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Phenylbutazone


Presentation

  • After taking this treatment for 1 month, she presented with fever, diarrhea, localized edemas, generalized pruritic papular and erythematous rash and lymphadenopathies. She presented the same symptoms after oral intake of metamizole.[ncbi.nlm.nih.gov]
  • The Agency finds that such extralabel use presents a risk to the public health for the purposes of the Animal Medicinal Drug Use Clarification Act of 1994 (AMDUCA).[web.archive.org]
Weight Gain
  • . • Metabolic : Sudden weight gain, swelling of feet and ankles and difficulty in breathing. • Miscellaneous : Bloody or black stools, chills, fever, sore throat, yellowing of the eyes and skin, unusual bleeding or bruising, difficult urination, skin[medindia.net]
Localized Edema
  • After taking this treatment for 1 month, she presented with fever, diarrhea, localized edemas, generalized pruritic papular and erythematous rash and lymphadenopathies. She presented the same symptoms after oral intake of metamizole.[ncbi.nlm.nih.gov]
Swollen Knee
  • She had taken phenylbutazone during 1 month for painful swollen knees.[ncbi.nlm.nih.gov]
Nausea
  • The most frequently reported adverse effects were nausea, vomiting, and headache.[ncbi.nlm.nih.gov]
  • You may get the following symptoms: nausea, vomiting, diarrhoea, abdominal pain, bleeding in your stomach/intestines, headache, ringing in your ears, deafness, difficulty in breathing and seizures (fits).[drugs.com]
  • • Gastrointestinal : Nausea, vomiting and indigestion. • Central Nervous System : Headache, dizziness and drowsiness. • Metabolic : Sudden weight gain, swelling of feet and ankles and difficulty in breathing. • Miscellaneous : Bloody or black stools,[medindia.net]
  • ADVERSE EFFECTS Nausea, vomiting, epigastric distress, diarrhoea, edema due to salt retention, skin rashes, dizziness, drowsiness, headache, and blurred vision.[path.upmc.edu]
Morning Stiffness
  • After six weeks of treatment, morning stiffness, joint symptoms, and grip strength all improved almost equally in both groups.[ncbi.nlm.nih.gov]
Headache
  • The most frequently reported adverse effects were nausea, vomiting, and headache.[ncbi.nlm.nih.gov]
  • . • Central Nervous System : Headache, dizziness and drowsiness. • Metabolic : Sudden weight gain, swelling of feet and ankles and difficulty in breathing. • Miscellaneous : Bloody or black stools, chills, fever, sore throat, yellowing of the eyes and[medindia.net]
  • ADVERSE EFFECTS Nausea, vomiting, epigastric distress, diarrhoea, edema due to salt retention, skin rashes, dizziness, drowsiness, headache, and blurred vision.[path.upmc.edu]
Seizure
  • He developed grand mal seizures, coma, hypotension, respiratory and renal failure, and hepatic injury. Serum phenylbutazone concentration obtained approximately eight hours after presentation was 900 micrograms/mL.[ncbi.nlm.nih.gov]
  • You may get the following symptoms: nausea, vomiting, diarrhoea, abdominal pain, bleeding in your stomach/intestines, headache, ringing in your ears, deafness, difficulty in breathing and seizures (fits).[drugs.com]
  • AND INTESTINAL TRACT Constipation Loss of appetite Nausea MUSCLES AND BONES Muscle spasms Muscle stiffness Neck or face stiffness NERVOUS SYSTEM Drowsiness, coma Difficulty walking Dizziness Fever Hypothermia (body temperature is lower than normal) Seizures[medlineplus.gov]
Convulsions
  • Accidental acute intoxication with phenylbutazone in a 2 1/2-year-old child produced an acute picture of coma, convulsions, diarrhoea, and of cholestatic jaundice which evolved over the succeeding 10 days.[ncbi.nlm.nih.gov]
  • Phenytoin No known manufacture for veterinary use in Canada Convulsions Primidone No known manufacture for veterinary use in Canada Gastrointestinal Bethanechol No known manufacture for veterinary use in Canada Gastrointestinal Dioctyl Sodium Sulfosuccinate[inspection.gc.ca]

Workup

Liver Biopsy
  • Sections of liver biopsy specimens 6 months later showed no granulomas or other pathologic changes. Previously reported cases are reviewed.[ncbi.nlm.nih.gov]

Treatment

  • Patients in all three treatment groups showed significant (P less than 0.05) improvement as early as the third treatment day.[ncbi.nlm.nih.gov]

Etiology

  • Rheumatism of any etiology and localization. Destination Species: Sport equines non destined to human food consumption. Posology: 10 ml. to 20 ml. daily. The dose and duration of treatment depends on the veterinarian doctor criteria.[ekinos.com.ar]

Epidemiology

  • Ross, Epidemiology of Renal Cell Carcinoma, Carcinoma of the Kidney and Testis, and Rare Urologic Malignancies, 10.1007/978-3-642-59839-5_1, (3-13), (1999).[doi.org]
Sex distribution
Age distribution

Prevention

  • By SHIVANI VORA Photo Credit Christopher Lee for The New York Times Making Playgrounds a Little More Dangerous “I came to the counterintuitive conclusion that engaging in risk is actually very important in preventing injuries,” a researcher says.[nytimes.com]
  • Related Disease Conditions Treatment & Diagnosis Medications & Supplements Prevention & Wellness Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA.[medicinenet.com]
  • Toward the primary prevention of cancer. Science. 1991 Nov 22; 254 (5035):1131–1138. [ PubMed ] [ Google Scholar ] Solomon E, Borrow J, Goddard AD. Chromosome aberrations and cancer.[ncbi.nlm.nih.gov]
  • You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week. Take the container with you to the hospital, if possible.[medlineplus.gov]

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