wikirefua.org.il]
- Confusion
[…] and can lead to: a rapid heartbeat increasing difficulty breathing caused by swelling and tightening of the neck a sudden intense feeling of apprehension and fear a sharp and sudden drop in your blood pressure, which can make you feel light-headed and confused [nhs.uk]
Side effects of penicillin antibiotics include diarrhea, dizziness, heartburn, insomnia, nausea, itching, vomiting, confusion, abdominal pain, easy bruising, bleeding, rash, and allergic reactions. [medicinenet.com]
[…] more than three days Vomits to the point that s/he cannot keep anything down Has serious abdominal cramping Has bloody stool Has symptoms ofdehydration: dry mouth or sticky saliva, does not urinate or dark urine, dizziness, and/or, lightheadedness Is confused [goaskalice.columbia.edu]
[…] face scaly, red skin vaginal itching and discharge, due to either a yeast infection or bacterial vaginosis sore mouth and tongue, sometimes with white patches abdominal cramps, spasms, tenderness, or pain Rare side effects include: anxiety, fear, or confusion [medicalnewstoday.com]
- Headache
vaginal candidiasis, metallic taste Avoid alcohol use during treatment and for up to 3 days after, combined use may lead to cramps, nausea/vomiting, flushing, headache; may discolor urine red-brown There are several side effects that are common to most [drugs.com]
Other possible side effects include diarrhea, vomiting and headache, but it is possible also that white patches in the mouth or throat will appear, or sore tongue. [ic.steadyhealth.com]
Symptoms show up usually between 18 and 36 hours after eating contaminated food and may include headache, blurred vision, muscle weakness, nausea, vomiting, constipation, urinary retention, reduced salivation, and/or eventual paralysis. [goaskalice.columbia.edu]
[…] depression of CNS resulting in seizures and coma patients appear "drunk without smelling like alcohol" within 4 - 12 hours, calcium oxalate crystals deposit in the brain causing CNS toxicity, cerebral edema, meningismus (nuchal rigidity, photophobia, headache [medbullets.com]
The most commmon side effects of taking penicillins include: diarrhea nausea a headache skin rashes and hives Less common side effects include: shortness of breath or irregular breathing joint pain sudden lightheadedness and fainting puffiness and redness [medicalnewstoday.com]
- Convulsions
[…] white patches abdominal cramps, spasms, tenderness, or pain Rare side effects include: anxiety, fear, or confusion a sense of impending doom hallucinations yellowing of the eyes and skin a sore throat unusual bleeding diarrhea and reduced urination convulsions [medicalnewstoday.com]
[…] acid Fluoride Ca-channel blockers Black widow spider (Latrodectus) IV g 15 A A A B Carnitine Valproic acid IV g 20 B Cyproheptadine Serotonin syndrome PO mg 32 C יוחזק באגף לשע"ח, משרד הבריאות Deferoxamine Iron IV g 8 A Diazepam Poison-induced convulsions [wikirefua.org.il]
- Agitation
Ca-channel blockers Black widow spider (Latrodectus) IV g 15 A A A B Carnitine Valproic acid IV g 20 B Cyproheptadine Serotonin syndrome PO mg 32 C יוחזק באגף לשע"ח, משרד הבריאות Deferoxamine Iron IV g 8 A Diazepam Poison-induced convulsions, anxiety, agitation [wikirefua.org.il]
Treatment
The first chapter presents a general approach to differential diagnosis, diagnosis, and treatment of poisoning. [books.google.com]
But if you're concerned, or your symptoms don't respond to treatment, you should call your GP for advice. If you can't contact your GP, call NHS 111. [nhs.uk]
It is also used as a disease-modifying antirheumatic drug in treatment of refractory rheumatoid arthritis. pen·i·cil·la·mine ( pen'i-sil'ă-mēn ), A degradation product of penicillin; a chelating agent used in the treatment of lead poisoning, hepatolenticular [medical-dictionary.thefreedictionary.com]
Treatment is drug discontinuation, supportive treatment (eg, with antihistamines), and sometimes desensitization. [merckmanuals.com]
During treatment, evaluate renal and hepatic function and serum electrolyte levels regularly. Do not continue CaNa 2 EDTA treatment for more than 5 days (Piomelli et al., 1984). [cdc.gov]
Prognosis
the prognosis is good. [45] Even if the cause is unknown, if appropriate preventative medication is available, the prognosis is generally good. [12] If death occurs, it is usually due to either respiratory (typically asphyxia ) or cardiovascular causes [en.wikipedia.org]
Etiology
The etiology of this reaction is yet under cover. Beta-lactam is the family to which penicillin antibiotic belongs. Amoxicillin also falls under the same category. [home-remedies-for-you.com]
Drug reactions can be classified into immunologic and nonimmunologic etiologies ( Table 1 ). [aafp.org]
The possibility of lead encephaliopathy should be considered in the differential diagnosis of children presenting with coma and convulsions of unknown etiology. [cdc.gov]
Epidemiology
"An update on epidemiology of anaphylaxis in children and adults". Current Opinion in Allergy and Clinical Immunology. 11 (5): 492–6. doi : 10.1097/ACI.0b013e32834a41a1. PMID 21760501. ^ Fromer, L (December 2016). [en.wikipedia.org]
Epidemiology Adverse drug reactions caused by immune and nonimmune mechanisms are a major cause of morbidity and mortality worldwide. [aafp.org]
Epidemiology Drug allergy accounts for 11.3% of all adverse drug reaction [ 1 ]. Betalactams antibiotics are the most frequent drugs that cause allergic reactions [ 4, 5 ]. [omicsonline.org]
View Article Google Scholar Barranco P, Lopez-Serrano MC: General and epidemiological aspects of allergic drug reactions. Clin Exp Allergy. 1998, 28 (Suppl 4): 61-62. PubMed Google Scholar Adkinson NF: Risk factors for drug allergy. [aacijournal.biomedcentral.com]
Pathophysiology
Subsequent chapters focus on specific drugs, chemicals, and toxidromes and provide details on clinical presentation, pathophysiology, diagnosis, and treatment. [books.google.com]
"Pathophysiology of anaphylaxis". Current Opinion in Allergy and Clinical Immunology. 11 (4): 319–25. doi : 10.1097/ACI.0b013e3283481ab6. [en.wikipedia.org]
Copeland, PharmD Educational Objectives Upon completion of this educational activity, participants should be able to: Describe the pathophysiology of and risk factors for anaphylaxis. http://www.ikatanapotekerindonesia.net/articles/pharma-update/pharmaceutical-research [pharmacistschools.org]
Prevention
Peptidoglycans create a mesh-like structure around the plasma membrane of bacterial cells, which increases the strength of the cell walls and prevents external fluids and particles from entering the cell. [medicalnewstoday.com]
Probenecid (Benemid) causes an increase in the amount of penicillins in the body by preventing excretion of penicillin by the kidneys. Combining ampicillin with allopurinol (Zyloprim) can increase the incidence of drug-related skin rash. [medicinenet.com]
[…] doi=10.2340/00015555-0650&html=1 Peanut Allergy http://www.medsafe.govt.nz/Profs/PUarticles/peanut.htm Preventing Allergic Reactions to Drugs Documenting and reporting drug allergies is a multidisciplinary process involving several steps. [pharmacistschools.org]
Sometimes, these medications are used in order to prevent particular infections before or after the surgery. [ic.steadyhealth.com]
In addition, health care providers usually discourage people from using medication to prevent and/or stop the vomiting or diarrhea. [goaskalice.columbia.edu]