Presentation
In addition, hyper- and hypopigmentation are present together, resulting in a polymorphous skin presentation. There have also been severe cases accompanied by fever and a reduced general condition. [ncbi.nlm.nih.gov]
A photoallergic reaction generally presents as an eczema (also called dermatitis ) confined to the areas in contact with the responsible chemical and exposed to the sun. [dermnetnz.org]
Entire Body System
- Inflammation
An interesting new approach to preventative external therapy involves topical application of suitable antioxidants, because pathophysiologically the inflammation reactions are most likely mediated by free radicals generated in the skin. [ncbi.nlm.nih.gov]
- Fever
There have also been severe cases accompanied by fever and a reduced general condition. Differential diagnosis Erythropoietic and hepatic porphyrias must be excluded by determining the level of porphyrins in the blood and urine. [ncbi.nlm.nih.gov]
Skin
- Eczema
Synonym(s) Dermatitis phototoxic; Eczema phototoxic; Photocontact dermatitis; Phototoxic contact eczema; Phototoxic dermatitis; Phototoxic eczema; Phototoxic reaction Definition This section has been translated automatically. [altmeyers.org]
In extreme cases artificial lighting at work can also contribute to continued persistence of the eczema. [ncbi.nlm.nih.gov]
A photoallergic reaction generally presents as an eczema (also called dermatitis ) confined to the areas in contact with the responsible chemical and exposed to the sun. [dermnetnz.org]
- Hyperpigmentation
Often it is only the "cosmetically disturbing" residual hyperpigmentations that lead to a visit to the doctor. Amiodarone leads to grey-blue colour changes of the skin. [altmeyers.org]
Occasionally, however, persistent hyperpigmentation develops. In these cases laser therapy (Rubin laser) can help. Photoallergic dermatitis Photoallergic reactions occur, unlike phototoxicity, only if a specific sensitization has been acquired. [ncbi.nlm.nih.gov]
- Petechiae
Induction of erythema and wheals after radiation with UV-A Differential diagnosis Erythropoietic protoporphyria (diffuse swellings with petechiae rather than wheals, pain, no pruritus), urticarial phototoxic reaction after taking medication, physical [ncbi.nlm.nih.gov]
Treatment
Treatment Treatment is very difficult. The treatment of choice is thalidomide, the use of which must be examined in depth considering the serious adverse reactions (teratogenicity, irreversible neuropathies). [ncbi.nlm.nih.gov]
Phytophotocontact dermatitis What is the treatment for photocontact dermatitis ? The main goal of treatment is to identify the photosensitising agent and if possible to avoid touching it. [dermnetnz.org]
Etiology
They are referred to as idiopathic primary photodermatoses if the etiology is unknown ( 1, 2 ). [ncbi.nlm.nih.gov]
Epidemiology
Larger series have been described in England and Scandinavia although precise epidemiological data are lacking. A familial variant is present in indigenous peoples in North and Latin America ( 15 ). [ncbi.nlm.nih.gov]
Pathophysiology
Repeated solar radiation leads to light hardening that can probably be ascribed to exhaustion of the pathophysiological steps and which is used therapeutically. [ncbi.nlm.nih.gov]
Prevention
Prevention is just as important as treatment. Many diseases are directly or indirectly provoced or exacerbated by sunlight. [ncbi.nlm.nih.gov]