Presentation
An eight-year-old Ethiopian male child, resident in Khartoum, Sudan presented with tender progressing fluctuant nodules and alopecia on his scalp for nine months. The lesions often oozed a serosanguinous discharge and occasionally bled. [khartoumspace.uofk.edu]
This condition often presents in males of African American origin. This article describes the clinical presentation, diagnosis, and treatment of an Aboriginal Canadian male suffering from PCAS. [ncbi.nlm.nih.gov]
A healthy 19-year-old male presented with a solitary, soft, alopecic nodule that had appeared 1 year before. [ijtrichology.com]
At present, this condition is defined as a primary disorder of follicular keratinization, being part of the triad or tetrad of follicular occlusion. One third of the cases are associated with acne conglobata as a primary event. [colombiamedica.univalle.edu.co]
Entire Body System
- Fever
Systemic symptoms also occur and include osteolytic bone lesions of the clavicle and sternum, fever, arthralgias, myalgias, and hepatosplenomegaly. Diagnosis is clinical. [accessemergencymedicine.mhmedical.com]
Here is the patient's anamnesis: July '06 Mono like illness-- severe fatigue, prolonged diarrhea (lost 30 pounds), upper abdominal pain, swollen neck lymph nodes, fever, folliculitis breakouts on face and back. [vgrd.org]
Psychogenic excoriation 651 205 Pyoderma gangrenosum 654 206 Pyogenic granuloma 659 207 Radiation dermatitis 662 208 Raynaud disease and phenomenon 665 209 Reactive arthritis 669 210 Relapsing polychondritis 673 211 Rhinophyma 677 212 Rocky Mountain spotted fever [books.google.com]
Less commonly, tender lymph nodes and/or fever may occur. The condition is usually diagnosed by a dermatologist after examination of your scalp, but in some cases, a biopsy under local anesthesia may be required for confirmation. [skinofcolorsociety.org]
- Surgical Procedure
Using a combination of written text, color photographs, and tables, eleven leading physicians and practitioners in the field discuss the latest surgical procedures to restore a natural-looking frame of hair to the face. [books.google.ro]
Severe cases can involve specific surgical procedures. Treatment aims to prevent relapses. But often it is unsuccessful. New treatments make use of specific types of inhibitors. These include TNF-a inhibitors which have shown potential. [ecellulitis.com]
Surgical [ edit ] Surgical excision of a sebaceous cyst is a simple procedure to completely remove the sac and its contents. [8] A sebaceous cyst that has been surgically removed. [en.wikipedia.org]
- Amyloidosis
Chronic course over years to decades, possible development of secondary amyloidosis; no recurrence after radical surgical excision. Literature This section has been translated automatically. [altmeyers.org]
Rarely squamous cell carcinoma or secondary amyloidosis can develop in chronic inflammatory skin lesions. PCAS is also associated with acne inversa (3–6). [medicaljournals.se]
- Recurrent Infection
Two similar cases of malignant proliferating cysts of the scalp with perifolliculitis in KID syndrome (sensorineural hearing loss, photophobia, palmoplantar keratoderma, and recurrent infection). [dermatologyadvisor.com]
The rst step in treatment should be toe pustules and obtain a sensitivity report.s with a history of recurrent infections;Figureimmunresponcloxacnationto broHowevdisconFigurescarrintules.Scarring Alopecia 383Table 3 Treatment of Neutrophilic and Mixed [vdocuments.site]
- Malaise
Regional lymphadenopathy, fever and malaise may be associated features. [docksci.com]
Skin
- Alopecia
It is an inflammatory condition of the scalp that can lead to scarring alopecia, which begins with deep inflammatory nodules, primarily over occiput, that progresses to coalescing regions of boggy scalp. [khartoumspace.uofk.edu]
[…] dissecting folliculitis of the scalp, perifolliculitis capitis abscedens et suffodiens of Hoffman, perifolliculitis abscedens et suffodiens, or folliculitis abscedens et suffodiens, is an inflammatory condition of the scalp that can lead to scarring alopecia [wikiwand.com]
Scarring alopecia or cicatricial alopecia results from follicular damage that is sufficient to cause the destruction and replacement of pilosebaceous structures by scar tissue. [pubfacts.com]
The subsequent scarring alopecia results in permanent, patchy hair loss. [dermnetnz.org]
Perifolliculitis capitis abscedens et suffodiens (also known as "Perifolliculitis capitis abscedens et suffodiens of Hoffman," "Dissecting folliculitis," and "Dissecting cellulitis of the scalp") is an inflammatory condition of the scalp that can lead to scarring alopecia [wiki30.com]
- Dermatitis
[…] purl.bioontology.org/ontology/MESH/D012536 http://purl.bioontology.org/ontology/MESH/D012873 MDA 20121105 MeSH Frequency 31 MMR 20160929 notation C562486 prefLabel Perifolliculitis Capitis Abscedens Et Suffodiens, Familial SC 3 Scope Statement A chronic DERMATITIS [purl.bioontology.org]
Page 516 - Werner Y, Lindberg M: Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm Venereol (Stockh) 1985;65:102-105. [books.google.com]
Existen tratamientos naturales para el picor del cuero cabelludo muy poda ser sntoma de afecciones de la piel como la dermatitis la psoriasis y los la sequedad extrema del cuero cabelludo y la dermatitis seborreica. [activethroughpassive.eu]
Perifolliculitis capitis abscedens et suffodiens, also referred to as dissecting cellulitis (DC), is a chronic relapsing suppurative dermatitis of the scalp,1 characterized by relapsing folliculitis and painful fluctuant abscesses of the scalp.2 DC is [dermatologyadvisor.com]
Diagnosis Granulomatous dermatitis with mixed inflammatory infiltrate. [ncbi.nlm.nih.gov]
- Papule
[…] scarring alopecia without nodules, sinuses, and abscesses Kerion — an acute abscess due to dermatophyte infection Bacterial folliculitis — acute or chronic follicular papules and pustules. [dermnetnz.org]
Lesions begin as follicular papules; evolve into firm, keloidal nodules; and typically are located on the neck and occipital scalp. [aafp.org]
Inflamed papules and pustules are present on the centrofacial region and can coalesce into large plaques. Diagnosis is clinical. Severe scarring can occur without treatment. [accessemergencymedicine.mhmedical.com]
detail of the facial papules. [docksci.com]
- Hypertrichosis
Cicatricial alopecia, unspecified L67 Hair color and hair shaft abnormalities L67.0 Trichorrhexis nodosa L67.1 Variations in hair color L67.8 Other hair color and hair shaft abnormalities L67.9 Hair color and hair shaft abnormality, unspecified L68 Hypertrichosis [icd10data.com]
Its side effects include redness and scaling of the scalp; rarely, contact dermatitis; and hypertrichosis in women—mostly at the temples. [aerzteblatt.de]
- Chronic Abscess
With continued disease, chronic abscesses become lined with squamous epithelium forming sinus tracts. [37] Differential Diagnosis Other diagnoses that should be considered when suspecting DCS include tinea capitis, [128,129] hidradentis suppurativa, folliculitis [medscape.com]
With time, the chronic abscesses become lined with squamous or scaly epithelium, and true sinus tracts – a characteristic of dissecting cellulitis form. End stage disease is characterized by complete destruction of the follicles. [keratin.com]
Psychiatrical
- Suggestibility
This suggested that topical ALA-PDT could be an effective and safe alternative for DCS patients who were refractory to other conventional therapies. [pubfacts.com]
You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license [commons.wikimedia.org]
The fluid collection was connected to the base of widened hair follicles and presented inner echoes suggestive of debris as well as several hyperechoic linear structures compatible with fragments of hair tracts [Figure 2]. [ijtrichology.com]
[…] carcinoma in patients with long-standing disease.4 The prevalence of DCS is unknown as it is recognized as a rare disease by the National Institute of Health, however research and data on HS indicates a prevalence of 0.3 to 4%, and practice patterns suggest [jddonline.com]
The literature suggests that now most cases of DC can be treated effectively. However, the lack of clinical studies regarding DC prevents full understanding of the disease and limits the ability to define a consensus treatment algorithm. [ncbi.nlm.nih.gov]
Neurologic
- Irritability
Perifolliculitis capitis abscedens et suffodiens can be confused with other inflammatory conditions of the scalp including: Folliculitis keloidalis nuchae — firm irritable papules on the nape of the neck Folliculitis decalvans — follicular pustules and [dermnetnz.org]
Use the safest and most effective drugs possible with new chapters on irritants and allergens in topical therapeutic agents, plus a new, separate chapter on mycophenolate mofetil. [books.google.it]
Unknown; tufted hairs with a wide acroinfundibulum susceptible to infections and irritation of the epidermis seem to be favourable. Manifestation This section has been translated automatically. [altmeyers.org]
While I tell patients they can still get their hair cut, I emphasize that caution should be taken to reduce the amount of trauma and irritation to the scalp. [socahcenter.com]
This was supposed to stop the inflammation processes in my scalp, but it has only irritated my scalp and new swelling nodules started emerging around that original bump. [tuftedfolliculitis.com]
Workup
Serum
- Neutrophilia
The hemogram revealed leukocytosis with neutrophilia, C-reactive protein elevated 100 times the reference value, the rheumatoid factor, VDRL and HIV were negative. [go.gale.com]
Treatment
Isotretinoin proves to be the medicine of choice for the treatment of the disease. [1] [2] : 649 [3] : 761 [4] This page is based on a Wikipedia article written by contributors ( read / edit ). [wikiwand.com]
The treatment of the disease is usually difficult and often disappointing. Successful treatment with isotretinoin 1 mg/kg body mass could be achieved only after regular systematic administration in the course of 3–4 months. [scienceopen.com]
The treatment of the disease is usually difficult and often disappointing. Successful treatment with isotretinoin 1 mg/kg body mass could be achieved only after regular systematic administration in the course of 3-4 months. [doaj.org]
The treatment is usually difficult and often disappointing. In the case presented in the current work, the remission was achieved with nine-month isotretinoin treatment. [pubfacts.com]
What is the treatment for perifolliculitis capitis abscedens et suffodiens? Treatment of perifolliculitis capitis abscedens et suffodiens often requires a multi-pronged approach, especially initially and during acute flares. [dermnetnz.org]
Prognosis
In 2 patients, keratosis-ichthyosis-deafness (KID) syndrome has been reported to be associated with the follicular occlusion tetrad. [7, 8] Prognosis The prognosis for complete recovery from PCAS is poor. [thehealthscience.com]
The treatment measures may include the use of topical applications, oral medications, antibiotics, and cosmetic procedures, if necessary The prognosis of Dissecting Cellulitis of Scalp depends upon several factors including on the severity of the signs [dovemed.com]
The prognosis for complete recovery from PCAS is poor. [emedicine.medscape.com]
Etiology
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
[…] with a combination therapy: Systemic antibiosis (Metronidazole Plus Clindamycin), dermatosurgical approach, and high-dose isotretinoin Abstract Read online Folliculitis et perifolliculitis capitis abscedens et suffodiens is a rare disease of unknown etiology [doaj.org]
Etiologic factors are unknown. Diagnosis is proven histologically. Management is very difficult and consists in systemic administration or intralesional injection of several drugs or in surgical manipulations. [ncbi.nlm.nih.gov]
(See Etiology and Pathophysiology, Treatment, and Medication.) [1, 2] PCAS is an uncommon disease. [thehealthscience.com]
The purpose of this paper is to report 6 cases observed by the authors at Letterman General Hospital and to add to the available information on the etiology, pathology, and treatment of this disease. [jamanetwork.com]
Epidemiology
From Etiology idiopathic Epidemiology occurs predominantly in black males in their second to fourth decade of life occurs less commonly in women & persons of different race Pathology dissecting cellulitis of the scalp Clinical-manifestations perifollicular [anvita.info]
A 17-year epidemiological study. ( 26774593 ) Lova-Navarro M....Crespo-Erchiga V. 2016 38 Tinea capitis outbreak among paediatric refugee population, an evolving healthcare challenge. ( 27061446 ) Mashiah J....Harel A. 2016 39 Factors in Etiology and [malacards.org]
You might also be interested in Dermatology Occurrence/Epidemiology This section has been translated automatically. Especially common among members of the black population/person of color. [altmeyers.org]
We discuss the diseases T related to the hair that may cause a red face and will present an update on their RI P epidemiology, clinics, pathogenesis, and therapy. [docksci.com]
Pathophysiology
Case Overview dissecting folliculitis Member Rated 0 Patient case no. 10926 Date added 02 February 2011 Patient details Age Adult Location Brazil Localisation Head / scalp Primary Lesions Cystic nodule Pathophysiology inflammatory skin appendage disorders [dermquest.com]
(See Etiology and Pathophysiology, Treatment, and Medication.) [1, 2] PCAS is an uncommon disease. [thehealthscience.com]
[…] improvement prior to starting isotretinoin.10 Combination oral rifampicin 300 mg and clindamycin 300 mg, both twice daily, increases overall efficacy in HS and reduces the risk of antibiotic resistance, and again while not studied in DCS the similar pathophysiology [jddonline.com]
Pathophysiology of these disorders is similar. Sebum secretion is increased within the sebaceous follicle by androgen stimulation. Keratin accumulates in the hair follicle as well as sebum. [accessemergencymedicine.mhmedical.com]
Indian Dermatol Online J 2014;5:491-3 Follicular occlusion tetrad is a complex consisting of four conditions having a similar pathophysiology. [idoj.in]
Prevention
Additionally, treatment involves preventing complications from occurring. One common form of treatment for dissecting cellulitis of the scalp is a course of antibiotics, which prevents further infections. [ecellulitis.com]
[…] of Perifolliculitis capitis abscedens Yes, it may be possible to prevent Perifolliculitis capitis abscedens. [tabletwise.net]
[…] minus' sign Virchow -triad Use Parentheses water AND (cup OR glass) Add an asterisk (*) at end of a word to include word stems Neuro* will search for Neurology, Neuroscientist, Neurological, and so on Use quotes to search for an exact phrase "primary prevention [readbyqxmd.com]
An understanding of response to damaging agents is central to the problems of preventing or forestalling the early effects of aging in skin (a goal that is responsible for the current expansion in dermatological research). [books.google.com]
[…] several factors including on the severity of the signs and symptoms Please find comprehensive information on Dissecting Cellulitis of Scalp regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention [dovemed.com]