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Pertussis Vaccine


Presentation

  • Blocking of TLR2 and TLR4 showed that differences in antigen-presenting cell activation could be largely attributed to vaccine-dependent variation in hTLR4 signalling.[ncbi.nlm.nih.gov]
  • A 4-year-old boy with extensive swelling after vaccination with diphtheria-tetanus toxoid-acellular pertussis vaccine is presented.[ncbi.nlm.nih.gov]
  • In line with the results of these 2 recent Tdap effectiveness studies, we should examine our present Tdap immunization recommendations. It is my opinion that we should continue with our present Tdap schedules.[pediatrics.aappublications.org]
  • The results question the efficacy of the present immunization programmes. Copyright 2013 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.[ncbi.nlm.nih.gov]
  • This lack of knowledge presents a barrier against pertussis vaccination thus it is imperative that any future adult immunisation policy recommendations around pertussis vaccine include awareness programs in the target population.[ncbi.nlm.nih.gov]
Hunting
  • In the pages of Reader’s Digest, Paul DeKruif, a Grand Rapids native and author of the best seller Microbe Hunters, celebrated their study as one of the “greatest field tests in microbe-hunting history” ( 16 ).[wwwnc.cdc.gov]
  • In 1610, when witch-hunting was one of Europe's most popular blood sports, the exceptional Inquisitor Alnso Salazar y Frias took a first, serious look at who was being burned for what in the town of Logrono in Navarre, Spain.[overlawyered.com]
Localized Pain
  • However, an unexpected rise in the incidence of fever, irritability, local pain, redness and swelling was seen among children primed and boosted with acellular vaccines compared with those boosted with acellular vaccines after whole‐cell priming ( Appendix[doi.org]
Dentist
  • ., medical, nursing, and pharmaceutical), dentists, social workers, chaplains, volunteers, and dietary and clerical workers.[web.archive.org]
Acute Cough
  • The incidence of pertussis, defined as an acute cough illness of at least 5 days with laboratory confirmation, by culture, PCR, and/or serology, was 370 per 100,000 person-years.[cdc.gov]
Trismus
  • Generalized tetanus typically presents with trismus (lockjaw), followed by generalized rigidity caused by painful contractions of the skeletal muscles that can impair respiratory function.[cdc.gov]
Febrile Convulsions
  • In addition, we noted the occurrence of hypotonichyporesponsive episodes, febrile convulsions, and high-pitched unusual crying in association with DTP vaccine.[web.archive.org]
  • Acellular vaccines are also less likely to cause febrile convulsions and hypotonic‐hyporesponsive episodes during the primary series.[doi.org]

Workup

Hypsarrhythmia
  • […] yahoo.com Abstract The boy (case 1) at the age of 12 weeks started having attacks and jercked after the first injection of triple vaccine (diphtheria, retanus and whole cell pertussis) The electro-encephalogram (EEG) confirmed the typical features of hypsarrhythmia[ncbi.nlm.nih.gov]

Treatment

  • Among infants aged CONCLUSIONS: The first pertussis vaccine dose and antibiotic treatment protect against death, hospitalization, and pneumonia. Copyright 2015 by the American Academy of Pediatrics.[ncbi.nlm.nih.gov]
  • Treatment with sodium valproate was commenced. The children of both cases belong to a family in which there is a trendency to seizures. It seems unlikely the triple vaccine produced the infantile spasms in case 1.[ncbi.nlm.nih.gov]
  • Besides, positive association with pertussis was observed in subjects with a history of steroid treatment (OR 5.67) and those with a recent contact with a lasting cough (OR 4.12).[ncbi.nlm.nih.gov]
  • Treatment and Care Treatment for pertussis is generally limited to supportive care.[historyofvaccines.org]
  • If you are using any of these medications, you may not be able to receive the vaccine, or may need to wait until the other treatments are finished. This list is not complete.[drugs.com]

Etiology

  • Plausible outcomes of interest with elevated incidence rate ratios (IRRs) were further evaluated by reviewing individual patient records to confirm the diagnosis, timing (temporal relationship), alternative etiology, and other health record details to[ncbi.nlm.nih.gov]
  • Changes in genomic content of the etiologic agent, Bordetella pertussis, observed in the postvaccination era can have a bearing on the efficacy of vaccines currently in use.[ncbi.nlm.nih.gov]

Epidemiology

  • The epidemiologic situation and current knowledge of the limitations of pertussis vaccine point out the need to design improved vaccines. Several alternative approaches and their challenges are summarized.[ncbi.nlm.nih.gov]
  • Author information 1 Oregon Immunization Program. 2 Office of Disease Prevention and Epidemiology, Oregon Health Authority, Portland.[ncbi.nlm.nih.gov]
  • We have analyzed data on the diagnosis, epidemiology and vaccine history in order to understand the factors that might explain the trends of the disease.[ncbi.nlm.nih.gov]
  • Abstract The aim of this study was to describe recent changes in the epidemiology of pertussis and existing policies regarding recommended and mandatory occupational vaccinations for healthcare professionals (HCPs).[ncbi.nlm.nih.gov]
  • Pertussis - Epidemiology Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book). 13 th ed. 2015. 15 CDC Achievements in Public Health, 1900-1999 Impact of Vaccines Universally Recommended for Children -- United States, 1990-1998.[nvic.org]
Sex distribution
Age distribution

Pathophysiology

  • Ideally, new vaccination strategies for pertussis should be studied in a reasonably accessible animal model that can sense differences in clinical manifestations (more or less resembling human pathophysiology) after infection with B. pertussis strain[doi.org]

Prevention

  • Prevention of pertussis in industrialized countries is mainly based on immunization with acellular vaccines in combination with other antigens.[ncbi.nlm.nih.gov]
  • The results showed that even though there is general acceptance of prevention by vaccines, there is low awareness about pertussis vaccination.[ncbi.nlm.nih.gov]
  • Acellular pertussis vaccine (aP) with three or more antigens prevents around 85% of typical whooping cough cases in children.[en.wikipedia.org]
  • Our study population was categorized by age group and vaccination status based on the Centers for Disease Control and Prevention recommended pertussis vaccination schedule.[ncbi.nlm.nih.gov]
  • Centers for Disease Control and Prevention[medlineplus.gov]

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