A case of ruptured pheochromocytoma is presented, the pathophysiology discussed, and the literature reviewed. [ncbi.nlm.nih.gov]

[…] to the emergency department because of substernal chest pain and dyspnea that had been present for two. . . [nejm.org]

• Intravenous Administration

  Phentolamine has a half-life in the blood of 19 minutes following intravenous administration. Approximately 13% of a single intravenous dose appears in the urine as unchanged drug. [medicineonline.com]

  The blood levels of phentolamine were determined following its administration intraorally and intravenously. [ncbi.nlm.nih.gov]

  […] phen·tol·a·mine test a test for pheochromocytoma; intravenous administration of phentolamine (5 mg) reduces hypertension due to a pheochromocytoma but not that due to other causes, for example, essential hypertension; the blood pressure is raised by the [medical-dictionary.thefreedictionary.com]

  administration or extravasation of norepinephrine. [druglib.com]

• Intravenous Drugs

  Separate data on the introduction of intravenous drug (10 mg in 20 ml isotonic sodium chloride solution; The speed of 1, 3 mg per minute or kapelno to 10 mg / h) as a peripheral vazodilatatora in acute heart failure and hypertension in acute heart attack [lekarstwo.ru]

  […] drip method of drug delivery [...] ^ Hirschfeld S, Hyman HT, Wanger JJ (February 1931). "Influence of velocity on the response to intravenous injections". [en.wikipedia.org]

• Wound Infection

  When epinephrine is accidentally discharged into a digit, ischemic skin necrosis resulting from the alpha-adrenergic blocking effects of this agent can lead to the need for multiple operations, wound infection, and even loss of the digit. [ncbi.nlm.nih.gov]

• Plethora

  Invicorp (Plethora Solutions, London, UK) is a combination of vasoactive intestinal polypeptide (VIP) 25 microg and phentolamine mesylate 1 or 2 mg for ICI in the management of moderate to severe ED. [ncbi.nlm.nih.gov]

• Formication

  Chromatographic separation was carried out on an Acquity UPLC BEH C18 column using an isocratic mobile phase system composed of acetonitrile and 1% formic acid in water (33:67, v/v) at a flow rate of 0.45 mL/min. [ncbi.nlm.nih.gov]

• Female Sexual Dysfunction

  Further studies are needed to assess the potential value of phentolamine and other vasoactive agents in the treatment of female sexual dysfunction. [ncbi.nlm.nih.gov]

The Tmax for lidocaine occurred later and the Cmax for lidocaine was slightly higher when comparing the 4L2P treatment and the 4L treatment. [ncbi.nlm.nih.gov]

[…] if necessary q2-4hr Extravasation Treatment Epinephrine or norepinephrine extravastation treatment Treatment: 5-10 mg in 10 mL NS local injection within 12 hr Prevention: 10 mg for each liter of IV fluids (pressor effect of NE is unaffected) Dental Anesthesia [reference.medscape.com]

Outlook (Prognosis) Most people who have noncancerous tumors that are removed with surgery are still alive after 5 years. The tumors come back in some people. Levels of the hormones norepinephrine and epinephrine return to normal after surgery. [mountsinai.org]

Etiology and management". American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions. 3 (1): 21–31. doi:10.2165/00129784-200303010-00003. PMID 14727943. [en.wikipedia.org]

[…] of ED (organic or psychogenic) the most common form of ED has a mixture of organic and psychogenic origins. 3 Because of the complex etiology of ED, multiple approaches may be necessary to successfully treat the majority of individuals with the disorder [nature.com]

Beijing: 2010 15 Liu CC, Tseng HW, Wang SM, Wang JR and Su IJ: An outbreak of enterovirus 71 infection in Taiwan, 1998: Epidemiologic and clinical manifestations. J Clin Virol. 17:23–30. 2000. [spandidos-publications.com]

^ "Pinkbook | Vaccine Administration | Epidemiology of VPDs | CDC". www.cdc.gov. 25 September 2019. Retrieved 12 September 2020. ^ "Epinephrine Injection". MedlinePlus. Last revised 03/15/2017 ^ Zimmermann PG (February 2010). [en.wikipedia.org]

A case of ruptured pheochromocytoma is presented, the pathophysiology discussed, and the literature reviewed. [ncbi.nlm.nih.gov]

Circulating and/or locally released catecholamines may activate platelets directly via α-adrenoceptor stimulation during stressful physiological and pathophysiological conditions in humans. adrenaline α-adrenoceptors lipolysis phentolamine platelet aggregability [clinsci.org]

Diagnosis of pheochromocytoma and to prevent or control hypertensive episodes prior to or during pheochromocytomectomy. Prevention of dermal necrosis and sloughing following IV administration or extravasation of norepinephrine. [robholland.com]

Prevention or control of hypertensive episodes in the patient with pheochromocytoma. [medicineonline.com]

Its mesylate salt is used intravenously or intramuscularly to prevent and treat hypertension occurring before and during surgery for pheochromocytoma and is also used intravenously to prevent and treat cutaneous necrosis and sloughing when extravasation [medical-dictionary.thefreedictionary.com]

Such results provide a pathway for the development of a prevention strategy for ED. [ncbi.nlm.nih.gov]