We report two cases of unusual penile clinical presentations of varicella zoster virus infection in immunocompetent men. [ncbi.nlm.nih.gov]

A 30-year-old man presents with mildly painful sores that have been present on his penis for three days. He had no symptoms before the lesions appeared, and he has never had similar genital lesions before. [clinicaladvisor.com]

Case report: We report two cases of unusual penile clinical presentations of varicella zoster virus infection in immunocompetent men. [scielo.br]

An individual infected with the herpes simplex virus is contagious even when symptoms are not present. [chemistclick.co.uk]

At the time of recurrent episodes, anti–HSV-1 antibody is already present, which explains the milder nature of recurrent episodes compared with the initial episode. 6 The most plausible source of the virus in the present case was acquisition from the [journals.lww.com]

• Fatigue

  If symptoms are present, they are generally mild flu-like symptoms, dark urine, light stools, jaundice, fatigue, and fever. [knowmystatus.org]

  These outbreaks may follow exposure to UV light, stress or fatigue. Tingling, aching or discomfort in the affected area often precedes the lesions by 12 to 24 hours, warning that the virus is reactivating. [livestrong.com]

  · Scientists speculate that chronic fatigue might be caused by herpes virus 6 (HHV-6). · Some studies suggest HSV-1, the herpes that causes cold sores, might play a role in the development of Alzheimer’s disease. [livescience.com]

  […] clinically, with confirmation by culture, direct fluorescent antibody, skin biopsy and PCR for viral DNA Primary outbreak: occurs 3 - 14 days after exposure; patients usually asymptomatic but rarely have systemic symptoms of fever, headache, muscle ache, fatigue [pathologyoutlines.com]

  Headaches Backaches Flu -like symptoms, including fever, swollen lymph nodes, and fatigue Genital herpes is not the only condition that can produce these symptoms. [webmd.com]

• Weakness

  The herpes virus enters the body through the: Lining of the mouth Labia Vagina Regular skin that has small cracks or cuts People with a weak immune system can get a herpes infection more easily. [publichealth.va.gov]

  They occur most often in unborn babies, newborns, and people who have a long-term illness or weak immune system. [aad.org]

  The virus can be more serious in newborn babies or in people with weak immune systems. Repeat outbreaks are common, especially during the first year. Over time, you get them less often and the symptoms become milder. [nlm.nih.gov]

  Common symptoms include headaches, fevers, drowsiness, hyperactivity, and/or general weakness. [rarediseases.org]

• Unconsciousness

  These are possible symptoms of meningoencephalitis: Headache Fever Neck stiffness Sensitivity to light Seizures Trouble thinking clearly Personality changes Hallucinations, visual and auditory Unusual behaviors Unconsciousness How is herpes meningoencephalitis [hopkinsmedicine.org]

• Common Cold

  Influenza and the common cold are all too familiar. Genital herpes is also common but, unlike colds and flu, mostly travels incognito. This chronic viral infection, marked by recurrent genital skin lesions, spreads by sexual contact. [livestrong.com]

  “While HSV-1 in adults can cause the common cold sore, HSV-1 infection in newborns is very serious,” a department statement says. Since 2000, there have been 13 reports in New York City of infants contracting HSV-1, two of whom died from the virus. [edition.cnn.com]

  "While HSV-1 in adults can cause the common cold sore, HSV-1 infection in newborns is very serious," a department statement says. Since 2000, there have been 13 reports in New York City of infants contracting HSV-1, two of whom died from the virus. [cnn.com]

  A common cold is a frequent trigger for oral herpes, but not for genital herpes. [mens-app.net]

  cold.[24] After the development of acyclovir in the 1970s, the drug company Burroughs Wellcome launched an extensive marketing campaign that publicized the illness, including creating victim's support groups.[24] Research There are efforts to develop [en.wikipedia.org]

• Sputum

  A 41-year-old woman, with no significant history, attended the emergency room with a 4-day history of fever, cough, bloody sputum, and dyspnea at rest. Physical examination revealed a temperature of 39.3 °C; BP 100/50 mmHg; pulse 101 bpm. [archbronconeumol.org]

• Dyspnea

  A 41-year-old woman, with no significant history, attended the emergency room with a 4-day history of fever, cough, bloody sputum, and dyspnea at rest. Physical examination revealed a temperature of 39.3 °C; BP 100/50 mmHg; pulse 101 bpm. [archbronconeumol.org]

• Diarrhea

  Adverse effects are infrequent with oral administration but may include nausea, vomiting, diarrhea, headache, and rash. Topical antiviral drugs have only little value, and their use is discouraged. [merckmanuals.com]

  Symptoms That Suggest Sexually Transmitted Infections May Include: HIV/AIDS Headaches Difficulty swallowing Fever Night sweats Fatigue/weakness Appetite loss Weight loss Chronic diarrhea Nausea/vomiting Itchy, rashy skin/skin lesions Chronic coughing [healthychildren.org]

  Nausea, vomiting, headache, diarrhea, vertigo, myalgia, rash Initial infection 400 mg three times daily for 7 to 10 days $63 to 93 ($45 to 65) 200 mg five times daily for 7 to 10 days 56 to 80 (36 to 51) Recurrences 400 mg three times daily for 5 days [aafp.org]

  The most common side effects with these medications are nausea and vomiting, diarrhea, headache, fatigue, dizziness and muscle aches. [13] Method 2 Changing Your Routine to Treat HSV 1 Eat better. [wikihow.com]

• Quickening

  Usually a healthcare provider prescribes various medications that help quicken the healing process and make the signs and symptoms less obvious or painful. Though the medications are effective, they are useless in killing the virus itself. [realhealthvision.com]

  Your health care provider can prescribe medications that quicken healing, make symptoms less painful, and lower the risk of getting outbreaks. These medications don’t kill the virus and don’t prevent you from getting outbreaks in the future. [youngmenshealthsite.org]

• Tingling

  Because HSV infection is contagious, people with infection of the lips should avoid kissing as soon as they feel the first tingling (or, if no tingling is felt, when a blister appears) until the sore has completely healed. [msdmanuals.com]

  Tingling, itching and aching, along with red and cracked skin, may accompany the skin lesions. The whole cycle can take 2 to 4 weeks. Some men may not develop skin lesions. [livestrong.com]

  […] the area where blisters will appear After the initial tingling and itching, one or more clusters of small blisters (sometimes painful) appear, which are filled with slightly cloudy liquid. [dred.com]

• Headache

  If you have viral meningitis, symptoms may include fever, light sensitivity, headache, and a stiff neck. [hopkinsmedicine.org]

  Symptoms include: Stiff neck Fever Headache Vomiting Eye pain when looking at light (photophobia) You may also need this test if you have symptoms of encephalitis, or brain inflammation. [urmc.rochester.edu]

  Symptoms of the first outbreak may include: Flu-like symptoms, such as fever, headache, and muscle aches. These symptoms usually get better within a week. Tingling, burning, itching, and redness at the site where an outbreak is about to occur. [stanfordhealthcare.org]

• Meningism

  The meninges are the layers of thin tissue that cover your brain. If these tissues become infected, it’s called meningitis. When your brain becomes inflamed or infected, the problem is called encephalitis. [hopkinsmedicine.org]

  Herpes meningitis lasts for roughly 7 days and tends to fade without any long-term consequences. In very rare cases, herpes meningitis may be recurrent. This is known as "Mollaret Meningitis." [progressivehealth.com]

  HSV-2 is more often associated with monophasic or recurrent aseptic meningitis in adults (previously classified as “Mollaret’s meningitis”) and also myelitis or radiculitis [1,4,8]. [remedypublications.com]

  Most Common Silent or no symptoms (two-thirds of cases) Less Common Sores or blisters on the penis Fever Headache Tiredness Body aches Swollen lymph nodes Least Common Sores, blisters, or ulcers Inside or around the anus Around the buttocks and thighs Meningitis [stdcheck.com]

• Dizziness

  Possible side-effects of aciclovir include skin rash, light sensitivity, headache, dizziness, tummy upset and tirednesss. [netdoctor.co.uk]

  […] vomiting, fatigue, paresthesias, pruritus Initial infection 250 mg three times daily for 7 to 10 days 92 to 132 Recurrences 125 mg twice daily for 5 days 40 Suppressive therapy 250 mg twice daily 263 Valacyclovir (Valtrex) Headache, nausea, vomiting, dizziness [aafp.org]

  The most common side effects with these medications are nausea and vomiting, diarrhea, headache, fatigue, dizziness and muscle aches. [13] Method 2 Changing Your Routine to Treat HSV 1 Eat better. [wikihow.com]

• Paresthesia

  Frequently, patients feel genital paresthesias before a manifestation of recurrent herpes genitalis becomes visible. [urology-textbook.com]

  Complications in both sexes can include paresthesias of the legs and perineum. Urinary retention, more common in women than in men, may be reported. [emedicine.medscape.com]

  […] crusts.[8] In rare cases, involvement of the sacral region of the spinal cord can cause acute urinary retention and one-sided symptoms and signs of myeloradiculitis (a combination of myelitis and radiculitis): pain, sensory loss, abnormal sensations (paresthesia [en.wikipedia.org]

  400 mg three times daily for 5 days 47 (32 to 34) 200 mg five times daily for 5 days 40 (25 to 28) 800 mg twice daily for 5 days 60 (40 to 42) Suppressive therapy 400 mg twice daily 187 (129) Famciclovir (Famvir) Headache, nausea, vomiting, fatigue, paresthesias [aafp.org]

• Painful Erection

  Peyronie’s disease—A disease that causes scar tissue to develop inside the penis, leading to curved, painful erections. What STDs Cause Bumps on the Penis? Finding a bump on your penis may not always mean that you have an STD, but sometimes it can. [stdcheck.com]

  Presenting symptoms are pruritus, burning, painful erections, difficulty in retracting the foreskin, dysuria, and a poor urinary stream. [onlinelibrary.wiley.com]

• Penile Lesion

  A micrograph picture of the herpes simplex virus, within tissue taken from a penile lesion of a patient with genital herpes. Credit: CDC Additional pictures of herpes are available from the CDC’s image library. [livescience.com]

  Elsewhere on the skin the lesions may be few or many, but it is very rare not to have penile lesions in scabies ( Fig. 4 ). The chief clinical symptom is pruritus, that is usually worse at night or after hot baths. [onlinelibrary.wiley.com]

Once the maternal disease classification is determined (eg, first episode primary/nonprimary, recurrent), further management options include further diagnostic workup and/or neonatal empiric IV acyclovir or IV acyclovir for treatment of surface, CNS, [emedicine.medscape.com]

• Herpes Simplex Virus Type 2

  Herpes Simplex Virus Type 2 (HSV-2) caused this lesion at the base of a man’s penis. Medically, the lesion is called primary vesiculopapular herpes genitalis. [livescience.com]

  There are two types of Herpes Simplex Virus: Herpes Simplex Virus Type 1 is the most common form of herpes that affects most people at least once during childhood. It is passed from person-to-person through contact with saliva. [amatoskincare.com]

  Seite 35 - In these cases, genital herpes can be caused by either herpes simplex virus type 1 or type 2. ‎ [books.google.de]

  Type-specific antibodies to herpes simplex virus type 2 (HSV-2) glycoprotein G in pregnant women, infants exposed to maternal HSV-2 infection at delivery, and infants with neonatal herpes. J Infect Dis. 1988; 157 :164–171. [ PubMed ] 78. [ncbi.nlm.nih.gov]

• Human Herpesvirus 6

  Terminology Herpesviridae family has at least 8 viruses known to infect man: HSV1, HSV2, Epstein-Barr virus (EBV), cytomegalovirus (CMV), varicella zoster virus (VZV), Human herpesvirus 6 (exanthum subitum or roseola infantum), Human herpesvirus 7 and [pathologyoutlines.com]

Treatment There is no cure for HIV or AIDS. Anti-retroviral treatment can slow the progression of HIV disease & delay the onset of AIDS. Early diagnosis & treatment can improve an infected person’s chances of living a longer, healthier life. [shs.wustl.edu]

Even if the bump doesn’t clear up after treatment, it’s still best to identify and treat STDs as quickly as possible to prevent serious health problems. Treatment for Penis Bumps The proper treatment for penis bumps depends on what is causing it. [stdcheck.com]

Ease of administration and cost also are important considerations for prolonged treatment. [cdc.gov]

Learn more about the treatment of HPV. 5. [tuasaude.com]

Antiviral treatment very early in the course of the disease may decrease the length of recurrences. [britannica.com]

Links: clinical features diagnosis management complications prognosis genital herpes simplex and pregnancy [gpnotebook.co.uk]

Prognosis Most patients experience one episode only, i.e. without any recurrences. Emotional and physical stresses are likely to perpetuate recurrences. [iusti.org]

The presence of concomitant bacterial pathogens leads to an increase in hospital admissions and mortality with a worse prognosis in all cases. 11 An association between infection with influenza and bacterial infection was established during the first [archbronconeumol.org]

The prognosis of genital herpes is variable: there is no cure, and the recurrent outbreaks may vary in frequency and severity. Genital herpes prevention is difficult. [medicinenet.com]

Outlook / Prognosis What is the outlook for people with genital ulcer disease? If you receive the appropriate therapy, genital ulcer treatment is often successful. It may take a few days for you to feel better. Most people make a full recovery. [my.clevelandclinic.org]

Etiology and Pathophysiology HSV is a double-stranded DNA virus of the Herpetoviridae family ( 1 ). Spread via genital-to-genital contact, oral-to-genital contact, and via maternal–fetal transmission ( 2 ) Incubation is 4 to 7 days after exposure. [unboundmedicine.com]

[…] and Human herpesvirus 8 (Kaposi sarcoma associated herpesvirus) Epidemiology Sexually transmitted; spreads by direct contact with lesions Also spreads by asymptomatic shedding when no lesion is apparent Sites Genital region, mouth; also other areas Etiology [pathologyoutlines.com]

A non-STD etiology can be considered, although given this man’s sexual history, STDs should first be excluded. Q: Does the current epidemiology of herpes, syphilis, and chancroid influence your presumptive diagnosis? Yes. [clinicaladvisor.com]

Treatment with a broad spectrum antibiotic is usually used until viral etiology is proven and concerning the use of corticosteroids. [remedypublications.com]

Serology is of more value for epidemiological surveys than for individual clinical diagnosis. Histopathology Ballooning degeneration of keratinocytes and intercellular oedema lead to deep intra-epidermal vesiculation. [iusti.org]

American Journal of Epidemiology 1987;125:1048-1057. Raiteri R, Fora R, Sinicco A. No HIV-1 transmission through lesbian sex. Lancet 1994;344:270. Darrow WW, Echenberg DF, Jaffe HW et al. [cdc.gov]

Herpes Simplex Virus Infection in a University Health Population: Clinical Manifestations, Epidemiology, and Implications. J Am Coll Health, 59, 69. [dermatology.about.com]

Sipetic III I MD, PhD; Head of Department of Venereal Diseases, City Institute for Skin and Venereal Diseases, Belgrade, Serbia II MD, Practicing Dermatologist, City Institute for Skin and Venereal Diseases, Belgrade, Serbia III MD, PhD; Institute of Epidemiology [scielo.br]

Reactivation: recurrent episodes Synonym(s): herpes genitalis Epidemiology Most commonly infected from age 15 to 30 years; prevalence increases with age due to cumulative likelihood of exposure. [unboundmedicine.com]

Etiology and Pathophysiology HSV is a double-stranded DNA virus of the Herpetoviridae family ( 1 ). Spread via genital-to-genital contact, oral-to-genital contact, and via maternal–fetal transmission ( 2 ) Incubation is 4 to 7 days after exposure. [unboundmedicine.com]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Herpes simplex virus (HSV) types 1 and 2 are members of the Herpesviridae family, and produce infections that may range from [mayocliniclabs.com]

HSV infection is mediated through attachment via ubiquitous receptors to cells, including sensory neurons, leading to establishment of latency. [1] Pathophysiology HSV-1 and HSV-2 are characterized by the following unique biological properties: [1] Neurovirulence [emedicine.medscape.com]

22% ≥ 10 partners: 19% to 37% Oral-genital contact Increases risk of transmitting HSV-1 from latent or active infection at oral site to genital site of uninfected partner Presence of other sexually transmitted diseases Increases OR of shedding to 3.1 Pathophysiology [aafp.org]

Can a condom prevent genital herpes from being passed on? Yes, a condom can prevent you from passing genital herpes onto your sexual partner but it must cover the infected area. [zavamed.com]

There are currently no vaccines to prevent a person from contracting a genital herpes virus. [medicalnewstoday.com]

Seeking to prevent and treat it effectively has been a priority for several decades. Determining which approach to a preventive vaccine is an ongoing process in many countries. [allhealthsite.com]

Use a condom correctly and consistently to help prevent spread of the disease. Only latex condoms prevent infection. Animal membrane (sheepskin) condoms do not work because the virus can pass through them. [ufhealth.org]