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Periventricular Leukomalacia


Presentation

  • METHODS: Referential recordings to stimuli consisting of photic stimulation presented in blocks were obtained. A total of 25 blocks, 15-stimuli each, were presented. Intrablock and interblock habituation effects were analyzed.[ncbi.nlm.nih.gov]
Sudden Infant Death Syndrome
  • However, it is important to distinguish death caused by PVL from the Sudden Infant Death Syndrome because the implications for the family are quite different. This case report emphasizes that PVL may be fatal.[ncbi.nlm.nih.gov]
Painter
  • Painter, Bharath Wootla, Louisa M. Papke, Aleksandar Denic, Jill M. Weimer, William A.[doi.org]
Hydrops Fetalis
  • We describe a preterm infant of 32 weeks' gestation with hydrops fetalis due to intrauterine supraventricular tachycardia.[ncbi.nlm.nih.gov]
Tonic-Clonic Seizure
  • The most common seizure pattern observed was generalized tonic clonic seizures (n 13) and complex partial seizures (n 11).[ncbi.nlm.nih.gov]

Workup

  • […] involved in neurosciences, as well as rehabilitation professionals, will be interested by this ensuing publication.The volume covers pathogenic aspects of brain lesions occurring in the fetal and neonatal period, and addresses the issues of diagnostic workup[books.google.ro]
Hypsarrhythmia
  • They showed similar clinical courses including oculoclonic seizure, hypsarrhythmia and severe mental retardation, in addition, to spastic quadriplegia.[ncbi.nlm.nih.gov]
Epileptiform Activity
  • KEYWORDS: cerebral palsy; preterm birth; sleep-potentiated epileptiform activity[ncbi.nlm.nih.gov]
Ischemic Changes
  • Periventricular leukomalacia (PVL) is a pathological entity characterized by ischemic changes in areas adjacent to the external angles of the lateral ventricles. It is associated with serious neurodevelopmental sequelae, especially spastic diplegia.[ncbi.nlm.nih.gov]

Treatment

  • However, neotrofin treatment in the postnatal period was not as effective as intrauterine treatment.[ncbi.nlm.nih.gov]
  • Treatment [ edit ] Current treatments [ edit ] Currently, there are no treatments prescribed for PVL. All treatments administered are in response to secondary pathologies that develop as a consequence of the PVL.[en.wikipedia.org]
  • Treatment There is no specific treatment for PVL. Treatment is symptomatic and supportive. Children with PVL should receive regular medical screenings to determine appropriate interventions. Treatment There is no specific treatment for PVL.[ninds.nih.gov]

Prognosis

  • Prognosis The prognosis for individuals with PVL depends upon the severity of the brain damage.[ninds.nih.gov]
  • It is suggested that echography is of value in the early diagnosis of this lesion which may be similar to intraparenchymal hemorrhage in its mechanism and prognosis.[ncbi.nlm.nih.gov]
  • PVL Prognosis Prognosis greatly depends upon the severity of the disease. While some children will have relatively minor problems, others may have severe disabilities and deficits for life.[birthinjuryguide.org]
  • Outlook (Prognosis) PVL often leads to nervous system and developmental problems in growing babies. These problems most often occur during the first to second year of life.[mountsinai.org]

Etiology

  • Gov't Video-Audio Media MeSH terms Animals Brain Ischemia/etiology Brain Ischemia/metabolism Brain Ischemia/pathology Disease Models, Animal* Humans Hypoxia-Ischemia, Brain/etiology Hypoxia-Ischemia, Brain/metabolism Hypoxia-Ischemia, Brain/pathology[ncbi.nlm.nih.gov]
  • Cerebral Palsy Etiology Etiology is the study of the causes and origins of diseases. Cerebral palsy etiology is the study of how cerebral palsy starts and what causes it.[childbirthinjuries.com]
  • The etiologic fraction is interpreted as the proportion of periventricular leukomalacia cases that are potentially preventable by administration of antenatal steroids.[journals.lww.com]
  • (Etiology) The exact cause of development of Periventricular Leukomalacia is currently unknown.[dovemed.com]
  • […] cesarean section, APGAR score, ante and postnatal indomethacin, acidosis, hypotension, tension pneumothorax, hypocarbia, oxygen dependency at 3 28 day) and infectious factors (premature rupture of membranes, chorioamnionitis, neonatal sepsis) in the etiology[nature.com]

Epidemiology

  • Author information 1 Department of Epidemiology and Biostatistics, Radboud University, Nijmegen, The Netherlands. cynthiakusters@gmail.com Abstract Intraventricular hemorrhage and cystic periventricular leukomalacia are often co-occurring characteristics[ncbi.nlm.nih.gov]
  • Developmental Epidemiology Network Investigators. Pediatr Res. 1999 Nov. 46(5):566-75. [Medline]. Liao SL, Lai SH, Chou YH, Kuo CY.[emedicine.com]
Sex distribution
Age distribution

Pathophysiology

  • Two separate decision trees (DTs) have been developed for the classification purpose and more importantly to discover hidden relationships that exist among the data to help us better understand PVL pathophysiology.[ncbi.nlm.nih.gov]
  • ; schema:name " Nervous system--Diseases " ;. # Nervous system--Pathophysiology a schema:Intangible ; schema:name " Nervous system--Pathophysiology " ;. rdfs:comment " Accès réservé UdeM " ;. # Neuropathology (En ligne) schema:name " Neuropathology ([worldcat.org]
  • Pathophysiology The pathophysiology of periventricular leukomalacia is a complex process. Periventricular leukomalacia occurs because of ischemia induced injury to oligodendrocytes in the periventricular area of the developing brain.[emedicine.com]
  • Google Scholar Crossref Medline ISI Hotchkiss RS, Karl IE : The pathophysiology and treatment of sepsis. N Engl J Med 2003 ;348: 138 — 150.[doi.org]

Prevention

  • Supplementation of surfactant treatment with spD may be the key point in prevention of PVL by supression of inflammation and preventing damage to pre-OLs in a vulnerable premature brain operating through TLRs.[ncbi.nlm.nih.gov]
  • What research is being done to prevent PVL? Because PVL can’t be reversed, researchers are trying to find a way to prevent the loss of cells needed to form the white matter in the brain by using neuroprotective therapies.[hopefn3.org]
  • Is There Any Way to Prevent PVL? Since PVL can be caused by unknown factors, prevention can be difficult.[cerebralpalsyguidance.com]
  • […] of PVL to developing protocols for the prevention of PVL development.[en.wikipedia.org]
  • Prevention and treatment of periventricular leukomalacia (PVL) Delaying premature birth, or preventing decreased oxygenation during an inevitable premature birth, is the most important step in decreasing the risk of PVL.[abclawcenters.com]

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