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Peripheral Sensory Neuropathy


Presentation

  • The present study aimed to identify genetic variants associated with paclitaxel induced neuropathy via a whole genome approach.[ncbi.nlm.nih.gov]
  • Overt malnutrition was not present, but a deficit of micronutrients, in particular thiamine, cobalamine, folate and sulfur amino acids appears to have been a primary determinant of this epidemic.[ncbi.nlm.nih.gov]
  • The remaining clinical and behavioral details of the participants are presented in Table 2.[jdmdonline.biomedcentral.com]
  • Symptoms of sensory peripheral neuropathy The following symptoms may be present: Gradual numbness and tingling in the hands or feet (may spread to arms and legs) Burning pain Impaired ability to sense the position of one’s limbs Loss of balance and coordination[healthxchange.sg]
  • With oxaliplatin therapy, neurotoxicity usually presents as peripheral sensory neuropathy (PSN), which in its persistent form is the main dose-limiting toxicity of oxaliplatin.[academic.oup.com]
Cerebral Palsy
  • As cerebral palsy is a typical upper motor neuron disorder, peripheral sensory neuropathy is unexplained.[ncbi.nlm.nih.gov]
  • Conclusion As cerebral palsy is a typical upper motor neuron disorder, peripheral sensory neuropathy is unexplained.[link.springer.com]
Food Poisoning
  • For example, one theory about Guillain-Barré syndrome involves complications following infection with Campylobacter jejuni, a bacterium commonly associated with food poisoning.[medical-dictionary.thefreedictionary.com]
Peripheral Neuropathy
  • Abstract An epidemic outbreak of peripheral neuropathy affected Cuba in 1992-93 resulting in 50,862 cases (national cumulative incidence rate (CIR) 461.4 per 100,000).[ncbi.nlm.nih.gov]
  • Abstract The relationships between predialysis and postdialysis erythrocyte transketolase activities and symptoms of uremic peripheral neuropathy were studied prospectively for 21 months in 19 chronic hemodialysis patients.[ncbi.nlm.nih.gov]
  • The risk of developing new peripheral neuropathy at follow-up was determined using a Cox proportional hazard model analysis.[ncbi.nlm.nih.gov]
  • Although previous reviews of the health effects of 1,1,1-trichloroethane have not indicated long-term neurotoxicity, there are recent animal studies that suggest chronic central neurotoxic effects and previous case reports of peripheral neuropathy in[ncbi.nlm.nih.gov]
  • "Sensory peripheral neuropathy tends to affect people aged over 60.[healthxchange.sg]
Dysesthesia
  • Patients complained of dysesthesias and paresthesias in hands and feet. Clinically, there was progressive decrease or loss of tendon reflexes, decreased vibratory sense, and mild decrease in light touch and pin sensation.[ncbi.nlm.nih.gov]
  • People with sensory neuropathy may experience dysesthesia, which translates as abnormal sensation.[diabetes.co.uk]
  • The symptoms of CTS include decreased sensation in the radial digits (sparing the palm) along with potential dysesthesias provoked by wrist position (including at night).[dartmouth.edu]
  • My Response Presentation/Physical Findings The patient’s presentation is typical of chemotherapy-induced peripheral neuropathy (CIPN) that is characterized by tingling (71%), numbness (58%), and paresthesias or dysesthesias (45%), or spontaneous burning[hematology.org]
Clonus
  • Rootlets with clonus reaction against intraoperative electrical stimulation show dysmyelination, and in one child, axonal degeneration can also be observed. Rootlets with normal reaction have only minimum changes on their myelin sheath.[ncbi.nlm.nih.gov]
Involuntary Movements

Workup

  • Complete electrodiagnostic studies [Nerve conduction studies (NCS) and needle electromyography (EMG)]: Perform if unclear after initial workup or presence of atypical symptoms: asymmetry, motor predominance, non-length dependence, prominent autonomic[clinicaladvisor.com]
  • (See Workup.) Management of diabetic neuropathy should begin at the initial diagnosis of diabetes.[emedicine.medscape.com]
Albuminuria
  • Multiple logistic regression analysis showed that older age, longer diabetes duration, central adiposity, increased height, higher fasting serum glucose, albuminuria and aboriginality were significant independent positive predictors of prevalent neuropathy[ncbi.nlm.nih.gov]

Treatment

  • Oxaliplatin-induced cumulative PSN may also be managed by temporary cessation of treatment.[ncbi.nlm.nih.gov]
  • II/III colon cancer), EFC4584 (second-line treatment; metastatic CRC), and EFC2962 (first-line treatment; metastatic CRC).[ncbi.nlm.nih.gov]
  • Baseline examination was assessed with a logistic regression analysis controlling for age, education level, history of drug/alcohol use, and anti-retroviral treatment.[ncbi.nlm.nih.gov]
  • Treatment of patients with B-group vitamins and folate produced rewarding results. Most patients improved significantly and less than 0.1% of them remained with sequelae; there were no fatal cases.[ncbi.nlm.nih.gov]

Prognosis

  • Prognosis The outcome for peripheral neuropathy depends heavily on the cause. Peripheral neuropathy ranges from a reversible problem to a potentially fatal complication. In the best cases, a damaged nerve regenerates.[medical-dictionary.thefreedictionary.com]
  • What You Need to Know There are more than 100 types of peripheral neuropathy, each with its own set of symptoms and prognosis. Peripheral neuropathy has many different causes.[hopkinsmedicine.org]
  • The prognosis of neuropathy can differ depending on the etiology.[opedge.com]
  • Types of peripheral neuropathy There are more than 100 types of peripheral neuropathy, each with its own set of symptoms and prognosis. To help doctors classify them, they are often broken down into the following categories: Motor neuropathy.[columbianeurology.org]

Etiology

  • Since observed neuropathy is mainly on the myelin sheath, the etiology is considered to be the chronic overload of afferent impulses from muscle spindles in the spastic muscle.[ncbi.nlm.nih.gov]
  • All 3 profiles were represented in each etiology evaluated, although there were differences in their distribution.[clinicalpainadvisor.com]
  • […] by these etiologies overlap considerably.[journals.lww.com]
  • Mechanisms NT may have different mechanisms of action, depending on the etiology. For instance, when the sensory input is impaired or altered, the resulting misinformation may cause tremor despite the brain and spinal cord functioning correctly.[news-medical.net]

Epidemiology

  • For epidemiological purposes, cases were classified as optic forms (CIR 242.39) or peripheral forms (CIR 219.25).[ncbi.nlm.nih.gov]
  • An epidemiological study to assess the prevalence of diabetic peripheral neuropathic pain among adults with diabetes attending private and institutional outpatient clinics in South Africa.[jdmdonline.biomedcentral.com]
  • He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education.[lifeinthefastlane.com]
  • Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014;155(4):654-62.[spine-health.com]
  • Differential Diagnoses and Epidemiology 46. Clinical Patterns – Philip Thompson & P. K. Thomas 47. Differential Diagnoses of Polyneuropathy – Ian A. Grant, Timothy J. Benstead & Peter J. Dyck 48.[elsevier.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of neuropathy induced by oxaliplatin may be different from that associated with DM.[academic.oup.com]
  • Pathophysiology/complications Peripheral sensory neuropathy is associated with altered postocclusive reactive hyperemia in the diabetic foot Alex L Barwick 1 , John W Tessier 1 , Xanne Janse de Jonge 2 , James R Ivers 1 , Vivienne H Chuter 1 1 Faculty[drc.bmj.com]
  • These 3 profiles may be related to pathophysiological mechanisms and may be useful in clinical trial design to enrich the study population for treatment responders,” the researchers wrote.[clinicalpainadvisor.com]
  • The number and type of intrinsic patterns—if reproducible—can then be related back to pathophysiological and pharmacological mechanisms in future studies.[journals.lww.com]
  • Their presentation varies depending on the underlying pathophysiology. The speed of progression of the polyneuropathy coupled with its nature (axonal or demyelinating) can help identify its aetiology.[rcemlearning.co.uk]

Prevention

  • It is therefore predicted that such measurements may be usefully applied in ascertaining the extent of hemodialysis needed to prevent the development of this pathological state.[ncbi.nlm.nih.gov]
  • Prevention Peripheral neuropathies are preventable only to the extent that the underlying causes are preventable.[medical-dictionary.thefreedictionary.com]
  • Prevention The patient plays a vital role in minimizing the risk of developing diabetic peripheral neuropathy and in preventing its possible consequences. Some important preventive measures include: Keep blood sugar levels under control.[acfas.org]
  • Peripheral Neuropathy Prevention Lifestyle choices can play a role in preventing peripheral neuropathy.[hopkinsmedicine.org]
  • SLIDESHOW Diabetic Peripheral Neuropathy: Improve Diabetes Nerve Pain See Slideshow Can peripheral neuropathy be prevented? Certain forms of peripheral neuropathy can be prevented.[medicinenet.com]

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