Presentation
Extramammary presentation of Paget's disease is characterized by the presence of epithelial cells associated with intraepithelial adenocarcinoma. [scielo.br]
Entire Body System
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Asymptomatic
Pruritus (70%), burning, suppuration, and bleeding are common symptoms, but in about 10% of cases the disease is asymptomatic.1 Chronic skin disorders and refractory fungal infections are the main differential diagnoses, and biopsy thus becomes essential [scielo.br]
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Hodgkin Lymphoma
She had a history of prior non-Hodgkin's lymphoma in remission (chemotherapy ended in 2012). [scielo.br]
Skin
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Skin Atrophy
Typical side effects of perianal radiotherapy include acute dermatitis, moist desquamation, and skin atrophy.3 Case report A 79-year-old woman presented with a 1-year history of an anal lesion that became pruritic. [scielo.br]
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Eruptions
We report a case of extramammary Paget's disease in the perianal region that initially presented as an irregular, circumferential, scaling lesion with eczematous eruptions. Immunology and immunohistochemistry confirmed the diagnosis. [scielo.br]
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Dermatitis
Typical side effects of perianal radiotherapy include acute dermatitis, moist desquamation, and skin atrophy.3 Case report A 79-year-old woman presented with a 1-year history of an anal lesion that became pruritic. [scielo.br]
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Eczema
The immunohistochemical profile shows positive staining for low molecular weight cytokeratins, contributing to differentiate it from other skin tumors.3 The differential diagnosis includes benign conditions, such as eczema and contact dermatitis, and [scielo.br]
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Pruritus
Pruritus (70%), burning, suppuration, and bleeding are common symptoms, but in about 10% of cases the disease is asymptomatic.1 Chronic skin disorders and refractory fungal infections are the main differential diagnoses, and biopsy thus becomes essential [scielo.br]
Psychiatrical
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Suggestibility
The cells stained positive for CK7 and BRST-2, suggesting an adnexal gland origin from the pilosebaceous infundibulum. [scielo.br]
Treatment
Fig. 1 Lesion before treatment: irregular, circumferential, scaling, pale-pink anal lesion of 3 cm long with eczematous eruptions. Fig. 2 Outcome after treatment with pelvic radiotherapy associated with radiosensitizing chemotherapy. [scielo.br]
Prognosis
The prognosis is favorable, with depth of invasion as the most important prognostic indicator.5 Histologically, primary Paget's disease is characterized by large vacuolated cells containing mucin, the so-called Paget cells.6 They may also contain cytokeratin [scielo.br]
Epidemiology
Discussion Clinical cases of EMPD are unusual, which explains the lack of accurate epidemiological data on this disease and the importance of this report.5 The disease has a predilection for postmenopausal white women, and clinical signs include eczematous [scielo.br]