I report a case of a 33-year-old Caucasian man who presented with sudden onset paralysis, following previous similar presentations without investigation. Blood tests revealed undetectable serum potassium levels in the context of paralysis. [ncbi.nlm.nih.gov]

• Noncompliance

  In this case, a 43-year-old African American woman with thyrotoxic periodic paralysis had recurrent lower extremity myopathy and acute respiratory failure precipitated by noncompliance with treatment for Graves disease. [ncbi.nlm.nih.gov]

• Xerostomia

  The patient, who had no xerostomia and xerophthalmia, was diagnosed with primary SS from serologic and histologic findings of minor salivary gland biopsy. The patient recovered after potassium replacement therapy. [ncbi.nlm.nih.gov]

• Chvostek Sign

  Chvostek's sign and Trousseau's sign were positive. Neurologically, she was fully oriented. She had Grade 3 power in all the four limbs with intact sensation. [ncbi.nlm.nih.gov]

• Trousseau Sign

  Chvostek's sign and Trousseau's sign were positive. Neurologically, she was fully oriented. She had Grade 3 power in all the four limbs with intact sensation. [ncbi.nlm.nih.gov]

• Inappropriate Laughter

  One month later, the patient presented with dizziness and behavioral symptoms, such as inappropriate laughter and anger. [ncbi.nlm.nih.gov]

• Onset at Age <20

  […] before age 20 years. [ncbi.nlm.nih.gov]

• Clumsiness

  After an attack, affected individuals report clumsiness, weakness, and irritability, and in 62% muscle pain secondary to the attack. Between attacks, the majority report no or mild symptoms. [ncbi.nlm.nih.gov]

• Neurologic Manifestation

  To our knowledge this is the first reported coexistence of potentially treatable TPP and EAATD as initial neurological manifestations of Graves' disease, thereby underscoring the necessity of suspicion of possible underlying Graves' disease in patients [ncbi.nlm.nih.gov]

• Meningism

  Brain magnetic resonance imaging revealed meningeal enhancement and cerebrospinal fluid analysis showed a mild protein increase, with a blood-brain barrier disruption. [ncbi.nlm.nih.gov]

The patient was admitted to the intensive care unit where further workup revealed thyrotoxicosis and the patient was subsequently diagnosed with TPP. [ncbi.nlm.nih.gov]

An association with thyroid disease is well established and further workup revealed Grave's disease in this patient. [casesjournal.biomedcentral.com]

• Right Bundle Branch Block

  Our patient was found to have an extremely low serum potassium concentration, as well as an electrocardiogram that revealed a prolonged QT interval and right bundle branch block. [ncbi.nlm.nih.gov]

Treatment includes the supplementation of potassium, a nonselective beta-blocker, and ultimately treatment of the underlying hyperthyroidism. [ncbi.nlm.nih.gov]

OBJECTIVE: This review emphasizes the etiology, pathogenesis, management and prognosis of TPP and aims to highlight clinical awareness of early diagnosis and rapid initiation of treatment. [ncbi.nlm.nih.gov]

Antenatal diagnosis Prenatal diagnosis is theoretically possible if the disease-causing mutation in the family has been identified but is rarely performed because of the non life-threatening prognosis. [orpha.net]

Prognosis [ edit ] The prognosis for periodic paralysis varies. [en.wikipedia.org]

Prognosis Most patients learn to prevent their attacks well enough that no significant deterioration in the quality of life occurs. Strenuous exercise must be avoided, however. Attacks often lessen in severity and frequency during middle age. [encyclopedia.com]

The etiology of these abnormalities and the patient's symptoms was found to be undiagnosed and uncontrolled hyperthyroidism from Grave's disease, which resulted in this dramatic presentation of thyrotoxic hypokalemic paralysis. [ncbi.nlm.nih.gov]

Summary Epidemiology Prevalence is estimated at around 1 in 100,000. Clinical description The paralysis most often affects the four limbs, thus resulting in tetraplegia. [orpha.net]

Epidemiology There are primary and secondary forms. The primary form is genetic and follows an autosomal dominant pattern of inheritance. [unboundmedicine.com]

Epidemiology Hypokalaemic periodic paralysis (HOKPP) has a prevalence of 1 case per 100,000 population. [patient.info]

Home, Search, Index, Links, Pathology, Molecules, Syndromes, Muscle, NMJ, Nerve, Spinal, Ataxia, Antibody & Biopsy, Patient Info EPISODIC MUSCLE WEAKNESS Hypokalemic Periodic Paralysis Hypokalemic periodic paralysis, Hereditary: General features Epidemiology [neuromuscular.wustl.edu]

Here we report three cases of TPP in the Netherlands, and review the literature on clinical features, pathophysiological hypothesis and treatment. [ncbi.nlm.nih.gov]

Overview This article on periodic paralysis and related disorders introduces readers to the clinical presentations, basic concepts, and current understanding of the pathophysiology of these rare disorders or channelopathies. [medlink.com]

Rüdel R (1986) The pathophysiological basis of the myotonias and the periodic paralyses. In: Engel AG, Banker BQ (eds) Myology, 1st edn. Mc-Graw-Hill, New York, pp 1297–1311 Google Scholar 12. [link.springer.com]

Episodes can be prevented by achieving a euthyroid state. This report describes a young gentleman presenting with thyrotoxic hypokalemic paraparesis. [ncbi.nlm.nih.gov]