AB - We are presenting the morphological features of 121 cases of atypical penile intraepithelial lesions. [jhu.pure.elsevier.com]

[…] in the middle and lower third of the epithelium If penile carcinoma is present, is usually warty, basaloid or warty basaloid variant Microscopic (histologic) images Images hosted on PathOut server: Contributed by Alcides Chaux, M.D. and Antonio Cubilla [pathologyoutlines.com]

Aims We describe the clinical presentation, diagnostic process and management of PIN cases presenting to the sexual health clinic. Results Five cases were identified from August 2010 to March 2011. [sti.bmj.com]

OBJECTIVES To describe the presentation and treatment of patients with PIN. METHODS Thirty-five patients presenting with PIN over a 7-year period are described. [wwww.unboundmedicine.com]

List of publications » Penile intraepithelial neoplasia: histopathological evaluation, HPV typing, clinical presentation and treatment A1 Journal article – refereed Penile intraepithelial neoplasia: histopathological evaluation, HPV typing, clinical presentation [research.utu.fi]

• Papule

  Condylomata acuminata, papules, and macules were observed in 309 of the 480 men (64.4 percent). In 204 of them (42.5 percent), macules or slightly elevated papules were detected only after application of acetic acid. [cirp.org]

  Characteristic findings on physical examination Presents as well circumscribed, solitary or multiple, small, pigmented papules with a flat-to-verrucous surface ( Figure 1 ). Papules may coalesce into larger plaques. [dermatologyadvisor.com]

  Methods: Ninety-two patients who presented with lesions suggesting intraepithelial neoplasia (pigmented or leukoplastic papules, keratinized condylomata, or erythroplastic macules) underwent biopsy, for histologic and virologic studies. [eurekamag.com]

  The morphological features of PeIN can be classified as flat lesions, leukoplakic lesions, pigmented papules, or a mixture of the three 9. The noninvasive nature of PeIN allows for curative penile-preserving therapy. [journals.lww.com]

• Erythema

  These changes were observed on a background of erythema (Fig 1). Fig 1. Penile intraepithelial neoplasia. Clinical photo demonstrating erosion, irregular hyperpigmentation, and erythema on the dorsal prepuce. [docksci.com]

  […] associated with invasive carcinoma is more prevalent in regions with a high incidence of penile cancer Common in HIV+ men with anal dysplasia ( J Invest Dermatol 2008;128:2316 ) Clinical features Whitish areas in glans, coronal sulcus or inner foreskin Erythema [pathologyoutlines.com]

  Mild burning sensation and erythema at the site of application were the only adverse effects observed in this case series, with rapid clinical clearing of disease. [dermatologyadvisor.com]

  Take Quiz Sunburn and solar erythema Take Quiz Rare types of melanoma Take Quiz Prevention and detection of melanoma on the back Take Quiz CDC report: Melanoma incidence Take Quiz Incidence of BCC Take Quiz Health concerns associated with sunscreen use [mdedge.com]

• Skin Lesion

  Topical imiquimod: a review of its use in the management of anogenital warts, actinic keratoses, basal cell carcinoma and other skin lesions. Drugs 2007;67(15):2187-210. 8. Berth-Jones J. Topical treatment. [content.sciendo.com]

  lesions & tick bites Take Quiz Cutaneous reactions to spider, mosquito and fire ant bites Take Quiz Animal & human bites Take Quiz Rash associated with Lyme disease Take Quiz Lesion configuration & Lyme disease Take Quiz Primary lesions & human scabies [mdedge.com]

• Flushing

  […] photochemotherapy for psoriasis Take Quiz Guidelines: Inside AD Take Quiz Guidelines for the topical treatment of AD: Part 2 Take Quiz Guidelines for the topical treatment of AD: Part 1 Take Quiz Quiz Allergic contact dermatitis: Sensitivity testing Take Quiz Flushing [mdedge.com]

• Confusion

  It may be abbreviated PIN ; [1] however, this can cause confusion with the prostatic intraepithelial neoplasia (the presursor of prostate carcinoma ). General Not very common overall. Typically seen adjacent to squamous cell carcinoma of the penis. [librepathology.org]

  Pre-cancerous lesions The names or terms used to describe pre-cancerous lesions can be confusing. The correct medical term is PeIN3 (Penile Intraepithelial Neoplasia 3) but there may be other names for these conditions that the medical team may use. [orchid-cancer.org.uk]

  Variations in basaloid carcinomas were also noted in head and neck tumors, although at these sites, other anatomical considerations (presence of salivary glands) may add to the confusion [ 4 ]. [appliedcr.biomedcentral.com]

• Penile Lesion

  This review focuses on premalignant penile lesions and the associations of these lesions with the development of invasive penile cancer. Read this article (multiple options) Comments Related Papers [readbyqxmd.com]

  Exposing the penile surface to ultraviolet rays causes penile tumors. Signs and symptoms HPV penile lesions occur in the form of lobules with an irregular surface that appears on the perineum and perianal areas. [news-medical.net]

  Histologically: all biopsies had evidence of HPV infection, 4/5 had PIN3 and 1 had PIN1. 2/5 also had anal intraepithelial neoplasia; 1 presented to the surgeons with an anal lesion, but his penile lesion was missed. [sti.bmj.com]

  A 32-year-old heterosexual man with acquired immunodeficiency syndrome (AIDS) who had penile lesions of KS with overlying epithelial changes characteristic of intraepithelial neoplasia associated with concurrent infection by human papillomavirus (HPV) [ncbi.nlm.nih.gov]

• Genital Lesions

  This increased incidence of genital lesions requires a review of the clinicopathological classification of penile intraepithelial neoplasia (PIN) to help the clinician differentiate the aetiology in order to propose the least mutilating treatment. [ncbi.nlm.nih.gov]

  HPV type16 predominates and in one study represented 79% of all high-risk human papillomavirus infections. [4] In a biopsy cohort of 2754 men with external genital lesions, condyloma primarily contained HPV 6 or 11; penile intraepithelial neoplasia lesions [emedicine.medscape.com]

  Only 3 of the 25 men (12%) were aware of any genital lesions, but peniscopy after acetic acid washes revealed clinical lesions suggestive of HPV lesions in 20 men (80%). [jaoa.org]

The total recurrence rate in our cohort was 13.8%, but if the treatment was divided into surgical and topical treatment, the recurrence rates would be 57% for topical treatment and 3.4% for surgical excision. [journals.lww.com]

Exact prognosis of PEIN unknown as most studies were retrospective. advertisement advertisement [auanet.org]

In addition to the extent of tumor invasion and lymph node status, histologic type plays a role in prognosis. Worse prognosis is associated with basaloid and sarcomatoid subtypes. [emedicine.medscape.com]

Encyclopedia) Hyperthermia for treating cancer (Medical Encyclopedia) Laser therapy for cancer (Medical Encyclopedia) Photodynamic therapy for cancer (Medical Encyclopedia) Targeted therapies for cancer (Medical Encyclopedia) Understanding your cancer prognosis [icdlist.com]

In this study we are also demonstrating this cell to be an indicator of adverse prognosis as compared with the maturing keratining typical squamous cell. [appliedcr.biomedcentral.com]

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Giuliano DOI: 10.1158/1538-7445.AM2013-4848 Published April 2013 Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Abstract The human papillomavirus (HPV) is an established etiologic agent in 50% of penile cancers. [cancerres.aacrjournals.org]

Karger AG, Basel References Dillner J, von Krogh G, Horenblas S, Meijer CJ: Etiology of squamous cell carcinoma of the penis. [karger.com]

The theory that penile and cervical cancer may have a common etiology was proposed as early as 35 years ago. [jaoa.org]

The lesion is an intraepithelial or in situ neoplasm; the associated risk for progression to invasive carcinoma has been documented as up to 33%. [7] The specific etiologic factors remain unclear. [emedicine.medscape.com]

These conditions are distinct clinical entities and have different epidemiological and aetiological associations and prognostic implications. OBJECTIVES To describe the presentation and treatment of patients with PIN. [wwww.unboundmedicine.com]

Epidemiology, Hui-Yi Lin, William Fulp, Martha Abrahamsen, Beibei Lu, Luisa L. Villa, Eduardo Lazcano-Ponce and Anna R. [cancerres.aacrjournals.org]

These conditions are distinct clinical entities and have different epidemiological and aetiological associations and prognostic implications. Objectives To describe the presentation and treatment of patients with PIN. [bjdonline.com]

Take Quiz Treatment of actinic keratosis Take Quiz Actinic keratosis: Epidemiology & etiology Take Quiz Quiz Recognizing seborrheic keratosis Take Quiz Seborrheic keratosis: Systemic implications & complications Take Quiz Quiz JAAD Guidelines: Acne fulminans [mdedge.com]

[…] and is usually due to HPV 16 ( Int J Exp Pathol 2009;90:182 ) Bowen disease: clinical designation of carcinoma in situ located in the shaft Erythroplasia of Queyrat: clinical designation of carcinoma in situ located in the glans, usually erythematous Epidemiology [pathologyoutlines.com]

Pathophysiology Bowen disease is a clinical presentation of in situ squamous cell carcinoma that involves the shaft of the penis. [emedicine.medscape.com]

Disease burden & QOL in psoriasis patients Take Quiz Psoriasis & risk of depression Take Quiz Understanding patient-reported experiences of living with psoriasis Take Quiz Psoriasis treatment: Part 2 Take Quiz Systemic therapies for psoriasis Take Quiz Pathophysiology [mdedge.com]

This acknowledges the role of HPV in the pathophysiology of these lesions ( 7 ). [tau.amegroups.com]

[…] abrasions and areas of inflammation tend to react by turning white. 19, 20 One investigation comparing specimens obtained by clinicians with those collected by the patients themselves found a greater yield of usable cells in self-collected specimens. 21 Pathophysiology [jaoa.org]

Early detection and treatment of premalignant penile lesions may prevent malignant progression while avoiding penile amputation. [readbyqxmd.com]

Most importantly, the detection and treatment of these lesions participate in the prevention of cervical cancer. [ncbi.nlm.nih.gov]

Heidelberg, Springer, 2011; Minhas S, Manseck A, Watya S, Hegarty PK: Penile cancer - Prevention and premalignant conditions. Urology 2010;76:S24-S35 von Krogh G, Horenblas S: The management and prevention of premalignant penile lesions. [karger.com]

Take Quiz Sunburn and solar erythema Take Quiz Rare types of melanoma Take Quiz Prevention and detection of melanoma on the back Take Quiz CDC report: Melanoma incidence Take Quiz Incidence of BCC Take Quiz Health concerns associated with sunscreen use [mdedge.com]

[…] with HPV exposure to arsenic – this is a risk factor only for Bowen’s disease not being circumcised Although there is some evidence that circumcision reduces the risk of penile cancer, there is not enough evidence to recommend circumcision as a way of preventing [cancer.ca]