I report a case of a 33-year-old Caucasian man who presented with sudden onset paralysis, following previous similar presentations without investigation. Blood tests revealed undetectable serum potassium levels in the context of paralysis. [ncbi.nlm.nih.gov]

The patient was admitted to the intensive care unit where further workup revealed thyrotoxicosis and the patient was subsequently diagnosed with TPP. [ncbi.nlm.nih.gov]

An association with thyroid disease is well established and further workup revealed Grave's disease in this patient. [casesjournal.biomedcentral.com]

Treatment includes the supplementation of potassium, a nonselective beta-blocker, and ultimately treatment of the underlying hyperthyroidism. [ncbi.nlm.nih.gov]

OBJECTIVE: This review emphasizes the etiology, pathogenesis, management and prognosis of TPP and aims to highlight clinical awareness of early diagnosis and rapid initiation of treatment. [ncbi.nlm.nih.gov]

Severe prognosis in a large family with hypokalemic periodic paralysis. Muscle Nerve. 2003;27:165–9. Mutation analysis of two patients with hypokalemic periodic paralysis and suspected malignant hyperthermia. Muscle Nerve. 2004;30:114–7. [revistas.fucsalud.edu.co]

Antenatal diagnosis Prenatal diagnosis is theoretically possible if the disease-causing mutation in the family has been identified but is rarely performed because of the non life-threatening prognosis. [orpha.net]

Prognosis [ edit ] The prognosis for periodic paralysis varies. [en.wikipedia.org]

The etiology of these abnormalities and the patient's symptoms was found to be undiagnosed and uncontrolled hyperthyroidism from Grave's disease, which resulted in this dramatic presentation of thyrotoxic hypokalemic paralysis. [ncbi.nlm.nih.gov]

Home, Search, Index, Links, Pathology, Molecules, Syndromes, Muscle, NMJ, Nerve, Spinal, Ataxia, Antibody & Biopsy, Patient Info EPISODIC MUSCLE WEAKNESS Hypokalemic Periodic Paralysis Hypokalemic periodic paralysis, Hereditary: General features Epidemiology [neuromuscular.wustl.edu]

Summary Epidemiology Prevalence is estimated at around 1 in 100,000. Clinical description The paralysis most often affects the four limbs, thus resulting in tetraplegia. [orpha.net]

Epidemiology There are primary and secondary forms. The primary form is genetic and follows an autosomal dominant pattern of inheritance. [unboundmedicine.com]

Epidemiology Hypokalaemic periodic paralysis (HOKPP) has a prevalence of 1 case per 100,000 population. [patient.info]

Here we report three cases of TPP in the Netherlands, and review the literature on clinical features, pathophysiological hypothesis and treatment. [ncbi.nlm.nih.gov]

Overview This article on periodic paralysis and related disorders introduces readers to the clinical presentations, basic concepts, and current understanding of the pathophysiology of these rare disorders or channelopathies. [medlink.com]

Rüdel R (1986) The pathophysiological basis of the myotonias and the periodic paralyses. In: Engel AG, Banker BQ (eds) Myology, 1st edn. Mc-Graw-Hill, New York, pp 1297–1311 Google Scholar 12. [link.springer.com]

Prevention There is no way to prevent the occurrence of either disease in a person with the gene for the disease. [encyclopedia.com]

Taking potassium supplements may help prevent muscle weakness. Eating a low-carbohydrate diet may help decrease symptoms. A medicine called acetazolamide may be prescribed to prevent attacks. [nlm.nih.gov]

As we see, acetazolamide prevents attacks in many cases. [flipper.diff.org]

Treat episodes by correcting serum potassium and prevent episodes by recommending lifestyle changes. Click here for Patient Education [msdmanuals.com]

Episodes can be prevented by achieving a euthyroid state. This report describes a young gentleman presenting with thyrotoxic hypokalemic paraparesis. [ncbi.nlm.nih.gov]