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Peritoneal Fibrosis


Presentation

  • Abstract Three cases of peritoneal fibrosis induced by the beta adrenoceptor blocking agent practolol are presented.[ncbi.nlm.nih.gov]
  • Children may present with hip or gluteal pain.[patient.info]
  • Recent experimental trials in animal models and clinical studies are presented in this review.[ncbi.nlm.nih.gov]
  • Based on these findings, here we present our hypothesis that extracellular microRNAs associated with peritoneal epithelial-to-mesenchymal transition and fibrosis could potentially be detected in peritoneal dialysis effluent, and serve as novel biomarkers[ncbi.nlm.nih.gov]
  • Invasive lobular carcinoma of the breast presenting as retroperitoneal fibrosis: a case report. J Med Case Reports 2010 Jun 9;4:175. [ CrossRef ] [ Pubmed ][ijcasereportsandimages.com]
Camping
  • The antimitogenic and antifibrotic effects of DP appear to be predominantly mediated through the cAMP pathway, as DP increased intracellular cAMP in a dose-dependent manner.[ncbi.nlm.nih.gov]
  • The effects of PTX on matrix metalloproteinase (MMP) activity and cAMP level in HPFBs were measured by immunoassays. In the in vivo study, Wistar rats were randomly divided into five groups.[ncbi.nlm.nih.gov]
Ascitic Fluid
  • In addition to these peritoneal injuries or inflammations, the faster ascitic fluid circulation in shunted patients may have increased deposition of fibrin upon the peritoneum.[ncbi.nlm.nih.gov]
Infertility
  • BACKGROUND: Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction.[ncbi.nlm.nih.gov]
Asymptomatic
  • In 14/26 the fibrosis was asymptomatic, an incidental autopsy finding. Intestinal obstruction in 12/26 (46%), the only symptomatic manifestation, was fatal in five. The etiology of peritoneal fibrosis in shunted patients is unknown.[ncbi.nlm.nih.gov]
Peritoneal Disease
  • Diseases Digestive System Diseases Spironolactone Mineralocorticoid Receptor Antagonists Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Diuretics, Potassium Sparing Diuretics Natriuretic Agents[clinicaltrials.gov]
Vascular Disease
  • Reduced blood flow to the lower limbs may cause features of peripheral vascular disease. The most common presentation is pain, which may occur in the loin, back, scrotum or the lower abdomen.[patient.info]
Suggestibility
  • In recent researches, Wnt/β-catenin induced epithelial to mesenchymal transition was suggested to be an important reason for tissues and organs fibrosis.[ncbi.nlm.nih.gov]
  • An association has also been identified between increased submesothelial thickness in the peritoneal membrane and increased solute transport, suggesting a relationship between PF and loss of ultrafiltration capacity.[ncbi.nlm.nih.gov]
  • Emerging evidence suggests that extracellular microRNAs in body fluids are promising biomarkers for the diagnosis of diseases. microRNAs were reported to be involved in multiple fibrotic diseases and the serum levels of specific microRNAs were correlated[ncbi.nlm.nih.gov]
  • CONCLUSION: These results suggested that exogenous HGF could possibly prevent peritoneal fibrosis.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Our results suggest that p38MAPK signaling contributes to peritoneal fibrosis by regulating fibrocyte function.[ncbi.nlm.nih.gov]

Workup

  • Pipitone N, Versari A, Vaglio A, Salvarani C: Role of 18 F-fluorodeoxyglucose positron emission tomography in the workup of retroperitoneal fibrosis. Clin Exp Rheumatol 2011;29(1 suppl 64):S72-S78. Author Contacts Dr. med.[karger.com]
Glucose Increased
  • In MeT-5A cells, high glucose increased TGF-β expression and VEGF secretion, which were blocked by Y-27632. CONCLUSIONS: The activation of Rho-kinase is involved in peritoneal damage at multiple stages including tissue fibrosis and angiogenesis.[ncbi.nlm.nih.gov]

Treatment

  • In a PD rat model, treatment with an SRF inhibitor silenced miR-199a-5p and miR-214-3p and alleviated HG-PD fluid-induced damage and fibrosis.[ncbi.nlm.nih.gov]
  • Therefore, the prevention and treatment of peritoneal fibrosis is important to maintain peritoneal membrane integrity and prolong peritoneal dialysis treatment.[ncbi.nlm.nih.gov]
  • Abstract Peritoneal dialysis (PD) is a modality for treatment of patients with end-stage renal disease (ESRD) that depends on the structural and functional integrity of the peritoneal membrane.[ncbi.nlm.nih.gov]
  • The key issue is how to diagnose EPS early enough to allow for curative treatment.[ncbi.nlm.nih.gov]
  • In a rat model, intraperitoneal injection of Staphylococcus aureus and fibrinogen induced severe EPS features, which were attenuated by PTX treatment.[ncbi.nlm.nih.gov]

Prognosis

  • References: [3] [1] [4] [5] Pathophysiology Clinical features References: [3] [1] [4] [6] [7] [8] [9] Diagnostics Treatment Prognosis[amboss.com]
  • […] has a poor prognosis.[patient.info]
  • What is the Prognosis of a Patient suffering from Retroperitoneal Fibrosis? Prognosis or outcome of retroperitoneal fibrosis depends on the extent of kidney damage.[medindia.net]
  • University, Shenyang, China; 2 Department of Surgical Oncology, The First Hospital of China Medical University, Shenyang, China Background: Peritoneal metastasis frequently occurs in patients with advanced ovarian cancer and is the main basis for a poor prognosis[dovepress.com]
  • The prognosis for patients with the disorder varies according to the type. It is relatively good for idiopathic retroperitoneal fibrosis, with a small long-term effect on quality and quantity of life.[news-medical.net]

Etiology

  • Etiology Secondary retroperitoneal fibrosis Malignancies and exposure to methysergide are the most common causes of secondary RPF ![amboss.com]
  • The etiology of peritoneal fibrosis in shunted patients is unknown.[ncbi.nlm.nih.gov]
  • Displacement of the aorta and IVC anteriorly away from the vertebral bodies is suggestive of malignant etiology. Invasion and disruption of bone and/or soft tissue structures suggests an aggressive process - infection or malignancy.[radiopaedia.org]
  • […] secondarily Some cases belong to the spectrum of IgG4 related disease Terminology Also called Ormond's disease, idiopathic retroperitoneal fibrosis Sites Arises in retroperitoneum, often at aortic bifurcation Gastrointestinal tract involvement is rare Etiology[pathologyoutlines.com]
  • As the etiology of idiopathic RPF remains unclear and due to the lack of controlled trials, the medical treatment of RPF is still rather empirical.[karger.com]

Epidemiology

  • Epidemiology Epidemiological data refers to the US, unless otherwise specified. Etiology Secondary retroperitoneal fibrosis Malignancies and exposure to methysergide are the most common causes of secondary RPF ![amboss.com]
  • Epidemiology Retroperitoneal fibrosis is an uncommon disease that affects 1 person per 200,000-500,000 population per year, depending on the specific location.[news-medical.net]
  • Epidemiology Retroperitoneal fibrosis is rare disease. Idiopathic retroperitoneal fibrosis accounts for over 70% of cases.[patient.info]
  • Changes in the worldwide epidemiology of peritoneal dialysis. Nat Rev Nephrol 2017; 13(2): 90–103 doi: 10.1038/nrneph.2016.181 pmid: 28029154 3 Loureiro J, Gónzalez-Mateo G, Jimenez-Heffernan J, Selgas R, López-Cabrera M, Aguilera Peralta A.[journal.hep.com.cn]
Sex distribution
Age distribution

Pathophysiology

  • Recently, the pathophysiologic mechanisms that contribute to the fibrosing process have been intensively studied. Transforming growth factor-beta has been shown to be a key mediator of PF.[ncbi.nlm.nih.gov]
  • This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammation and angiogenesis, including Toll-like receptor ligand-mediated, NOD-like receptor protein 3[ncbi.nlm.nih.gov]
  • References: [3] [1] [4] [5] Pathophysiology Clinical features References: [3] [1] [4] [6] [7] [8] [9] Diagnostics Treatment Prognosis[amboss.com]
  • Mesenchymal conversion of mesothelial cells is a key event in the pathophysiology of the peritoneum during peritoneal dialysis. Adv Med 2014; 2014: 473134 doi: 10.1155/2014/473134 16 Di Paolo N, Sacchi G. Atlas of peritoneal histology.[journal.hep.com.cn]

Prevention

  • CONCLUSION: These results suggested that exogenous HGF could possibly prevent peritoneal fibrosis.[ncbi.nlm.nih.gov]
  • This review will describe the role and mechanisms of RTKs in peritoneal fibrosis and discuss the possibility of using them as therapeutic targets for prevention and treatment of this complication.[ncbi.nlm.nih.gov]
  • This study aimed to determine the efficacy of a high-density collagen xerogel thread (CXT) for the prevention of peritoneal fibrosis.[pubs.rsc.org]
  • As cannabinoid receptor (CBR) ligands have been reported to be beneficial to ameliorate the process of liver fibrosis, we strove to investigate their therapeutic potential to prevent peritoneal fibrosis.[ncbi.nlm.nih.gov]
  • Thus, to maintain long-term PD and improve quality of life for patients, it is important to develop interventions for prevention and treatment of PF.[ncbi.nlm.nih.gov]

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