Toxidromes "A pattern of signs or symptoms that suggests a specific class of poisoning" Opioids triad of respiratory depression, pinpoint pupils, decreased LOC bradycardia, hypotension, hypothermia needle tracks Sedative / Hypnotics - benzodiazepines, [mcgill.ca]

Rapid sunburn if exposed to the sun Skin discoloration, bluish (changing to purplish) Stomach and intestinal tract: Constipation Loss of appetite Nausea Other: Changes in menstrual pattern (in women, from chronic doses) Fever Low body temperature (hypothermia [indiatoday.intoday.in]

Temperature - hypothermia (phenothiazines, barbiturates, or tricyclics) or hyperthermia (amfetamines, ecstasy, MAOIs, cocaine, antimuscarinics, theophylline, serotonin syndrome). Muscle rigidity (ecstasy, amfetamines). [patient.info]

TOXIDROMES Opioids • Triad: respiratory depression, PPP, decreased level of consc • Bradycardia, hypotension, hypothermia Cholinergics: carbamate and organophosphate • SLUDGE • Seizures, coma • Muscle fasciculations • Miosis Serotonin Syndrome: fluoxetine [slideshare.net]

[…] short-term adjunctive management of anxiety, psychomotor agitation, excitement, and violent or dangerously impulsive behaviour; intractable hiccup; nausea and vomiting of terminal illness (where other drugs have failed or are not available); induction of hypothermia [inchem.org]

organ dysfunction syndrome, and much more. [books.google.de]

Complication Phenothiazine Antipsychotic Drug Poisoning Complications Complications of arrhythmia and hypotension Cardiovascular system mainly manifested as tachycardia and other arrhythmia, hypotension and even shock. [healthfrom.com]

Resuscitation: Reduced GCS: Prompt intubation and ventilation Hypotension: Give 10 – 20 ml/kg of IV crystalloid, if response is not adequate start noradrenaline ( adrenaline is contraindicated due to paradoxical hypotension from beta 2 mediated vasodilatation [lifeinthefastlane.com]

Hypotension has rarely presented a problem with fluphenazine, however, patients with phaeochromocytoma, cerebral vascular insufficiency, or a severe cardiac reserve deficiency such as mitral insufficiency appear to be particularly prone to hypotensive [home.intekom.com]

HYPOTENSION Hypotension should be managed by the administration of intravenous fluids and by physical means. [inchem.org]

Other toxic effects include bloody stools and vomitus, hypotension, shock, seizures, and coma. Heart failure is the usual cause of death. [glowm.com]

Unexplainable tachypnea and paradoxical miosis were noted in severe cases. In one case in the study phenothiazine intoxication was present in the newborn infant of a schizophrenic mother. [ncbi.nlm.nih.gov]

Miosis occurred in only 13.9% of the patients. Fluid boluses were administered to 28.7% of the patients but about a quarter of these had coingested potentially cardiotoxic drugs. [tandfonline.com]

TOXIDROMES Opioids • Triad: respiratory depression, PPP, decreased level of consc • Bradycardia, hypotension, hypothermia Cholinergics: carbamate and organophosphate • SLUDGE • Seizures, coma • Muscle fasciculations • Miosis Serotonin Syndrome: fluoxetine [slideshare.net]

The physician should be aware that the following have occurred with one or more phenothiazines and should be considered whenever one of these drugs is used: Autonomic Reactions: Miosis, obstipation, anorexia, paralytic ileus. [rxlist.com]

[…] poisoning caused by rare, and the side effects of treatment are more Common for the extrapyramidal reaction, the clinical can be seen in the following three categories: tremor paralysis syndrome; sit still (akathisia); acute tension disorders such as torticollis [healthfrom.com]

Extrapyramidal Symptoms: Akathisia, agitation, motor restlessness, dystonic reactions, trismus, torticollis, opisthotonus, oculogyric crises, tremor, muscular rigidity, akinesia. [rxlist.com]

These reactions are characterized by spastic contraction of discrete muscle groups and may include torticollis, opisthotonos, carpopedal spasm, trismus, difficulty swallowing, perioral spasms with protrusion of the tongue, and oculogyric crisis. [drugs.com]

Antipsychotics (antipsychotics) refers to the treatment of various types of mental illness and various psychiatric symptoms of drugs, also known as strong stabilizer or nerve blockers. [healthfrom.com]

Central Nervous System : The side effects most frequently reported with phenothiazine compounds are extrapyramidal symptoms including pseudo-parkinsonism, dystonia, dyskinesia, akathisia, oculogyric crises, opisthotonus, and hyperreflexia. [home.intekom.com]

[…] agitation, AMS hyperreflexia, tremor, myoclonus, trismus ataxia, incoordination flushing,diaphoresis diarrhea fever Difficult to distinguish from NMS, MH, cocaine intoxication, thyroid storm Extrapyramidal haloperidol, phenothiazines rigidity, tremor opisthotonus [mcgill.ca]

[…] fluoxetine, trazadone, meperidine • Irritability, agitation, altered mental status • Hyperreflexia, tremor, myoclonus, trismus • Ataxia, incoordination • Flushing, diaphoresis, fever • Diarrhea Extrapyramidal: haloperidol, phenothiazines • Rigidity, tremor • Opisthotonus [slideshare.net]

Extrapyramidal Symptoms: Akathisia, agitation, motor restlessness, dystonic reactions, trismus, torticollis, opisthotonus, oculogyric crises, tremor, muscular rigidity, akinesia. [rxlist.com]

The syndrome is characterized by involuntary choreoathetoid movements which variously involve the tongue, face, mouth, lips, or jaw (e.g., protrusion of the tongue, puffing of cheeks, puckering of the mouth, chewing movements), trunk, and extremities. [rxlist.com]

Reverse ocular bobbing due to combined phenothiazine and benzodiazepine poisoning. Statistics from Altmetric.com This is a PDF-only article. The first page of the PDF of this article appears above. [jnnp.bmj.com]