Metastatic spread of malignant tumors into the peritoneum, a two-layered (parietal and visceral) mesothelial lining, is almost universally fatal within a short period of time, as only palliative therapeutic measures may be implemented at this stage of progression [1] [2] [3] [4] [5]. Neoplasms of the gastrointestinal system (particularly colorectal cancer) and the genitourinary tract, as well as hepatic, pancreatic, and primary peritoneal tumors (mesothelioma), are known for their propensity to metastasize into this anatomical landmark, and they are able to do so in several ways [1] [2] [4] [6]. Proximal masses (eg. gastrointestinal or ovarian cancers) are able to directly penetrate into the peritoneum, whereas spread via the lymphatic or hematogenous routes (typical for more distant primary malignancies, such as melanoma, lung cancer, or breast cancer), as well as intraperitoneal dissemination of the tumor through ascitic fluid (a potential complication during surgical procedures), are other possible routes [1] [2] [6]. The clinical presentation of peritoneal metastasis is quite variable, and often depends on the location and the severity of tumor invasion, but in most cases, the initial course is asymptomatic [2]. The majority of patients, however, develop symptoms of abdominal pain, distension, and discomfort (developing as a result of bowel obstruction), followed by weight loss, nausea, vomiting, and severe fatigue with cachexia [1] [2] [4].

• Pain

  The most frequent grade 3/4 adverse events were neutropenia (38.6%) and abdominal pain (30.8%). The incidence of abdominal pain cumulatively increased in the later treatment cycles. [ncbi.nlm.nih.gov]

  The clinical presentation is initially asymptomatic, but at some point, complaints of abdominal pain, weight loss, and ascites appear. [symptoma.com]

  Symptoms include ascites, abdominal pain, nausea, vomiting. [wikidoc.org]

• Weight Loss

  The clinical presentation is initially asymptomatic, but at some point, complaints of abdominal pain, weight loss, and ascites appear. [symptoma.com]

  We report an unusual presentation of chronic appendicitis with a synchronous peritoneal nodule on CT in a 76-year-old woman who presented with poor appetite, weight loss and a mass in the right iliac fossa. [ncbi.nlm.nih.gov]

  Symptoms and Diagnosis The symptoms of local spread of bowel cancer can be vague, but are likely to include unexplained pain, tenderness over the area, or unusual discharges, changed appetite or unexpected weight loss. [bowelcanceraustralia.org]

  Presents with abdominal pain and distension, fever, night sweats, weight loss, and altered bowel habits. Ascites is present in about half of cases. Abdominal mass may be felt in a third of cases. [wikidoc.org]

• Pleural Effusion

  Seventeen (37.0%) and 5 patients (11.0%) had malignant pleural effusion (MPE) and brain metastasis at MPC diagnosis, respectively. [dovepress.com]

  […] carcinosis [ edit ] Pleural carcinosis is associated with malignant pleural effusion and poor prognosis. [7] Leptomeningeal carcinomatosis [ edit ] The meningeal covering of the central nervous system may be the site of tumor growth. [en.wikipedia.org]

  Chest X-Ray showed a left-sided pleural effusion. As a palliative measure, the patient was treated with chemotherapy consisting of gemcitabine and carboplatin due to poor performance status. [ijcasereportsandimages.com]

  Many studies have shown that cells of mesothelial lineage can be successfully obtained by in vitro culture of peritoneal or pleural effusion [ 9 – 11 ]. [journals.plos.org]

  Based on results of studies now available, NACT regimen should be personalized and administered to patients with bulky intraperitoneal disease at risk of incomplete CRS, or to patients with small metastatic pleural effusion or with small isolated liver [intechopen.com]

• Abdominal Pain

  The most frequent grade 3/4 adverse events were neutropenia (38.6%) and abdominal pain (30.8%). The incidence of abdominal pain cumulatively increased in the later treatment cycles. [ncbi.nlm.nih.gov]

  The clinical presentation is initially asymptomatic, but at some point, complaints of abdominal pain, weight loss, and ascites appear. [symptoma.com]

  Symptoms include ascites, abdominal pain, nausea, vomiting. [wikidoc.org]

• Abdominal Distension

  There has been no standard treatment for this severe disease, and the conventional palliative therapy could only reach an overall survival of 6 to 14 months PATIENT CONCERNS:: A 38-year-old male with a chief complain of "abdominal distension and diagnosis [ncbi.nlm.nih.gov]

  Presents with abdominal pain and distension, fever, night sweats, weight loss, and altered bowel habits. Ascites is present in about half of cases. Abdominal mass may be felt in a third of cases. [wikidoc.org]

  CASE SUMMARY A 50-year-old male with history of cirrhosis secondary to Hepatitis B and C and treated multiple myeloma presented to the emergency department with abdominal distension, confusion, and lethargy. [appliedradiology.com]

  Case report We report the case of a 36-year-old woman with previous complains of abdominal pain and moderate abdominal distension who was admitted in our hospital. [medichub.ro]

• Abdominal Mass

  The abdominal mass was 26 x 17 x 12 cm in size, as determined by magnetic resonance imaging, and was diagnosed as a peritoneal relapse of GIST. Treatment with 400 mg of imatinib daily was started. [ncbi.nlm.nih.gov]

  On the left a 33-year-old man who complains of an increasing abdominal girth, abdominal fullness, and a palpable abdominal mass. First study the images on the left and continue with the MR. [radiologyassistant.nl]

  Presents with abdominal pain and distension, fever, night sweats, weight loss, and altered bowel habits. Ascites is present in about half of cases. Abdominal mass may be felt in a third of cases. [wikidoc.org]

• Constipation

  Gastrointestinal symptoms (nausea/vomiting, constipation, diarrhoea, anorexia) remained stable under PIPAC therapy. [ncbi.nlm.nih.gov]

  The beginning symptoms of peritoneal mesothelioma include abdominal distension, abdominal pain, swelling or tenderness around the abdomen and constipation or diarrhea. [asbestos.com]

  Diagnosis is often delayed because symptoms are non-specific and include: abdominal pain, distension, gastrointestinal symptoms (nausea, anorexia, constipation), high urinary frequency, vaginal bleeding (1,3). [medichub.ro]

  Symptoms of peritoneal carcinomatosis may include the following: [4] Abdominal distension Nausea Bloating Intermittent abdominal pain Vomiting Alternating diarrhea and constipation Physical Examination Patients with peritoneal carcinomatosis usually appear [wikidoc.org]

• Pelvic Mass

  We present a case of a 36-year-old woman with cough, hemoptysis, dyspnea with detection of lung mass, and incidental detection of pelvic mass. Fine needle aspiration cytology failed to reveal the true nature of both the lesions. [ncbi.nlm.nih.gov]

  […] ultrasound demonstrating a multicystic pelvic lesion next to the uterus, which proved to be a peritoneal inclusion cyst. [radiologyassistant.nl]

• Agitation

  HIPEC is the subsequent administration of high dosages of chemotherapy into the peritoneum under hyperthermia (40 °C-42 °C) for 60-90 min under constant agitation. [wjgnet.com]

• Incontinence

  Indications Permanent: for rectal amputation to avoid permanent incontinence of poor anal sphincter function (Hartmann's operation) to relieve an inoperable fistula anally from the stoma Temporary: for preoperative radiation relief of rectal ileus Sigmoid [oncolex.org]

The clinical manifestation of peritoneal metastasis is nonspecific, but the observation of a newly formed ascites must raise suspicion toward a malignant etiology [2]. For this reason, the physician must obtain a detailed patient history that will assess the duration of symptoms, their onset, as well as progression, whereas anamnestic data of malignant diseases is crucial for making a presumptive diagnosis. In fact, up to 50% of gastric cancers and 10-35% of colorectal cancers recur as peritoneal metastasis [3]. After a thorough physical examination, imaging studies need to be employed. Abdominal ultrasonography, a common first-line procedure, provides little benefit when it comes to visualizing the metastatic deposits, but its use as a guide to obtain a viable sample of the ascitic fluid or of superficial tumors for histopathological testing is invaluable [6]. Instead, more advanced methods - computed tomography and magnetic resonance imaging are the cornerstones for identifying peritoneal metastasis and tumor spread [2] [3] [6] [7]. Typical findings range from multifocal nodules to aggressive infiltrating masses, whereas stellate lesions and calcifications might also be encountered [2] [7]. MRI is particularly effective if used with gadolinium as a contrast, and images should be obtained 5-10 minutes after the agent is administered [2]. The diagnosis can be further solidified through the use of fluorodeoxyglucose (FDG)-PET [2].

• Pleural Effusion

  Seventeen (37.0%) and 5 patients (11.0%) had malignant pleural effusion (MPE) and brain metastasis at MPC diagnosis, respectively. [dovepress.com]

  […] carcinosis [ edit ] Pleural carcinosis is associated with malignant pleural effusion and poor prognosis. [7] Leptomeningeal carcinomatosis [ edit ] The meningeal covering of the central nervous system may be the site of tumor growth. [en.wikipedia.org]

  Chest X-Ray showed a left-sided pleural effusion. As a palliative measure, the patient was treated with chemotherapy consisting of gemcitabine and carboplatin due to poor performance status. [ijcasereportsandimages.com]

  Many studies have shown that cells of mesothelial lineage can be successfully obtained by in vitro culture of peritoneal or pleural effusion [ 9 – 11 ]. [journals.plos.org]

  Based on results of studies now available, NACT regimen should be personalized and administered to patients with bulky intraperitoneal disease at risk of incomplete CRS, or to patients with small metastatic pleural effusion or with small isolated liver [intechopen.com]

CRS and HIPEC for PM were compared in others trials with different intraperitoneal treatments without hyperthermia or with no intraperitoneal treatment or with intravenous chemotherapy. Inclusions were closed for the French study - PRODIGE 7. [ncbi.nlm.nih.gov]

BACKGROUND/AIMS: Peritoneal metastasis (PM) is a well-known predictor of poor prognosis. This study aims at identifying factors affecting recurrence and prognosis after R0 resection for colorectal cancer (CRC) with synchronous PM. [ncbi.nlm.nih.gov]

The clinical manifestation of peritoneal metastasis is nonspecific, but the observation of a newly formed ascites must raise suspicion toward a malignant etiology. [symptoma.com]

Sari R, Yildirim B, Sevinc A, et al: The importance of serum and ascites fluid alpha-fetoprotein, carcinoembryonic antigen, CA 19-9, and CA 15-3 levels in differential diagnosis of ascites etiology. [mayomedicallaboratories.com]

Pathologically it is a chronic inflammation of unknown etiology. This entity is more common than previously thought. The signs and symptoms are variable. [radiologyassistant.nl]

Intraperitoneal abscesses Most common etiologies being Gastrointestinal perforations, postoperative complications, and penetrating injuries. [wikidoc.org]

The epidemiology of patients with peritoneal metastases mirrors that of affected patients. [radiopaedia.org]

Epidemiology and risk factors of urothelial bladder cancer. Eur Urol 2013 Feb;63(2):234–41. [ CrossRef ] [ Pubmed ] Quinn DI. Nonurothelial bladder cancer. UptoDate. 2014. Pevarski DJ, Mergo PJ, Ros PR. [ijcasereportsandimages.com]

Epidemiology and Demographics The prevalence of peritoneal carcinomatosis is approximately 0.03 per 100,000 individuals worldwide. [5] Age Peritoneal carcinomatosis is more commonly observed among patients aged 50 - 70 years. [6] Peritoneal carcinomatosis [wikidoc.org]

Asbestos: Risk Assessment, Epidemiology, and Health Effects, Second Edition. Taylor & Francis: Boca Raton, 2012. Bridda, A. et al. (2007). Peritoneal mesothelioma: A review. Med Gen Med., 9(2), 32. [asbestos.com]

Useful For Suggests clinical disorders or settings where the test may be helpful An adjunct to cytology to differentiate between malignancy-related ascites and benign causes of ascites formation Clinical Information Discusses physiology, pathophysiology [mayomedicallaboratories.com]

"Pathophysiology and biology of peritoneal carcinomatosis". World J Gastrointest Oncol. 2 (1): 12–8. doi : 10.4251/wjgo.v2.i1.12. PMC 2999153. PMID 21160812. ↑ Thomassen I, van Gestel YR, Lemmens VE, de Hingh IH (2013). [wikidoc.org]

RESULTS: Four trials (Dutch, French, Italian and Spanish) focussed on a preventive strategy to decrease the rate of CRC-PM. Inclusions were closed for the French study - ProphyloCHIP. [ncbi.nlm.nih.gov]

The present report suggests the importance of paying close attention to procedures during laparoscopic colorectal resection to prevent peritoneal seeding. J. Med. Invest. 64: 288-290, August, 2017 [jstage.jst.go.jp]

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