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Peripheral Neuroblastoma


Presentation

  • The patient, a 39-year-old male, presented with sciatalgia and progressive crural monoplegia. Characteristic histological features of this rare tumor are described.[ncbi.nlm.nih.gov]
  • Ancillary information for classification of neuroblastoma and related neoplasms is also presented.[scholars.northwestern.edu]
  • This report describes a peripheral neuroblastoma in a 2 year old Boxer that presented with signs of renal disease and a palpable abdominal mass.[ncbi.nlm.nih.gov]
  • At least one third present metastases at onset, with bone and bone marrow being the most frequent metastatic sites.[moh-it.pure.elsevier.com]
Chronic Fatigue Syndrome
  • Abstract Patients with chronic hepatitis C virus (HCV) infection show an increased incidence of nervous system disorders such as chronic fatigue syndrome, depression and cognitive dysfunction.[ncbi.nlm.nih.gov]
Respiratory Distress
  • A 46-year-old man with severe adult respiratory distress syndrome had a 2.5 2.0 2.0-cm, rapidly growing, fleshy nodule over his nose. The clinical impression was pyogenic granuloma (PG) or keratoacanthoma (KA).[journals.lww.com]
  • Thoracic tumours are either found coincidentally or may cause respiratory distress, dysphagia and circulatory problems. Cervical neuroblastomas may lead to Horner's syndrome.[atlasgeneticsoncology.org]
  • Large masses often cause respiratory distress. Children with high thoracic and cervical tumors may present with Horner's syndrome.[aafp.org]
Hypertension
  • Also fever and hypertension may occur.[atlasgeneticsoncology.org]
  • ., severe headache, hypertension, visual changes, lethargy, or seizures). Capillary Leak Syndrome Severe (Grade 3 to 5) capillary leak syndrome occurred in 31 (23%) patients in the Unituxin/RA group and in no patients treated with RA alone.[unituxin.com]
  • This malignancy can also present with abdominal pain, gross hematuria, fever and hypertension.[aafp.org]
  • […] of cases), treatment-resistant diarrhea (tumor vasoactive intestinal peptide secretion, 4% of cases), Horner's syndrome (cervical tumor, 2.4% of cases), opsoclonus myoclonus syndrome [9] and ataxia (suspected paraneoplastic cause, 1.3% of cases), and hypertension[en.wikipedia.org]
Cutaneous Manifestation
Bone Pain
  • Symptoms may include bone pain, a lump in the abdomen, neck, or chest, or a painless bluish lump under the skin. Occasionally neuroblastoma may be due to a mutation inherited from a person's parents.[play.google.com]
  • Additional symptoms that should prompt concern include pallor, petechiae or ecchymoses, bone pain and significant weight loss.[aafp.org]
  • Common symptoms of neuroblastoma include: a lump in the neck, chest, or abdomen bulging eyes dark circles under the eyes abdominal swelling bone pain weakness in the upper or lower extremities paralysis of, or an inability to move, the upper or lower[healthline.com]
  • Metastatic disease can cause jaundice, circulatory and respiratory problems, bone pain, proptosis (Hutchinson syndrome) and periorbital ecchymoses. Also fever and hypertension may occur.[atlasgeneticsoncology.org]
Long Arm
  • Interestingly, also structural chromosome aberrations like MYCN amplifications, deletions at the chromosomal regions 1p36.3, or 11q, gains of long arms of chromosome 17, can be found in near-triploid tumours.[atlasgeneticsoncology.org]
Facial Pain
  • Volume 1 covers the visual sensory system, the autonomic nervous system, the ocular motor system, the eyelid, facial pain and headache, and nonorganic disease.[books.google.com]
Monoplegia
  • The patient, a 39-year-old male, presented with sciatalgia and progressive crural monoplegia. Characteristic histological features of this rare tumor are described.[ncbi.nlm.nih.gov]

Workup

  • The diagnosis of CN was made and an extensive radiologic and laboratory workup was initiated, but the results were negative for another primary tumor.[journals.lww.com]

Treatment

  • The greatest problem is posed by children with metastatic disease or amplified MYCN gene, who continue to do badly despite intensive treatments.[moh-it.pure.elsevier.com]
  • This finding implies a significant difference ( P 0.04) in the response to treatment and TH m-RNA expression; accordingly, TH m-RNA may be used as a predictive factor for response to treatment.[ehj.eg.net]
  • Of the 14 patients for whom follow-up information could be obtained, nine died within a period of 2 years and two were alive and well for over 5 years after the initial treatment.[ncbi.nlm.nih.gov]
  • It also provides guidelines for treatment with surgery, radiotherapy and chemotherapy.[books.google.com]

Prognosis

  • Peripheral neuroblastic tumors in childhood present unique problems in terms of diagnosis, classification, and histologic determinants of prognosis.[scholars.northwestern.edu]
  • Divided into three main sections, this work focuses on tumor biology, clinical management, and prognosis and future perspectives.[books.google.com]
  • Prognosis The outcome of patients with neuroblastoma depends largely on the age of the patient at diagnosis, the tumour spread and the tumour biology/genetics. Stage 1 and 2 patients usually have a very good prognosis with surgery alone.[atlasgeneticsoncology.org]
  • ., differentiating neuroblasts and ganglion cells, is well documented in peripheral neuroblastic tumors (pNTs), and considered as one of the signs of tumor maturation and an indication of a better prognosis of the patients.[link.springer.com]
  • Key Words: Peripheral neuroblastoma ; Small cell carcinoma ; Craniectomy ; Radiotherapy ; Metastasis ; Prognosis in skull metastasis[jkns.or.kr]

Etiology

  • PMID 10519894 Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors.[atlasgeneticsoncology.org]
  • […] anywhere in distribution of sympathoadrenal neuroendocrine system Most in adrenal gland ( 40%), followed by connective / subcutaneous / soft tissue ( 20%), retroperitoneum ( 15%), mediastinum ( 10%) ( SEER Program: NIH Pub No 99-4649; Bethesda, MD, 1999 ) Etiology[pathologyoutlines.com]

Epidemiology

  • Introduction Neuroblastoma is a malignant tumor which develops from sympathetic neural tissue it is the most common solid tumor of childhood most cases of neuroblastoma arise in the adrenal gland or near the spinal cord Epidemiology occurs in approximately[orthobullets.com]
  • PMID 10379019 Epidemiological features of Wilms' tumor: results of the National Wilms' Tumor Study. Breslow NE, Beckwith JB Journal of the National Cancer Institute. 1982 ; 68 (3) : 429-436.[atlasgeneticsoncology.org]
  • […] however, reported somewhat better survival rates in patients with localized disease, with 2 large trials showing 2-year and 3-year survival rates of 65% and 56%, respectively. [10, 11] A study by Jiang et al, using information from the Surveillance, Epidemiology[emedicine.medscape.com]
  • "The epidemiology of neuroblastoma: a review". Paediatric and Perinatal Epidemiology. 23 (2): 125–43. doi : 10.1111/j.1365-3016.2008.00983.x. PMID 19159399. Esthesioneuroblastoma at eMedicine Cheung, Nai-Kong (2005). Neuroblastoma.[en.wikipedia.org]
  • General principles of the epidemiology of childhood cancer. In: Pizzo PA, Poplack DG, eds. Principles and practice of pediatric oncology. 3d ed. Philadelphia: Lippincott-Raven, 1997:1–10. ... 2. Linet MS, Ries LA, Smith MA, Tarone RE, Devesa SS.[aafp.org]
Sex distribution
Age distribution

Prevention

  • Mechanistically, multi-site phosphorylation of Ascl1 on these sites limits its association with promoters and enhancers of downstream targets, and this prevents activation of these multiple targets that are needed for the differentiation process.[thenode.biologists.com]
  • To prevent tissue detachment during antigen retrieval, unbaked slides must be baked for at least 30 to 120 minutes at 60 C. before putting into xylene for de-paraffinization. Baked slides were sent out baked for 2 hours.[biomax.us]
  • Splints called ankle-foot-orthoses may be suggested to prevent the ankle from moving too much from side to side and to support the foot when walking. Pain Management Your doctor may prescribe medicine to control pain, tingling, and burning.[curesearch.org]
  • Ask them about the risks of specific treatment options, your child’s treatment schedule, and strategies to prevent, identify, and manage potential complications.[healthline.com]
  • These finding might be beneficial in future therapeutic strategies for treating and preventing peripheral meroblastic tumors.[rcm.mums.ac.ir]

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