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Periosteal Chondrosarcoma


Presentation

  • Common morphologic subtypes of conventional (high grade) osteosarcoma: often coexist in one tumor Osteoblastic osteosarcoma : abundant synthesis of bone matrix Chondroblastic osteosarcoma: cartilaginous matrix present (always high grade cartilage) Fibroblastic[pathologyoutlines.com]
  • Symptoms pain is the most common symptom variable rapidity of presentation dependent on tumor grade and location may present with slowly growing mass or symptoms of bowel/bladder obstruction due to mass effect in the pelvis 50% of de-differentiated chondrosarcomas[orthobullets.com]
  • The typical presentation is in the 4 th and 5 th decades and there is a slight male predominance of 1.5-2:1. Patients usually present with pain, pathological fracture, a palpable lump or local mass effect.[radiopaedia.org]

Treatment

  • Percent treatment response: 60% ( 40% residual viable tumor) Grade of treatment response: II of IV, 50 - 90% treatment response Discontinuous tumor foci: Not identified Lymphovascular invasion: Not identified Surgical margins: Negative for tumor Lymph[pathologyoutlines.com]
  • Treatment and prognosis Prognosis varies with both grade and location. In general: grade grade 1: 90% 5-year survival grade 3: 29% 5-year survival location long bones have a better prognosis than axial skeleton[radiopaedia.org]

Prognosis

  • Treatment and prognosis Prognosis varies with both grade and location. In general: grade grade 1: 90% 5-year survival grade 3: 29% 5-year survival location long bones have a better prognosis than axial skeleton[radiopaedia.org]
  • […] grade, intramedullary) osteosarcoma Essential features Bone is necessary for diagnosis (typically has a filigree microscopic appearance) Most cases occur in children (10 - 14 years old) and are primary; secondary osteosarcoma is most common in adults Prognosis[pathologyoutlines.com]
  • […] male predominance location most common locations include the pelvis, proximal femur, distal femur, scapula tumor location is important for diagnosis as the same histology may be diagnosed as benign in the hand but malignant if located in the long bones Prognosis[orthobullets.com]

Epidemiology

  • […] osteochondroma ( multiple hereditary exostosis (1-10% risk of malignant transformation) enchondromas (1% risk of malignant transformation) Ollier's disease (25-40% risk of malignant transformation) Maffucci's (100% risk of malignant transformation) Epidemiology[orthobullets.com]
  • Other lines of differentiation are not present Most cases are primary; secondary cases (usually after radiation therapy) represent a minority of cases See diagram ICD coding ICD-10: C41.9 - malignant neoplasm of bone and articular cartilage, unspecified Epidemiology[pathologyoutlines.com]
Sex distribution
Age distribution

Prevention

  • […] enlarging mass lesion is common Pathologic fracture in a minority of cases (5 - 10%) Diagnosis Typically suspected on imaging and diagnosed via biopsy (biopsy performed such that biopsy tract may be entirely removed upon resection of tumor, so as to prevent[pathologyoutlines.com]

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