The present study reports the case of a patient belonging to the latter group. To the best of our knowledge, the present study is one of few clearly diagnosed cases of CML combined with Ph− NHL reported between 1980 and the present time (3,7,8). [spandidos-publications.com]

Apa Standard Harvard Vancouver BIBTEX RIS Batista, D, Hawkins, A, Murphy, KM & Griffin, CA 2005, 'BCR/ABL rearrangement in two cases of Philadelphia chromosome negative chronic myeloid leukemia: Deletion on the derivative chromosome 9 may or not be present [jhu.pure.elsevier.com]

We conclude that genomic changes in the bcr gene characteristic of CML can be present in the absence of a Ph1 chromosome. [Indexed for MEDLINE] Free full text [ncbi.nlm.nih.gov]

Case presentation The patient was a 48-year-old man, who initially presented with splenomegaly and leukocytosis with a white blood cell count of 474 K/µL in August, 2010. He was diagnosed with CML, chronic phase. [sci.amegroups.com]

• Splenomegaly

  These patients presented with high white blood cell counts, neutrophilia, occasional basophilia, splenomegaly, and a hypercellular bone marrow with granulocytic hyperplasia and a left shift in myeloid maturation. [ncbi.nlm.nih.gov]

  After 7 months, abrupt increase in leukocyte count (108,000/μ l ) and splenomegaly developed. Decreased neutrophil alkaline phophatase activity and morphological features fulfilled the diagnostic terms for CML. [ci.nii.ac.jp]

  They reported that patients with disease that manifested as AML were less likely to have splenomegaly or peripheral blood basophilia and to have lower bone marrow cellularity and lower myeloid/erythroid ratios than patients with M-BP. [academic.oup.com]

  Splenomegaly, hepatomegaly and mild lymphadenopathy. Abdominal discomfort and acute pain in the left upper quadrant Symptomatic patients (not all). Fever, bone pain, bleeding and sweating. Splenomegaly. Organ infiltration Aggressive presentation. [scielo.br]

  Splenomegaly (Extramedullary hematopoiesis) 가 동반될 수 있다. * 각 그룹마다 Accelerated phase, Blast phase 의 정의가 다르다. [sondoctor.co.kr]

• Pain

  When they occur, signs and symptoms may include: Bone pain Easy bleeding Feeling full after eating a small amount of food Feeling run-down or tired Fever Weight loss without trying Loss of appetite Pain or fullness below the ribs on the left side Excessive [mayoclinic.org]

  Necrotizing periodontal diseases, whose characteristic clinical phenotype includes typical features (papilla necrosis, bleeding, and pain) and are associated with host immune response impairments, remain a distinct periodontitis category. [onlinelibrary.wiley.com]

  Painful chewing. Pus around the teeth. Bad breath. Receding gums. A change in your bite when your lower and upper teeth are together. Teeth that appear longer. If you notice any of these symptoms, you should see your dental care provider. [my.clevelandclinic.org]

  The most common side effects include high blood pressure, rash, abdominal pain, fatigue, headache, dry skin, constipation, fever, joint pain, and nausea. [cancer.net]

• Anemia

  […] complicates bcr-positive CML, the natural history of our 11 Ph-negative, bcr-negative CML patients was characterized by increasing leukemia burden with leukocytosis, pronounced organomegaly, extramedullary infiltrates, and eventual bone marrow failure (anemia [ncbi.nlm.nih.gov]

  Anemia Anemia (low red blood cell count) at diagnosis is a less favourable prognostic factor. Leukemia cells in the bone marrow The prognosis is less favourable if there is a large number of leukemia cells in the bone marrow. [cancer.ca]

  […] in various sources for Philadelphia-negative chronic myeloid leukemia includes the symptoms listed below: • Fever • Fatigue • Weight loss • Enlarged spleen • Blood related abnormalities (Increased white blood cell count, decrease of red blood cells (anemia [checkorphan.org]

• Fatigue

  Symptoms The list of signs and symptoms mentioned in various sources for Philadelphia-negative chronic myeloid leukemia includes the symptoms listed below: • Fever • Fatigue • Weight loss • Enlarged spleen • Blood related abnormalities (Increased white [checkorphan.org]

  The most common side effects include high blood pressure, rash, abdominal pain, fatigue, headache, dry skin, constipation, fever, joint pain, and nausea. [cancer.net]

  In this study, improvements were documented by treating physicians in terms of rash, diarrhea, bone pain, headaches, itching, fatigue, shortness of breath, indigestion, anaphylactic reactions, and spleen size. [clincancerres.aacrjournals.org]

  These include: Fatigue Fever Weight loss Night sweats (excessive sweating while sleeping) Joint or bone pain Some people with CML or Ph-positive ALL have no symptoms, or very mild symptoms, especially in the early stages of the disease. [medlineplus.gov]

  The characteristic symptoms of this disease are chronic fatigue, weight loss, bleeding and fever; whereas signals are anemia, granulocytosis, and immature granulocytes, presence of basophils, thrombocytosis and splenomegaly ( 3 ). [scielo.br]

• Weight Loss

  Symptoms The list of signs and symptoms mentioned in various sources for Philadelphia-negative chronic myeloid leukemia includes the symptoms listed below: • Fever • Fatigue • Weight loss • Enlarged spleen • Blood related abnormalities (Increased white [checkorphan.org]

  When they occur, signs and symptoms may include: Bone pain Easy bleeding Feeling full after eating a small amount of food Feeling run-down or tired Fever Weight loss without trying Loss of appetite Pain or fullness below the ribs on the left side Excessive [mayoclinic.org]

  These include: Fatigue Fever Weight loss Night sweats (excessive sweating while sleeping) Joint or bone pain Some people with CML or Ph-positive ALL have no symptoms, or very mild symptoms, especially in the early stages of the disease. [medlineplus.gov]

  loss and night sweats that had been present for the previous 2 weeks. [spandidos-publications.com]

  The characteristic symptoms of this disease are chronic fatigue, weight loss, bleeding and fever; whereas signals are anemia, granulocytosis, and immature granulocytes, presence of basophils, thrombocytosis and splenomegaly ( 3 ). [scielo.br]

• Fever

  Symptoms The list of signs and symptoms mentioned in various sources for Philadelphia-negative chronic myeloid leukemia includes the symptoms listed below: • Fever • Fatigue • Weight loss • Enlarged spleen • Blood related abnormalities (Increased white [checkorphan.org]

  When they occur, signs and symptoms may include: Bone pain Easy bleeding Feeling full after eating a small amount of food Feeling run-down or tired Fever Weight loss without trying Loss of appetite Pain or fullness below the ribs on the left side Excessive [mayoclinic.org]

  The most common side effects include high blood pressure, rash, abdominal pain, fatigue, headache, dry skin, constipation, fever, joint pain, and nausea. [cancer.net]

  Fever, bone pain, bleeding and sweating. Splenomegaly. Organ infiltration Aggressive presentation. Symptoms similar to those of the accelerated phase worsened. Fever, sweats, bone pain, weakness, loss of sense of well-being and splenomegaly. [scielo.br]

  Signs and symptoms in the chronic phase are as follows: Fatigue, weight loss, loss of energy, decreased exercise tolerance Low-grade fever and excessive sweating from hypermetabolism Elevated white blood cell (WBC) count or splenomegaly on routine assessment [emedicine.medscape.com]

• Diarrhea

  The most common side effects include diarrhea, nausea and vomiting, low levels of blood cells, abdominal pain, fatigue, fever, allergic reactions, and liver problems. Ponatinib (Iclusig). [cancer.net]

  http://www.torsades.org/medical-pros/drug-lists/printable-drug-list.cfm.) 14)Impaired gastrointestinal functions or gastrointestinal diseases that may alter the absorption of the study drug (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea [cris.nih.go.kr]

  In this study, improvements were documented by treating physicians in terms of rash, diarrhea, bone pain, headaches, itching, fatigue, shortness of breath, indigestion, anaphylactic reactions, and spleen size. [clincancerres.aacrjournals.org]

  Less frequent (ie, less than 20%) side effects include diarrhea, alopecia, stomatitis, and neurotoxicity, usually in the form of recent memory loss or depression [91]. [cancernetwork.com]

• Abdominal Pain

  The most common side effects include high blood pressure, rash, abdominal pain, fatigue, headache, dry skin, constipation, fever, joint pain, and nausea. [cancer.net]

  The patient possessed no history of bone or abdominal pains and had received no treatment prior to the onset of the symptoms. [spandidos-publications.com]

  pain from spleen infarction Hepatomegaly The following are signs and symptoms of progressive disease: Bleeding, petechiae, and ecchymoses during the acute phase Bone pain and fever in the blast phase Increasing anemia, thrombocytopenia, basophilia, and [emedicine.medscape.com]

• Nausea

  The most common side effects include high blood pressure, rash, abdominal pain, fatigue, headache, dry skin, constipation, fever, joint pain, and nausea. [cancer.net]

  […] for complete list: http://www.torsades.org/medical-pros/drug-lists/printable-drug-list.cfm.) 14)Impaired gastrointestinal functions or gastrointestinal diseases that may alter the absorption of the study drug (e.g., ulcerative disease, uncontrolled nausea [cris.nih.go.kr]

  Grade 3 nonhematologic adverse events occurring in the subgroup of patients with SM comprised headache (four cases), pain (three cases), dyspnea and pleural effusion (two cases each), and ascites, fatigue, hyperuricemia, nausea/vomiting, palpitations, [clincancerres.aacrjournals.org]

• Constipation

  The most common side effects include high blood pressure, rash, abdominal pain, fatigue, headache, dry skin, constipation, fever, joint pain, and nausea. [cancer.net]

• Hypertension

  Hypertension, hypercholesterolaemia and smoking showed the strongest associations with ACVD (table 2). [jech.bmj.com]

  […] brachycardia at rest(<50 times per minute) -QTcF ≥450msec in three consecutive baseline screening ECGs -History of clinically confirmed myocardial infarction -History of unstable angina pectoris(within past 12 months) -Uncontrolled congestive heart failure or hypertension [cris.nih.go.kr]

  Other clinically significant uncontrolled heart disease (e.g. unstable angina, congestive heart failure or uncontrolled hypertension) 6. [clinicaltrialsregister.eu]

  The side effects include anemia, a low level of white blood cells called neutropenia, a low level of platelets called thrombocytopenia, and lung problems that include fluid around the lung and/or pulmonary hypertension. [cancer.net]

  Sprycel (dasatinib): Drug Safety Communication – Risk of Pulmonary Arterial Hypertension. US Food and Drug Administration. Available at http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm275176.htm. [emedicine.medscape.com]

• Thrombosis

  Association of Blood Banks, American Clinical and Climatological Association, American Society for Clinical Pathology, American Society of Hematology, College of American Pathologists, International Society of Blood Transfusion, International Society on Thrombosis [emedicine.medscape.com]

• Night Sweats

  […] during sleep (night sweats) When to see a doctor Make an appointment with your doctor if you have any persistent signs or symptoms that worry you. [mayoclinic.org]

  These include: Fatigue Fever Weight loss Night sweats (excessive sweating while sleeping) Joint or bone pain Some people with CML or Ph-positive ALL have no symptoms, or very mild symptoms, especially in the early stages of the disease. [medlineplus.gov]

  sweats that had been present for the previous 2 weeks. [spandidos-publications.com]

  sweats, splenomegaly, and anemia. [academic.oup.com]

  Some patients may have fever, night sweats, and progressive enlargement of the spleen. At least 20% of patients enter a blastic phase without evidence of having had accelerated phase [3]. [cancernetwork.com]

• Long Arm

  The literature on translocations involving chromosome 3 and the long arm of chromosome 5 is reviewed. The importance of breakpoints in band 5q31 is discussed. [ncbi.nlm.nih.gov]

  FIGURE Translocation in the BCR-ABL1 geneA) ABL: located on the long arm of chromosome 9. [scielo.br]

  long arm (q) of chromosome 22. [en.wikipedia.org]

  This translocation relocates an oncogene called ABL from the long arm of chromosome 9 to a specific breakpoint cluster region ( BCR ) in the long arm of chromosome 22. The ABL oncogene encodes a tyrosine protein kinase. [emedicine.medscape.com]

  arm in specimens of patients with CML—opened a new era of investigation into genetic abnormalities of human neoplasms. [academic.oup.com]

• Bone Pain

  When they occur, signs and symptoms may include: Bone pain Easy bleeding Feeling full after eating a small amount of food Feeling run-down or tired Fever Weight loss without trying Loss of appetite Pain or fullness below the ribs on the left side Excessive [mayoclinic.org]

  For a bone marrow aspiration, which is usually performed first, the health care provider will insert a needle through the bone and pull out bone marrow fluid and cells. You may feel a sharp but brief pain when the needle is inserted. [medlineplus.gov]

  Abdominal discomfort and acute pain in the left upper quadrant Symptomatic patients (not all). Fever, bone pain, bleeding and sweating. Splenomegaly. Organ infiltration Aggressive presentation. [scielo.br]

  In this study, improvements were documented by treating physicians in terms of rash, diarrhea, bone pain, headaches, itching, fatigue, shortness of breath, indigestion, anaphylactic reactions, and spleen size. [clincancerres.aacrjournals.org]

  […] from spleen infarction Hepatomegaly The following are signs and symptoms of progressive disease: Bleeding, petechiae, and ecchymoses during the acute phase Bone pain and fever in the blast phase Increasing anemia, thrombocytopenia, basophilia, and a [emedicine.medscape.com]

• Arthralgia

  (facial edema, peripheral edema, arthralgia, GI trouble) * Dasatinib : Pleural effusion 등의 독특한 부작용. Pulmonary HTN 인 경우 약제를 영구중단해야 한다. * Nilotinib : Metabolic event 들을 잘 생기게 한다. [sondoctor.co.kr]

• Confusion

  However, the information regarding methods to detect minimal residual disease and its significance may be confusing, and the clinician has to be careful with interpretation of the results. [cancernetwork.com]

  The use of the “log reduction” terminology has led to some degree of 27 confusion since it seems to imply that the value is a relative one. [cml.org.il]

The diagnosis of CML is based on the histopathologic findings in the peripheral blood and the Philadelphia chromosome in bone marrow cells (see Workup ). CML accounts for 20% of all leukemias affecting adults. [emedicine.medscape.com]

Previous relapse during attempt at TFR (Treatment Free Remission) 4. [clinicaltrialsregister.eu]

Doctors want to learn whether the new treatment is safe, effective, and possibly better than the standard treatment. Clinical trials can test a new drug, a new combination of standard treatments, or new doses of standard drugs or other treatments. [cancer.net]

The goals of treatment are to achieve hematologic, cytogenetic, and molecular remission. [emedicine.medscape.com]

Response to treatment Doctors measure how effective the treatment is based on if there is a major cytogenetic response. This means a decrease to 35% or less of the leukemia cells with the Ph chromosome. [cancer.ca]

This may mean your treatment is not working and/or you've become resistant to a certain treatment. The amount of BCR-ABL in your blood or bone marrow is decreasing. This may mean your treatment is working. [medlineplus.gov]

People with chronic myelogenous leukemia (CML) may have questions about their prognosis and survival. Prognosis and survival depend on many factors. [cancer.ca]

We suggest that deletion rather than location of the chimeric gene alone is more likely to be associated with prognosis. [jhu.pure.elsevier.com]

The positive Ph’ chromosome in acute lymphoblastic leukemia has been known to be associated with poor prognosis. [dspace.ewha.ac.kr]

Some authors consider this chromosome as an indicator of poor prognosis, particularly before imatinib was used for treatment [11]. [bloodresearch.or.kr]

The clinical and histopathological signs and the etiology of periodontitis were described. Cross-sectional studies were analyzed to determine when onset of periodontitis most frequently occurs in adults. [ncbi.nlm.nih.gov]

Etiology The etiology of CML is not clear. There is little evidence for genetic factors linked to CML. Offspring of parents with CML do not have a higher incidence of CML than does the general population [19]. [cancernetwork.com]

Several cross-sectional epidemiological studies on the relationship between periodontitis and cardiovascular disease have been performed. [jech.bmj.com]

In this population-based study, we utilized the Surveillance, Epidemiology and End Results (SEER) database to analyze the characteristics and outcomes of BCR/ABL negative CML. [ncbi.nlm.nih.gov]

For more information on CML, see Chronic Myelogenous Leukemia (CML) Guidelines Pathophysiology CML is an acquired abnormality that involves the hematopoietic stem cell. [emedicine.medscape.com]

The data of the CML and ALL patients were analyzed together as they presented the same molecular findings and, according to the present consensus, they correspond to the same pathophysiological process or are even different spectra of the same disease [ncbi.nlm.nih.gov]

New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance. Ann Intern Med. 2006 ; 145 : 913 – 923. 44. Chronic myelogenous leukaemia, BCR-ABL1 positive. In: eds. [academic.oup.com]

A large body of data supports a role for PDGFR TKs in the pathophysiology of several subtypes of MDS and MPD (18). Mutated genes in molecularly defined CEL include those encoding for PDGFRα and PDGFRβ and fibroblast growth factor receptor 1. [clincancerres.aacrjournals.org]

Periodontitis Treatment and Prevention Preventing periodontal disease and the development of gingivitis is rather straight forward. Simply put, prevention is the best periodontal disease treatment. [oralb.com]

Source: National cancer institute Prevention •No known preventive strategies Diagnosis The clinical manifestations of chronic myelogenous leukemia are insidious. [checkorphan.org]

They walked 14 miles to help raise awareness for Veteran suicide prevention. Read the full story » External Link Disclaimer: By clicking on the links above you will leave the Department of Veterans Affairs Website. [benefits.va.gov]

It is a severe and chronic form of gum disease but it can be prevented. What is periodontitis? Periodontitis is a severe and chronic form of gum disease. [my.clevelandclinic.org]

To help prevent or control periodontal diseases, it is important to: Brush and floss every day to remove the bacteria that cause gum disease. [cdc.gov]