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Periorbital Edema


Presentation

  • It often presents with a classic heliotrope eyelid rash. We present a case of juvenile dermatomyositis presenting with significant bilateral periorbital edema, with its complete resolution after systemic antiinflammatory therapy.[ncbi.nlm.nih.gov]
  • We report a case of juvenile dermatomyositis that presented with periorbital edema.[ncbi.nlm.nih.gov]
  • Orofacial granulomatosis is a relapsing nonnecrotizing granulomatous syndrome that classically presents with lip and perioral swelling.[ncbi.nlm.nih.gov]
  • Metastasis of mammary cancer involving the orbit is common, and it typically presents with enophthalmos and restrictions of ocular motility. We report a case of mammary cancer with the unusual presentation of unilateral periorbital edema only.[ncbi.nlm.nih.gov]
  • We describe three patients with rosacea in whom periorbital edema was the initial presentation. This symptom may be confused with other dermatoses and may be refractory to conventional treatments for rosacea.[ncbi.nlm.nih.gov]
Chronic Urticaria
  • We documented localized periorbital edema in two patients with aspirin sensitivity without underlying chronic urticaria. The reaction developed 30 min after ingestion of 62.5 and 125 mg of aspirin, respectively. No systemic symptoms were observed.[ncbi.nlm.nih.gov]
  • Abstract We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria. The reaction developed one hour after ingestion of 200 mg of ibuprofen. No systemic symptoms were observed.[ncbi.nlm.nih.gov]

Workup

  • From your description, I do not think that I would pursue a workup for angioedema of any sort because more than likely your workup would be negative.[aaaai.org]
  • These patients should have a complete metastatic workup to rule out malignancy. It includes PAP smear, mammogram, CT chest / abdomen / pelvis, and colonoscopy.[aippg.net]
Normal Chest X-Ray
  • Hematological, biochemical and serological tests for antinuclear antibody, anti-DNA, C1q, C2 and C1 inhibitor were normal. Chest X-ray and the sinuses X-rays were normal.[panafrican-med-journal.com]
Mycobacterium Fortuitum
  • Chronic dacryocystitis caused by Mycobacterium fortuitum. Ophthalmology. 1993 May. 100(5):666-8. [Medline]. Asiyo MN, Stefani FH. Pyogenic granulomas of the lacrimal sac. Eye. 1992. 6 (Pt 1):97-101. [Medline]. Atkinson PL, Ansons AM, Patterson A.[medscape.com]

Treatment

  • In this IRB approved retrospective case series, we describe the clinical course of 5 such patients, including their presenting symptoms, diagnosis, and response to treatment.[ncbi.nlm.nih.gov]
  • The authors report the case of male patient age 63 years who developed severe periorbital edema after treatment with STI571 for chronic myelogenous leukemia.[ncbi.nlm.nih.gov]
  • This symptom may be confused with other dermatoses and may be refractory to conventional treatments for rosacea.[ncbi.nlm.nih.gov]
  • But with time, medical treatment, and home care, you can completely recover from this condition.[healthline.com]
  • Treatment with terfenadine enabled the patient to tolerate ibuprofen without experiencing any side effects. To the best of our knowledge, this is the first reported case of periorbital edema induced by ibuprofen.[ncbi.nlm.nih.gov]

Prognosis

  • Prognosis is very poor. Metastases : In children the orbit may be the site of secondary deposits from neuroblastoma or acute leukaemia.[patient.info]
  • Patients diagnosed over the age of 50 years have a worse prognosis overall. Risk factors for TED include age, gender, ethnicity, and family history. A positive family history of TED is noted in 61% of TED patients [2].[webeye.ophth.uiowa.edu]
  • Complications Ptosis, herniation of the orbital lobe of the lacrimal gland, prominent eyelid vascularity, and orbital fat pad atrophy are all complications which may arise from this condition. [7] Prognosis There is insufficient data regarding changes[eyewiki.aao.org]
  • Primary focal segmental glomerular sclerosis in children: clinical course and prognosis. Pediatr Nephrol. 2007 Mar. 22(3):389-95. [Medline]. Gipson DS, Massengill SF, Yao L, et al. Management of childhood onset nephrotic syndrome.[emedicine.medscape.com]

Etiology

  • A biopsy was performed to confirm the etiology after vague neuroimaging findings. The diagnosis was based on the histopathologic features of carcinomatous cells in the excised specimen.[ncbi.nlm.nih.gov]
  • The differential diagnosis of periorbital edema and possible etiologies of the edema are briefly discussed.[ncbi.nlm.nih.gov]
  • Because of the unknown etiology and benign character, which leads to spontaneous complete recovery, there is no specific treatment necessary for AHEI, and according to the literature, systemic corticosteroids do not seem to alter the course of the disease[ncbi.nlm.nih.gov]
  • This case review reveals the variety of etiologies that cause edema. An algorithm is created from these cases to assist in navigating the broad differential for eyelid edema.[iovs.arvojournals.org]

Epidemiology

  • Epidemiology and Pathogenesis of Periorbital Cellulitis Copyright 1995 by the American Academy of Pediatrics Log in using your username and password Log in through your institution You may be able to gain access using your login credentials for your institution[pedsinreview.aappublications.org]
  • Epidemiology Sinusitis affects 35 million Americans (Meltzer et al.), but this number is misleading, because it is often undiagnosed due to occasional subtle clinical presentation.[healio.com]
  • Epidemiology Because it is a rare syndrome, minimal epidemiologic data is available. Blepharochalasis has been reported more in females, though it is thought that it affects both genders at similar rates.[eyewiki.aao.org]
  • Epidemiology TED is the most common cause of orbital disease in North America and Europe and of both unilateral and bilateral exophthalmos.[webeye.ophth.uiowa.edu]
  • Dyslipidemia in pediatric renal disease: epidemiology, pathophysiology, and management. Curr Opin Pediatr. 2002 Apr. 14(2):197-204. [Medline]. Kerlin BA, Ayoob R, Smoyer WE.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology and etiology of edema formation are discussed in detail elsewhere, but the pathophysiology is briefly reviewed here.[anthesis-coaching.fr]
  • Chronic rhinosinusitis: Clinical manifestations, pathophysiology, and diagnosis. Available at www.uptodate.com. Accessed October 1, 2014. Hamilos DL. Management of chronic rhinosinusitis. Available at www.uptodate .com. Accessed October 1, 2014.[healio.com]
  • Several theories regarding the pathogenesis and pathophysiology of blepharochalasis have been explored, though none has been confirmed.[eyewiki.aao.org]
  • Dyslipidemia in pediatric renal disease: epidemiology, pathophysiology, and management. Curr Opin Pediatr. 2002 Apr. 14(2):197-204. [Medline]. Kerlin BA, Ayoob R, Smoyer WE.[emedicine.medscape.com]
  • Pathophysiology Development of TED is centered on inflammation of orbital tissue via stimulation of orbital fibroblasts (Figure 3).[webeye.ophth.uiowa.edu]

Prevention

  • Prevention of bacterial endocarditis. ‎[books.google.de]
  • Following a disciplined routine and drinking an adequate amount of water throughout the day is essential to avoid swelling of the eyes and at the same time, it prevents other diseases.[knowhow.ncvo.org.uk]
  • A low-carb diet can prevent eye puffiness by preventing water retention. [ citation needed ] Eating foods rich in vitamins, especially A, C and E, helps to reduce eye puffiness and to maintain clear, moist skin. [9] See also [ edit ] Angioedema, rapid[en.wikipedia.org]

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