METHODS: Referential recordings to stimuli consisting of photic stimulation presented in blocks were obtained. A total of 25 blocks, 15-stimuli each, were presented. Intrablock and interblock habituation effects were analyzed. [ncbi.nlm.nih.gov]

A moderate subdural effusion is present over the convexity. Caption: Semiaxial scan through anterior fontanelle. Description: Cystic changes of PVL are present in the perventricular white matter adjacent to the lateral ventricles. [sonoworld.com]

In the present study, 17 children had various degrees of mental retardation. [spandidos-publications.com]

• Encephalopathy

  This study underscores the potential role of secondary cortical injury in the encephalopathy of prematurity. [ncbi.nlm.nih.gov]

  The risk of a composite outcome including death, adverse respiratory outcomes, hypoglycemia, treated hyperbilirubinemia, generalized seizures, necrotizing enterocolitis, hypoxic ischemic encephalopathy, periventricular leukomalacia, and suspected or proven [medical-dictionary.thefreedictionary.com]

  The encephalopathy of CHD affects mature infants and has identical imaging and pathological features to WMI affecting preterm infants. [neuropathology-web.org]

  […] and Hypoxic Ischemic Encephalopathy Neonatal encephalopathy (NE) is a similar condition that overlaps with hypoxic ischemic encephalopathy. [childbirthinjuries.com]

• Quadriplegia

  They showed similar clinical courses including oculoclonic seizure, hypsarrhythmia and severe mental retardation, in addition, to spastic quadriplegia. [ncbi.nlm.nih.gov]

  Quadriplegia and diplegia were most common among the subtypes of CP, and hearing impairment was the most common comorbidity. The type of CP most commonly associated with comorbidity was quadriplegia. [spandidos-publications.com]

  Cerebral palsy - Spastic diplegia (tight muscles and limbs that do not bend easily) is the most common type of cerebral palsy caused by periventricular leukomalacia; quadriplegia is the most severe. Investigations: Cranial ultrasounds, CT and MRI. [neuroradiologycases.com]

[…] involved in neurosciences, as well as rehabilitation professionals, will be interested by this ensuing publication.The volume covers pathogenic aspects of brain lesions occurring in the fetal and neonatal period, and addresses the issues of diagnostic workup [books.google.ro]

Treatment [ edit ] Current treatments [ edit ] Currently, there are no treatments prescribed for PVL. All treatments administered are in response to secondary pathologies that develop as a consequence of the PVL. [en.wikipedia.org]

To evaluate the effect of antenatal steroid treatment on the development of neonatal periventricular leukomalacia. [ncbi.nlm.nih.gov]

There is no treatment for PVL and the prognosis varies depending on the severity of the damage to the brain. [childrenshospital.org]

Outlook (Prognosis) PVL often leads to nervous system and developmental problems in growing babies. These problems most often occur during the first to second year of life. [mountsinai.org]

Prognosis The prognosis for individuals with PVL depends upon the severity of the brain damage. [ninds.nih.gov]

Some will consider the presence of cysts, location, extent, and persistence of lesions in estimating prognosis. [em-consulte.com]

There is no treatment for PVL and the prognosis varies depending on the severity of the damage to the brain. [childrenshospital.org]

Gov't Video-Audio Media MeSH terms Animals Brain Ischemia/etiology Brain Ischemia/metabolism Brain Ischemia/pathology Disease Models, Animal* Humans Hypoxia-Ischemia, Brain/etiology Hypoxia-Ischemia, Brain/metabolism Hypoxia-Ischemia, Brain/pathology [ncbi.nlm.nih.gov]

[…] cesarean section, APGAR score, ante and postnatal indomethacin, acidosis, hypotension, tension pneumothorax, hypocarbia, oxygen dependency at 3 28 day) and infectious factors (premature rupture of membranes, chorioamnionitis, neonatal sepsis) in the etiology [nature.com]

Cerebral Palsy Etiology Etiology is the study of the causes and origins of diseases. Cerebral palsy etiology is the study of how cerebral palsy starts and what causes it. [childbirthinjuries.com]

The etiologic fraction is interpreted as the proportion of periventricular leukomalacia cases that are potentially preventable by administration of antenatal steroids. [journals.lww.com]

(Etiology) The exact cause of development of Periventricular Leukomalacia is currently unknown. [dovemed.com]

Author information 1 Department of Epidemiology and Biostatistics, Radboud University, Nijmegen, The Netherlands. [email protected] Abstract Intraventricular hemorrhage and cystic periventricular leukomalacia are often co-occurring characteristics [ncbi.nlm.nih.gov]

Developmental Epidemiology Network Investigators. Pediatr Res. 1999 Nov. 46(5):566-75. [Medline]. Liao SL, Lai SH, Chou YH, Kuo CY. [emedicine.medscape.com]

Two separate decision trees (DTs) have been developed for the classification purpose and more importantly to discover hidden relationships that exist among the data to help us better understand PVL pathophysiology. [ncbi.nlm.nih.gov]

Pathophysiology The pathophysiology of periventricular leukomalacia is a complex process. Periventricular leukomalacia occurs because of ischemia induced injury to oligodendrocytes in the periventricular area of the developing brain. [emedicine.medscape.com]

Supplementation of surfactant treatment with spD may be the key point in prevention of PVL by supression of inflammation and preventing damage to pre-OLs in a vulnerable premature brain operating through TLRs. [ncbi.nlm.nih.gov]

[…] of PVL to developing protocols for the prevention of PVL development. [en.wikipedia.org]

It is essential to prevent hypocarbia, hypoxemia, and abnormal blood pressure. [abclawcenters.com]

It is the medical professionals’ responsibility to prevent or delay a premature birth to minimize the risk of PVL. [michigancerebralpalsyattorneys.com]