Heart size was variable but some degree of cardiomegaly was commonly present. Tolazoline, a potent vasodilator, was useful diagnostically and may have resulted in increased survival. [ncbi.nlm.nih.gov]

Early or prophylactic treatment of respiratory distress syndrome (RDS) with surfactant appears to be more effective than treatment once RDS has developed. [ncbi.nlm.nih.gov]

Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. [books.google.com]

[…] in this case. 4) With a timely diagnosis and proper surgical treatment, ECMO, as a bridge treatment, can save the neonate's life without further complications. [synapse.koreamed.org]

Functional obstruction of pulmonary blood flow: This has a good prognosis if it is reversible. Causes include polycythemia and hyperfibrinogenemia. [en.wikipedia.org]

Poor prognosis. Secondary PFC Most commonly seen in infants with lung disease, where hypoxia and acidosis leads to pulmonary vasoconstriction and persistently elevated PVR. [openanesthesia.org]

The prognosis is much better for babies weighing over 1500 g. Prevention Antenatal corticosteroids (dexamethasone) accelerate fetal surfactant production and lung maturation. [patient.info]

Complications and Prognosis PPHN is a serious condition and intensive monitoring and treatment are critical. [chdbabies.com]

Prognosis FMH is followed by fetal anemia which has severe consequences such as neurologic injury, stillbirth, or neonatal death(3). [medichub.ro]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

We postulate that hypovolemia may be one factor in the etiology of persistent fetal circulation (PFC). [nature.com]

pathogenesis primary (idiopathic) — affects term infants an has no obvious pulmonary or cardiovascular causes secondary — with known etiology for example lung hypoplasia, masive meconium aspiration, pneumonia, congenital heart diseases or bronchopulmonary [atlases.muni.cz]

In our case, the etiology was unclear. [synapse.koreamed.org]

There are 3 main categories of etiologies of persistent fetal circulation (PFC) in the newborn: Congenital heart defect Any congenital heart defect which results in elevated pulmonary artery or RV pressures will have PFC in order to allow adequate cardiac [openanesthesia.org]

To conduct an epidemiologic study of persistent pulmonary hypertension of the newborn ( PPHN) infant. [clinicaltrials.gov]

CONCLUSIONS: This large multicenter epidemiologic study of PPHN risk revealed no evidence to support the hypothesis that maternal consumption during pregnancy of NSAIDs overall or ibuprofen in particular is associated with PPHN risk. [pediatrics.aappublications.org]

Our study is part of a large case–control study of risk factors for PPHN, conducted within the Birth Defects Study of the Slone Epidemiology Center. [doi.org]

NCT01203423 24 NO Need to Ventilate: A Trial of Non-invasive Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn Completed NCT00139217 Not Applicable iNO 25 Risk Factors for Pulmonary Hypertension of the Newborn Completed NCT00005497 26 Epidemiology [malacards.org]

Use of this method allows not only attainment of clinically useful information but also permits better insight into the pathophysiology of the disease state. [ncbi.nlm.nih.gov]

Etiology/Pathophysiology: Persistent or recurrent pulmonary artery hypertension with right to left shunting through a patent foramen ovale and patent ductus arteriosus in a patient with pulmonary disease. [virtualpediatrichospital.org]

Kilchemmann Fuentes C, Vallejos Vallejos C, Román Navarro A The fetal circulation, pathophysiology of hypoxemic respiratory failure and pulmonary hypertension in neonates, and the role of oxygen therapy. Lakshminrusimha S, Saugstad OD [medicbind.com]

Persistent Pulmonary Hypertension Of The Newborn Table of Contents Nomenclature Definition Changes in Pulmonary Circulation at Birth Pathophysiology Diagnosis Treatment - Discussion Treatment - Local Practice Outcome Nomenclature Persistent pulmonary [web.archive.org]

A clear understanding of the pathophysiology is required to optimize treatment. [link.springer.com]

0% Emergent - ED Care Needed - Preventable/Avoidable - 0% Emergent - ED Care Needed - Not Preventable/Avoidable - 0% Primary diagnosis of injury 0% Primary diagnosis of mental health problems 0% Primary diagnosis of substance abuse 0% Primary diagnosis [medicbind.com]

Thus, early treatment with surfactant prevents the development of PFC. [ncbi.nlm.nih.gov]

However, PPHN causes an infant to revert back to fetal circulation, in which blood flow bypasses the lungs, preventing the baby from breathing. [birthinjuryguide.org]

Terminated NCT00409526 Phase 4 Inhaled Iloprost 5 Sildenofil in Persistent Pulmonary Hypertension in Newborns Unknown status NCT01558466 Phase 3 Sildenafil;diluent 6 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed [malacards.org]

This condition then signals the body to direct the blood away from the infant’s lungs, which prevents the blood from becoming adequately oxygenated. [fronzutolaw.com]