Treatment of painful neuropathy should be directed at removing the offending metabolic injury, if possible. [ncbi.nlm.nih.gov]

Diabetic neuropathy commonly causes painful tingling or burning sensations in the hands and feet—a condition called distal polyneuropathy. Pain is often worse at night and may be aggravated by touch or by a change in temperature. [msdmanuals.com]

During this visit, he reported having a burning chest pain which made it difficult to breathe. The pain was daily and continuous, although it improved when lying down, and became more intense in the evening. [archbronconeumol.org]

Deep proximal aching pain is the first sign in the affected limb. Burning pain in the cutaneous distribution of the affected nerve is frequent. Weakness and numbness usually appear over several hours to several days after the pain. [intechopen.com]

Although for the moment we do not precisely understand its contributing role, hypoxemia could be the main factor in the development of this type of PN. 3 The neurophysiological characteristics are compatible with an axonal polyneuropathy with predominantly [archbronconeumol.org]

Bone marrow aspirate was usually normal. In seven patients definite reversibility of PPN was observed after irradiation of plasmacytoma. [ncbi.nlm.nih.gov]

Eleven patients had either osteoporosis or radiologically normal skeleton. The mean survival from the first symptom was about 28 months and from the diagnosis 20 months. The five-year survival was 21% and 20%, respectively. [ncbi.nlm.nih.gov]

During treatment, he suffered 2 vertebral fractures due to secondary osteoporosis and showed reactivation of hepatitis B and iatrogenic Cushing syndrome. He is currently treated with azathioprine; dysaesthesia and ataxic gait persist. [elsevier.es]

spasms Problems with balance It may not be possible to prevent nerve damage. [uihc.org]

Loss of sensation increases risk for foot injury, delays treatment and can lead to foot and leg ulceration and infections. Ulcers and infections may eventually lead to amputation of the lower extremities. [effectivehealthcare.ahrq.gov]

Diabetic foot ulcer A diabetic foot ulcer is an open wound or sore on the skin that's slow to heal. These are common in people with diabetic polyneuropathy. If you have numb feet, it's easy to cut your foot by stepping on something sharp. [nhsinform.scot]

If the underlying cause of peripheral neuropathy is not treated, you may be at risk of developing potentially serious complications, such as a foot ulcer that becomes infected. [nhs.uk]

In the U.S., diabetic neuropathy is the main cause of foot problems and ulcers in people with diabetes. Around half of all people with diabetes are believed to have diabetic neuropathy. [medicalnewstoday.com]

Diabetic neuropathy often involves the feet and legs and is responsible for lack of sensation, foot ulcers, and infections. [jamanetwork.com]

[…] vibration and proprioception Ataxia Clumsiness Areflexia Hypotonia "Tingling" "Pins and needles" Sensory (Small Fiber) Sensory loss to pain and temperature "Burning" "Stabbing" Autonomic Postural hypotension Anhidrosis Impotence Bowel or bladder disturbance Hyperhidrosis [casemed.case.edu]

[…] peripheral neuropathy may be treatable with medication, such as: erectile dysfunction constipation the slow movement of food through your stomach (gastroparesis) In some cases, you may need more invasive treatment, such as botulinum toxin injections for hyperhidrosis [nhsinform.scot]

This is most often secondary to anhidrosis in the limbs and thorax and reflects compensatory hyperhidrosis in the restricted areas that maintain normal sweating. [clevelandclinicmeded.com]

Decreased sweating. Problems with urination. Sexual dysfunction. Diarrhea. Weight loss (unintentional). Dizziness when standing up or fainting. Nausea or vomiting. Problems with digestion. Cleveland Clinic News & More [my.clevelandclinic.org]

INTRODUCTION: Female sexual dysfunction (FSD) in peripheral polyneuropathies besides diabetes mellitus is still a poorly studied subject. Little is known about sexual function in women with amyloidosis, Guillain-Barré syndrome, or porphyria. [ncbi.nlm.nih.gov]

Hyporeflexia is also rare except in the ankles. In fact, tendon reflexes other than at the ankle are lost only if the femoral, musculocutaneous, or radial nerves are affected proximally [ 12, 18, 19 ]. [intechopen.com]

Brisk reflexes point to a central cause, whereas hyporeflexia or areflexia suggest a peripheral problem. [rcemlearning.co.uk]

Subjects with the highest grade of PN were older and had significantly increased levels of creatinine, microalbuminuria, HbA1c, and plasma Hcy compared to the other two groups. [ncbi.nlm.nih.gov]

Elevated sedimentation rate was uncommon. Less than half of the patients had anemia, and six patients, all with osteosclerotic lesions, had polycythemia. Azotemia was detected in 44% of the cases. [ncbi.nlm.nih.gov]