Periostitis is a condition that describes inflammation of the periosteum which is a layer of dense connective tissue enveloping the bones. Periostitis may appear in various conditions, but trauma and infections are the most common causes. The diagnosis can be made through patient history, radiography, and magnetic resonance imaging.
The clinical presentation of periostitis may depend on the underlying cause but in most cases, local pain and swelling of the adjacent tissue are present. Additional symptoms of fever, chills, and profound tenderness are suggestive of an infectious etiology, most notable being osteomyelitis, secondary syphilis, actinomycosis (when periostitis of the mandible is seen) or odontogenic infections . In the setting of medial tibial stress syndrome (MTSS) (known as "shin splints”), inflammation of the periosteum leads to the appearance of vague and diffuse pain in the lower extremity, usually in the middle or distal tibia, which is provoked by exertion . In the early stages, pain is worse when starting the exercise and then gradually decreases during training and within minutes of stopping the exercise. However, as the injury progresses, pain occurs with less activity and may even occur at rest. . A similar clinical course can be observed in malignant or autoimmune diseases involving the skeletal system (e.g. leukemia, reactive arthritis, lung cancer with metastatic dissemination in the bones)  . In rare cases, multifocal periostitis involving more than one extremity (or even the axial skeleton) and diffuse pain can be seen in patients who are receiving long-term prophylaxis of voriconazole, as this antifungal drug contains fluoride, which is known to induce a periosteal reaction  .
Entire Body System
Florid-reactive periostitis, also known as fibroosseous pseudotumor, is a benign bone lesion. It occurs rarely among pediatric patients. Usually, it affects the phalanges of the hands and feet, where most lesions concern the proximal phalanx. [ncbi.nlm.nih.gov]
Rapidly growing fibro-osseous pseudotumor of the digits mimicking extraskeletal osteosarcoma. J Orthop Sci 2002;7:410–3. . Tang JB, Gu YQ, Xia RG. [journals.lww.com]
Fibro-osseous pseudotumor of the digits. Cancer 1986;58(09):2103-2109 [ Links ] 6 Fechner RE, Mills SE. Tumors of the Bones and Joints (Atlas of Tumor Pathology Series IV). [scielo.br]
This is frequently seen in psoriatic arthritis and Reiter's syndrome. A similar picture occurs with increased osteoclastic activity and reflects rapid demineralization, simulating periostitis. [ncbi.nlm.nih.gov]
Awareness of this potential syndrome, which manifests as bone pain, elevated serum alkaline phosphatase and a bone scan suggestive of periostitis, is necessary in LT recipients on long-term voriconazole. [ncbi.nlm.nih.gov]
Medial Tibial Stress Syndrome
Medial tibial stress syndrome: conservative treatment options, Curr Rev Musculoskelet Med, 2009; 2 : 127-133. 3 Hamstra-Wright KL, et al.. [kinatex.com]
It can be caused by excessive physical activity as well, as in the case of medial tibial stress syndrome (also referred to as tibial periostalgia, soleus periostalgia, or shin splints). [en.wikipedia.org]
In the setting of medial tibial stress syndrome (MTSS) (known as "shin splints”), inflammation of the periosteum leads to the appearance of vague and diffuse pain in the lower extremity, usually in the middle or distal tibia, which is provoked by exertion [symptoma.com]
Lower Leg Pain
All medical data were gathered from enrolled adults with sports-related lower leg pain. A total of 54 patients underwent triple-phase bone scans using skeletal nuclear scintigraphy, which confirmed periostitis in their lower limbs. [ncbi.nlm.nih.gov]
There are a number other causes of lower leg pain that can mimic periostitis. [painfreefeet.ca]
Periostitis deformans is an uncommon condition of the skeletal system, mainly manifested as bone pain with or without bony swellings. [ncbi.nlm.nih.gov]
Second metacarpal bone bears more weight than fourth metacarpal/metatarsal bone and is more prone to the formation of bony swellings or splints. [vetstream.com]
shins), but it is a far less common finding in acquired disease.9 Bone involvement often occurs in the long bones and can also be found in the skull.9 Patients present with pain over the bony regions. [jucm.com]
Patient history is quite important in evaluating the etiology and course of the disease-causing the symptoms reported by the patient, especially when information such as recent voriconazole use or presence of malignant diseases are obtained. The diagnosis of periostitis as an isolated finding, however, can only be made through imaging studies. Radiography is an easy, effective and quick method to detect some of the key features that support the diagnosis. Irregular nodular calcifications along the interosseous membrane, edema of the periosteum, the presence of exostoses (an exuberant growth of periosteal bone due to inflammation), gross thickening of the affected bones, and a periosteal reaction of various types (single layer, onion skin, sunburst type, etc) are the main findings   . In fact, the type of periosteal reaction can be helpful, as "onion skin" type is typical for periostitis ossificans, a type of non-suppurative osteomyelitis , and for malignant neoplasms (Ewing's sarcoma, for example), whereas "sunburst" reaction is primarily encountered in benign tumors, such as osteoblastoma  . More advanced imaging studies - magnetic resonance imaging (MRI) or computed tomography (CT), or nuclear bone scanning, can be useful for determination of the cause, and to assess the state of the surrounding soft tissue .
Dermatologists must be attentive to the possibility of autoimmune blistering diseases during ustekinumab treatment. [ncbi.nlm.nih.gov]
The prognosis for returning to perform at her previous level of activity without ongoing lameness problems in the right forelimb remained fair to guarded. [cal.vet.upenn.edu]
This is a relatively benign disease and has a good prognosis but continued insults may cause chronic pain and discomfort. [healthhema.com]
It needs no pharmacological or surgical treatment and has an excellent prognosis. References 1. Rana RS, Jim SW, Ronald LE. Periosteal reaction. AJR Am J Roentgenol 2009; 193:259-72. 2. James HB, Charles AR, James RK. Basic principles. [wajradiology.org]
Prevention and prognosis of periostitis Prognosis for periostitis is good as long as treatment is completed. For those with acute periostitis, surgery may be performed and antibiotics administered through IV. [belmarrahealth.com]
Mandibular cases were already described for an infectious dental cause, often with an "onion skin" radiographic aspect, but some rare reported cases showed no obvious etiology. [ncbi.nlm.nih.gov]
Additional symptoms of fever, chills, and profound tenderness are suggestive of an infectious etiology, most notable being osteomyelitis, secondary syphilis, actinomycosis (when periostitis of the mandible is seen) or odontogenic infections. [symptoma.com]
Detailed lesion descriptions and over 300 photographs and diagrams facilitate disease recognition and each condition is placed in context with discussion of its history, antiquity, etiology, epidemiology, geography, and natural history. [books.google.com]
Epidemiology The number of syphilis cases peaked in the United States in the late 1980s and early 1990s. [jucm.com]
Definition, pathogenesis, and epidemiology Peritonitis is defined as inflammation of the peritoneum, which may be caused by pathogens or non-pathogenic factors, e.g., barium enema. [ncbi.nlm.nih.gov]
"Noncontiguous and open fractures of the lower extremity: Epidemiology, complications, and unplanned procedures". Injury. 47 (3): 742–747. doi:10.1016/j.injury.2015.12.013. PMID 26776462. [en.wikipedia.org]
Epidemiology The overall incidence of peritoneal infection and abscess is difficult to establish and varies with the underlying abdominal disease processes. [emedicine.medscape.com]
Pathology and Pathophysiology of this disease are described in a clear way. All therapeutic modalities from surgery to antibiotic and hyperbaric oxygen therapy are comprehensively outlined and discussed. [books.google.com]
Pathophysiology Injury to interosseous ligament due to instability between MC/MT 2 and 4 and MC/MT 3 desmitis and proliferative new bone formation. [vetstream.com]
A study was performed to determine the frequency of periosteal reaction associated with chondroblastoma, to investigate the underlying pathophysiology of the periosteal reaction, and to postulate the clinical importance of this radiographic observation [mayoclinic.pure.elsevier.com]
Although POPP is considered to be a type of psoriatic arthritis, its pathology and pathophysiology are poorly understood. [escholarship.org]
(See Pathophysiology.) Did this answer your question? Yes No Additional feedback? (Optional) Thank you for your feedback! Leppaniemi A, Kimball EJ, De Laet I, Malbrain ML, Balogh ZJ, De Waele JJ. Management of abdominal sepsis--a paradigm shift?. [medscape.com]
Early recognition of this phenomenon is important to prevent unnecessary tests and procedures. Prompt discontinuation of voriconazole should result in improvement of symptoms. [ncbi.nlm.nih.gov]
This prevents the transmission of the infection to other tissues. Treatment of root canals is therefore crucial to prevent and completely eliminate inflammation. For preventive reasons, tooth extraction (pulling teeth) is sometimes necessary. [schill.sk]
By treating minor injuries right away, you can prevent chronic periostitis from occurring. Prevention of chronic periostitis involves preventing overuse injuries. [belmarrahealth.com]
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- Galbraith RM, Lavallee ME. Medial tibial stress syndrome: conservative treatment options. Curr Rev Musculoskelet Med. 2009;2(3):127-133.
- Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds. Harrison's Principles of Internal Medicine, 18e. New York, NY: McGraw-Hill; 2012.
- Wermers RA, Cooper K, Razonable RR, et al. Fluoride excess and periostitis in transplant patients receiving long-term voriconazole therapy. Clin Infect Dis. 2011;52(5):604-611.
- Skaug M, Spak C, Oza U. Painful periostitis in the setting of chronic voriconazole therapy. Proc (Bayl Univ Med Cent). 2014;27(4):350-352.
- Shah KM, Karagir A, Adaki S. Chronic non-suppurative osteomyelitis with proliferative periostitis or Garre's osteomyelitis BMJ Case Rep. 2013;2013: bcr2013009859.
- Kannan SK, Sandhya G, Selvarani R. Periostitis ossificans (Garrè's osteomyelitis) radiographic study of two cases. Int J Paediatr Dent. 2006;16(1):59-64.
- Sharma V, Chew FS, Hoch B. Periosteal osteoblastoma: Multimodal imaging of a rare neoplasm. Radiol Case Rep. 2009;4(4):329.